المؤلفون: Krzysztof M. Zak, Mark J. Bostock, Irena Waligorska, Ida B. Thøgersen, Jan J. Enghild, Grzegorz M. Popowicz, Przemyslaw Grudnik, Jan Potempa, Miroslaw Ksiazek

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1267-1281 (2021)

مصطلحات موضوعية: periodontitis, proteolysis, tannerella forsythia, nmr-based fragment screening, protease inhibitors, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

URL الوصول: https://doaj.org/article/facc41ee0c7f40019822708c69e05cfb

المؤلفون: Tibisay Guevara, Arturo Rodriguez-Banqueri, Miroslaw Ksiazek, Jan Potempa, F. Xavier Gomis-Rüth

المصدر: IUCrJ, Vol 7, Iss 1, Pp 18-29 (2020)

مصطلحات موضوعية: pappalysin family, metallopeptidases, mirolysin, peridontopathogens, zymogens, catalytic mechanisms, Crystallography, QD901-999

وصف الملف: electronic resource

Relation: http://scripts.iucr.org/cgi-bin/paper?S2052252519013848; https://doaj.org/toc/2052-2525

URL الوصول: https://doaj.org/article/25296af507af4334ad354c0e4cb88394

المؤلفون: Mariusz Madej, Zuzanna Nowakowska, Miroslaw Ksiazek, Anna M. Lasica, Danuta Mizgalska, Magdalena Nowak, Anna Jacula, Monika Bzowska, Carsten Scavenius, Jan J. Enghild, Joseph Aduse-Opoku, Michael A. Curtis, F. Xavier Gomis-Rüth, Jan Potempa

المصدر: mBio, Vol 12, Iss 1 (2021)

مصطلحات موضوعية: Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2161-2129; https://doaj.org/toc/2150-7511

URL الوصول: https://doaj.org/article/da74c30a8ca24a36ba46e4f453049b0e

المؤلفون: Stanislaw Malicki, Miroslaw Ksiazek, Pawel Majewski, Aleksandra Pecak, Piotr Mydel, Przemyslaw Grudnik, Grzegorz Dubin

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 638-643 (2019)

مصطلحات موضوعية: aptamer, ssdna, trypsin, protease inhibitor, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

URL الوصول: https://doaj.org/article/bdf17d8dea0e4e3a9c78cd0b1d122473

المؤلفون: Rielana Wichert, Anna Ermund, Stefanie Schmidt, Matthias Schweinlin, Miroslaw Ksiazek, Philipp Arnold, Katharina Knittler, Frederike Wilkens, Barbara Potempa, Björn Rabe, Marit Stirnberg, Ralph Lucius, Jörg W. Bartsch, Susanna Nikolaus, Maren Falk-Paulsen, Philip Rosenstiel, Marco Metzger, Stefan Rose-John, Jan Potempa, Gunnar C. Hansson, Peter J. Dempsey, Christoph Becker-Pauly

المصدر: Cell Reports, Vol 21, Iss 8, Pp 2090-2103 (2017)

مصطلحات موضوعية: host-microbiome interaction, mucus, intestinal mucus barrier, ectodomain shedding, metalloprotease, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124717315504; https://doaj.org/toc/2211-1247

URL الوصول: https://doaj.org/article/b24e999113e241ad82f86e3fbecdd8d3

المؤلفون: Anna M. Lasica, Miroslaw Ksiazek, Mariusz Madej, Jan Potempa

المصدر: Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)

مصطلحات موضوعية: secretion, T9SS, Porphyromonas gingivalis, pathogenesis, gliding motility, proteins, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fcimb.2017.00215/full; https://doaj.org/toc/2235-2988

URL الوصول: https://doaj.org/article/d011e1e7524849e881e2321c8b9947ca

المؤلفون: Peter Durand Skottrup, Grete Sørensen, Miroslaw Ksiazek, Jan Potempa, Erik Riise

