نتائج البحث - "Modena, A."

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PipEracillin Tazobactam Versus MERoPENem for Treatment of Bloodstream Infections Caused by Cephalosporin-resistant Enterobacteriaceae (PETERPEN) (PETERPEN)

المؤلفون: Rabin Medical Center, University of Modena and Reggio Emilia, Tel Aviv Medical Center, Meir Medical Center, Soroka University Medical Center, The Chaim Sheba Medical Center, McGill University Health Centre/Research Institute of the McGill University Health Centre, Jewish General Hospital, Canadian Institutes of Health Research (CIHR), Hadassah Medical Organization

المصدر: Piperacillin Tazobactam Versus Meropenem for Treatment of Bloodstream Infections Caused by Cephalosporin-resistant Enterobacteriaceae- a Non-inferiority Randomized Controlled Trial
Bitterman R, Koppel F, Mussini C, Geffen Y, Chowers M, Rahav G, Nesher L, Ben-Ami R, Turjeman A, Huberman Samuel M, Cheng MP, Lee TC, Leibovici L, Yahav D, Paul M. Piperacillin-tazobactam versus meropenem for treatment of bloodstream infections caused by third-generation cephalosporin-resistant Enterobacteriaceae: a study protocol for a non-inferiority open-label randomised controlled trial (PeterPen). BMJ Open. 2021 Feb 8;11(2):e040210. doi: 10.1136/bmjopen-2020-040210.

View record in ClinicalTrials.gov

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Early-access Avacopan in Real-world ANCA-associated Vasculitis (AVAC-EUR)

المؤلفون: University of Udine, University of Modena and Reggio Emilia, Hospital Universitari de Bellvitge, ZOL Hospital Genk Belgium

المساهمون: Y.K.Onno Teng, Clinical Professor

المصدر: Evaluating Clinical Practice of Early Access Avacopan Treatment for ANCA-associated Vasculitis in European Countries

View record in ClinicalTrials.gov

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Dual Anti-glutamate Therapy in Super-refractory Status Epilepticus After Cardiac Arrest (SUPER-CAT)

المؤلفون: Azienda Ospedaliera San Gerardo di Monza, Azienda Ospedaliero-Universitaria di Modena, Azienda Ospedaliera Universitaria Integrata Verona, Ospedale Centrale Bolzano, Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, Azienda Ospedaliero-Universitaria Careggi, Azienda Ospedaliero-Universitaria di Parma, Santa Chiara Hospital, Ospedale M. Bufalini Cesena, Azienda Ospedaliera Brotzu, Istituto Di Ricerche Farmacologiche Mario Negri

المصدر: SUPER-refractory Status Epilepticus After Cardiac Arrest: a Multicenter, Retrospective, Cohort Study of Dual Anti-glutamate Therapy with Ketamine and Perampanel
Mani R, Schmitt SE, Mazer M, Putt ME, Gaieski DF. The frequency and timing of epileptiform activity on continuous electroencephalogram in comatose post-cardiac arrest syndrome patients treated with therapeutic hypothermia. Resuscitation. 2012 Jul;83(7):840-7. doi: 10.1016/j.resuscitation.2012.02.015. Epub 2012 Feb 23.
Lybeck A, Friberg H, Aneman A, Hassager C, Horn J, Kjaergaard J, Kuiper M, Nielsen N, Ullen S, Wise MP, Westhall E, Cronberg T; TTM-trial Investigators. Prognostic significance of clinical seizures after cardiac arrest and target temperature management. Resuscitation. 2017 May;114:146-151. doi: 10.1016/j.resuscitation.2017.01.017. Epub 2017 Feb 3.
Cronberg T. Should Postanoxic Status Epilepticus Be Treated Agressively? Yes! J Clin Neurophysiol. 2015 Dec;32(6):449-51. doi: 10.1097/WNP.0000000000000209.
Dragancea I, Wise MP, Al-Subaie N, Cranshaw J, Friberg H, Glover G, Pellis T, Rylance R, Walden A, Nielsen N, Cronberg T; TTM trial investigators. Protocol-driven neurological prognostication and withdrawal of life-sustaining therapy after cardiac arrest and targeted temperature management. Resuscitation. 2017 Aug;117:50-57. doi: 10.1016/j.resuscitation.2017.05.014. Epub 2017 May 12.
Ruijter BJ, Keijzer HM, Tjepkema-Cloostermans MC, Blans MJ, Beishuizen A, Tromp SC, Scholten E, Horn J, van Rootselaar AF, Admiraal MM, van den Bergh WM, Elting JJ, Foudraine NA, Kornips FHM, van Kranen-Mastenbroek VHJM, Rouhl RPW, Thomeer EC, Moudrous W, Nijhuis FAP, Booij SJ, Hoedemaekers CWE, Doorduin J, Taccone FS, van der Palen J, van Putten MJAM, Hofmeijer J; TELSTAR Investigators. Treating Rhythmic and Periodic EEG Patterns in Comatose Survivors of Cardiac Arrest. N Engl J Med. 2022 Feb 24;386(8):724-734. doi: 10.1056/NEJMoa2115998.
Leitinger M, Trinka E, Gardella E, Rohracher A, Kalss G, Qerama E, Hofler J, Hess A, Zimmermann G, Kuchukhidze G, Dobesberger J, Langthaler PB, Beniczky S. Diagnostic accuracy of the Salzburg EEG criteria for non-convulsive status epilepticus: a retrospective study. Lancet Neurol. 2016 Sep;15(10):1054-62. doi: 10.1016/S1474-4422(16)30137-5. Epub 2016 Aug 8.
Nolan JP, Sandroni C, Bottiger BW, Cariou A, Cronberg T, Friberg H, Genbrugge C, Haywood K, Lilja G, Moulaert VRM, Nikolaou N, Mariero Olasveengen T, Skrifvars MB, Taccone F, Soar J. European Resuscitation Council and European Society of Intensive Care Medicine Guidelines 2021: Post-resuscitation care. Resuscitation. 2021 Apr;161:220-269. doi: 10.1016/j.resuscitation.2021.02.012. Epub 2021 Mar 24. Erratum In: Resuscitation. 2021 Oct;167:109-110. doi: 10.1016/j.resuscitation.2021.08.013.
Dragancea I, Backman S, Westhall E, Rundgren M, Friberg H, Cronberg T. Outcome following postanoxic status epilepticus in patients with targeted temperature management after cardiac arrest. Epilepsy Behav. 2015 Aug;49:173-7. doi: 10.1016/j.yebeh.2015.04.043. Epub 2015 Jun 24.
Beretta S, Coppo A, Bianchi E, Zanchi C, Carone D, Stabile A, Padovano G, Sulmina E, Grassi A, Bogliun G, Foti G, Ferrarese C, Pesenti A, Beghi E, Avalli L. Neurologic outcome of postanoxic refractory status epilepticus after aggressive treatment. Neurology. 2018 Dec 4;91(23):e2153-e2162. doi: 10.1212/WNL.0000000000006615. Epub 2018 Oct 31.
Beretta S, Padovano G, Stabile A, Coppo A, Bogliun G, Avalli L, Ferrarese C. Efficacy and safety of perampanel oral loading in postanoxic super-refractory status epilepticus: A pilot study. Epilepsia. 2018 Oct;59 Suppl 2:243-248. doi: 10.1111/epi.14492. Epub 2018 Aug 29.

