يعرض 1 - 20 نتائج من 81 نتيجة بحث عن '"Mickler, Elizabeth A."', وقت الاستعلام: 0.57s تنقيح النتائج
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    Academic Journal

    المساهمون: Medicine, School of Medicine

    المصدر: PMC

    مصطلحات موضوعية: Lung cancer, Carcinogenesis, Mouse, Kras, Copy number alterations

    وصف الملف: application/pdf

    Relation: International Journal of Molecular Sciences; Mickler EA, Zhou H, Phang TL, Geraci MW, Stearman RS, Sears CR. Low-Coverage Whole Genome Sequencing Using Laser Capture Microscopy with Combined Digital Droplet PCR: An Effective Tool to Study Copy Number and Kras Mutations in Early Lung Adenocarcinoma Development. Int J Mol Sci. 2021;22(21):12034. Published 2021 Nov 6. doi:10.3390/ijms222112034; https://hdl.handle.net/1805/32126

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    Academic Journal
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    Academic Journal

    المساهمون: Medicine, School of Medicine

    المصدر: PMC

    مصطلحات موضوعية: DAF fragments, Lentiviral therapy, C5b-9, IPF, ER stress

    وصف الملف: application/pdf

    Relation: American Journal of Respiratory Cell and Molecular Biology; Vittal R, Fisher AJ, Thompson EL, et al. Overexpression of Decay Accelerating Factor Mitigates Fibrotic Responses to Lung Injury. Am J Respir Cell Mol Biol. 2022;67(4):459-470. doi:10.1165/rcmb.2021-0463OC; https://hdl.handle.net/1805/38425

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    Academic Journal

    المساهمون: Medicine, School of Medicine

    المصدر: PMC

    مصطلحات موضوعية: High altitude, Hypoxia, Lung growth, Pulmonary hypertension, RNA-Seq

    وصف الملف: application/pdf

    Relation: American Journal of Physiology: Lung Cellular and Molecular Physiology; Krishnan S, Stearman RS, Zeng L, et al. Transcriptomic modifications in developmental cardiopulmonary adaptations to chronic hypoxia using a murine model of simulated high-altitude exposure. Am J Physiol Lung Cell Mol Physiol. 2020;319(3):L456-L470. doi:10.1152/ajplung.00487.2019; https://hdl.handle.net/1805/31856

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    المصدر: Arthritis & Rheumatism ; volume 42, issue 6, page 1140-1146 ; ISSN 0004-3591 1529-0131

    الاتاحة: http://dx.doi.org/10.1002/1529-0131(199906)42:6%3C1140::aid-anr10%3E3.0.co%3B2-7
    https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2F1529-0131(199906)42:6%3C1140::AID-ANR10%3E3.0.CO%3B2-7
    https://onlinelibrary.wiley.com/doi/full/10.1002/1529-0131(199906)42:6%3C1140::AID-ANR10%3E3.0.CO%3B2-7

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    Academic Journal

    المساهمون: Medicine, School of Medicine

    المصدر: PMC

    وصف الملف: application/pdf

    Relation: American Journal of Respiratory Cell and Molecular Biology; Stearman, R. S., Bui, Q. M., Speyer, G., Handen, A., Cornelius, A. R., Graham, B. B., Kim, S., Mickler, E. A., Tuder, R. M., Chan, S. Y., & Geraci, M. W. (2018). Systems Analysis of the Human Pulmonary Arterial Hypertension Lung Transcriptome. American Journal of Respiratory Cell and Molecular Biology, 60(6), 637–649. https://doi.org/10.1165/rcmb.2018-0368OC; https://hdl.handle.net/1805/24317

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    مصطلحات موضوعية: DAF, C5b‐9, C3a, C5a, ER stress, Biology, Science

