نتائج البحث - "Micolochick Steuer, Holly M."

1

Academic Journal

Control of Hepatitis B Virus with Imdusiran, a Small Interfering RNA Therapeutic.

المؤلفون: Thi, Emily P., Ye, Xin, Snead, Nicholas M., Lee, Amy C. H., Micolochick Steuer, Holly M., Ardzinski, Andrzej, Graves, Ingrid E., Espiritu, Christine, Cuconati, Andrea, Abbott, Cory, Jarosz, Agnes, Teng, Xiaowei, Paratala, Bhavna, McClintock, Kevin, Harasym, Troy, Rijnbrand, Rene, Lam, Angela M., Sofia, Michael J.

المصدر: ACS Infectious Diseases; 10/11/2024, Vol. 10 Issue 10, p3640-3649, 10p

2

Academic Journal

Conformationally Constrained Isoquinolinones as Orally Efficacious Hepatitis B Capsid Assembly Modulators.

المؤلفون: Mesaros, Eugen F., Cole, Andrew G., Kultgen, Steven G., Mani, Nagraj, Fan, Kristi Yi, Dugan, Benjamin J., Ardzinski, Andrzej, Stever, Kim, Micolochick Steuer, Holly M., Graves, Ingrid, Tang, Sunny, Harasym, Troy O., Lam, Angela M., Thi, Emily P., Dorsey, Bruce D., Sofia, Michael J.

المصدر: ACS Medicinal Chemistry Letters; 9/12/2024, Vol. 15 Issue 9, p1627-1634, 8p

3

Academic Journal

Biological characterization of AB-343, a novel and potent SARS-CoV-2 Mpro inhibitor with pan-coronavirus activity

المصدر: Antiviral Research ; volume 232, page 106038 ; ISSN 0166-3542

الاتاحة: https://doi.org/10.1016/j.antiviral.2024.106038
https://api.elsevier.com/content/article/PII:S0166354224002493?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0166354224002493?httpAccept=text/plain

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4

Academic Journal

Discovery of C-Linked Nucleoside Analogues with Antiviral Activity against SARS-CoV-2

المصدر: ACS Infectious Diseases ; volume 10, issue 5, page 1780-1792 ; ISSN 2373-8227 2373-8227

الاتاحة: http://dx.doi.org/10.1021/acsinfecdis.4c00122
https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.4c00122

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5

Academic Journal

Host Poly(A) Polymerases PAPD5 and PAPD7 Provide Two Layers of Protection That Ensure the Integrity and Stability of Hepatitis B Virus RNA

المؤلفون: Liu, Fei, Lee, Amy C. H., Guo, Fang, Kondratowicz, Andrew S., Micolochick Steuer, Holly M., Miller, Angela, Bailey, Lauren D., Wang, Xiaohe, Chen, Shuai, Kultgen, Steven G., Cuconati, Andrea, Cole, Andrew G., Gotchev, Dimitar, Dorsey, Bruce D., Rijnbrand, Rene, Lam, Angela M., Sofia, Michael J., Gao, Min

المساهمون: James Ou, J.-H.

المصدر: Journal of Virology ; volume 95, issue 18 ; ISSN 0022-538X 1098-5514

الاتاحة: http://dx.doi.org/10.1128/jvi.00574-21
https://journals.asm.org/doi/pdf/10.1128/JVI.00574-21

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6

Academic Journal

Preclinical Profile of AB-423, an Inhibitor of Hepatitis B Virus Pregenomic RNA Encapsidation

المصدر: Antimicrobial Agents and Chemotherapy ; volume 62, issue 6 ; ISSN 0066-4804 1098-6596

الاتاحة: http://dx.doi.org/10.1128/aac.00082-18
https://journals.asm.org/doi/pdf/10.1128/AAC.00082-18

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7

Academic Journal

Preclinical characterization of AB-506, an inhibitor of HBV replication targeting the viral core protein

المصدر: Antiviral Research ; volume 197, page 105211 ; ISSN 0166-3542

الاتاحة: http://dx.doi.org/10.1016/j.antiviral.2021.105211
https://api.elsevier.com/content/article/PII:S0166354221002011?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0166354221002011?httpAccept=text/plain

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8

Academic Journal

Genotype and Subtype Profiling of PSI-7977 as a Nucleotide Inhibitor of Hepatitis C Virus

المؤلفون: Lam, Angela M., Espiritu, Christine, Bansal, Shalini, Micolochick Steuer, Holly M., Niu, Congrong, Zennou, Veronique, Keilman, Meg, Zhu, Yuao, Lan, Shuiyun, Otto, Michael J., Furman, Phillip A.