View record in ClinicalTrials.gov

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Crosscultural Adaptation And Validation Of The Italian Version Of The New Knee Society Knee Scoring System (KSS-ITALIAN)

المؤلفون: Ortopedia e Traumatologia - AO Ordine Mauriziano - Torino, Traumatologia dello Sport - Campus Bio-medico- Roma, Ortopedia e traumatologia - Policlinico di Modena, Ortopedia e Traumatologia-Istituto IFCA Firenze, Ortopedia e Traumatologia-Fondazione Poliambulanza Istituto Ospedaliero Brescia

المصدر: Crosscultural Adaptation And Validation Of The Italian Version Of The New Knee Society Knee Scoring System
Goh GS, Liow MHL, Bin Abd Razak HR, Tay DK, Lo NN, Yeo SJ. Patient-Reported Outcomes, Quality of Life, and Satisfaction Rates in Young Patients Aged 50 Years or Younger After Total Knee Arthroplasty. J Arthroplasty. 2017 Feb;32(2):419-425. doi: 10.1016/j.arth.2016.07.043. Epub 2016 Aug 10.

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Bone Health in Aging HIV Infected Women (BEING)

المؤلفون: University of Modena and Reggio Emilia, San Raffaele University Hospital, Italy, Gilead Sciences, CIHR Canadian HIV Trials Network

المساهمون: University Health Network-Toronto General Hospital, Professor of Medicine

المصدر: Bone Health in Aging HIV Infected Women: Improvement or Prevention of Changes in Bone Mineral Density by Switching Antiretroviral Agents. Is There an Optimal Time to Intervene?
Walmsley S, Clarke R, Lee T, Singer J, Cheung AM, Smaill F, De Pokomandy A, Trottier S, Messina E, Guaraldi G. BEING: Bone Health in Aging Women with HIV: Impact of Switching Antiretroviral Therapy on Bone Mineral Density During the Perimenopausal Period. AIDS Res Hum Retroviruses. 2023 Apr;39(4):204-210. doi: 10.1089/AID.2022.0106. Epub 2023 Jan 20.

View record in ClinicalTrials.gov

6

Patent

Melanocortin agents for use in the therapeutic treatment of melanoma, tumors of the gastrointestinal tract, and thyroid carcinoma

View record in USPTO Patent Grants

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Compactly supported anomalous weak solutions for 2D Euler equations with vorticity in Hardy spaces

المؤلفون: Buck, Miriam, Modena, Stefano

مصطلحات موضوعية: Mathematics - Analysis of PDEs, 35Q31

URL الوصول: http://arxiv.org/abs/2405.19214

View record in Arxiv

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Clinical Application and Usability of Blood Biomarkers As Screening Tool in Alzheimer Disease: a Validation Study (BIOVALID-AD)

المؤلفون: Istituto Superiore di Sanità, Azienda Ospedaliera dei Colli, Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo, A.O.U. Città della Salute e della Scienza, Neurologia Arzignano AULSS8 Berica, Azienda Ospedaliero-Universitaria di Modena

المساهمون: Marra Camillo, Professor

المصدر: Clinical Application and Usability of Blood Biomarkers As Screening Tool in Alzheimer Disease: a Validation Study

View record in ClinicalTrials.gov

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TeleNEURO-Rehabilitation Systems for Neurodegenerative Conditions: the FIT4TeleNEURO Pragmatic Trial (FIT4TeleNEURO)

