المؤلفون: Johanna I. Kiiski, Mikko Neuvonen, Mika Kurkela, Päivi Hirvensalo, Kreetta Hämäläinen, E. Katriina Tarkiainen, Johanna Sistonen, Mari Korhonen, Sofia Khan, Arto Orpana, Anne M. Filppula, Marko Lehtonen, Mikko Niemi

المصدر: Human Genomics, Vol 18, Iss 1, Pp 1-16 (2024)

مصطلحات موضوعية: CYP2D6, Solanidine, Drug metabolism, Biomarkers, Medicine, Genetics, QH426-470

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1479-7364

URL الوصول: https://doaj.org/article/18cc2cbe5e4e47a0accb684473def9e1

المؤلفون: Lotta Ulander, Piia Simonen, Heli Tolppanen, Otto Hartman, Tuomas T. Rissanen, Kari K. Eklund, Marita Kalaoja, Mika Kurkela, Mikko Neuvonen, Mikko Niemi, Janne T. Backman, Helena Gylling, Juha Sinisalo

المصدر: Atherosclerosis Plus, Vol 53, Iss , Pp 26-32 (2023)

مصطلحات موضوعية: Cholesterol metabolism, Hydroxychloroquine, Myocardial infarction, ST-Elevation myocardial infarction, Non-ST-Elevation myocardial infarction, Diseases of the circulatory (Cardiovascular) system, RC666-701

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2667089523000123; https://doaj.org/toc/2667-0895

URL الوصول: https://doaj.org/article/e6fa16665d3e4070973c4a24f88db3bd

المؤلفون: Sari Kytölä, Ida Vänttinen, Heikki Kuusanmäki, Tanja Ruokoranta, Mika Kurkela, Johanna Kiiski, Annasofia Holopainen, Anu Partanen, Milla E.L. Kuusisto, Sirpa Koskela, Riikka Räty, Maija Itälä-Remes, Pia Ettala, Johanna Rimpiläinen, Timo Siitonen, Marja Pyörälä, Janne T. Backman, Mikko Niemi, Mika Kontro

المصدر: HemaSphere, Vol 7, p e53119c1 (2023)

مصطلحات موضوعية: Diseases of the blood and blood-forming organs, RC633-647.5

وصف الملف: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000969152.53119.c1; https://doaj.org/toc/2572-9241

URL الوصول: https://doaj.org/article/2f819d817a31442ca22a448adf20a3b5

المؤلفون: Joanna M. Little, Mika Kurkela, Julia Sonka, Sirkku Jäntti, Raimo Ketola, Stacie Bratton, Moshe Finel, Anna Radominska-Pandya

المصدر: Journal of Lipid Research, Vol 45, Iss 9, Pp 1694-1703 (2004)

مصطلحات موضوعية: uridine diphosphate-glucuronosyltransferase, prostaglandins, hydroxyeicosatetraenoic acid, human liver, human intestine, liquid chromatography-mass spectrometry, Biochemistry, QD415-436

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520312864; https://doaj.org/toc/0022-2275

URL الوصول: https://doaj.org/article/5c9e886cdafb4e4088f609e2f22ae357

المؤلفون: Johanna I. Kiiski, Mikko Neuvonen, Mika Kurkela, Päivi Hirvensalo, Kreetta Hämäläinen, E. Katriina Tarkiainen, Johanna Sistonen, Mari Korhonen, Sofia Khan, Arto Orpana, Anne M. Filppula, Marko Lehtonen, Mikko Niemi

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Physiology, Pharmacology, Cancer, Mental Health, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, CYP2D6, Solanidine, Drug metabolism, Biomarkers

Relation: https://figshare.com/articles/journal_contribution/Additional_file_1_of_Solanidine_is_a_sensitive_and_specific_dietary_biomarker_for_CYP2D6_activity/25132101

الاتاحة: https://doi.org/10.6084/m9.figshare.25132101.v1
https://figshare.com/articles/journal_contribution/Additional_file_1_of_Solanidine_is_a_sensitive_and_specific_dietary_biomarker_for_CYP2D6_activity/25132101

المؤلفون: Johanna Kujala, Niklas Wester, Terhi J. Lohela, Mika Kurkela, Janne T. Backman, Björn Mikladal, Tomi Laurila, Jari Koskinen, Tuomas O. Lilius, Eija A. Kalso

المصدر: British Journal of Clinical Pharmacology.

