المؤلفون: Abdellah Allali-Hassani, Magdalena M. Szewczyk, Danton Ivanochko, Shawna L. Organ, Jabez Bok, Jessica Sook Yuin Ho, Florence P. H. Gay, Fengling Li, Levi Blazer, Mohammad S. Eram, Levon Halabelian, David Dilworth, Genna M. Luciani, Evelyne Lima-Fernandes, Qin Wu, Peter Loppnau, Nathan Palmer, S. Zakiah A. Talib, Peter J. Brown, Matthieu Schapira, Philipp Kaldis, Ronan C. O’Hagan, Ernesto Guccione, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, John M. Sanders, Solomon D. Kattar, D. Jonathan Bennett, Benjamin Nicholson, Masoud Vedadi

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/38d967925aeb49498c5e1209a2983c26

المؤلفون: Elvin D. de Araujo, Fettah Erdogan, Heidi A. Neubauer, Deniz Meneksedag-Erol, Pimyupa Manaswiyoungkul, Mohammad S. Eram, Hyuk-Soo Seo, Abdul K. Qadree, Johan Israelian, Anna Orlova, Tobias Suske, Ha T. T. Pham, Auke Boersma, Simone Tangermann, Lukas Kenner, Thomas Rülicke, Aiping Dong, Manimekalai Ravichandran, Peter J. Brown, Gerald F. Audette, Sarah Rauscher, Sirano Dhe-Paganon, Richard Moriggl, Patrick T. Gunning

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/f8b672c48f8f4b91911646f53ce84f0b

المؤلفون: Yudao Shen (1476319), Fengling Li (176389), Magdalena M. Szewczyk (3119427), Levon Halabelian (710679), Irene Chau (2276365), Mohammad S. Eram (1399684), Carlo Dela Seña (10151727), Kwang-Su Park (10151730), Fanye Meng (8299767), He Chen (104732), Hong Zeng (24161), Aiping Dong (141147), Hong Wu (105254), Viacheslav V. Trush (10429365), David McLeod (2086192), Carlos A. Zepeda-Velázquez (8805626), Robert M. Campbell (2443825), Mary M. Mader (1398535), Brian M. Watson (2521252), Matthieu Schapira (51934), Cheryl H. Arrowsmith (246847), Rima Al-Awar (9985073), Dalia Barsyte-Lovejoy (1399687), H. Ümit Kaniskan (1476325), Peter J. Brown (499896), Masoud Vedadi (210076), Jian Jin (351142)

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Molecular Biology, Pharmacology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, PRMT 6 functions, Protein Arginine Methyltransferase ., well-characterized PRMT 6 chemical ., PRMT 6, 6870N, PRMT 6 inhibitor, Cell-Active Allosteric Inhibitor, SGC, IC

Relation: https://figshare.com/articles/journal_contribution/A_First-in-Class_Highly_Selective_and_Cell-Active_Allosteric_Inhibitor_of_Protein_Arginine_Methyltransferase_6/14043573

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02160.s001

المؤلفون: Mohammad S. Eram, Benozir Sarafuddin, Frank Gong, Kesen Ma

المصدر: Data in Brief, Vol 5, Iss C, Pp 489-497 (2015)

مصطلحات موضوعية: Acetohydroxyacid synthase, Hyperthermophiles, Thermotoga, Heat-treatment, Computer applications to medicine. Medical informatics, R858-859.7, Science (General), Q1-390

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352340915002127; https://doaj.org/toc/2352-3409

URL الوصول: https://doaj.org/article/3c7a0f63181a4359863bd3df2757b81c

المؤلفون: Mohammad S. Eram, Kesen Ma

المصدر: Biomolecules, Vol 3, Iss 3, Pp 578-596 (2013)

مصطلحات موضوعية: pyruvate decarboxylase, hyperthermophiles, alcohol fermentation, alcohol dehydrogenase, pyruvate ferredoxin oxidoreductase, pyruvate, acetaldehyde, ethanol, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: http://www.mdpi.com/2218-273X/3/3/578; https://doaj.org/toc/2218-273X

