المؤلفون: Kade D. Roberts, Yan Zhu, Mohammad A. K. Azad, Mei-Ling Han, Jiping Wang, Lynn Wang, Heidi H. Yu, Andrew S. Horne, Jo-Anne Pinson, David Rudd, Nicolas H. Voelcker, Nitin A. Patil, Jinxin Zhao, Xukai Jiang, Jing Lu, Ke Chen, Olga Lomovskaya, Scott J. Hecker, Philip E. Thompson, Roger L. Nation, Michael N. Dudley, David C. Griffith, Tony Velkov, Jian Li

المصدر: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/0e3e6c3ab9774848b67a0f077533e996

المؤلفون: Richard G. Wunderink, Evangelos J. Giamarellos-Bourboulis, Galia Rahav, Amy J. Mathers, Matteo Bassetti, Jose Vazquez, Oliver A. Cornely, Joseph Solomkin, Tanaya Bhowmick, Jihad Bishara, George L. Daikos, Tim Felton, Maria Jose Lopez Furst, Eun Jeong Kwak, Francesco Menichetti, Ilana Oren, Elizabeth L. Alexander, David Griffith, Olga Lomovskaya, Jeffery Loutit, Shu Zhang, Michael N. Dudley, Keith S. Kaye

المصدر: Infectious Diseases and Therapy, Vol 7, Iss 4, Pp 439-455 (2018)

مصطلحات موضوعية: Best available therapy, Carbapenem-resistant Enterobacteriaceae, Meropenem–vaborbactam, Randomized clinical trial, TANGO II, Infectious and parasitic diseases, RC109-216

وصف الملف: electronic resource

Relation: http://link.springer.com/article/10.1007/s40121-018-0214-1; https://doaj.org/toc/2193-8229; https://doaj.org/toc/2193-6382

URL الوصول: https://doaj.org/article/106733a022be48b9ab7ef1601be3b1a5

المؤلفون: Joshua P. Metlay, John H. Powers, Michael N. Dudley, Keryn Christiansen, Roger G. Finch

المصدر: Emerging Infectious Diseases, Vol 12, Iss 2, Pp 183-190 (2006)

مصطلحات موضوعية: Antibiotic resistance, Bacterial infections, Clinical trials, Drug approval, Drug industry, Drug resistance, microbial, Medicine, Infectious and parasitic diseases, RC109-216

وصف الملف: electronic resource

Relation: https://wwwnc.cdc.gov/eid/article/12/2/05-0078_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059

URL الوصول: https://doaj.org/article/6647c84a5050461da0b2d2d40b227a02

المؤلفون: K. Raja Reddy (2325832), Jonathan Parkinson (7220564), Mojgan Sabet (35195), Ziad Tarazi (8658438), Serge H. Boyer (2245465), Olga Lomovskaya (2983224), David C. Griffith (8658426), Scott J. Hecker (2245453), Michael N. Dudley (5745498)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Pharmacology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, pharmacokinetics across species, optimal properties across, negative bacterial infections, directed toward identifying, orally bioavailable prodrug, key properties investigated, effective oral therapies, na , oral prodrug, key attributes, treat gram, seventeen prodrugs, active form

Relation: https://figshare.com/articles/journal_contribution/Selection_of_QPX7831_an_Orally_Bioavailable_Prodrug_of_Boronic_Acid_Lactamase_Inhibitor_QPX7728/17075897

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01722.s001

المؤلفون: Olga Lomovskaya, Maxim Totrov, Dongxu Sun, K. Raja Reddy, Tomasz W. Glinka, Mojgan Sabet, Debora Rubio-Aparicio, Serge H. Boyer, Orville A. Pemberton, Ruslan Tsivkovski, Scott J. Hecker, Michael N. Dudley, David C. Griffith, Jonathan Parkinson, Kirk Nelson, Yu Chen, Ziad Tarazi

المصدر: Journal of Medicinal Chemistry. 63:7491-7507

مصطلحات موضوعية: Carboxylic Acids, Microbial Sensitivity Tests, 01 natural sciences, Serine, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Animals, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Vaborbactam, Bacteria, biology, biology.organism_classification, Boronic Acids, Enterobacteriaceae, Klebsiella Infections, 0104 chemical sciences, Acinetobacter baumannii, Multiple drug resistance, 010404 medicinal & biomolecular chemistry, Enzyme, chemistry, Biochemistry, Molecular Medicine, Efflux, Borinic Acids, beta-Lactamase Inhibitors, Boronic acid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0120b5dd24d3ace9b34c3d9db7858b70
https://doi.org/10.1021/acs.jmedchem.9b01976