    وصف الملف: application/pdf

    Relation: Cipolla, Ellyse; Fisher, Amanda J.; Gu, Hongmei; Mickler, Elizabeth A.; Agarwal, Manisha; Wilke, Carol A.; Kim, Kevin K.; Moore, Bethany B.; Vittal, Ragini (2017). "IL‐17A deficiency mitigates bleomycin‐induced complement activation during lung fibrosis." The FASEB Journal 31(12): 5543-5556.; https://hdl.handle.net/2027.42/154482; The FASEB Journal; Suzuki, H., Lasbury, M. E., Fan, L., Vittal, R., Mickler, E. A., Benson, H. L., Shilling, R., Wu, Q., Weber, D. J., Wagner, S. R., Lasaro, M., Devore, D., Wang, Y., Sandusky, G. E., Lipking, K., Pandya, P., Reynolds, J., Love, R., Wozniak, T., Gu, H., Brown, K.M., and Wilkes, D. S. ( 2013 ) Role of complement activation in obliterative bronchiolitis post‐lung transplantation. J. Immunol. 191, 4431 – 4439; Choi, J. E., Lee, S. S., Sunde, D. A., Huizar, I., Haugk, K. L., Thannickal, V. J., Vittal, R., Plymate, S. R., and Schnapp, L. M. ( 2009 ) Insulin‐like growth factor‐I receptor blockade improves outcome in mouse model of lung injury. Am. J. Respir. Crit. CareMed. 179, 212 – 219; Gu, H., Fisher, A. J., Mickler, E. A., Duerson III, F., Cummings, O. W., Peters‐Golden, M., Twigg III, H. L., Woodruff, T. M., Wilkes, D. S., and Vittal, R. ( 2016 ) Contribution of the anaphylatoxin receptors, C3aR and C5aR, to the pathogenesis of pulmonary fibrosis. FASEB J. 30, 2336 – 2350; Witt, C. A., Gaut, J. P., Yusen, R. D., Byers, D. E., Iuppa, J. A., Bennett Bain, K., Alexander Patterson, G., Mohanakumar, T., Trulock, E. P., and Hachem, R.R. ( 2013 ) Acute antibody‐mediated rejection after lung transplantation. J. Heart Lung Transplant. 32, 1034 – 1040; Addis‐Lieser, E., Köhl, J., and Chiaramonte, M. G. ( 2005 ) Opposing regulatory roles of complement factor 5 in the development of bleomycin‐induced pulmonary fibrosis. J. Immunol. 175, 1894 – 1902; Silasi‐Mansat, R., Zhu, H., Georgescu, C., Popescu, N., Keshari, R.S., Peer, G., Lupu, C., Taylor, F. B., Pereira, H. A., Kinasewitz, G., Lambris, J. D., and Lupu, F. ( 2015 ) Complement inhibition decreases early fibrogenic events in the lung of septic baboons. J. Cell. Mol. Med. 19, 2549 – 2563; Vittal, R., Fisher, A., Gu, H., Mickler, E. A., Panitch, A., Lander, C., Cummings, O. W., Sandusky, G. E., and Wilkes, D. S. ( 2013 ) Peptide‐mediated inhibition of mitogen‐activated protein kinase‐activated protein kinase‐2 ameliorates bleomycin‐induced pulmonary fibrosis. Am. J. Respir. Cell Mol. Biol. 49, 47 – 57; Vittal, R., Mickler, E. A., Fisher, A. J., Zhang, C., Rothhaar, K., Gu, H., Brown, K. M., Emtiazdjoo, A., Lott, J. M., Frye, S. B., Smith, G. N., Sandusky, G. E., Cummings, O. W., and Wilkes, D. S. ( 2013 ) Type V collagen induced tolerance suppresses collagen deposition, TGF‐β and associated transcripts in pulmonary fibrosis. PLoS One 8, e76451; Zhang, Z., Zheng, M., Bindas, J., Schwarzenberger, P., and Kolls, J. K. ( 2006 ) Critical role of IL‐17 receptor signaling in acute TNBS‐induced colitis. Inflamm. Bowel Dis. 12, 382 – 388; Inglis, J. E., Radziwon, K.A., and Maniero, G. D. ( 2008 ) The serum complement system: a simplified laboratory exercise to measure the activity of an important component of the immune system. Adv. Physiol. Educ. 32, 317 – 321; Lederer, D. J., Jelic, S., Basner, R.C., Ishizaka, A., and Bhattacharya, J. ( 2009 ) Circulating KL‐6, a biomarker of lung injury, in obstructive sleep apnoea. Eur. Respir. J. 33, 793 – 796; Tavernier, S. J., Osorio, F., Vandersarren, L., Vetters, J., Vanlangenakker, N., Van Isterdael, G., Vergote, K., De Rycke, R., Parthoens, E., van de Laar, L., Iwawaki, T., Del Valle, J. R., Hu, C. A., Lambrecht, B. N., and Janssens, S. ( 2017 ) Regulated IRE1‐dependent mRNA