URL الوصول: https://doaj.org/article/f7f7c85aaf4b4f5e9a13aa0a2c3646f6

المؤلفون: Jian Jin, Levon Halabelian, Fengling Li, Masoud Vedadi, Rima Al-awar, Carlo C. dela Seña, Mohammad S. Eram, Aiping Dong, Carlos Zepeda-Velázquez, He Chen, Matthieu Schapira, Robert M. Campbell, Dalia Barsyte-Lovejoy, David McLeod, Cheryl H. Arrowsmith, Hong Zeng, Hong Wu, Yudao Shen, Mary M. Mader, Viacheslav V. Trush, Brian Morgan Watson, Kwang-Su Park, Irene Chau, Fanye Meng, Peter Brown, H. Ümit Kaniskan, Magdalena M. Szewczyk

المصدر: J Med Chem

مصطلحات موضوعية: Protein-Arginine N-Methyltransferases, Methyltransferase, Arginine, Stereochemistry, Cell, Allosteric regulation, Crystallography, X-Ray, 01 natural sciences, Article, 03 medical and health sciences, Allosteric Regulation, Drug Discovery, medicine, Humans, Enzyme Inhibitors, IC50, 030304 developmental biology, Benzodiazepinones, 0303 health sciences, Chemistry, Nuclear Proteins, Stereoisomerism, Highly selective, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, HEK293 Cells, medicine.anatomical_structure, Molecular Medicine, Enantiomer, Selectivity, Allosteric Site, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cda514e73beafd941778da58b838824
https://doi.org/10.1021/acs.jmedchem.0c02160

المؤلفون: Mohammad S. Eram, Erica Oduaran, Kesen Ma

المصدر: Archaea, Vol 2014 (2014)

مصطلحات موضوعية: Microbiology, QR1-502

Relation: http://dx.doi.org/10.1155/2014/349379; https://doaj.org/toc/1472-3646; https://doaj.org/toc/1472-3654; https://doaj.org/article/aea6b6b5f5b14d7cbbc2d41adee66e69

الاتاحة: https://doi.org/10.1155/2014/349379
https://doaj.org/article/aea6b6b5f5b14d7cbbc2d41adee66e69

المؤلفون: Fengling Li, Masoud Vedadi, Magdalena Szewczyk, Hong Zeng, H. Ümit Kaniskan, David McLeod, Mohammad S. Eram, Rima Al-awar, Kwang-Su Park, Brian Morgan Watson, Carlo Dela Sena, Mary M. Mader, Carlos Zepeda-Velázquez, He Chen, Matthieu Schapira, Robert M. Campbell, Yudao Shen, Irene Chau, Peter Brown, Cheryl H. Arrowsmith, Jian Jin, Dalia Barsyte-Lovejoy, Levon Halabelian, Fanye Meng

مصطلحات موضوعية: Methyltransferase, medicine.anatomical_structure, Biochemistry, Arginine, Protein-arginine methyltransferase, Chemistry, Allosteric regulation, Cell, medicine, Enantiomer, Highly selective, IC50

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0c02a7bc147f729d2d3ae77ade37b61a
https://doi.org/10.1101/2020.12.04.412569

المؤلفون: Levon Halabelian, Nozomu Sakai, David McLeod, Anne-Claude Gingras, Rima Al-awar, Hiroshi Nara, Dalia Barsyte-Lovejoy, Masoud Vedadi, David Dilworth, Hideto Fukushi, Stéphane Richard, Carlos Zepeda, Cheryl H. Arrowsmith, María Sánchez-Osuna, Ahmed Aman, Carlo C. dela Seña, Kozo Hayashi, Suzanne Ackloo, Magdalena M. Szewczyk, Yoshinori Ishikawa, Peter Brown, Fengling Li, Eric Bonneil, Mike Tyers, Mohammad S. Eram, Masayuki Takizawa, Amber L. Couzens, Shawna Organ, Rachel Harding, Shinji Takagi, Tsukasa Sugo

المصدر: Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)

مصطلحات موضوعية: Protein-Arginine N-Methyltransferases, Arginine, Science, General Physics and Astronomy, Pharmacology, Biology, Methylation, General Biochemistry, Genetics and Molecular Biology, Target validation, Stress signalling, Text mining, Transferases, Stress, Physiological, Cellular stress response, Sf9 Cells, Animals, Humans, HSP70 Heat-Shock Proteins, lcsh:Science, Author Correction, Multidisciplinary, business.industry, General Chemistry, HCT116 Cells, Recombinant Proteins, Gene Knockdown Techniques, lcsh:Q, business, Protein Processing, Post-Translational