مصطلحات موضوعية: Pharmacology, Pharmacology (medical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::89274119668bafc06a97b6719350bdb3
https://doi.org/10.1111/bcp.15794

المؤلفون: Marie-Noëlle, Paludetto, Mika, Kurkela, Helinä, Kahma, Janne T, Backman, Mikko, Niemi, Anne M, Filppula

المصدر: Drug metabolism and disposition: the biological fate of chemicals.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::bf12af47f18cbe32047c366fa899a35a
https://pubmed.ncbi.nlm.nih.gov/36446607

المؤلفون: Janne T. Backman, Anri Tienhaara, Mika Kurkela, Tero Vahlberg, Marko A. Peltoniemi, Klaus T. Olkkola, Teijo I. Saari, Alexey Schramko, Martina Havrdová, Jouko Jalonen

المصدر: The Journal of Clinical Pharmacology. 61:522-530

مصطلحات موضوعية: Adult, Male, Adolescent, Pyridines, 030226 pharmacology & pharmacy, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Edoxaban, Oral administration, medicine, Coagulation testing, Humans, Pharmacology (medical), Longitudinal Studies, Blood Coagulation, Blood coagulation test, Pharmacology, Prothrombin time, medicine.diagnostic_test, business.industry, Blood Viscosity, Healthy Volunteers, 3. Good health, Thiazoles, Thromboelastometry, chemistry, Clotting time, 030220 oncology & carcinogenesis, Anesthesia, Blood Coagulation Tests, business, Partial thromboplastin time

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c348b3af3760bf6bcab3023bda23aef
https://doi.org/10.1002/jcph.1758

المؤلفون: Anne-Sisko Patana, Mika Kurkela, Adrian Goldman, Moshe Finel

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://molpharm.aspetjournals.org/content/molpharm/72/3/604.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1086.9963; http://molpharm.aspetjournals.org/content/molpharm/72/3/604.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1086.9963
http://molpharm.aspetjournals.org/content/molpharm/72/3/604.full.pdf

المؤلفون: Leena Luukkanen, Jyrki Taskinen, Mika Kurkela, Risto Kostiainen, Jouni Hirvonen, Moshe Finel

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://dmd.aspetjournals.org/content/dmd/33/7/1017.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1037.6615; http://dmd.aspetjournals.org/content/dmd/33/7/1017.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1037.6615
http://dmd.aspetjournals.org/content/dmd/33/7/1017.full.pdf

المؤلفون: Mika Kurkela, Anne-Sisko Patana, Adrian Goldman, Moshe Finel

المصدر: Molecular Pharmacology. 72:604-611

مصطلحات موضوعية: Stereochemistry, Molecular Sequence Data, Mutant, Plasma protein binding, Nucleotide sugar, 030226 pharmacology & pharmacy, Cofactor, Substrate Specificity, 03 medical and health sciences, chemistry.chemical_compound, Glucuronides, 0302 clinical medicine, Humans, Amino Acid Sequence, Homology modeling, Glucuronosyltransferase, Binding site, 030304 developmental biology, Pharmacology, chemistry.chemical_classification, Scopoletin, 0303 health sciences, Binding Sites, Sequence Homology, Amino Acid, biology, Nucleotides, Protein superfamily, Amino acid, Kinetics, Models, Chemical, chemistry, Biochemistry, Mutation, biology.protein, Molecular Medicine, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5987e8252975b77873d10d1301501f7d
https://doi.org/10.1124/mol.107.036871

المؤلفون: Antti Siiskonen, Moshe Finel, Tobias Rüffer, Mika Kurkela, Heinrich Lang, Tanmaya Joshi, Mikko Vahermo, Bohumila Suchanova, Jari Yli-Kauhaluoma, Ingo Bichlmaier