decay sets the threshold for dendritic cell survival. Nat. Cell Biol. 19, 698 – 710; Seaayfan, E., Defontaine, N., Demaretz, S., Zaarour, N., and Laghmani, K. ( 2016 ) OS9 protein interacts with Na‐K‐2Cl co‐transporter (NKCC2) and targets its immature form for the endo‐plasmic reticulum‐associated degradation pathway. J. Biol. Chem. 291, 4487 – 4502; Jiang, X., Nguyen, T. T., Tian, W., Sung, Y. K., Yuan, K., Qian, J., Rajadas, J., Sallenave, J. M., Nickel, N. P., de Jesus Perez, V., Rabinovitch, M., and Nicolls, M. R. ( 2015 ) Cyclosporine does not prevent microvascular loss in transplantation but can synergize with a neutrophil elastase inhibitor, elafin, to maintain graft perfusion during acute rejection. Am. J. Transplant. 15, 1768 – 1781; McAllister, F., Henry, A., Kreindler, J. L., Dubin, P. J., Ulrich, L., Steele, C., Finder, J. D., Pilewski, J. M., Carreno, B. M., Goldman, S. J., Pirhonen, J., and Kolls, J. K. ( 2005 ) Role of IL‐17A, IL‐17F, and the IL‐17 receptor in regulating growth‐related oncogene‐alpha and granulocyte colony‐stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis. J. Immunol. 175, 404 – 412; Dong, C. ( 2008 ) Regulation and pro‐inflammatory function of interleukin‐17 family cytokines. Immunol. Rev. 226, 80 – 86; Braun, R. K., Martin, A., Shah, S., Iwashima, M., Medina, M., Byrne, K., Sethupathi, P., Wigfield, C. H., Brand, D.D., and Love, R. B. ( 2010 ) Inhibition of bleomycin‐induced pulmonary fibrosis through pre‐treatment with collagen type V. J. Heart Lung Transplant. 29, 873 – 880; Strunk, R.C., Eidlen, D. M., and Mason, R.J. ( 1988 ) Pulmonary alveolar type II epithelial cells synthesize and secrete proteins of the classical and alternative complement pathways. J. Clin. Invest. 81, 1419 – 1426; Parra, E. R., Boufelli, G., Bertanha, F., Samorano, Lde. P., Aguiar, A. C., Jr., Costa, F. M., Capelozzi, V. L., and Barbas‐Filho, J. V. ( 2008 ) Temporal evolution of epithelial, vascular and interstitial lung injury in an experimental model of idiopathic pulmonary fibrosis induced by butyl‐hydroxytoluene. Int. J. Exp. Pathol. 89, 350 – 357; Luzina, I. G., Todd, N. W., Iacono, A. T., and Atamas, S. P. ( 2008 ) Roles of T lymphocytes in pulmonary fibrosis. J. Leukoc. Biol. 83, 237 – 244; Hackett, T. L., Warner, S. M., Stefanowicz, D., Shaheen, F., Pechkovsky, D. V., Murray, L.A., Argentieri, R., Kicic, A., Stick, S. M., Bai, T. R., and Knight, D. A. ( 2009 ) Induction of epithelial‐mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor‐beta1. Am. J. Respir. Crit. Care Med. 180, 122 – 133; Simonian, P. L., Roark, C. L., Wehrmann, F., Lanham, A. K., Diaz del Valle, F., Born, W. K., O’Brien, R. L., and Fontenot, A. P. ( 2009 ) Th17‐polarized immune response in a murine model of hypersensitivity pneumonitis and lung fibrosis. J. Immunol. 182, 657 – 665; Luo, F., Le, N.B., Mills, T., Chen, N. Y., Karmouty‐Quintana, H., Molina, J. G., Davies, J., Philip, K., Volcik, K.A., Liu, H., Xia, Y., Eltzschig, H. K., and Blackburn, M. R. ( 2016 ) Extracellular adenosine levels are associated with the progression and exacerbation of pulmonary fibrosis. FASEB J. 30, 874 – 883; Yuan, T., Luo, B. L., Wei, T. H., Zhang, L., He, B. M., and Niu, R.C. ( 2012 ) Salubrinal protects against cigarette smoke extract‐induced HBEpC apoptosis likely via regulating the activity of PERK‐eIF2a signaling pathway. Arch. Med. Res. 43, 522 – 529; Pacello, F., D’Orazio, M., and Battistoni, A. ( 2016 ) An ERp57‐mediated disulphide exchange promotes the interaction between Burkholderia cenocepacia and epithelial respiratory cells. Sci. Rep. 6, 21140; Faria, D., Lentze, N., Almaça, J., Luz, S., Alessio, L., Tian, Y., Martins, J. P., Cruz, P., Schreiber, R., Rezwan, M., Farinha, C. M., Auerbach, D., Amaral, M. D., and