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcb412e86f19159fc6fc6183076c9350
http://europepmc.org/articles/PMC7250816

المؤلفون: Hideto Fukushi, Masayuki Takizawa, Shawna Organ, Masoud Vedadi, Peter Brown, Rima Al-awar, Carlo C. dela Seña, Mike Tyers, Carlos Zepeda, Levon Halabelian, David Dilworth, Suzanne Ackloo, Ahmed Aman, Amber L. Couzens, Yoshinori Ishikawa, David Macleod, Nozomu Sakai, Rachel Harding, Stéphane Richard, Tsukasa Sugo, Anne-Claude Gingras, Hiroshi Nara, Fengling Li, Eric Bonneil, Mohammad S. Eram, Cheryl H. Arrowsmith, Shinji Takagi, Dalia Barsyte-Lovejoy, María Sánchez-Osuna, Kozo Hayashi, Magdalena M. Szewczyk

المصدر: Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

مصطلحات موضوعية: 0301 basic medicine, Methyltransferase, Arginine, Science, Cell, General Physics and Astronomy, Methylation, General Biochemistry, Genetics and Molecular Biology, Article, Target validation, 03 medical and health sciences, Stress signalling, 0302 clinical medicine, Transferases, Cellular stress response, medicine, lcsh:Science, Multidisciplinary, Chemistry, General Chemistry, Hsp70, Cell biology, 030104 developmental biology, Proteostasis, medicine.anatomical_structure, Proteasome, 030220 oncology & carcinogenesis, lcsh:Q

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6695ed88c284dadac746547f2c89b8a2
http://europepmc.org/articles/PMC7224190

المؤلفون: Dalia Barsyte-Lovejoy, Yuji Baba, Peter Brown, Atsushi Kiba, Daisuke Tomita, Douglas R. Cary, Aiping Dong, Hong Zeng, Mihoko Kunitomo, Kazuhide Nakayama, Cheryl H. Arrowsmith, Fengling Li, Matthieu Schapira, Mohammad S. Eram, Charles E. Grimshaw, Yasuhiro Imaeda, Carlo C. dela Seña, Kumar Singh Saikatendu, Hong Wu, Akihiro Ohashi, Michiko Tawada, Renato Ferreira de Freitas, Magdalena M. Szewczyk, Masoud Vedadi

المصدر: Oncotarget

مصطلحات موضوعية: 0301 basic medicine, crystal structure, Methyltransferase, Arginine, CARM1, Chemistry, Protein subunit, small molecule inhibitor, Cell cycle, TP-064, Small molecule, 3. Good health, multiple myeloma, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Oncology, Biochemistry, Cell culture, 030220 oncology & carcinogenesis, PRMT4, IC50, Research Paper

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b42f730291d23ed704d496e9284d84
https://doi.org/10.18632/oncotarget.24883

المؤلفون: Zhengtian Yu, Sean Xiao, Dalia Barsyte-Lovejoy, Xiaobao Yang, Peter Atadja, Sun-Joon Min, Kehao Zhao, Matthieu Schapira, Jian Jin, Fengling Li, En Li, Mohammad S. Eram, Xiao Luo, Elena Dobrovetsky, Magdalena M. Szewczyk, Jennifer Lin-Jones, Keith Schmidt, H. Ümit Kaniskan, Miao Dai, Ying Lin, Feng He, David Smil, Feng Liu, Peter Brown, Cheryl H. Arrowsmith, Masoud Vedadi, Irene Zang

المصدر: Journal of Medicinal Chemistry

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Protein-Arginine N-Methyltransferases, Arginine, Protein Conformation, Allosteric regulation, Ribosome, Article, 03 medical and health sciences, Inhibitory Concentration 50, Structure-Activity Relationship, Protein structure, Allosteric Regulation, In vivo, Drug Discovery, Structure–activity relationship, Transferase, Humans, 030102 biochemistry & molecular biology, Chemistry, HEK 293 cells, Hydrogen Bonding, Bridged Bicyclo Compounds, Heterocyclic, 3. Good health, 030104 developmental biology, HEK293 Cells, Biochemistry, Drug Design, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96482bc8dc84f4cb8d89e0561eacbb24
http://europepmc.org/articles/PMC5808361