المؤلفون: Fondazione Don Carlo Gnocchi Onlus, IRCCS Milano, Fondazione Don Carlo Gnocchi Onlus, Centro S Maria della Provvidenza, Roma, Istituto Neurologico Nazionale IRCCS Casimiro Mondino, Pavia, Italy, Istituti Clinici Scientifici Maugeri SpA, IRCCS Bari, Istituti Clinici Scientifici Maugeri SpA, IRCCS Pavia, Istituti Clinici Scientifici Maugeri SpA, IRCCS Milano, Istituti Clinici Scientifici Maugeri SpA, IRCCS Montescano, Istituti Clinici Scientifici Maugeri SpA, IRCCS Telese, IRCCS Azienda Ospedaliera Universitaria San Martino - Genova, University of Modena and Reggio Emilia, Centro Riabilitativo Villa Beretta

المصدر: Effectiveness of TeleNEUROrehabilitation Systems for Timely and Personalized Interventions and Vigilant Care in Neurodegenerative Conditions: the FIT4TeleNEURO Pragmatic Trial

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Open-label, Pivotal Clinical Trial to Confirm Efficacy and Safety of Autologous Grafts Containing Stem Cells Genetically Modified for Epidermis Restoration in Patients With Junctional Epidermolysis Bullosa (HOLOGENE 5)

المؤلفون: IRCCS San Raffaele, University of Modena and Reggio Emilia

المصدر: Multicentre, Open-label, Uncontrolled, Pivotal Clinical Trial to Confirm the Efficacy and Safety of Autologous Fibrin-cultured Epidermal Grafts Containing Epidermal Stem Cells Genetically Modified for Restoration of Epidermis in Patients With Junctional Epidermolysis Bullosa

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Clinical Trial to Assess the Safety and Efficacy of Investigational Product in Patients Due to Hypospadias Treatment Failure (HOLOUR)

المؤلفون: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, University of Modena and Reggio Emilia

المصدر: Prospective, Open-label, Uncontrolled Pilot Clinical Trial to Assess the Safety and Efficacy of Autologous Cultured Oral Mucosa Grafts for Urethral Reconstruction in Patients Due to Hypospadias Treatment Failure

View record in ClinicalTrials.gov

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Using NLP and Neural Networks to Autonomously Identify Severe Asthma and Determine Study Eligibility in a Large Healthcare System

المؤلفون: GlaxoSmithKline, Scripps Health, Modena Allergy + Asthma, La Jolla, CA, University of California, San Diego

المساهمون: Yusuf Ozturk, Professor

المصدر: Using NLP and Neural Networks to Autonomously Identify Severe Asthma and Determine Study Eligibility in a Large Healthcare System

View record in ClinicalTrials.gov

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The Effectiveness of Eptinezumab During a Migraine Attack (the BE-FREE Study): a TACHIS Sub-study (BEFREE)

المؤلفون: Società italiana per lo studio delle Cefalee (SISC), Fondazione Policlinico Universitario Campus Bio-Medico, Azienda Ospedaliero Universitaria Policlinico Modena, SISC RICe Group

المساهمون: Luigi Francesco Iannone, Researcher

المصدر: The Effectiveness of Eptinezumab During a Migraine Attack (the BE-FREE Study): a TACHIS Sub-study
Winner PK, McAllister P, Chakhava G, Ailani J, Ettrup A, Krog Josiassen M, Lindsten A, Mehta L, Cady R. Effects of Intravenous Eptinezumab vs Placebo on Headache Pain and Most Bothersome Symptom When Initiated During a Migraine Attack: A Randomized Clinical Trial. JAMA. 2021 Jun 15;325(23):2348-2356. doi: 10.1001/jama.2021.7665.

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Contrast Enhancement Mammography vs MRI for the Surveillance of Women at High Risk of Breast Cancer: Con-trust Randomized Controlled Trial (CEM)

المؤلفون: Istituto Oncologico Veneto I.O.V. - I.R.C.C.S., Azienda Ospedaliera Universitaria (AOU) Messina, Azienda Ospedaliera Universitaria (AOU) Bari, Azienda Ospedaliera Universitaria Integrata Verona, Fondazione IRCCS Policlinico San Matteo di Pavia, Azienda Ospedaliero-Universitaria di Modena, Azienda USL della Romagna, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

المساهمون: Paolo Giorgi Rossi, Doctor of Philosophy Managing Director at Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia

