المؤلفون: Małgorzata Benedyk-Machaczka, Piotr Mydel, Karsten Mäder, Marta Kaminska, Nadine Taudte, Marcel Naumann, Martin Kleinschmidt, Sandra Sarembe, Andreas Kiesow, Sigrun Eick, Mirko Buchholz

المصدر: Antibiotics, Vol 13, Iss 11, p 1012 (2024)

مصطلحات موضوعية: periodontitis, proof-of-concept, adjunctive therapy, minocycline, local application, controlled release, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2079-6382/13/11/1012; https://doaj.org/toc/2079-6382

URL الوصول: https://doaj.org/article/bfce8408e0ae4645872f2ef651191c15

المؤلفون: Kathrin Tan, Christian Jäger, Stefanie Geissler, Dagmar Schlenzig, Mirko Buchholz, Daniel Ramsbeck

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)

مصطلحات موضوعية: Meprin, metalloprotease, hydroxamate, inhibitor, pyrazole, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

URL الوصول: https://doaj.org/article/6cf1ad89dd504526bad8c27cce359ded

المؤلفون: Leila Issmail, Christin Möser, Christian Jäger, Basma Altattan, Daniel Ramsbeck, Martin Kleinschmidt, Mirko Buchholz, David Smith, Thomas Grunwald

المصدر: Frontiers in Virology, Vol 2 (2022)

مصطلحات موضوعية: respiratory syncial virus, antiviral, peptide, DNA nanostructure, multivalence, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fviro.2022.994843/full; https://doaj.org/toc/2673-818X

URL الوصول: https://doaj.org/article/e691e42ef8224ec587f1da3b430fc2ac

المؤلفون: Daniel Ramsbeck, Nadine Taudte, Nadine Jänckel, Stefanie Strich, Jens-Ulrich Rahfeld, Mirko Buchholz

المصدر: Pharmaceuticals, Vol 14, Iss 12, p 1206 (2021)

مصطلحات موضوعية: PgQC, Porphyromonas gingivalis, periodontitis, glutaminyl cyclase, Medicine, Pharmacy and materia medica, RS1-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1424-8247/14/12/1206; https://doaj.org/toc/1424-8247

URL الوصول: https://doaj.org/article/c83c92b5888541eb8c2136912ad25b5a

المؤلفون: Jan-Luca Schmid, Martin Kirchberg, Sandra Sarembe, Andreas Kiesow, Anton Sculean, Karsten Mäder, Mirko Buchholz, Sigrun Eick

المصدر: Pharmaceutics, Vol 12, Iss 4, p 352 (2020)

مصطلحات موضوعية: controlled release, periodontitis, local antibiotics, in vitro model, gingival flow, Pharmacy and materia medica, RS1-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1999-4923/12/4/352; https://doaj.org/toc/1999-4923

URL الوصول: https://doaj.org/article/d7ff464fa7884dafb36d4e1676e75743

المؤلفون: Stephanie Hielscher-Michael, Carola Griehl, Mirko Buchholz, Hans-Ulrich Demuth, Norbert Arnold, Ludger A. Wessjohann

المصدر: Marine Drugs, Vol 14, Iss 11, p 203 (2016)

مصطلحات موضوعية: glutaminyl cyclase (QC) inhibitor, microalgae, sulfolipids, AD, reverse metabolomics, Scenedesmus sp., natural product, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.mdpi.com/1660-3397/14/11/203; https://doaj.org/toc/1660-3397

URL الوصول: https://doaj.org/article/220f62f3723643dea6ecd9177e396cc2

المؤلفون: Kevin Böhm, Eric Schulze‐Niemand, Thilo Kähne, Elisa Siddiqui, Christian Täger, Daniel Ramsbeck, Mirko Buchholz, Michael Naumann

المصدر: Archiv der Pharmazie.

مصطلحات موضوعية: Drug Discovery, Pharmaceutical Science

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b0d1c5d4bbb97983c88e1916c2919cc8
https://doi.org/10.1002/ardp.202200661

المؤلفون: Anett Stephan, Simone Hahn-Löbmann, Fred Rosche, Mirko Buchholz, Anatoli Giritch, Yuri Gleba

المصدر: International Journal of Molecular Sciences; Volume 19; Issue 1; Pages: 95

مصطلحات موضوعية: Nicotiana benthamiana, colicin, food additives, alkaloids, plant-made recombinant proteins, nicotine

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Biochemistry; https://dx.doi.org/10.3390/ijms19010095