المصدر: PLoS ONE, Vol 7, Iss 10, p e48537 (2012)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC3485312?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/45224428fd3e48158a3b929160097668

المؤلفون: Danuta Mizgalska, Arturo Rodríguez-Banqueri, Florian Veillard, Mirosław Książęk, Theodoros Goulas, Tibisay Guevara, Ulrich Eckhard, Jan S. Potempa, F. Xavier Gomis-Ruth

مصطلحات موضوعية: Biochemistry and cell biology not elsewhere classified, biochemistry, structural biology, microbiology

Relation: https://figshare.com/articles/presentation/Supplementary_Materials_from_Structural_and_functional_insights_into_the_C-terminal_signal_domain_of_the_Bacteroidetes_type-IX_secretion_system/25981534

الاتاحة: https://doi.org/10.6084/m9.figshare.25981534.v1
https://figshare.com/articles/presentation/Supplementary_Materials_from_Structural_and_functional_insights_into_the_C-terminal_signal_domain_of_the_Bacteroidetes_type-IX_secretion_system/25981534

المؤلفون: Danuta Mizgalska, Arturo Rodríguez-Banqueri, Florian Veillard, Mirosław Książęk, Theodoros Goulas, Tibisay Guevara, Ulrich Eckhard, Jan Potempa, F. Xavier Gomis-Rüth

المصدر: Open Biology, Vol 14, Iss 6 (2024)

مصطلحات موضوعية: periodontal disease, bacterial virulence factor, infectious disease, protein secretion, X-ray crystal structure, T9SS, Biology (General), QH301-705.5

Relation: https://doaj.org/toc/2046-2441; https://doaj.org/article/ad1a5dec84394926a6901eee7856ddc6

الاتاحة: https://doi.org/10.1098/rsob.230448
https://doaj.org/article/ad1a5dec84394926a6901eee7856ddc6

المؤلفون: Krzysztof M. Zak (3222534), Mark J. Bostock (4503976), Irena Waligorska (11065082), Ida B. Thøgersen (110178), Jan J. Enghild (110183), Grzegorz M. Popowicz (179378), Przemyslaw Grudnik (3222552), Jan Potempa (19854), Miroslaw Ksiazek (301023)

مصطلحات موضوعية: Biophysics, Biochemistry, Pharmacology, Biotechnology, Evolutionary Biology, Infectious Diseases, Virology, Chemical Sciences not elsewhere classified, Periodontitis, proteolysis, Tannerella forsythia, NMR-based fragment screening, protease inhibitors

Relation: https://figshare.com/articles/journal_contribution/Latency_thermal_stability_and_identification_of_an_inhibitory_compound_of_mirolysin_a_secretory_protease_of_the_human_periodontopathogen_i_Tannerella_forsythia_i_/14898878

الاتاحة: https://doi.org/10.6084/m9.figshare.14898878.v1

المؤلفون: Claus Schmitz, Mariusz Madej, Zuzanna Nowakowska, Anna Cuppari, Anna Jacula, Miroslaw Ksiazek, Katarzyna Mikruta, Jerzy Wisniewski, Natalia Pudelko-Malik, Anshu Saran, Natalie Zeytuni, Piotr Mlynarz, Richard J Lamont, Isabel Usón, Virginijus Siksnys, Jan Potempa, Maria Solà

المساهمون: National Science Centre (Poland), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España), Generalitat de Catalunya, National Institute of Dental and Craniofacial Research (US), Ministry of Science and Higher Education (Poland), Wroclaw Center for Biotechnology

المصدر: Nucleic acids research, Oxford : Oxford University Press, 2022, vol. 50, no. 21, p. 12558-12577

مصطلحات موضوعية: Bacterial Proteins, PorX, PglZ, virulence factor, Virulence Factors, Genetics, Oligonucleotides, Gene Expression, Alkaline Phosphatase