المصدر: Comparison Between Contrast-Enhanced Mammography and Magnetic Resonance Imaging in the Surveillance of High-Risk Women for Breast Cancer: The Randomized Controlled Trial 'Con-trust. Funded by European Commission NextGenerationEU - Ministero Della Salute PNRR: M6/C2_CALL 2023 Full Proposal
Alonso-Coello P, Schunemann HJ, Moberg J, Brignardello-Petersen R, Akl EA, Davoli M, Treweek S, Mustafa RA, Rada G, Rosenbaum S, Morelli A, Guyatt GH, Oxman AD; GRADE Working Group. GRADE Evidence to Decision (EtD) frameworks: a systematic and transparent approach to making well informed healthcare choices. 1: Introduction. BMJ. 2016 Jun 28;353:i2016. doi: 10.1136/bmj.i2016. No abstract available.
Cortesi L, Baldassarri B, Ferretti S, Razzaboni E, Bella M, Bucchi L, Canuti D, De Iaco P, De Santis G, Falcini F, Galli V, Godino L, Leoni M, Perrone AM, Pignatti M, Saguatti G, Santini D, Sassoli de'Bianchi P, Sebastiani F, Taffurelli M, Tazzioli G, Turchetti D, Zamagni C, Naldoni C. A regional population-based hereditary breast cancer screening tool in Italy: First 5-year results. Cancer Med. 2020 Apr;9(7):2579-2589. doi: 10.1002/cam4.2824. Epub 2020 Feb 11.
Houssami N, Zackrisson S, Blazek K, Hunter K, Bernardi D, Lang K, Hofvind S. Meta-analysis of prospective studies evaluating breast cancer detection and interval cancer rates for digital breast tomosynthesis versus mammography population screening. Eur J Cancer. 2021 May;148:14-23. doi: 10.1016/j.ejca.2021.01.035. Epub 2021 Mar 9.
Thompson RP. The medical career structure in 1985. J R Coll Physicians Lond. 1985 Jan;19(1):31-3. No abstract available.
Armaroli P, Frigerio A, Correale L, Ponti A, Artuso F, Casella D, Falco P, Favettini E, Fonio P, Giordano L, Marra V, Milanesio L, Morra L, Presti P, Riggi E, Vergini V, Segnan N. A randomised controlled trial of digital breast tomosynthesis vs digital mammography as primary screening tests: Screening results over subsequent episodes of the Proteus Donna study. Int J Cancer. 2022 Nov 15;151(10):1778-1790. doi: 10.1002/ijc.34161. Epub 2022 Jun 30.
Pattacini P, Nitrosi A, Giorgi Rossi P, Duffy SW, Iotti V, Ginocchi V, Ravaioli S, Vacondio R, Mancuso P, Ragazzi M, Campari C; RETomo Working Group. A Randomized Trial Comparing Breast Cancer Incidence and Interval Cancers after Tomosynthesis Plus Mammography versus Mammography Alone. Radiology. 2022 May;303(2):256-266. doi: 10.1148/radiol.211132. Epub 2022 Feb 1.
Liao GJ, Henze Bancroft LC, Strigel RM, Chitalia RD, Kontos D, Moy L, Partridge SC, Rahbar H. Background parenchymal enhancement on breast MRI: A comprehensive review. J Magn Reson Imaging. 2020 Jan;51(1):43-61. doi: 10.1002/jmri.26762. Epub 2019 Apr 19.
Eriksson M, Czene K, Vachon C, Conant EF, Hall P. Long-Term Performance of an Image-Based Short-Term Risk Model for Breast Cancer. J Clin Oncol. 2023 May 10;41(14):2536-2545. doi: 10.1200/JCO.22.01564. Epub 2023 Mar 17.
Eriksson M, Czene K, Strand F, Zackrisson S, Lindholm P, Lang K, Fornvik D, Sartor H, Mavaddat N, Easton D, Hall P. Identification of Women at High Risk of Breast Cancer Who Need Supplemental Screening. Radiology. 2020 Nov;297(2):327-333. doi: 10.1148/radiol.2020201620. Epub 2020 Sep 8.
Gastounioti A, Desai S, Ahluwalia VS, Conant EF, Kontos D. Artificial intelligence in mammographic phenotyping of breast cancer risk: a narrative review. Breast Cancer Res. 2022 Feb 20;24(1):14. doi: 10.1186/s13058-022-01509-z.
van Geel K, Kok EM, Krol JP, Houben IPL, Thibault FE, Pijnappel RM, van Merrienboer JJG, Lobbes MBI. Reversal of the hanging protocol of Contrast Enhanced Mammography leads to similar diagnostic performance yet decreased reading times. Eur J Radiol. 2019 Aug;117:62-68. doi: 10.1016/j.ejrad.2019.05.013. Epub 2019 May 15.
Geach R, Jones LI, Harding SA, Marshall A, Taylor-Phillips S, McKeown-Keegan S, Dunn JA; FAST MRI Study Group. The potential utility of abbreviated breast MRI (FAST MRI) as a tool for breast cancer screening: a systematic review and meta-analysis. Clin Radiol. 2021 Feb;76(2):154.e11-154.e22. doi: 10.1016/j.crad.2020.08.032. Epub 2020 Sep 30.
Kuhl CK. Abbreviated Magnetic Resonance Imaging (MRI) for Breast Cancer Screening: Rationale, Concept, and Transfer to Clinical Practice. Annu Rev Med. 2019 Jan 27;70:501-519. doi: 10.1146/annurev-med-121417-100403.
Rotili A, Trimboli RM, Penco S, Pesapane F, Tantrige P, Cassano E, Sardanelli F. Double reading of diffusion-weighted magnetic resonance imaging for breast cancer detection. Breast Cancer Res Treat. 2020 Feb;180(1):111-120. doi: 10.1007/s10549-019-05519-y. Epub 2020 Jan 14.
Trimboli RM, Verardi N, Cartia F, Carbonaro LA, Sardanelli F. Breast cancer detection using double reading of unenhanced MRI including T1-weighted, T2-weighted STIR, and diffusion-weighted imaging: a proof of concept study. AJR Am J Roentgenol. 2014 Sep;203(3):674-81. doi: 10.2214/AJR.13.11816.
Patel BK, Gray RJ, Pockaj BA. Potential Cost Savings of Contrast-Enhanced Digital Mammography. AJR Am J Roentgenol. 2017 Jun;208(6):W231-W237. doi: 10.2214/AJR.16.17239. Epub 2017 Apr 5.
James JR, Pavlicek W, Hanson JA, Boltz TF, Patel BK. Breast Radiation Dose With CESM Compared With 2D FFDM and 3D Tomosynthesis Mammography. AJR Am J Roentgenol. 2017 Feb;208(2):362-372. doi: 10.2214/AJR.16.16743.