الاتاحة: https://doi.org/10.3390/ijms19010095

المؤلفون: Franziska Seifert, Stephan Schilling, Oliver Kupski, Hans-Ulrich Demuth, Lisa-Marie Funk, Viktor Sautner, Franc Meyer, Ulf Diederichsen, Brigitte Worbs, Daniel Ramsbeck, Mirko Buchholz, Kai Tittmann

المصدر: Biochemistry. 59:2585-2591

مصطلحات موضوعية: Models, Molecular, Protein Conformation, Stereochemistry, Druggability, Peptide, Crystallography, X-Ray, Hydrazide, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Alzheimer Disease, In vivo, Humans, Molecular Targeted Therapy, Enzyme Inhibitors, Deamidation, Neurotensin, chemistry.chemical_classification, 0303 health sciences, 030302 biochemistry & molecular biology, Glutamate receptor, Aminoacyltransferases, 3. Good health, Hydrazines, Enzyme, chemistry, Cyclization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7744ff16652a4699ae8ab2f5632ec2e
https://doi.org/10.1021/acs.biochem.0c00337

المؤلفون: Miriam Linnert, Stephan Schilling, Hans-Ulrich Demuth, Mirko Buchholz, Jens-Ulrich Rahfeld, John A. Houston, Christoph Parthier, Florian Veillard, Nadine Taudte, Anke Piechotta, Milton T. Stubbs, Petr Kolenko, Jan Potempa, Daniel Ramsbeck, Sigrun Eick

المساهمون: Publica

المصدر: The Journal of Biological Chemistry
Taudte, Nadine; Linnert, Miriam; Rahfeld, Jens-Ulrich; Piechotta, Anke; Ramsbeck, Daniel; Buchholz, Mirko; Kolenko, Petr; Parthier, Christoph; Houston, John A; Veillard, Florian; Eick, Sigrun; Potempa, Jan; Schilling, Stephan; Demuth, Hans-Ulrich; Stubbs, Milton T (2021). Mammalian-like type II glutaminyl cyclases in Porphyromonas gingivalis and other oral pathogenic bacteria as targets for treatment of periodontitis. The journal of biological chemistry, 296, p. 100263. American Society for Biochemistry and Molecular Biology 10.1016/j.jbc.2021.100263 <http://dx.doi.org/10.1016/j.jbc.2021.100263>

مصطلحات موضوعية: 0301 basic medicine, glutaminyl cyclase, periodontal disease, TRH, thyrotropin-releasing hormone, Crystallography, X-Ray, Biochemistry, Prevotella intermedia, Catalytic Domain, bacterial pathogens, Tannerella forsythia, 610 Medicine & health, ACAP, auto-antibodies against citrullinated peptides, Bibliographie, chemistry.chemical_classification, biology, Chemistry, Aminoacyltransferases, Glutaminyl cyclase, Enzyme structure, Pyrrolidonecarboxylic Acid, enzyme structure, AD, Alzheimer's disease, Bacterial outer membrane, Porphyromonas gingivalis, Research Article, crystal structure, drug design, PPAD, P. gingivalis peptidylarginine deiminase, FRIL, freeze-fracture replica immunolabeling, 03 medical and health sciences, ORF, open reading frame, medicine, GnRH, gonadotropin-releasing hormone, Humans, Periodontitis, Molecular Biology, 030102 biochemistry & molecular biology, Cell Biology, Periplasmic space, NMM, N-methylmorpholine, medicine.disease, biology.organism_classification, Protein Structure, Tertiary, 030104 developmental biology, Enzyme

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b44849e5bf631c10995725a3bbf87c2
https://publica.fraunhofer.de/handle/publica/267517

المؤلفون: Mirko Buchholz, Christian Jäger, Stefanie Geissler, Daniel Ramsbeck, Kathrin Tan, Dagmar Schlenzig, Walter Stöcker, Hagen Körschgen

المصدر: Chemmedchem

مصطلحات موضوعية: Scaffold, Tertiary amine, Stereochemistry, Cell Survival, Antineoplastic Agents, scaffold hopping, Matrix metalloproteinase, Scaffold hopping, hydroxamate, 01 natural sciences, Biochemistry, Hydrocarbons, Aromatic, metalloproteinases, Structure-Activity Relationship, meprin, Very Important Paper, Drug Discovery, Tumor Cells, Cultured, Humans, Protease Inhibitors, General Pharmacology, Toxicology and Pharmaceutics, Amines, Pharmacology, Dose-Response Relationship, Drug, Molecular Structure, Full Paper, 010405 organic chemistry, Chemistry, Organic Chemistry, Metalloendopeptidases, Full Papers, ovastacin, Recombinant Proteins, heteroaromatics, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Metalloproteases, Molecular Medicine, Astacin, Drug Screening Assays, Antitumor, Selectivity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06bea260fe451d5839ed36838f04fb7c
https://pubmed.ncbi.nlm.nih.gov/33369214