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c935bf9b05c227dadb08504ba97a8824
https://pubmed.ncbi.nlm.nih.gov/36464236

المؤلفون: Anna Straczek, Jan Potempa, Jan J. Enghild, Irena Waligorska, Miroslaw Ksiazek, Malgorzata Benedyk, Alicja Sochaj-Gregorczyk, Danuta Mizgalska, Ida B. Thøgersen

المصدر: Sochaj-Gregorczyk, A, Ksiazek, M, Waligorska, I, Straczek, A, Benedyk, M, Mizgalska, D, Thøgersen, I B, Enghild, J J & Potempa, J 2020, ' Plasmin inhibition by bacterial serpin : Implications in gum disease ', FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 34, no. 1, pp. 619-630 . https://doi.org/10.1096/fj.201901490RR
FASEB J

مصطلحات موضوعية: 0301 basic medicine, Plasmin, medicine.medical_treatment, Serpin, Biochemistry, Article, 03 medical and health sciences, 0302 clinical medicine, Forsythia, In vivo, Catalytic Domain, Fibrinolysis, Genetics, medicine, Animals, Humans, Tannerella forsythia, Protease Inhibitors, Fibrinolysin, periodontitis, Molecular Biology, Periodontal Diseases, Serpins, plasmin, Bacteria, biology, Chemistry, serpin, Biofilm, biology.organism_classification, Antifibrinolytic Agents, Mice, Inbred C57BL, stomatognathic diseases, 030104 developmental biology, Female, fibrinolysis, Bacterial outer membrane, 030217 neurology & neurosurgery, Biotechnology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2a237075ab349f02798f59ef0d235da
https://doi.org/10.1096/fj.201901490rr

المؤلفون: Tibisay Guevara, Anna M. Lasica, Miroslaw Ksiazek, Barbara Potempa, F. Xavier Gomis-Rüth, Arturo Rodríguez-Banqueri, Jan Potempa

المساهمون: National Institutes of Health (US), Ministry of Science and Higher Education (Poland), Ministerio de Economía y Competitividad (España), Generalitat de Catalunya, Fundació La Marató de TV3, Ministerio de Ciencia, Innovación y Universidades (España)

المصدر: Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, Benzylamines, Virulence Factors, Virulence, lcsh:Medicine, Crystallography, X-Ray, Article, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Drug Development, Protein Domains, Catalytic Domain, Hydrolase, Bacteroidaceae Infections, Structure–activity relationship, Protease Inhibitors, Periodontitis, lcsh:Science, Pathogen, Porphyromonas gingivalis, Gingipain K, X-ray crystallography, Bacterial structural biology, Multidisciplinary, biology, Chemistry, lcsh:R, biology.organism_classification, 3. Good health, Hydrazines, 030104 developmental biology, Biochemistry, Enzyme mechanisms, Gingipain Cysteine Endopeptidases, lcsh:Q, Carbamates, Salt bridge, Hydrophobic and Hydrophilic Interactions, 030217 neurology & neurosurgery, Cysteine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea3cb3af287bdd1838fd3234f102e85e
http://link.springer.com/article/10.1038/s41598-019-41354-3

المؤلفون: Danuta Mizgalska, Arturo Rodríguez-Banqueri, Florian Veillard, Mirosław Książęk, Theodoros Goulas, Tibisay Guevara, Ulrich Eckhard, Jan Potempa, F. Xavier Gomis-Rüth

الاتاحة: http://dx.doi.org/10.1098/rsob.230448/v2/response1

المؤلفون: Ida B. Thøgersen, Krzysztof M. Zak, Mark J Bostock, Jan Potempa, Irena Waligorska, Jan J. Enghild, Grzegorz M Popowicz, Przemyslaw Grudnik, Miroslaw Ksiazek