Haas JS, Hill DA, Wellman RD, Hubbard RA, Lee CI, Wernli KJ, Stout NK, Tosteson AN, Henderson LM, Alford-Teaster JA, Onega TL. Disparities in the use of screening magnetic resonance imaging of the breast in community practice by race, ethnicity, and socioeconomic status. Cancer. 2016 Feb 15;122(4):611-7. doi: 10.1002/cncr.29805. Epub 2015 Dec 28.
Morrell BL, Morrell MB, Ball JA, Ochoa AC, Seewaldt VL. Disparities in the use of screening breast magnetic resonance imaging persist in Louisiana after the Affordable Care Act: A question of access, policy, institutional support, or something else? Cancer. 2023 Mar 15;129(6):829-833. doi: 10.1002/cncr.34605. Epub 2023 Jan 12.
Wernli KJ, Callaway KA, Henderson LM, Kerlikowske K, Lee JM, Ross-Degnan D, Wallace JK, Wharam JF, Zhang F, Stout NK. Trends in screening breast magnetic resonance imaging use among US women, 2006 to 2016. Cancer. 2020 Dec 15;126(24):5293-5302. doi: 10.1002/cncr.33140. Epub 2020 Sep 28.
Expert Panel on Breast Imaging; Weinstein SP, Slanetz PJ, Lewin AA, Battaglia T, Chagpar AB, Dayaratna S, Dibble EH, Goel MS, Hayward JH, Kubicky CD, Le-Petross HT, Newell MS, Sanford MF, Scheel JR, Vincoff NS, Yao K, Moy L. ACR Appropriateness Criteria(R) Supplemental Breast Cancer Screening Based on Breast Density. J Am Coll Radiol. 2021 Nov;18(11S):S456-S473. doi: 10.1016/j.jacr.2021.09.002.
Hurson AN, Pal Choudhury P, Gao C, Husing A, Eriksson M, Shi M, Jones ME, Evans DGR, Milne RL, Gaudet MM, Vachon CM, Chasman DI, Easton DF, Schmidt MK, Kraft P, Garcia-Closas M, Chatterjee N; B-CAST Risk Modelling Group. Prospective evaluation of a breast-cancer risk model integrating classical risk factors and polygenic risk in 15 cohorts from six countries. Int J Epidemiol. 2022 Jan 6;50(6):1897-1911. doi: 10.1093/ije/dyab036. Epub 2021 Mar 23.
Brentnall AR, Evans DG, Cuzick J. Distribution of breast cancer risk from SNPs and classical risk factors in women of routine screening age in the UK. Br J Cancer. 2014 Feb 4;110(3):827-8. doi: 10.1038/bjc.2013.747. Epub 2014 Jan 21. No abstract available.
Sardanelli F, Podo F, Santoro F, Manoukian S, Bergonzi S, Trecate G, Vergnaghi D, Federico M, Cortesi L, Corcione S, Morassut S, Di Maggio C, Cilotti A, Martincich L, Calabrese M, Zuiani C, Preda L, Bonanni B, Carbonaro LA, Contegiacomo A, Panizza P, Di Cesare E, Savarese A, Crecco M, Turchetti D, Tonutti M, Belli P, Maschio AD; High Breast Cancer Risk Italian 1 (HIBCRIT-1) Study. Multicenter surveillance of women at high genetic breast cancer risk using mammography, ultrasonography, and contrast-enhanced magnetic resonance imaging (the high breast cancer risk italian 1 study): final results. Invest Radiol. 2011 Feb;46(2):94-105. doi: 10.1097/RLI.0b013e3181f3fcdf.
Sardanelli F, Boetes C, Borisch B, Decker T, Federico M, Gilbert FJ, Helbich T, Heywang-Kobrunner SH, Kaiser WA, Kerin MJ, Mansel RE, Marotti L, Martincich L, Mauriac L, Meijers-Heijboer H, Orecchia R, Panizza P, Ponti A, Purushotham AD, Regitnig P, Del Turco MR, Thibault F, Wilson R. Magnetic resonance imaging of the breast: recommendations from the EUSOMA working group. Eur J Cancer. 2010 May;46(8):1296-316. doi: 10.1016/j.ejca.2010.02.015. Epub 2010 Mar 19.
Schunemann HJ, Lerda D, Dimitrova N, Alonso-Coello P, Grawingholt A, Quinn C, Follmann M, Mansel R, Sardanelli F, Rossi PG, Lebeau A, Nystrom L, Broeders M, Ioannidou-Mouzaka L, Duffy SW, Borisch B, Fitzpatrick P, Hofvind S, Castells X, Giordano L, Warman S, Saz-Parkinson Z; European Commission Initiative on Breast Cancer Contributor Group. Methods for Development of the European Commission Initiative on Breast Cancer Guidelines: Recommendations in the Era of Guideline Transparency. Ann Intern Med. 2019 Aug 20;171(4):273-280. doi: 10.7326/M18-3445. Epub 2019 Jul 23.
Sardanelli F, Cozzi A, Trimboli RM, Schiaffino S. Gadolinium Retention and Breast MRI Screening: More Harm Than Good? AJR Am J Roentgenol. 2020 Feb;214(2):324-327. doi: 10.2214/AJR.19.21988. Epub 2019 Dec 4.
Lamb LR, Bahl M. Evidence-Based Pragmatic Approach to the Management of Borderline or High-Risk Breast Lesions. AJR Am J Roentgenol. 2022 Jan;218(1):186-187. doi: 10.2214/AJR.21.26340. Epub 2021 Jul 21.
Yala A, Mikhael PG, Lehman C, Lin G, Strand F, Wan YL, Hughes K, Satuluru S, Kim T, Banerjee I, Gichoya J, Trivedi H, Barzilay R. Optimizing risk-based breast cancer screening policies with reinforcement learning. Nat Med. 2022 Jan;28(1):136-143. doi: 10.1038/s41591-021-01599-w. Epub 2022 Jan 13.
Kerlikowske K, Chen S, Golmakani MK, Sprague BL, Tice JA, Tosteson ANA, Rauscher GH, Henderson LM, Buist DSM, Lee JM, Gard CC, Miglioretti DL. Cumulative Advanced Breast Cancer Risk Prediction Model Developed in a Screening Mammography Population. J Natl Cancer Inst. 2022 May 9;114(5):676-685. doi: 10.1093/jnci/djac008.
Bakker MF, de Lange SV, Pijnappel RM, Mann RM, Peeters PHM, Monninkhof EM, Emaus MJ, Loo CE, Bisschops RHC, Lobbes MBI, de Jong MDF, Duvivier KM, Veltman J, Karssemeijer N, de Koning HJ, van Diest PJ, Mali WPTM, van den Bosch MAAJ, Veldhuis WB, van Gils CH; DENSE Trial Study Group. Supplemental MRI Screening for Women with Extremely Dense Breast Tissue. N Engl J Med. 2019 Nov 28;381(22):2091-2102. doi: 10.1056/NEJMoa1903986.