المؤلفون: Masoud Vedadi, Mohammad S. Eram, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, Levi L. Blazer, Taraneh Hajian

المصدر: Protein Science. 26:662-676

مصطلحات موضوعية: 0301 basic medicine, Genetics, Substrate Specificities, Methyltransferase, Chemistry, MLL1 complex, Computational biology, Biochemistry, 3. Good health, 03 medical and health sciences, 030104 developmental biology, Transcription (biology), WDR5, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3bbc7b0cf791f1c93d19908d755351a2
https://doi.org/10.1002/pro.3129

المؤلفون: Ernesto Guccione, Philipp Kaldis, Dalia Barsyte-Lovejoy, Danton Ivanochko, Magdalena M. Szewczyk, David Dilworth, Matthieu Schapira, Peter Loppnau, S. Zakiah A. Talib, Fengling Li, Solomon Kattar, Levon Halabelian, Ronan C. O'Hagan, Jabez Bok, Levi L. Blazer, Evelyne Lima-Fernandes, Genna M. Luciani, Nathan Palmer, Mohammad S. Eram, Cheryl H. Arrowsmith, Benjamin Nicholson, John M. Sanders, Peter Brown, Abdellah Allali-Hassani, Masoud Vedadi, Shawna Organ, Jessica Sook Yuin Ho, D. Jonathan Bennett, Qin Wu

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Genome instability, S-Adenosylmethionine, Subfamily, Methyltransferase, Science, Protein domain, General Physics and Astronomy, Molecular Dynamics Simulation, Crystallography, X-Ray, medicine.disease_cause, Gene, Article, General Biochemistry, Genetics and Molecular Biology, PR Domain, Histones, Inhibitory Concentration 50, 03 medical and health sciences, 0302 clinical medicine, Protein Domains, Transferases, Histone post-translational modifications, medicine, Humans, Enzyme Inhibitors, lcsh:Science, PRDM9, Multidisciplinary, biology, Drug discovery, Chemistry, HEK 293 cells, Histone-Lysine N-Methyltransferase, General Chemistry, DNA Methylation, 3. Good health, Cell biology, Histone, HEK293 Cells, 030104 developmental biology, Molecular Probes, 030220 oncology & carcinogenesis, biology.protein, lcsh:Q, Chemical tools, Carcinogenesis

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a33e807d4565f7990902109995ea70c8
https://vb.gamtc.lt/GTC:ELABAPDB54740056&prefLang=en_US

المؤلفون: Masoud Vedadi, Carlo C. dela Seña, Fengling Li, Alice Shi Ming Li, Mohammad S. Eram, Albina Bolotokova

المصدر: Methods (San Diego, Calif.). 175

مصطلحات موضوعية: Protein-Arginine N-Methyltransferases, S-Adenosylmethionine, Methyltransferase, Arginine, Chemical probe, Peptide, General Biochemistry, Genetics and Molecular Biology, Histones, 03 medical and health sciences, Transcription (biology), Neoplasms, Humans, Enzyme Inhibitors, Molecular Biology, Phylogeny, 030304 developmental biology, Cell Proliferation, Enzyme Assays, chemistry.chemical_classification, 0303 health sciences, Chemistry, F-Box Proteins, 030302 biochemistry & molecular biology, DNA Damage Repair, Kinetics, Biochemistry, RNA Splicing Factors, Methyl donor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::053203cbaf728b6ecc1a476927a6140c
https://pubmed.ncbi.nlm.nih.gov/31809836

المؤلفون: Gary G. Chiang, Masoud Vedadi, Alberto Martin, Dalia Barsyte-Lovejoy, William N. Pappano, Cheryl H. Arrowsmith, Alexander Nuber, Vijayaratnam Santhakumar, Kenneth M. Comess, Judd C. Rice, Maricel Torrent, Gunnar Schotta, Peter Brown, Conglei Li, Anup K. Upadhyay, Fengling Li, Alex R Shoemaker, Ramzi F. Sweis, Mikkel Algire, Yujia Dai, Loren M. Lasko, Taylor R H Mitchell, Creighton T. Tuzon, Kenneth D. Bromberg, Mohammad S. Eram, Michael R. Michaelides, Niru B. Soni, Clarissa G. Jakob, Chaohong Sun, Manisha A Jhala, Vlasios Manaves