المصدر: Zak, K M, Bostock, M J, Waligorska, I, Thøgersen, I B, Enghild, J J, Popowicz, G M, Grudnik, P, Potempa, J & Ksiazek, M 2021, ' Latency, thermal stability, and identification of an inhibitory compound of mirolysin, a secretory protease of the human periodontopathogen Tannerella forsythia ', Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 36, no. 1, pp. 1267-1281 . https://doi.org/10.1080/14756366.2021.1937619
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1267-1281 (2021)

مصطلحات موضوعية: MECHANISM, PERIODONTAL HEALTH, Proteases, proteolysis, medicine.medical_treatment, Proteolysis, protease inhibitors, RM1-950, medicine.disease_cause, ACTIVATION, nmr-based fragment screening, Forsythia, GINGIPAINS, Zymogen, PORPHYROMONAS-GINGIVALIS, Drug Discovery, medicine, Tannerella forsythia, tannerella forsythia, periodontitis, SUPPRESSION, Pharmacology, chemistry.chemical_classification, Mutation, Protease, biology, medicine.diagnostic_test, General Medicine, biology.organism_classification, PREVALENCE, NMR-based fragment screening, RED COMPLEX, stomatognathic diseases, Enzyme, chemistry, Biochemistry, NMR-SPECTROSCOPY, Therapeutics. Pharmacology, VIRULENCE FACTORS

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe83f78b12e748673165bea71b66b00

المؤلفون: Joseph Aduse-Opoku, A. Jacula, N. Magdalena, Danuta Mizgalska, Jan Potempa, Mariusz Madej, Jan J. Enghild, Michael A. Curtis, Carsten Scavenius, Miroslaw Ksiazek, Anna M. Lasica, Zuzanna Nowakowska, F.X. Gomis-Ruth

مصطلحات موضوعية: Lipid A, Biochemistry, biology, Effector, Sortase, Chemistry, Secretion, Ligand (biochemistry), Bacterial outer membrane, biology.organism_classification, Porphyromonas gingivalis, Mannan

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a7d58159d7d1222986878ac6e856da2e
https://doi.org/10.1101/2020.07.16.206169

المؤلفون: Miroslaw Ksiazek, Arturo Rodríguez-Banqueri, Jan Potempa, F.X. Gomis-Ruth, Tibisay Guevara

المساهمون: Generalitat de Catalunya, National Institutes of Health (US), Polish Academy of Sciences, Ministerio de Economía y Competitividad (España), Fundació La Marató de TV3, Ministry of Science and Higher Education (Poland)

المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instname
IUCrJ, Vol 7, Iss 1, Pp 18-29 (2020)
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
IUCrJ

مصطلحات موضوعية: Peridontopathogens, Metallopeptidase, mirolysin, catalytic mechanisms, Cleavage (embryo), pappalysin family, Biochemistry, 03 medical and health sciences, zymogens, Zymogens, Zymogen, Hydrolase, Mirolysin, Tannerella forsythia, General Materials Science, Methanosarcina acetivorans, Metallo­peptidases, lcsh:Science, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, biology, peridontopathogens, Catalytic mechanisms, 030302 biochemistry & molecular biology, General Chemistry, Condensed Matter Physics, biology.organism_classification, Research Papers, metallopeptidases, Pappalysin family, Enzyme, chemistry, metallo­peptidases, lcsh:Q, Cysteine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57cd8b99a7fa67f83b978036f790ef66
http://hdl.handle.net/10261/241436

المؤلفون: Jan Potempa, Miroslaw Ksiazek, Vibeke Baelum, Peter Durand Skottrup, Rodrigo López, Jakub Zbigniew Kaczmarek, Peter Højrup

المصدر: J Immunol Methods
Skottrup, P D, López, R, Ksiazek, M, Højrup, P, Baelum, V, Potempa, J & Kaczmarek, J Z 2019, ' An IgY-based immunoassay to evaluate the biomarker potential of the Tannerella forsythia virulence factor karilysin in human saliva ', Journal of Immunological Methods, vol. 469, pp. 26-32 . https://doi.org/10.1016/j.jim.2019.03.003