View record in ClinicalTrials.gov

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Gepant TreAtments: EffectIveNess and TolERability (GAINER) (GAINER)

المؤلفون: IRCCS National Neurological Institute 'C. Mondino' Foundation, Società italiana per lo studio delle Cefalee (SISC), Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, Università degli Studi dell'Aquila, University of Roma La Sapienza, Azienda Ospedaliero Universitaria Policlinico Modena, Ospedale di Piove di Sacco, Azienda Ospedaliero-Universitaria di Parma, Azienda Ospedaliera S. Maria della Misericordia, A.O.U. Città della Salute e della Scienza, Cliniche Humanitas Gavazzeni, University of Campania Luigi Vanvitelli, Ospedale di Prato, Azienda Policlinico Umberto I, Auxologico San Luca, Milano, Asst Degli Spedali Civili Di Brescia, Carlo Besta Neurological Institute

المساهمون: Luigi Francesco Iannone, Researcher

المصدر: Effectiveness and Tolerability of Rimegepant As Acute Migraine Treatment: a Prospective, Multicentric, Cohort Study (GAINER)
Lipton RB, Croop R, Stock EG, Stock DA, Morris BA, Frost M, Dubowchik GM, Conway CM, Coric V, Goadsby PJ. Rimegepant, an Oral Calcitonin Gene-Related Peptide Receptor Antagonist, for Migraine. N Engl J Med. 2019 Jul 11;381(2):142-149. doi: 10.1056/NEJMoa1811090.
Croop R, Goadsby PJ, Stock DA, Conway CM, Forshaw M, Stock EG, Coric V, Lipton RB. Efficacy, safety, and tolerability of rimegepant orally disintegrating tablet for the acute treatment of migraine: a randomised, phase 3, double-blind, placebo-controlled trial. Lancet. 2019 Aug 31;394(10200):737-745. doi: 10.1016/S0140-6736(19)31606-X. Epub 2019 Jul 13.
Lipton RB, Blumenfeld A, Jensen CM, Croop R, Thiry A, L'Italien G, Morris BA, Coric V, Goadsby PJ. Efficacy of rimegepant for the acute treatment of migraine based on triptan treatment experience: Pooled results from three phase 3 randomized clinical trials. Cephalalgia. 2023 Feb;43(2):3331024221141686. doi: 10.1177/03331024221141686.

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Effect of Increasing Total Antioxidant Capacity in Autism Spectrum Disorder (TACASD)

المؤلفون: University of Modena and Reggio Emilia, Indonesia University, RSUP Dr. Wahidin Sudirohusodo