المصدر: Antimicrobial Agents and Chemotherapy ; volume 56, issue 6, page 3359-3368 ; ISSN 0066-4804 1098-6596

الاتاحة: http://dx.doi.org/10.1128/aac.00054-12
https://journals.asm.org/doi/pdf/10.1128/AAC.00054-12

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9

Academic Journal

Hepatitis C Virus Nucleotide Inhibitors PSI-352938 and PSI-353661 Exhibit a Novel Mechanism of Resistance Requiring Multiple Mutations within Replicon RNA

المؤلفون: Lam, Angela M., Espiritu, Christine, Bansal, Shalini, Micolochick Steuer, Holly M., Zennou, Veronique, Otto, Michael J., Furman, Phillip A.

المصدر: Journal of Virology ; volume 85, issue 23, page 12334-12342 ; ISSN 0022-538X 1098-5514

الاتاحة: http://dx.doi.org/10.1128/jvi.05639-11
https://journals.asm.org/doi/pdf/10.1128/JVI.05639-11

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10

Academic Journal

Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of β-d-2′-Deoxy-2′-α-Fluoro-2′-β- C-Methylguanosine

المؤلفون: Lam, Angela M., Espiritu, Christine, Murakami, Eisuke, Zennou, Veronique, Bansal, Shalini, Micolochick Steuer, Holly M., Niu, Congrong, Keilman, Meg, Bao, Haiying, Bourne, Nigel, Veselenak, Ronald L., Reddy, P. Ganapati, Chang, Wonsuk, Du, Jinfa, Nagarathnam, Dhanapalan, Sofia, Michael J., Otto, Michael J., Furman, Phillip A.

المصدر: Antimicrobial Agents and Chemotherapy ; volume 55, issue 6, page 2566-2575 ; ISSN 0066-4804 1098-6596

الاتاحة: http://dx.doi.org/10.1128/aac.00032-11
https://journals.asm.org/doi/pdf/10.1128/AAC.00032-11

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11

Academic Journal

The Mechanism of Action of β- d -2′-Deoxy-2′-Fluoro-2′- C -Methylcytidine Involves a Second Metabolic Pathway Leading to β- d -2′-Deoxy-2′-Fluoro-2′- C -Methyluridine 5′-Triphosphate, a Potent Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

المؤلفون: Murakami, Eisuke, Niu, Congrong, Bao, Haiying, Micolochick Steuer, Holly M., Whitaker, Tony, Nachman, Tammy, Sofia, Michael A., Wang, Peiyuan, Otto, Michael J., Furman, Phillip A.

المصدر: Antimicrobial Agents and Chemotherapy ; volume 52, issue 2, page 458-464 ; ISSN 0066-4804 1098-6596

الاتاحة: http://dx.doi.org/10.1128/aac.01184-07
https://journals.asm.org/doi/pdf/10.1128/AAC.01184-07

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12

Academic Journal

Mechanism of Activation of β- d -2′-Deoxy-2′-Fluoro-2′- C -Methylcytidine and Inhibition of Hepatitis C Virus NS5B RNA Polymerase

المؤلفون: Murakami, Eisuke, Bao, Haiying, Ramesh, Mangala, McBrayer, Tamara R., Whitaker, Tony, Micolochick Steuer, Holly M., Schinazi, Raymond F., Stuyver, Lieven J., Obikhod, Aleksandr, Otto, Michael J., Furman, Phillip A.

المصدر: Antimicrobial Agents and Chemotherapy ; volume 51, issue 2, page 503-509 ; ISSN 0066-4804 1098-6596

الاتاحة: http://dx.doi.org/10.1128/aac.00400-06
https://journals.asm.org/doi/pdf/10.1128/AAC.00400-06

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13

Academic Journal

Use of 2′-Spirocyclic Ethers in HCV Nucleoside Design

المؤلفون: Du, Jinfa, Chun, Byoung-Kwon, Mosley, Ralph T., Bansal, Shalini, Bao, Haiying, Espiritu, Christine, Lam, Angela M., Murakami, Eisuke, Niu, Congrong, Micolochick Steuer, Holly M., Furman, Phillip A., Sofia, Michael J.

