المؤلفون: Ricardo Ramirez, Li Li, William E. Delaney, Stephan Menne, Sarina Ma, Changsuek Yon, Don Kang, Jason Chamberlain, Christian Voitenleitner, William Rowe, Ruth Chu, Dhivya Ramakrishnan, Magdeleine Hung, Manasa Suresh, Divya Pattabiraman, Stephane Daffis, Paul J. Cote, Rex Santos, Bei Li, Simon P. Fletcher, Scott Balsitis, Sandra Spurlock, Mish Michael R, Jim Zheng, Richard L. Mackman

المصدر: Hepatology (Baltimore, Md.)

مصطلحات موضوعية: 0301 basic medicine, Agonist, medicine.drug_class, Viral Hepatitis, viruses, Pharmacology, Virus Replication, medicine.disease_cause, Antiviral Agents, 03 medical and health sciences, Hepatitis B, Chronic, 0302 clinical medicine, Immune system, Antigen, medicine, Animals, Hepatitis B Virus, Woodchuck, Humans, Hepatitis Antibodies, Hepatitis B virus, Hepatology, biology, business.industry, Woodchuck hepatitis virus, Hepatitis Antigens, Original Articles, biochemical phenomena, metabolism, and nutrition, Hepatitis B, biology.organism_classification, medicine.disease, digestive system diseases, Disease Models, Animal, Pyrimidines, 030104 developmental biology, Toll-Like Receptor 8, Marmota, DNA, Viral, biology.protein, Original Article, 030211 gastroenterology & hepatology, Antibody, Hexanols, business, Viral load

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4412f0d4ba1f1e34adb633cd495c9bc8
https://doi.org/10.1002/hep.31255

المؤلفون: Peter Abbink, Jinyan Liu, Mish Michael R, Po-Ting Liu, Noe B. Mercado, Dan H. Barouch, Joseph Hesselgesser, Elena Bekerman, Erica N. Borducchi, Brandon F. Keele, Abishek Chandrashekar, Gregory Chin, Esther A. Bondzie, Romas Geleziunas

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications

مصطلحات موضوعية: CD4-Positive T-Lymphocytes, Male, 0301 basic medicine, Viral rebound, viruses, Simian Acquired Immunodeficiency Syndrome, General Physics and Astronomy, HIV Infections, Virus Replication, law.invention, 0302 clinical medicine, Retrovirus, law, lcsh:Science, Lymph node, Multidisciplinary, biology, RNA sequencing, Viral Load, Provirus, Virus Latency, medicine.anatomical_structure, Anti-Retroviral Agents, Recombinant DNA, Female, Simian Immunodeficiency Virus, Patient Dropouts, Science, Peripheral blood mononuclear cell, Article, General Biochemistry, Genetics and Molecular Biology, Virus, Viral reservoirs, 03 medical and health sciences, medicine, Animals, Humans, business.industry, General Chemistry, biology.organism_classification, Macaca mulatta, Virology, Discontinuation, 030104 developmental biology, HIV-1, lcsh:Q, business, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1171507b0cb0f660261c5c3bb2e89c
http://link.springer.com/article/10.1038/s41467-020-19254-2

المؤلفون: Wanchi Fung, Kobayashi Tetsuya, Anita Niedziela-Majka, Bob Jiang, Kim Jordan, Saritha Kusam, David G. Breckenridge, Hai Yang, Britton Kenneth Corkey, Kristyna Elbel, Chin Tay, Elaine Kan, Sammy Metobo, David Sperandio, Du Jinfa, Richard M. Neve, Sophia L. Shevick, Eric B. Lansdon, Kerim Babaoglu, Gregory Chin, Heather Webb, Debi Jin, Annapurna Sapre, Vangelis Aktoudianakis, Latesh Lad, Jamie Bates, Xiaowu Chen, Jeff Zablocki, Gene Eisenberg, Nate Larson, Richard L. Mackman, Martinez Ruben, Magdeleine Hung, Zachary Newby, Mish Michael R