المؤلفون: Ziad Tarazi, K. Raja Reddy, Olga Lomovskaya, Jonathan Parkinson, Michael N. Dudley, Serge H. Boyer, Scott J. Hecker, David C. Griffith, Mojgan Sabet

المصدر: Journal of medicinal chemistry. 64(23)

مصطلحات موضوعية: Carboxylic Acids, Administration, Oral, Biological Availability, Pharmacology, Prodrug, In vitro, Bioavailability, chemistry.chemical_compound, chemistry, Pharmacokinetics, β lactamase inhibitor, Drug Discovery, Molecular Medicine, Animals, Humans, Prodrugs, Borinic Acids, beta-Lactamase Inhibitors, Boronic acid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d60110ef6fc895102d041e03ea9e74
https://pubmed.ncbi.nlm.nih.gov/34817182

المؤلفون: J Stuart Elborn, David E Geller, Douglas Conrad, Shawn D Aaron, Alan R Smyth, Rainald Fischer, Eitan Kerem, Scott C Bell, Jeffery S Loutit, Michael N Dudley, Elizabeth E Morgan, Donald R Vandevanter, Patrick A Flume

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://www.fibrosisquistica.org.ar/images/profesionales/levofloxacina_vs_tobramicina.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1077.3881; http://www.fibrosisquistica.org.ar/images/profesionales/levofloxacina_vs_tobramicina.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1077.3881
http://www.fibrosisquistica.org.ar/images/profesionales/levofloxacina_vs_tobramicina.pdf

المؤلفون: Scott J. Hecker, Maxim Totrov, Dongxu Sun, Jeffery S. Loutit, Olga Lomovskaya, Raja Reddy, Ruslan Tsivkovski, David A. Griffith, Michael N. Dudley

المصدر: Frontiers in Microbiology
Frontiers in Microbiology, Vol 12 (2021)

مصطلحات موضوعية: 0301 basic medicine, Microbiology (medical), medicine.drug_class, 030106 microbiology, Antibiotics, Review, medicine.disease_cause, Microbiology, 03 medical and health sciences, carbapenemase, Pseudomonas, medicine, beta-lactamase inhibitor, metallo β-lactamase, Vaborbactam, biology, Acinetobacter, Pseudomonas aeruginosa, CRE, biology.organism_classification, QR1-502, Acinetobacter baumannii, 030104 developmental biology, QPX7728, Efflux, Bacteria

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56083282633c3ccebe28d9aebab8f1f5
http://europepmc.org/articles/PMC8287861

المؤلفون: Michael Trang, Sujata M. Bhavnani, Paul G. Ambrose, Jeffrey S Loutit, Michael N. Dudley, David C. Griffith, Christopher M. Rubino

المصدر: Antimicrobial agents and chemotherapy. 65(9)

مصطلحات موضوعية: Pharmacology, Body surface area, medicine.medical_specialty, education.field_of_study, business.industry, Urinary system, Population, Urology, Renal function, Meropenem, Boronic Acids, End stage renal disease, NONMEM, Anti-Bacterial Agents, Drug Combinations, Heterocyclic Compounds, 1-Ring, Infectious Diseases, Pharmacokinetics, Medicine, Humans, Pharmacology (medical), business, education, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b892384f6cf18e49fba6113dba44a57a
https://pubmed.ncbi.nlm.nih.gov/34097490

المؤلفون: Debora Rubio-Aparicio, Olga Lomovskaya, Mariana Castanheira, Jeffery S. Loutit, Dongxu Sun, Kirk Nelson, Jill M. Lindley, Ruslan Tsivkovski, Michael N. Dudley