المصدر: Journal of Medicinal Chemistry. 50:2655-2664

مصطلحات موضوعية: Models, Molecular, Magnetic Resonance Spectroscopy, Chemistry, Stereochemistry, Molecular Conformation, Absolute configuration, Substituent, Stereoisomerism, Alcohol, Nuclear magnetic resonance spectroscopy, Crystallography, X-Ray, Isoenzymes, Structure-Activity Relationship, chemistry.chemical_compound, Non-competitive inhibition, Drug Discovery, Humans, Molecular Medicine, Glucuronosyltransferase, Sesquiterpenes, Two-dimensional nuclear magnetic resonance spectroscopy, Heteronuclear single quantum coherence spectroscopy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db956ae51f4c4af4fb32a09e3f4801da
https://doi.org/10.1021/jm061204e

المؤلفون: Jyrki Taskinen, Risto Kostiainen, Mika Kurkela, Leena Luukkanen, Moshe Finel, Jouni Hirvonen

المصدر: Drug Metabolism and Disposition. 33:1017-1026

مصطلحات موضوعية: UGT1A4, Stereochemistry, Kinetics, Glucuronidation, Pharmaceutical Science, 030226 pharmacology & pharmacy, Catalysis, Substrate Specificity, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Scopoletin, medicine, Humans, Entacapone, Glucuronosyltransferase, Ternary complex, 030304 developmental biology, Pharmacology, 0303 health sciences, Substrate (chemistry), Recombinant Proteins, Aglycone, Biochemistry, chemistry, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::538dc8e36682448f3144084555703ff2
https://doi.org/10.1124/dmd.105.004093

المؤلفون: Jouni Hirvonen, Mika Kurkela, Moshe Finel, Risto Kostiainen

المصدر: Biochemical Pharmacology. 68:2443-2450

مصطلحات موضوعية: Insecta, UGT1A4, Stereochemistry, Mutant, Glucuronidation, 030226 pharmacology & pharmacy, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Protein structure, Scopoletin, medicine, Animals, Humans, Entacapone, Glucuronosyltransferase, Cells, Cultured, 030304 developmental biology, Pharmacology, chemistry.chemical_classification, 0303 health sciences, Catechol-O-methyl transferase, Recombinant Proteins, Protein Structure, Tertiary, Isoenzymes, Enzyme, Amino Acid Substitution, chemistry, Mutation, Tyrosine, Dimerization, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e72c14797c360722c4831d4f72cb04d
https://doi.org/10.1016/j.bcp.2004.08.019

المؤلفون: Risto Kostiainen, Leena Luukkanen, Jouni Hirvonen, Mika Kurkela, J. Arturo Garcı́a-Horsman, Marc Baumann, Moshe Finel, Saila Mörsky, Jyrki Taskinen

المصدر: Journal of Biological Chemistry. 278:3536-3544

مصطلحات موضوعية: 0303 health sciences, Glucuronosyltransferase, Chromatography, biology, Glucuronidation, Cell Biology, 030226 pharmacology & pharmacy, Biochemistry, Fusion protein, 3. Good health, law.invention, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, chemistry, law, Scopoletin, biology.protein, Recombinant DNA, HA-tag, Molecular Biology, Polyacrylamide gel electrophoresis, Histidine, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ec109829075bcb7abb85be2532904088
https://doi.org/10.1074/jbc.m206136200

المؤلفون: Moshe Finel, Jouni Hirvonen, Marjo Yliperttula, Anne Soikkeli, Mika Kurkela

المصدر: Assay and drug development technologies. 9(5)

مصطلحات موضوعية: Drug, Stereochemistry, High-throughput screening, media_common.quotation_subject, Drug Evaluation, Preclinical, Naphthols, 030226 pharmacology & pharmacy, Fluorescence, law.invention, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Glucuronides, Pharmacokinetics, law, Drug Discovery, Humans, Drug Interactions, Molecular Targeted Therapy, Enzyme Inhibitors, Glucuronosyltransferase, Chromatography, High Pressure Liquid, 030304 developmental biology, media_common, chemistry.chemical_classification, 0303 health sciences, Chromatography, Dimethyl sulfoxide, Anti-Inflammatory Agents, Non-Steroidal, Metabolism, Salicylates, 3. Good health, High-Throughput Screening Assays, Enzyme, chemistry, Pharmaceutical Preparations, Recombinant DNA, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf12b789056fac652fa3535aebb62b3
https://pubmed.ncbi.nlm.nih.gov/21438674

