المؤلفون: Tamara Halkina (2379208), Jaclyn L. Henderson (2102971), Edward Y. Lin (10744817), Martin K. Himmelbauer (8463675), J. Howard Jones (2684047), Marta Nevalainen (1342470), Jun Feng (116162), Kristopher King (8042468), Michael Rooney (1601641), Joshua L. Johnson (1914394), Douglas J. Marcotte (8042471), Jayanth V. Chodaparambil (10744820), P. Rajesh Kumar (10744823), Thomas A. Patterson (10744826), Paramasivam Murugan (8042474), Eli Schuman (1960426), LaiYee Wong (10744829), Thomas Hesson (8042480), Sarah Lamore (10744832), Channa Bao (8681433), Michael Calhoun (6966182), Hannah Certo (10744835), Brenda Amaral (7521905), Gregory M. Dillon (8681430), Rab Gilfillan (8042486), Felix Gonzalez-Lopez de Turiso (8042489)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Immunology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, vivo proof, TTBK inhibitor, disease-relevant Ser 422 epitope, kinase domain, pharmacology studies, 315 nM, azaindazole TTBK 1 inhibitors, mouse hypothermia, tau phosphorylation, Vivo Structural analysis, CNS penetration, TTBK 1, cell IC 50, Brain-Penetrant Tau Tubulin Kinase 1, NIK inhibitor 3, 571 nM, Systematic optimization, novel class

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_Potent_and_Brain-Penetrant_Tau_Tubulin_Kinase_1_TTBK1_Inhibitors_that_Lower_Tau_Phosphorylation_In_Vivo/14535557

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00382.s001

المؤلفون: Tamara Halkina (2379208), Jaclyn L. Henderson (2102971), Edward Y. Lin (10744817), Martin K. Himmelbauer (8463675), J. Howard Jones (2684047), Marta Nevalainen (1342470), Jun Feng (116162), Kristopher King (8042468), Michael Rooney (1601641), Joshua L. Johnson (1914394), Douglas J. Marcotte (8042471), Jayanth V. Chodaparambil (10744820), P. Rajesh Kumar (10744823), Thomas A. Patterson (10744826), Paramasivam Murugan (8042474), Eli Schuman (1960426), LaiYee Wong (10744829), Thomas Hesson (8042480), Sarah Lamore (10744832), Channa Bao (8681433), Michael Calhoun (6966182), Hannah Certo (10744835), Brenda Amaral (7521905), Gregory M. Dillon (8681430), Rab Gilfillan (8042486), Felix Gonzalez-Lopez de Turiso (8042489)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Immunology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, vivo proof, TTBK inhibitor, disease-relevant Ser 422 epitope, kinase domain, pharmacology studies, 315 nM, azaindazole TTBK 1 inhibitors, mouse hypothermia, tau phosphorylation, Vivo Structural analysis, CNS penetration, TTBK 1, cell IC 50, Brain-Penetrant Tau Tubulin Kinase 1, NIK inhibitor 3, 571 nM, Systematic optimization, novel class

Relation: https://figshare.com/articles/dataset/Discovery_of_Potent_and_Brain-Penetrant_Tau_Tubulin_Kinase_1_TTBK1_Inhibitors_that_Lower_Tau_Phosphorylation_In_Vivo/14535560

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00382.s002