المصدر: Antimicrobial Agents and Chemotherapy

مصطلحات موضوعية: 0301 basic medicine, Carbapenem, medicine.medical_treatment, efflux pumps, 030106 microbiology, Biology, medicine.disease_cause, Meropenem, Microbiology, 03 medical and health sciences, Mechanisms of Resistance, medicine, Potency, Pharmacology (medical), Pharmacology, Pseudomonas aeruginosa, beta-lactams, Acinetobacter, biochemical phenomena, metabolism, and nutrition, OprD, biology.organism_classification, efflux, In vitro, 030104 developmental biology, Infectious Diseases, QPX7728, Beta-lactamase, Efflux, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0290222a344dd1c50ba5b6008fc88bb9
http://europepmc.org/articles/PMC8315991

المؤلفون: Michael N. Dudley, Jeffery S. Loutit, Elizabeth E. Morgan, David C. Griffith

المصدر: Antimicrob Agents Chemother

مصطلحات موضوعية: Pharmacology, 0303 health sciences, 030306 microbiology, business.industry, Nausea, Urinary system, Safety tolerability, Rash, 03 medical and health sciences, Infectious Diseases, Pharmacokinetics, Anesthesia, Vomiting, Medicine, Pharmacology (medical), medicine.symptom, business, Adverse effect, Biapenem, 030304 developmental biology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086564c5eeacaa7793685394efbe84ca
https://doi.org/10.1128/aac.02612-20

المؤلفون: Olga Lomovskaya, Maxim Totrov, Dongxu Sun, Kirk Nelson, Michael N. Dudley, Debora Rubio-Aparicio, Ruslan Tsivkovski

المصدر: Antimicrob Agents Chemother

مصطلحات موضوعية: medicine.medical_treatment, Meropenem, Microbiology, 03 medical and health sciences, Mechanisms of Resistance, polycyclic compounds, medicine, Potency, Pharmacology (medical), 030304 developmental biology, Pharmacology, 0303 health sciences, biology, 030306 microbiology, biochemical phenomena, metabolism, and nutrition, Acinetobacter, bacterial infections and mycoses, biology.organism_classification, In vitro, Acinetobacter baumannii, Infectious Diseases, Beta-lactamase, bacteria, Efflux, Bacteria, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e128d6e5b6e17cfebf96e152dbf117
https://doi.org/10.1128/aac.01406-20

المؤلفون: Olga Lomovskaya, Kirk Nelson, Michael N. Dudley, Dongxu Sun, Debora Rubio-Aparicio

المصدر: Antimicrob Agents Chemother

مصطلحات موضوعية: medicine.medical_treatment, Meropenem, Microbiology, Serine, 03 medical and health sciences, 0302 clinical medicine, Mechanisms of Resistance, Enterobacterales, polycyclic compounds, medicine, Potency, Pharmacology (medical), 030212 general & internal medicine, Pharmacology, 0303 health sciences, Vaborbactam, biology, 030306 microbiology, Chemistry, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, biology.organism_classification, In vitro, Infectious Diseases, Beta-lactamase, bacteria, Bacteria, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbdd6840e0bc95da7f0890f46e1e7580
https://doi.org/10.1128/aac.00757-20

المؤلفون: Dongxu Sun, Olga Lomovskaya, Michael N. Dudley, Kirk Nelson, Ruslan Tsivkovski, Debora Rubio-Aparicio

المصدر: Antimicrobial Agents and Chemotherapy

مصطلحات موضوعية: Acinetobacter baumannii, Carbapenem, porins, Klebsiella pneumoniae, metallo-beta-lactamases, Microbial Sensitivity Tests, medicine.disease_cause, beta-Lactamases, Microbiology, 03 medical and health sciences, serine beta-lactamases, Bacterial Proteins, Enterobacteriaceae, Mechanisms of Resistance, medicine, polycyclic compounds, Serine, Potency, Pharmacology (medical), 030304 developmental biology, Pharmacology, 0303 health sciences, biology, 030306 microbiology, Pseudomonas aeruginosa, Chemistry, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, Editor's Pick, efflux, Anti-Bacterial Agents, Multiple drug resistance, Infectious Diseases, QPX7728, Efflux, beta-Lactamase Inhibitors, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::513cea585ddb065c16f09d1c996aa931
http://europepmc.org/articles/PMC7269478

المؤلفون: Debora Rubio-Aparicio, Dongxu Sun, Maxim Totrov, Olga Lomovskaya, Kirk Nelson, Michael N. Dudley, Ruslan Tsivkovski