المصدر: Nature Chemical Biology. 13:317-324

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Methyltransferase, DNA Repair, DNA repair, Crystallography, X-Ray, Heterocyclic Compounds, 4 or More Rings, Methylation, Genomic Instability, Epigenesis, Genetic, 03 medical and health sciences, Transcription (biology), Cell Line, Tumor, Histone H2A, Humans, Epigenetics, Enzyme Inhibitors, Molecular Biology, Molecular Structure, biology, Histone-Lysine N-Methyltransferase, Cell Biology, Cell biology, 030104 developmental biology, Histone, Histone methyltransferase, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa83d9f95eebf4a7288c158fbe1c7aaf
https://doi.org/10.1038/nchembio.2282

المؤلفون: H. Ümit Kaniskan, Renato Ferreira de Freitas, David Smil, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, Jian Jin, Matthieu Schapira, Magdalena M. Szewczyk, Jing Liu, Fengling Li, Mohammad S. Eram, Guillermo Senisterra, Masoud Vedadi, Yudao Shen, Peter Brown

المصدر: Journal of Medicinal Chemistry. 59:9124-9139

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Protein-Arginine N-Methyltransferases, Methyltransferase, Arginine, Cell, Chemical biology, Crystallography, X-Ray, Article, 03 medical and health sciences, Drug Discovery, medicine, Humans, Epigenetics, Enzyme Inhibitors, Drug discovery, Chemistry, HEK 293 cells, Dual inhibitor, Nuclear Proteins, 3. Good health, HEK293 Cells, 030104 developmental biology, medicine.anatomical_structure, Biochemistry, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70502fd9eeb5026b08b88d95ed7a959f
https://doi.org/10.1021/acs.jmedchem.6b01033

المؤلفون: Mohammad S. Eram, Kesen Ma

المصدر: Biochemistry and Biophysics Reports. 7:394-399

مصطلحات موضوعية: 0301 basic medicine, Pyruvate decarboxylation, chemistry.chemical_classification, Pyruvate dehydrogenase kinase, biology, 030106 microbiology, Biophysics, Acetohydroxyacid synthase, Pyruvate dehydrogenase phosphatase, biology.organism_classification, Biochemistry, Pyruvate decarboxylase activity, 03 medical and health sciences, Enzyme, chemistry, Thermotoga maritima, Hyperthermophiles, Phosphofructokinase 2, Pyruvate decarboxylase, health care economics and organizations

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce7faae50d853ecf189df19187e02cb5

المؤلفون: Renato Ferreira de Freitas, Masoud Vedadi, David Smil, Steven Kennedy, Matthieu Schapira, Magdalena M. Szewczyk, Mohammad S. Eram, Cheryl H. Arrowsmith, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Peter Brown

المصدر: Journal of Medicinal Chemistry. 59:6838-6847

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Virtual screening, Methyltransferase, Dose-Response Relationship, Drug, Molecular Structure, CARM1, Arginine, Chemistry, HEK 293 cells, Drug Evaluation, Preclinical, Ligand (biochemistry), CARD Signaling Adaptor Proteins, Structure-Activity Relationship, 03 medical and health sciences, HEK293 Cells, 030104 developmental biology, Biochemistry, Guanylate Cyclase, Drug Discovery, Coactivator, Humans, Molecular Medicine, Structure–activity relationship, Enzyme Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0baca3658c1531e16f9dcadae6fa7b
https://doi.org/10.1021/acs.jmedchem.6b00668

المؤلفون: Peter Loppnau, Elisa Gibson, Masoud Vedadi, Matthieu Schapira, Cheryl H. Arrowsmith, Evelyne Lima-Fernandes, Levi L. Blazer, Mohammad S. Eram

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, Methyltransferase, substrate specificity, Lysine, Mutation, Missense, Biochemistry, Methylation, Serine, Histones, 03 medical and health sciences, Gene Duplication, Histone methylation, Humans, histone modification, histone methylation, Tyrosine, Molecular Biology, PRDM9, biology, epigenetics, zinc finger, Cell Biology, Histone-Lysine N-Methyltransferase, 030104 developmental biology, Histone, HEK293 Cells, Amino Acid Substitution, Mutagenesis, Histone methyltransferase, biology.protein, Enzymology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1144351be53db649355f9a3f3cb86787
http://europepmc.org/articles/PMC4919437