المصدر: Bioorganic & Medicinal Chemistry. 27:457-469

مصطلحات موضوعية: Benzimidazole, BRD4, Cell Survival, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Protein Domains, Cell Line, Tumor, Drug Discovery, Animals, Humans, Potency, Tumor growth, Epigenetics, Molecular Biology, Cell Proliferation, Dose-Response Relationship, Drug, Molecular Structure, Aryl, Organic Chemistry, Isoxazoles, Neoplasms, Experimental, Bioavailability, Bromodomain, chemistry, Molecular Medicine, Benzimidazoles, Multiple Myeloma, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32393d33e86182931fa91168f5389d3c
https://doi.org/10.1016/j.bmc.2018.11.020

المؤلفون: Jean-Yves Christophe Chiva, Peter Pyun, Andrew John Keats, Linos Lazarides, Karine G. Poullennec, Neil Andrew Dunbar, Brian E. Schultz, Mingzhe Ji, Gregory M. Watt, Karki Kapil Kumar, Ruby Cai, Carina E. Cannizzaro, Uli Schmitz, David Kenneth Dean, Yu-Jen Lee, Sangi Michael, Victoria Alexandra Steadman, Adam J. Schrier, Simon B. Pettit, Hans G. Fliri, Adrian John Highton, Todd C. Appleby, Carol Austin, Richard L. Mackman, Caroline A. Blakemore, Hui Hon Chung, Dustin Siegel, Gregory Chin, Bernard P. Murray, Hai Yang, Yang Tian, George Stepan, Jonathan Sanvoisin, Albert Liclican, Mish Michael R, David Sperandio, Rex Santos, Petr Jansa, Haolun Jin

المصدر: Journal of Medicinal Chemistry. 61:9473-9499

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Protein Conformation, Administration, Oral, Biological Availability, Hepacivirus, Isomerase, Pharmacology, Antiviral Agents, 01 natural sciences, Virus, Cell Line, Cyclophilins, Lactones, 03 medical and health sciences, Protein structure, Drug Discovery, Spiro Compounds, Enzyme Inhibitors, Cyclophilin, 010405 organic chemistry, Chemistry, Total synthesis, 0104 chemical sciences, Bioavailability, Ring size, 030104 developmental biology, Cell culture, Drug Design, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f349698a38c7c9924d318620a6fcc5d2
https://doi.org/10.1021/acs.jmedchem.8b00802

المؤلفون: Todd Appleby, Martijn Fenaux, Thomas Butler, Mark Charles Whitcomb, Gregory Chin, Rick Lee, Gabriel Birkus, Aesop Cho, Michael O'neil Hanrahan Clarke, Thorsten A. Kirschberg, Darius Babusis, Vangelis Aktoudianakis, Lijun Zhang, Thomas E. Edwards, Eisuke Murakami, Jie Xu, Choung U. Kim, Daniel Byun, Neil H. Squires, Edward Doerffler, Willard Lew, Adrian S. Ray, Joy Y. Feng, Ona Barauskas, Sammy Metobo, Ting Wang, Huiling Yang, Yeojin Park, Mish Michael R, Neeraj Tirunagari, Hong Ye

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:1840-1847

مصطلحات موضوعية: 0301 basic medicine, Halogenation, 030106 microbiology, Clinical Biochemistry, Mutant, Pharmaceutical Science, Hepacivirus, Viral Nonstructural Proteins, Virus Replication, Antiviral Agents, Methylation, Biochemistry, Cell Line, 03 medical and health sciences, Cricetinae, Drug Resistance, Viral, Drug Discovery, medicine, Animals, Humans, Point Mutation, Phosphoric Acids, Prodrugs, Nucleotide, Molecular Biology, chemistry.chemical_classification, Chemistry, Organic Chemistry, Nucleosides, Phosphoramidate, Prodrug, Amides, Hepatitis C, Adenosine, Molecular Docking Simulation, Molecular Medicine, Caco-2 Cells, Nucleoside, Isopropyl, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c64ac988d715937da5d9882b1446f78
https://doi.org/10.1016/j.bmcl.2017.02.037