Kunzelmann, K. ( 2012 ) Regulation of ENaC biogenesis by the stress response protein SERP1. Pflugers Arch. 463, 819 – 827; Hofmann, S., Fischer, A., Nothnagel, M., Jacobs, G., Schmid, B., Wittig, M., Franke, A., Gaede, K.I., Schümann, M., Petrek, M., Mrazek, F., Pabst, S., Grohé, C., Grunewald, J., Ronninger, M., Eklund, A., Rosenstiel, P., Höhne, K., Zissel, G., Müller‐Quernheim, J., and Schreiber, S. ( 2013 ) Genome‐wide association analysis reveals 12q13.3‐q14.1 as new risk locus for sarcoidosis. Eur. Respir. J. 41, 888 – 900; Ghali, J. R., O’Sullivan, K. M., Eggenhuizen, P. J., Holdsworth, S. R., and Kitching, A. R. ( 2017 ) Interleukin‐17RA promotes humoral responses and glomerular injury in experimental rapidly progressive glomerulonephritis. Nephron 135, 207 – 223; Lambré, C. R., le Maho, S., di Bella, G., de Cremoux, H., Atassi, K., and Bignon, J. ( 1986 ) Bronchoalveolar lavage fluid and serum complement activity in pulmonary sarcoidosis. Am. Rev. Respir. Dis. 134, 238 – 242; Gu, H., Mickler, E. A., Cummings, O. W., Sandusky, G. E., Weber, D. J., Gracon, A., Woodruff, T., Wilkes, D. S., and Vittal, R. ( 2014 ) Crosstalk between TGF‐β1 and complement activation augments epithelial injury in pulmonary fibrosis. FASEB J. 28, 4223 – 4234; Lawson, W. E., Crossno, P. F., Polosukhin, V. V., Roldan, J., Cheng, D. S., Lane, K.B., Blackwell, T. R., Xu, C., Markin, C., Ware, L. B., Miller, G. G., Loyd, J. E., and Blackwell, T. S. ( 2008 ) Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection. Am. J. Physiol. Lung Cell. Mol. Physiol. 294, L1119 – L1126; Korfei, M., Ruppert, C., Mahavadi, P., Henneke, I., Markart, P., Koch, M., Lang, G., Fink, L., Bohle, R. M., Seeger, W., Weaver, T. E., and Guenther, A. ( 2008 ) Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 178, 838 – 846; Kim, S. R., Kim, H. J., Kim, D. I., Lee, K. B., Park, H. J., Jeong, J. S., Cho, S. H., and Lee, Y. C. ( 2015 ) Blockade of interplay between IL‐17A and endoplasmic reticulum stress attenuates LPS‐induced lung injury. Theranostics 5, 1343 – 1362; Lajoie, S., Lewkowich, I. P., Suzuki, Y., Clark, J. R., Sproles, A. A., Dienger, K., Budelsky, A. L., and Wills‐Karp, M. ( 2010 ) Complement‐mediated regulation of the IL‐17A axis is a central genetic determinant of the severity of experimental allergic asthma. Nat. Immunol. 11, 928 – 935; Vittal, R., Fan, L., Greenspan, D. S., Mickler, E. A., Gopalakrishnan, B., Gu, H., Benson, H. L., Zhang, C., Burlingham, W., Cummings, O. W., and Wilkes, D. S. ( 2013 ) IL‐17 induces type V collagen overexpression and EMT via TGF‐β‐dependent pathways in obliterative bronchiolitis. Am. J. Physiol. Lung Cell. Mol. Physiol. 304, L401 – L414; Wilson, M. S., Madala, S. K., Ramalingam, T. R., Gochuico, B. R., Rosas, I. O., Cheever, A. W., and Wynn, T. A. ( 2010 ) Bleomycin and IL‐1beta‐mediated pulmonary fibrosis is IL‐17A dependent. J. Exp. Med. 207, 535 – 552; Fan, L., Benson, H. L., Vittal, R., Mickler, E. A., Presson, R., Fisher, A. J., Cummings, O. W., Heidler, K. M., Keller, M. R., Burlingham, W. J., and Wilkes, D. S. ( 2011 ) Neutralizing IL‐17 prevents obliterative bronchiolitis in murine orthotopic lung transplantation. Am. J. Transplant. 11, 911 – 922; Zhou, X., Loomis‐King, H., Gurczynski, S. J., Wilke, C. A., Konopka, K. E., Ptaschinski, C., Coomes, S. M., Iwakura, Y., van Dyk, L. F., Lukacs, N. W., and Moore, B. B. ( 2016 ) Bone marrow transplantation alters lung antigen‐presenting cells to promote TH17 response and the development of pneumonitis and fibrosis following gamma‐herpesvirus infection. Mucosal Immunol. 