المؤلفون: Moshe Finel, Nenad Manevski, Mika Kurkela, Timo Mauriala, Jari Yli-Kauhaluoma, Camilla Höglund, Michael H. Court

مصطلحات موضوعية: UGT1A6, Indoles, Glucuronidation, Pharmaceutical Science, 030226 pharmacology & pharmacy, Substrate Specificity, 03 medical and health sciences, 0302 clinical medicine, Glucuronides, Microsomes, medicine, Humans, RNA, Messenger, Glucuronosyltransferase, 030304 developmental biology, Pharmacology, Indole test, chemistry.chemical_classification, 0303 health sciences, Indole alkaloid, Chemistry, Reverse Transcriptase Polymerase Chain Reaction, Sulfhydryl Reagents, Metabolism, Articles, Metabolic Detoxication, Phase II, Recombinant Proteins, 3. Good health, Psilocybin, Isoenzymes, Kinetics, Enzyme, Biochemistry, Liver, Organ Specificity, Psilocin, UDP-Glucuronosyltransferase 1A9, Microsome, Hallucinogens, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a91494b93d11c4d60e4e2d32df0f44f9
https://europepmc.org/articles/PMC2835393/

المؤلفون: Taina Sten, Moshe Finel, Mika Kurkela, Tiia Kuuranne, Antti Leinonen

المصدر: Drug metabolism and disposition: the biological fate of chemicals. 37(11)

مصطلحات موضوعية: UGT1A4, Stereochemistry, medicine.medical_treatment, Diol, Glucuronidation, Pharmaceutical Science, Androsterone, 030226 pharmacology & pharmacy, Steroid, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, polycyclic compounds, medicine, Humans, Glucuronosyltransferase, 030304 developmental biology, Pharmacology, 0303 health sciences, Etiocholanolone, integumentary system, Recombinant Proteins, UGT2B7, Isoenzymes, chemistry, Androstane, Androstanes, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35f8c76ff1af87c6693478ef10acd81c
https://pubmed.ncbi.nlm.nih.gov/19661211

المؤلفون: V.S. Trubetskoy, F.M. Hoffman, M. Fitzgerald, Olga V. Trubetskoy, N.R. Peters, Mika Kurkela, Moshe Finel

المصدر: Assay and drug development technologies. 5(3)

مصطلحات موضوعية: High-throughput screening, Glucuronidation, Drug Evaluation, Preclinical, 030226 pharmacology & pharmacy, UDP Glucuronosyltransferase, Fluorescence, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, Drug Interactions, Enzyme Inhibitors, Glucuronosyltransferase, Chromatography, High Pressure Liquid, Micelles, 030304 developmental biology, 0303 health sciences, Polymeric micelles, Chemistry, Molecular biology, Combinatorial chemistry, Small molecule, Kinetics, Drug development, Molecular Medicine, Pharmacophore, Drug metabolism

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03c6bdf8eb46f10c4376991228baa9b1
https://pubmed.ncbi.nlm.nih.gov/17638534

المؤلفون: Moshe Finel, Antti Siiskonen, Mika Kurkela, Ingo Bichlmaier, Jari Yli-Kauhaluoma

المصدر: Bioorganic chemistry. 35(5)

مصطلحات موضوعية: Steric effects, Magnetic Resonance Spectroscopy, Stereochemistry, Glucuronidation, Chemistry, Organic, Alcohol, 030226 pharmacology & pharmacy, Biochemistry, Catalysis, Uridine Diphosphate, Cedrol, Substrate Specificity, 03 medical and health sciences, chemistry.chemical_compound, Inhibitory Concentration 50, 0302 clinical medicine, Non-competitive inhibition, Drug Discovery, Humans, Protein Isoforms, Glucuronosyltransferase, Molecular Biology, 030304 developmental biology, 0303 health sciences, Terpenes, Organic Chemistry, Diastereomer, Stereoisomerism, Hydrocarbons, Kinetics, chemistry, Alcohols, Drug Design, Epimer, Methyl group

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a44a2557ea8748402ed65650c5494a0
https://pubmed.ncbi.nlm.nih.gov/17706742