المؤلفون: Choung U. Kim, Lijun Zhang, Ke-Yu Wang, Adrian S. Ray, Mish Michael R, Aesop Cho, Martijn Fenaux, Yeojin Park, Darius Babusis, Joy Y. Feng, Thorsten A. Kirschberg, Neil H. Squires

المصدر: Bioorganic & Medicinal Chemistry Letters. 25:1040-1043

مصطلحات موضوعية: Halogenation, Pyrimidine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Hepacivirus, Antiviral Agents, Methylation, Biochemistry, Cell Line, chemistry.chemical_compound, Pyrimidine analogue, Drug Discovery, Humans, Phosphoric Acids, Prodrugs, Replicon, Molecular Biology, Polymerase, biology, Organic Chemistry, Cytidine, Phosphoramidate, Prodrug, Pyrimidine Nucleosides, RNA-Dependent RNA Polymerase, Amides, Hepatitis C, chemistry, biology.protein, Molecular Medicine, Derivative (chemistry)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e929ee839d0aa724863d04acd3ded658
https://doi.org/10.1016/j.bmcl.2015.01.021

المؤلفون: Aesop Cho, Adrian S. Ray, Yeojin Park, Joy Y. Feng, Martijn Fenaux, Mish Michael R, Darius Babusis, Jie Xu, C. Sebastian Zonte, Choung U. Kim, Thorsten A. Kirschberg

المصدر: Bioorganic & Medicinal Chemistry Letters. 24:3092-3095

مصطلحات موضوعية: Pyrimidine, Hepacivirus, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, RNA-dependent RNA polymerase, Microbial Sensitivity Tests, Viral Nonstructural Proteins, Antiviral Agents, Biochemistry, Ns5b polymerase, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Structure–activity relationship, heterocyclic compounds, Nucleotide, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Dose-Response Relationship, Drug, biology, organic chemicals, Organic Chemistry, Nucleosides, Phosphoramidate, Prodrug, Pyrimidine Nucleosides, RNA-Dependent RNA Polymerase, biology.organism_classification, chemistry, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a3272769c70034b0a5ae29f0250dfa0
https://doi.org/10.1016/j.bmcl.2014.05.015

المؤلفون: Manuel Tsiang, Matthew R. Wright, Choung U. Kim, Salman Y. Jabri, Sammy Metobo, Haolun Jin, Xiaowu Chen, Mish Michael R, Rachael A. Lansdown

المصدر: Bioorganic & Medicinal Chemistry Letters. 19:1187-1190

مصطلحات موضوعية: Anti-HIV Agents, Stereochemistry, Clinical Biochemistry, Human immunodeficiency virus (HIV), Administration, Oral, Pharmaceutical Science, medicine.disease_cause, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Drug Discovery, medicine, Animals, Humans, Potency, Pyrroles, HIV Integrase Inhibitors, Molecular Biology, chemistry.chemical_classification, Molecular Structure, Organic Chemistry, Rats, chemistry, Drug Design, Quinolines, Lactam, Molecular Medicine, Tricyclic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5aab536bd1fb1b3651b5924978573b1
https://doi.org/10.1016/j.bmcl.2008.12.079

المؤلفون: Choung U. Kim, Richard W. Pastor, Matthew R. Wright, Haolun Jin, Salman Y. Jabri, Peter Pyun, Sammy Metobo, Rachael A. Lansdown, Manuel Tsiang, Ruby Cai, Xiaowu Chen, Mish Michael R

المصدر: Bioorganic & Medicinal Chemistry Letters. 18:1388-1391

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Integrase inhibitor, Crystallography, X-Ray, Biochemistry, Dogs, Oral administration, Raltegravir Potassium, Drug Discovery, medicine, Animals, Humans, HIV Integrase Inhibitors, Organic Chemicals, Molecular Biology, chemistry.chemical_classification, biology, Organic Chemistry, Sulfonamide (medicine), biology.organism_classification, Pyrrolidinones, Rats, Integrase, stomatognathic diseases, Enzyme, chemistry, Enzyme inhibitor, Lentivirus, Azacitidine, biology.protein, Molecular Medicine, Tricyclic, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ece5ac258a10ac3035a295370face10
https://doi.org/10.1016/j.bmcl.2008.01.018