المساهمون: Rinvil Renaldi, MD, Child and Adolescent Psychiatrist

المصدر: Randomized, Placebo-controlled, Double-blind Study of Increasing Total Antioxidant Capacity with Vitamin E and C in Two Cohorts of Patients with Autism Spectrum Disorders
Persico AM, Arango C, Buitelaar JK, Correll CU, Glennon JC, Hoekstra PJ, Moreno C, Vitiello B, Vorstman J, Zuddas A; European Child and Adolescent Clinical Psychopharmacology Network. Unmet needs in paediatric psychopharmacology: Present scenario and future perspectives. Eur Neuropsychopharmacol. 2015 Oct;25(10):1513-31. doi: 10.1016/j.euroneuro.2015.06.009. Epub 2015 Jun 20.
Adams JB, Audhya T, McDonough-Means S, Rubin RA, Quig D, Geis E, Gehn E, Loresto M, Mitchell J, Atwood S, Barnhouse S, Lee W. Effect of a vitamin/mineral supplement on children and adults with autism. BMC Pediatr. 2011 Dec 12;11:111. doi: 10.1186/1471-2431-11-111.
Zambrelli E, Lividini A, Spadavecchia S, Turner K, Canevini MP. Effects of Supplementation With Antioxidant Agents on Sleep in Autism Spectrum Disorder: A Review. Front Psychiatry. 2021 Jun 28;12:689277. doi: 10.3389/fpsyt.2021.689277. eCollection 2021.
Wang L, Wang B, Wu C, Wang J, Sun M. Autism Spectrum Disorder: Neurodevelopmental Risk Factors, Biological Mechanism, and Precision Therapy. Int J Mol Sci. 2023 Jan 17;24(3):1819. doi: 10.3390/ijms24031819.
Vargason T, Kruger U, Roth E, Delhey LM, Tippett M, Rose S, Bennuri SC, Slattery JC, Melnyk S, James SJ, Frye RE, Hahn J. Comparison of Three Clinical Trial Treatments for Autism Spectrum Disorder Through Multivariate Analysis of Changes in Metabolic Profiles and Adaptive Behavior. Front Cell Neurosci. 2018 Dec 19;12:503. doi: 10.3389/fncel.2018.00503. eCollection 2018.
Traber MG. Vitamin E: necessary nutrient for neural development and cognitive function. Proc Nutr Soc. 2021 Aug;80(3):319-326. doi: 10.1017/S0029665121000914. Epub 2021 Apr 26.
Teleanu DM, Niculescu AG, Lungu II, Radu CI, Vladacenco O, Roza E, Costachescu B, Grumezescu AM, Teleanu RI. An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases. Int J Mol Sci. 2022 May 25;23(11):5938. doi: 10.3390/ijms23115938.
Silvestrini A, Meucci E, Ricerca BM, Mancini A. Total Antioxidant Capacity: Biochemical Aspects and Clinical Significance. Int J Mol Sci. 2023 Jul 1;24(13):10978. doi: 10.3390/ijms241310978.
Pangrazzi L, Balasco L, Bozzi Y. Natural Antioxidants: A Novel Therapeutic Approach to Autism Spectrum Disorders? Antioxidants (Basel). 2020 Nov 26;9(12):1186. doi: 10.3390/antiox9121186.
Hughes HK, R J Moreno, Ashwood P. Innate immune dysfunction and neuroinflammation in autism spectrum disorder (ASD). Brain Behav Immun. 2023 Feb;108:245-254. doi: 10.1016/j.bbi.2022.12.001. Epub 2022 Dec 6.
Liu X, Lin J, Zhang H, Khan NU, Zhang J, Tang X, Cao X, Shen L. Oxidative Stress in Autism Spectrum Disorder-Current Progress of Mechanisms and Biomarkers. Front Psychiatry. 2022 Mar 1;13:813304. doi: 10.3389/fpsyt.2022.813304. eCollection 2022.
Logan SL, Carpenter L, Leslie RS, Garrett-Mayer E, Hunt KJ, Charles J, Nicholas JS. Aberrant Behaviors and Co-occurring Conditions as Predictors of Psychotropic Polypharmacy among Children with Autism Spectrum Disorders. J Child Adolesc Psychopharmacol. 2015 May;25(4):323-36. doi: 10.1089/cap.2013.0119. Epub 2015 Apr 28.
Lee KH, Cha M, Lee BH. Neuroprotective Effect of Antioxidants in the Brain. Int J Mol Sci. 2020 Sep 28;21(19):7152. doi: 10.3390/ijms21197152.
Imataka G, Yui K, Shiko Y, Kawasaki Y, Sasaki H, Shiroki R, Yoshihara S. Urinary and Plasma Antioxidants in Behavioral Symptoms of Individuals With Autism Spectrum Disorder. Front Psychiatry. 2021 Sep 3;12:684445. doi: 10.3389/fpsyt.2021.684445. eCollection 2021.
Goel R, Hong JS, Findling RL, Ji NY. An update on pharmacotherapy of autism spectrum disorder in children and adolescents. Int Rev Psychiatry. 2018 Feb;30(1):78-95. doi: 10.1080/09540261.2018.1458706. Epub 2018 Apr 25.
Gabriele S, Sacco R, Persico AM. Blood serotonin levels in autism spectrum disorder: a systematic review and meta-analysis. Eur Neuropsychopharmacol. 2014 Jun;24(6):919-29. doi: 10.1016/j.euroneuro.2014.02.004. Epub 2014 Feb 19.
Frye RE. Mitochondrial Dysfunction in Autism Spectrum Disorder: Unique Abnormalities and Targeted Treatments. Semin Pediatr Neurol. 2020 Oct;35:100829. doi: 10.1016/j.spen.2020.100829. Epub 2020 Jun 23.
Doyle CA, McDougle CJ. Pharmacologic treatments for the behavioral symptoms associated with autism spectrum disorders across the lifespan. Dialogues Clin Neurosci. 2012 Sep;14(3):263-79. doi: 10.31887/DCNS.2012.14.3/cdoyle.
Cucinotta F, Ricciardello A, Turriziani L, Mancini A, Keller R, Sacco R, Persico AM. Efficacy and Safety of Q10 Ubiquinol With Vitamins B and E in Neurodevelopmental Disorders: A Retrospective Chart Review. Front Psychiatry. 2022 Mar 3;13:829516. doi: 10.3389/fpsyt.2022.829516. eCollection 2022.
Chauhan A, Chauhan V. Oxidative stress in autism. Pathophysiology. 2006 Aug;13(3):171-81. doi: 10.1016/j.pathophys.2006.05.007. Epub 2006 Jun 12.
Casanova MF, Frye RE, Gillberg C, Casanova EL. Editorial: Comorbidity and Autism Spectrum Disorder. Front Psychiatry. 2020 Nov 20;11:617395. doi: 10.3389/fpsyt.2020.617395. eCollection 2020. No abstract available.
Baraskewich J, von Ranson KM, McCrimmon A, McMorris CA. Feeding and eating problems in children and adolescents with autism: A scoping review. Autism. 2021 Aug;25(6):1505-1519. doi: 10.1177/1362361321995631. Epub 2021 Mar 2.
Aishworiya R, Valica T, Hagerman R, Restrepo B. An Update on Psychopharmacological Treatment of Autism Spectrum Disorder. Neurotherapeutics. 2022 Jan;19(1):248-262. doi: 10.1007/s13311-022-01183-1. Epub 2022 Jan 14.
Bjorklund G, Waly MI, Al-Farsi Y, Saad K, Dadar M, Rahman MM, Elhoufey A, Chirumbolo S, Jozwik-Pruska J, Kaluzna-Czaplinska J. The Role of Vitamins in Autism Spectrum Disorder: What Do We Know? J Mol Neurosci. 2019 Mar;67(3):373-387. doi: 10.1007/s12031-018-1237-5. Epub 2019 Jan 3.