9, 610 – 620; Campos, I. B., Herd, M., Moffitt, K. L., Lu, Y. J., Darrieux, M., Malley, R., Leite, L. C., and Gonçalves, V. M. ( 2017 ) IL‐17 Aand complement contribute to killing of pneumococci following immunization with a pneumococcal whole cell vaccine. Vaccine 35, 1306 – 1315; Van Kooten, C., Boonstra, J. G., Paape, M. E., Fossiez, F., Banchereau, J., Lebecque, S., Bruijn, J. A., De Fijter, J. W., Van Es, L. A., and Daha, M. R. ( 1998 ) Interleukin‐17 activates human renal epithelial cells in vitro and is expressed during renal allograft rejection. J. Am. Soc. Nephrol. 9, 1526 – 1534; Sugihara, T., Kobori, A., Imaeda, H., Tsujikawa, T., Amagase, K., Takeuchi, K., Fujiyama, Y., and Andoh, A. ( 2010 ) The increased mucosal mRNA expressions of complement C3 and interleukin‐17 in inflammatory bowel disease. Clin. Exp. Immunol. 160, 386 – 393; Katz, Y., Nadiv, O., Rapoport, M. J., and Loos, M. ( 2000 ) IL‐17 regulates gene expression and protein synthesis of the complement system, C3 and factor B, in skin fibroblasts. Clin. Exp. Immunol. 120, 22 – 29; Selman, M., and Pardo, A. ( 2006 ) Role of epithelial cells in idiopathic pulmonary fibrosis: from innocent targets to serial killers. Proc. Am. Thorac. Soc. 3, 364 – 372; Xu, Y., Mizuno, T., Sridharan, A., Du, Y., Guo, M., Tang, J., Wikenheiser‐Brokamp, K. A., Perl, A. T., Funari, V. A., Gokey, J. J., Stripp, B. R., and Whitsett, J. A. ( 2016 ) Single‐cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis. JCI Insight 1, e90558; Tanjore, H., Blackwell, T. S., and Lawson, W. E. ( 2012 ) Emerging evidence for endoplasmic reticulum stress in the pathogenesis of idiopathic pulmonary fibrosis. Am. J. Physiol. Lung Cell. Mol. Physiol. 302, L721 – L729; Ge, L., Habiel, D. M., Hansbro, P. M., Kim, R.Y., Gharib, S. A., Edelman, J. D., Königshoff, M., Parimon, T., Brauer, R., Huang, Y., Allen, J., Jiang, D., Kurkciyan, A. A., Mizuno, T., Stripp, B. R., Noble, P. W., Hogaboam, C. M., and Chen, P. ( 2016 ) miR‐323a‐3p regulates lung fibrosis by targeting multiple profibrotic pathways. JCI Insight 1, e90301; Reed, M., Morris, S. H., Owczarczyk, A. B., and Lukacs, N. W. ( 2015 ) Deficiency of autophagy protein Map1‐LC3b mediates IL‐17‐dependent lung pathology during respiratory viral infection via ER stress‐associated IL‐1. Mucosal Immunol. 8, 1118 – 1130; Ohshimo, S., Ishikawa, N., Horimasu, Y., Hattori, N., Hirohashi, N., Tanigawa, K., Kohno, N., Bonella, F., Guzman, J., and Costabel, U. ( 2014 ) Baseline KL‐6 predicts increased risk for acute exacerbation of idiopathic pulmonary fibrosis. Respir. Med. 108, 1031 – 1039; Collard, H. R., Calfee, C. S., Wolters, P. J., Song, J. W., Hong, S. B., Brady, S., Ishizaka, A., Jones, K. D., King, T. E., Jr., Matthay, M. A., and Kim, D. S. ( 2010 ) Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis. Am. J. Physiol. Lung Cell. Mol. Physiol. 299, L3 – L7; Yokoyama, A., Kondo, K., Nakajima, M., Matsushima, T., Takahashi, T., Nishimura, M., Bando, M., Sugiyama, Y., Totani, Y., Ishizaki, T., Ichiyasu, H., Suga, M., Hamada, H., and Kohno, N. ( 2006 ) Prognostic value of circulating KL‐6 in idiopathic pulmonary fibrosis. Respirology 11, 164 – 168; Yokoyama, A., Kohno, N., Hamada, H., Sakatani, M., Ueda, E., Kondo, K., Hirasawa, Y., and Hiwada, K. ( 1998 ) Circulating KL‐6 predicts the outcome of rapidly progressive idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 158, 1680 – 1684; Zhang, Y., and Kaminski, N. ( 2012 ) Biomarkers in idiopathic pulmonary fibrosis. Curr. Opin. Pulm. Med. 18, 441 – 446; Wheaton, A.K., Agarwal, M., Jia, S., and Kim, K. K. ( 2017 ) Lung epithelial cell focal adhesion kinase signaling inhibits lung injury and fibrosis. Am. J. Physiol. Lung Cell. Mol. Physiol. 312, L722 – L730