المؤلفون: Mirko Buchholz, Holger Cynis, Hans-Ulrich Demuth, Claudia Spahn, Ulrike Zeitschel, Daniel Ramsbeck, Michael Wermann, Maike Hartlage-Rübsamen, Steffen Roßner, Katja Menge, Dagmar Schlenzig, Anja Fothe, Stephan Schilling

المصدر: Journal of Alzheimer's Disease. 66:359-375

مصطلحات موضوعية: Male, 0301 basic medicine, Proteases, Dipeptidyl-peptidase activity, CHO Cells, Dipeptidyl peptidase, 03 medical and health sciences, Cricetulus, 0302 clinical medicine, Cricetinae, Animals, Humans, Amino Acid Sequence, Dipeptidyl-Peptidases and Tripeptidyl-Peptidases, Protein precursor, Peptide sequence, Aged, Aged, 80 and over, Exopeptidase activity, Amyloid beta-Peptides, biology, Chemistry, General Neuroscience, Brain, Metalloendopeptidases, General Medicine, Aminoacyltransferases, Peptide Fragments, Endopeptidase, Enzyme Activation, Psychiatry and Mental health, Clinical Psychology, HEK293 Cells, 030104 developmental biology, Biochemistry, biology.protein, Female, Geriatrics and Gerontology, Amyloid precursor protein secretase, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d94ec447859ba4fdfdc0d846dcf89a41
https://doi.org/10.3233/jad-171183

المؤلفون: Stephan Schilling, Mirko Buchholz, Daniel Ramsbeck, Dagmar Schlenzig, Antje Hamann

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:2428-2431

مصطلحات موضوعية: 0301 basic medicine, Proteases, Matrix metalloproteinase inhibitor, ADAM10, Clinical Biochemistry, Pharmaceutical Science, Matrix Metalloproteinase Inhibitors, Hydroxamic Acids, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Fibrosis, Drug Discovery, medicine, Structure–activity relationship, Protease Inhibitors, Molecular Biology, Sulfonamides, Metalloproteinase, Hydroxamic acid, Organic Chemistry, Metalloendopeptidases, medicine.disease, 030104 developmental biology, chemistry, Molecular Medicine, Astacin, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186b732b04e2c8f96258f4e2eb77075c
https://doi.org/10.1016/j.bmcl.2017.04.012

المؤلفون: Sigrun Eick, Mirko Buchholz, Andreas Kiesow, Karsten Mäder, Sandra Sarembe, Fred Rosche, Martin Kirchberg

المساهمون: Publica

مصطلحات موضوعية: Chemistry, Pharmaceutical, Polyesters, Pharmaceutical Science, Minocycline, 02 engineering and technology, Polyethylene glycol, 030226 pharmacology & pharmacy, Polyethylene Glycols, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Differential scanning calorimetry, Plasticizers, PEG ratio, Magnesium stearate, Periodontitis, 610 Medicine & health, Drug Carriers, Molar mass, Plasticizer, technology, industry, and agriculture, 021001 nanoscience & nanotechnology, Controlled release, Lipids, Anti-Bacterial Agents, Drug Liberation, extrusion, chemistry, Chemical engineering, Delayed-Action Preparations, Extrusion, 0210 nano-technology, controlled release, PEG-PLGA, Stearic Acids

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38c45c0ee959bf5f7c82bd3adba301a8

المؤلفون: Hagen Körschgen, Christian Jäger, Kathrin Tan, Mirko Buchholz, Walter Stöcker, Daniel Ramsbeck

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b44f6a53d7d8a5134b19574b64aa8f5
https://doi.org/10.26434/chemrxiv.11306867

المؤلفون: Sigrun Eick, Mirko Buchholz, Karsten Mäder, Martin Kirchberg, Sandra Sarembe, Andreas Kiesow

المساهمون: Publica

مصطلحات موضوعية: Staphylococcus aureus, medicine.drug_class, Drug Compounding, Tetracycline antibiotics, Pharmaceutical Science, Minocycline, 02 engineering and technology, Calcium stearate, 030226 pharmacology & pharmacy, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Drug Stability, Polylactic Acid-Polyglycolic Acid Copolymer, medicine, Chelation, Particle Size, Periodontitis, 610 Medicine & health, Active ingredient, Drug Carriers, Chemistry, 021001 nanoscience & nanotechnology, Controlled release, Anti-Bacterial Agents, PLGA, Drug Liberation, Kinetics, Delayed-Action Preparations, Doxycycline, Drug delivery, 0210 nano-technology, Stearic Acids, medicine.drug, Nuclear chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127d74bc6addf845468b25dc4d8e65d8