المصدر: Journal of Medicinal Chemistry ; volume 57, issue 5, page 1826-1835 ; ISSN 0022-2623 1520-4804

الاتاحة: http://dx.doi.org/10.1021/jm401224y
https://pubs.acs.org/doi/pdf/10.1021/jm401224y

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14

Academic Journal

β-d-2′-α-F-2′-β-C-Methyl-6-O-substituted 3′,5′-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: A structure–activity relationship study

المؤلفون: Du, Jinfa, Bao, Donghui, Chun, Byoung-Kwon, Jiang, Ying, Ganapati Reddy, P., Zhang, Hai-Ren, Ross, Bruce S., Bansal, Shalini, Bao, Haiying, Espiritu, Christine, Lam, Angela M., Murakami, Eisuke, Niu, Congrong, Micolochick Steuer, Holly M., Furman, Phillip A., Otto, Michael J., Sofia, Michael J.

المصدر: Bioorganic & Medicinal Chemistry Letters ; volume 22, issue 18, page 5924-5929 ; ISSN 0960-894X

الاتاحة: http://dx.doi.org/10.1016/j.bmcl.2012.07.066
https://api.elsevier.com/content/article/PII:S0960894X12009420?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0960894X12009420?httpAccept=text/plain

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15

The Mechanism of Action of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine Involves a Second Metabolic Pathway Leading to β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine 5′-Triphosphate, a Potent Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase▿

المؤلفون: Murakami, Eisuke, Niu, Congrong, Bao, Haiying, Micolochick Steuer, Holly M., Whitaker, Tony, Nachman, Tammy, Sofia, Michael A., Wang, Peiyuan, Otto, Michael J., Furman, Phillip A.

مصطلحات موضوعية: Structure-Activity Relationship, viruses, Humans, Replicon, Uridine Triphosphate, Cytidine, Hepacivirus, Microbial Sensitivity Tests, Phosphorylation, RNA-Dependent RNA Polymerase, Antiviral Agents, Deoxycytidine, Cell Line

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::82531bb89ff0e0349a877998573e4ec3
https://europepmc.org/articles/PMC2224766/

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16

Academic Journal

Use of 2′-SpirocyclicEthers in HCV NucleosideDesign.

المؤلفون: Du, Jinfa, Chun, Byoung-Kwon, Mosley, Ralph T., Bansal, Shalini, Bao, Haiying, Espiritu, Christine, Lam, Angela M., Murakami, Eisuke, Niu, Congrong, Micolochick Steuer, Holly M., Furman, Phillip A., Sofia, Michael J.

المصدر: Journal of Medicinal Chemistry; Mar2014, Vol. 57 Issue 5, p1826-1835, 10p

17

Periodical

Mechanism of Activation of {szligbeta}-D-2'-Deoxy-2'-Fluoro-2'-C-Methylcytidine and Inhibition of Hepatitis C Virus NS5B RNA Polymerase

المؤلفون: Murakami, Eisuke, Bao, Haiying, Ramesh, Mangala, McBrayer, Tamara R., Whitaker, Tony, Micolochick Steuer, Holly M., Schinazi, Raymond F., Stuyver, Lieven J., Obikhod, Aleksandr, Otto, Michael J., Furman, Phillip A.

المصدر: Antimicrobial Agents and Chemotherapy; February 2007, Vol. 51 Issue: 2 p503-509, 7p

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18

Academic Journal

Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977.

المؤلفون: Murakami, Eisuke¹ emurakami@pharmasset.com, Tolstykh, Tatiana¹, Haiying Bao¹, Niu, Congrong¹, Micolochick Steuer, Holly M.¹, Chang, Donghui Bac Wonsuk¹, Espiritu, Christine¹, Bansal, Shalini¹, Lam, Angela M.¹, Otto, Michael J.¹, Sofia, Michael J.¹, Furman, Phillip A.¹

المصدر: Journal of Biological Chemistry. 11/5/2010, Vol. 285 Issue 45, p34337-34347. 11p.

مصطلحات موضوعية: *GENE expression, *HEPATITIS C treatment, *PRODRUGS, *DIASTEREOISOMERS, *HYDROLYSIS, *RNA polymerases

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