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    Academic Journal

    المساهمون: Medicine, School of Medicine

    المصدر: PMC

    مصطلحات موضوعية: C3aR, C5aR, DAF, Smad7, miR-21, miR-200C

    وصف الملف: application/pdf

    Relation: Cellular & Molecular Medicine; Fisher, A. J., Cipolla, E., Varre, A., Gu, H., Mickler, E. A., & Vittal, R. (2017). Potential Mechanisms Underlying TGF-β-mediated Complement Activation in Lung Fibrosis. Cellular & Molecular Medicine: Open Access, 3(3), 14.; https://hdl.handle.net/1805/16434

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    Academic Journal
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    Academic Journal

    المساهمون: Department of Microbiology and Immunology, IU School of Medicine

    المصدر: PMC

    مصطلحات موضوعية: C3a, C5a, CD46, CD55, IPF

    وصف الملف: application/pdf

    Relation: The FASEB Journal; Gu, H., Mickler, E. A., Cummings, O. W., Sandusky, G. E., Weber, D. J., Gracon, A., … Vittal, R. (2014). Crosstalk between TGF-β1 and complement activation augments epithelial injury in pulmonary fibrosis. The FASEB Journal, 28(10), 4223–4234. http://doi.org/10.1096/fj.13-247650; https://hdl.handle.net/1805/10760

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