مصطلحات موضوعية: 0301 basic medicine, Male, Saliva, virulence factor, 0302 clinical medicine, Antibody Specificity, Immunology and Allergy, Tannerella forsythia, periodontitis, biology, medicine.diagnostic_test, Virulence, Antibodies, Bacterial, Titer, biomarker, Female, Antibody, Adolescent, Virulence Factors, Immunology, Immunoglobulins, Enzyme-Linked Immunosorbent Assay, Article, Microbiology, 03 medical and health sciences, Immune system, Forsythia, Bacterial Proteins, Predictive Value of Tests, IgY, medicine, Humans, Periodontitis, saliva, business.industry, karilysin, Reproducibility of Results, biology.organism_classification, medicine.disease, Matrix Metalloproteinases, 030104 developmental biology, inflammation, Immunoassay, Case-Control Studies, biology.protein, business, Gram-Negative Bacterial Infections, 030215 immunology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::207b54f90ed7a2b49bd748a4a0544df7
https://europepmc.org/articles/PMC6486437/

المؤلفون: Jan Potempa, Maryta Sztukowska, Ky-Anh Nguyen, Miroslaw Ksiazek, John A. Houston, Yonghua Guo, Lahari Koneru, Florian Veillard, Barbara Potempa

المصدر: Biological Chemistry. 396:377-384

مصطلحات موضوعية: Proteases, Clinical Biochemistry, Virulence, Biology, virulence factor, Biochemistry, Chromatography, Affinity, Article, law.invention, Affinity chromatography, law, protein secretion, Bacteroidaceae Infections, Humans, cysteine protease, Adhesins, Bacterial, periodontitis, Molecular Biology, Porphyromonas gingivalis, posttranslational modification, biology.organism_classification, Cysteine protease, Recombinant Proteins, Gingipain, Cysteine Endopeptidases, proteolytic processing, Gingipain Cysteine Endopeptidases, Recombinant DNA, Bacterial outer membrane

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed8e289a20233b770b7a60da04ac063
https://doi.org/10.1515/hsz-2014-0304

المؤلفون: Miroslaw Ksiazek, Ida B. Thøgersen, Jan J. Enghild, Carsten Scavenius, Danuta Mizgalska, Jan Potempa

المصدر: Journal of Biological Chemistry
Ksiazek, M, Mizgalska, D, Enghild, J J, Scavenius, C, Thogersen, I B & Potempa, J 2015, ' Miropin, a novel bacterial serpin from the periodontopathogen Tannerella forsythia, inhibits a broad range of proteases by using different peptide bonds within the reactive center loop ', Journal of Biological Chemistry, vol. 290, pp. 658-670 . https://doi.org/10.1074/jbc.M114.601716

مصطلحات موضوعية: Cathepsin G, serine protease, periodontal disease, Gene Expression, Biochemistry, Substrate Specificity, Serine, chemistry.chemical_compound, Catalytic Domain, Tannerella forsythia, Trypsin, Reactive center, 0303 health sciences, biology, 030302 biochemistry & molecular biology, serpin, Recombinant Proteins, embryonic structures, Thermodynamics, Proteases, animal structures, Serine Proteinase Inhibitors, infectious disease, Molecular Sequence Data, Serpin, Microbiology, protease inhibitor, 03 medical and health sciences, Bacterial Proteins, Escherichia coli, Humans, Periodontal Pocket, Amino Acid Sequence, Molecular Biology, Serpins, 030304 developmental biology, Serine protease, Bacteroidetes, Subtilisin, Cell Biology, biology.organism_classification, carbohydrates (lipids), Kinetics, chemistry, Enzymology, biology.protein, Leukocyte Elastase, Sequence Alignment

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2ccc88732975a3347d8a6980ea00ec
https://doi.org/10.1074/jbc.m114.601716