المصدر: Antimicrobial Agents and Chemotherapy

مصطلحات موضوعية: Klebsiella pneumoniae, medicine.medical_treatment, Tebipenem, Cefepime, metallo-beta-lactamases, Microbial Sensitivity Tests, Cefpodoxime, beta-Lactamases, Microbiology, 03 medical and health sciences, chemistry.chemical_compound, serine beta-lactamases, polycyclic compounds, medicine, Serine, Pharmacology (medical), beta-lactamase inhibitor, Mechanisms of Action: Physiological Effects, 030304 developmental biology, Pharmacology, 0303 health sciences, biology, 030306 microbiology, Chemistry, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, biology.organism_classification, Editor's Pick, Acinetobacter baumannii, Anti-Bacterial Agents, Infectious Diseases, QPX7728, Beta-lactamase, Ceftolozane, beta-Lactamase Inhibitors, medicine.drug, Piperacillin, Monobactams

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ecaee1216998118a930341e909e56ce
http://europepmc.org/articles/PMC7269471

المؤلفون: Michael N. Dudley, Paula King, Olga Lomovskaya, David C. Griffith, Jane L, In Vitro, Pharmacodynamics Levofloxacin

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://aac.asm.org/content/54/1/143.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.607.9315; http://aac.asm.org/content/54/1/143.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.607.9315
http://aac.asm.org/content/54/1/143.full.pdf

المؤلفون: Deidre Cho, Olga Lomovskaya, Michael N. Dudley, David C. Griffith, Erik Corcoran, Denene Lofl, Susceptibility Due, Different Efflux, Pharmacodynamics Of Levofloxacin Against

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://aac.asm.org/content/50/5/1628.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.602.1598; http://aac.asm.org/content/50/5/1628.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.602.1598
http://aac.asm.org/content/50/5/1628.full.pdf

المؤلفون: Olga Lomovskaya, David C. Griffith, Paul G. Ambrose, Brian VanScoy, Michael N. Dudley

المصدر: Current Opinion in Pharmacology. 36:86-93

مصطلحات موضوعية: 0301 basic medicine, Drug, medicine.medical_specialty, media_common.quotation_subject, 030106 microbiology, Drug resistance, Pharmacology, 03 medical and health sciences, β lactamase inhibitor, Need to know, Drug Discovery, medicine, Animals, Humans, Hospital pharmacy, Intensive care medicine, Antibacterial agent, media_common, Dose-Response Relationship, Drug, business.industry, Drug Resistance, Microbial, Bacterial Infections, Antimicrobial, Regimen, Treatment Outcome, beta-Lactamase Inhibitors, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64130302d4da9372d95adbbce648dae7
https://doi.org/10.1016/j.coph.2017.09.001

المؤلفون: Roger Echols, John H. Rex, George H. Talbot, Aaron Dane, John F. Tomayko, Michael N. Dudley, Mark Goldberger, Barry I. Eisenstein

المصدر: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America

مصطلحات موضوعية: 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, medicine.drug_class, 030106 microbiology, Antibiotics, Drug resistance, 03 medical and health sciences, 0302 clinical medicine, Antibiotic resistance, Drug Resistance, Multiple, Bacterial, Drug Discovery, Epidemic spread, medicine, Humans, antibacterial drug development, 030212 general & internal medicine, Intensive care medicine, Clinical Trials as Topic, Bacteria, antimicrobial drug resistance, business.industry, Bacterial Infections, bacterial resistance, Active control, Anti-Bacterial Agents, 3. Good health, Biotechnology, Pathogenic organism, Viewpoints, Infectious Diseases, Multidrug resistant bacteria, Drug development, noninferiority trial design, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ca7ee436488135bf8ec820fcfc6763
https://doi.org/10.1093/cid/cix246

المؤلفون: Adriana M. Nascimento, Gustavo H. Goldman, Steven Park, Salvatore A. E. Marras, Guillaume Delmas, Uma Oza, Michael N. Dudley, Paul A. Mann, David S. Perlin, Karen Lolans

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://aac.asm.org/content/47/5/1719.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.322.9062; http://aac.asm.org/content/47/5/1719.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.322.9062
http://aac.asm.org/content/47/5/1719.full.pdf