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Genetics and Environment INtersection in the ALS-FTD Spectrum: an Italian Twins Cohort StudY with a Multi-Omics Approach (GENIALITY)

المؤلفون: A.O.U. Città della Salute e della Scienza - Molinette Hospital, Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria Careggi, Firenze

المساهمون: JESSICA MANDRIOLI, Prof

المصدر: Genetics and Environment INtersection in the Amyotrophic Lateral Sclerosis - FrontoTemporal Dementia Spectrum: an Italian Twins Cohort StudY with a Multi-Omics Approach

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Rapamycin Treatment for ALS (RAP-ALS)

المؤلفون: University of Modena and Reggio Emilia, Azienda Ospedaliero Universitaria Maggiore della Carita, IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy, University of Turin, Italy, Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta, Azienda Ospedaliera Niguarda Cà Granda, Fondazione Salvatore Maugeri, University of Padova

المساهمون: JESSICA MANDRIOLI, MD, PI

المصدر: Rapamycin (Sirolimus) Treatment for Amyotrophic Lateral Sclerosis
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Chio A, Hammond ER, Mora G, Bonito V, Filippini G. Development and evaluation of a clinical staging system for amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2015 Jan;86(1):38-44. doi: 10.1136/jnnp-2013-306589. Epub 2013 Dec 13.
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Cloughesy TF, Yoshimoto K, Nghiemphu P, Brown K, Dang J, Zhu S, Hsueh T, Chen Y, Wang W, Youngkin D, Liau L, Martin N, Becker D, Bergsneider M, Lai A, Green R, Oglesby T, Koleto M, Trent J, Horvath S, Mischel PS, Mellinghoff IK, Sawyers CL. Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma. PLoS Med. 2008 Jan 22;5(1):e8. doi: 10.1371/journal.pmed.0050008.
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Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, Pahor M, Javors MA, Fernandez E, Miller RA. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature. 2009 Jul 16;460(7253):392-5. doi: 10.1038/nature08221. Epub 2009 Jul 8.
Kimura F, Fujimura C, Ishida S, Nakajima H, Furutama D, Uehara H, Shinoda K, Sugino M, Hanafusa T. Progression rate of ALSFRS-R at time of diagnosis predicts survival time in ALS. Neurology. 2006 Jan 24;66(2):265-7. doi: 10.1212/01.wnl.0000194316.91908.8a.
Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, Tanida I, Ueno T, Koike M, Uchiyama Y, Kominami E, Tanaka K. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature. 2006 Jun 15;441(7095):880-4. doi: 10.1038/nature04723. Epub 2006 Apr 19.
Lattante S, de Calbiac H, Le Ber I, Brice A, Ciura S, Kabashi E. Sqstm1 knock-down causes a locomotor phenotype ameliorated by rapamycin in a zebrafish model of ALS/FTLD. Hum Mol Genet. 2015 Mar 15;24(6):1682-90. doi: 10.1093/hmg/ddu580. Epub 2014 Nov 19.
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Thomas M, Alegre-Abarrategui J, Wade-Martins R. RNA dysfunction and aggrephagy at the centre of an amyotrophic lateral sclerosis/frontotemporal dementia disease continuum. Brain. 2013 May;136(Pt 5):1345-60. doi: 10.1093/brain/awt030. Epub 2013 Mar 9.
Wang IF, Guo BS, Liu YC, Wu CC, Yang CH, Tsai KJ, Shen CK. Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43. Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):15024-9. doi: 10.1073/pnas.1206362109. Epub 2012 Aug 29.
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