المؤلفون: Burkhard Möller, Andreas Egger, Jan Potempa, Sigrun Eick, Philip Bender, Mirko Buchholz, Nadine Taudte, Anton Sculean, Martin Westermann

المساهمون: Publica

مصطلحات موضوعية: Adult, Male, Periodontium, 0301 basic medicine, Blotting, Western, Interleukin-1beta, Enzyme-Linked Immunosorbent Assay, Pilot Projects, Real-Time Polymerase Chain Reaction, Article, Arthritis, Rheumatoid, 03 medical and health sciences, 0302 clinical medicine, In vivo, Humans, Medicine, RNA, Messenger, 610 Medicine & health, General Dentistry, Porphyromonas gingivalis, Pathogen, Chemokine CCL2, Aged, Periodontitis, Messenger RNA, biology, business.industry, Interleukin, biomarkers, Biomarker, 030206 dentistry, Cell Biology, General Medicine, Middle Aged, Aminoacyltransferases, biology.organism_classification, medicine.disease, peripheral blood, Chronic periodontitis, chronic inflammatory diseases, 030104 developmental biology, Otorhinolaryngology, gingival crevicular fluid, Rheumatoid arthritis, Chronic Periodontitis, Immunology, Female, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d44804848df53f21797550797c6007a
https://ruj.uj.edu.pl/xmlui/handle/item/65034

المؤلفون: Stephan Schilling, Mirko Buchholz, Dagmar Schlenzig, Christian Jäger, Daniel Ramsbeck, Kathrin Tan

المصدر: ChemMedChem. 13(16)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Proteases, Tertiary amine, medicine.medical_treatment, Matrix metalloproteinase, Hydroxamic Acids, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Catalytic Domain, Drug Discovery, medicine, Humans, Protease Inhibitors, General Pharmacology, Toxicology and Pharmaceutics, Enzyme Assays, Pharmacology, Metalloproteinase, Protease, Hydroxamic acid, Molecular Structure, Chemistry, Organic Chemistry, Metalloendopeptidases, 030104 developmental biology, Drug Design, Molecular Medicine, Astacin, Selectivity, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eab5e24640187eefed2cf6d23eb60a5
https://pubmed.ncbi.nlm.nih.gov/29927060

المؤلفون: Stephan Schilling, Vera Nykiel, Mirko Buchholz, Holger Cynis, Daniel Ramsbeck, Stefanie Geissler, Georg Richter, Dagmar Schlenzig, Antje Hamann

المصدر: Journal of medicinal chemistry. 61(10)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Cell Survival, Protein Conformation, Matrix metalloproteinase, Matrix Metalloproteinase Inhibitors, Crystallography, X-Ray, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Protein structure, Fibrosis, Catalytic Domain, Drug Discovery, Disintegrin, medicine, Structure–activity relationship, Humans, chemistry.chemical_classification, Metalloproteinase, biology, Molecular Structure, Chemistry, Metalloendopeptidases, Hep G2 Cells, medicine.disease, Sulfonamide, 030104 developmental biology, Enzyme, Biochemistry, 030220 oncology & carcinogenesis, Drug Design, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b4f9023d633ae5eebc5c70c32d6ec4
https://pubmed.ncbi.nlm.nih.gov/29694039

المؤلفون: Michael J. Delves, Jana Held, Diane Meitzner, Tanja C. Knaab, Michael Leven, Vicky M. Avery, Mirko Buchholz, Sergio Wittlin, Stephan Meister, Elizabeth A. Winzeler, Krystina Kuna, Christoph Fischli, Benjamin Mordmüller, Sandra Duffy, Beate Lungerich, Petra Stahlke, Thomas Kurz, Ursula Lehmann

المصدر: Journal of medicinal chemistry. 60(14)

مصطلحات موضوعية: 0301 basic medicine, Plasmodium berghei, Stereoisomerism, 01 natural sciences, 03 medical and health sciences, Antimalarials, Mice, Structure-Activity Relationship, In vivo, parasitic diseases, Drug Discovery, Gametocyte, Moiety, Structure–activity relationship, Parasite hosting, Animals, Humans, biology, 010405 organic chemistry, Chemistry, Hydrazones, Plasmodium falciparum, Hep G2 Cells, Phenanthrenes, biology.organism_classification, Amides, 0104 chemical sciences, 3. Good health, Malaria, 030104 developmental biology, Biochemistry, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f38109fe2ff8d2e063d96cd1e17f0e
https://pubmed.ncbi.nlm.nih.gov/28653845