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1Academic Journal
المؤلفون: Patrick B. Brady, Bryan K. Sorensen, Roberto M. Risi, Michael L. Curtin, Robert A. Mantei, Alan S. Florjancic, Anthony Mastracchio, Cheng Ji, Aaron R. Kunzer, Chunqiu Lai, Gregory E. Storer, Vincent S. Chan, Rodger F. Henry, Andrew J. Souers, Michael R. Michaelides, Andrew S. Judd, T. Matthew Hansen
مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Pharmacology, Biotechnology, Sociology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, enabled preclinical characterization, conformationally preorganized macrocyclization, challenging synthetic target, structural complexity, selective mcl, multiple myeloma, large size, key steps, highly potent, enantioselective hydrogenation, clinical trial, c –, bond formation, 1 inhibitor
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2
المؤلفون: Chris Tse, Charles Brenner, Saul H. Rosenberg, Wenqing Gao, Gary G. Chiang, F. Gregory Buchanan, David Maag, Michael R. Michaelides, Michael L. Curtin, Ilaria Badagnani, Shaun M. McLoughlin, Paul L. Richardson, Hua Tang, Vivek C. Abraham, Danli L. Towne, Steven Cepa, Alla V. Korepanova, Diana Raich, Kenton L. Longenecker, T. Matthew Hansen, Richard F. Clark, Bryan K. Sorensen, H. Robin Heyman, Sujatha Selvaraju, Yupeng He, Peter J. Kovar, Stormy L. Koeniger, Jun Guo, Yan Shi, Samuel A.J. Trammell, Dong Cheng, Min Cheng, Julie L. Wilsbacher
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3
المؤلفون: Chris Tse, Charles Brenner, Saul H. Rosenberg, Wenqing Gao, Gary G. Chiang, F. Gregory Buchanan, David Maag, Michael R. Michaelides, Michael L. Curtin, Ilaria Badagnani, Shaun M. McLoughlin, Paul L. Richardson, Hua Tang, Vivek C. Abraham, Danli L. Towne, Steven Cepa, Alla V. Korepanova, Diana Raich, Kenton L. Longenecker, T. Matthew Hansen, Richard F. Clark, Bryan K. Sorensen, H. Robin Heyman, Sujatha Selvaraju, Yupeng He, Peter J. Kovar, Stormy L. Koeniger, Jun Guo, Yan Shi, Samuel A.J. Trammell, Dong Cheng, Min Cheng, Julie L. Wilsbacher
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4
المؤلفون: Kathy Sarris, Ying Wang, Gary G. Chiang, Yupeng He, Mikkel Algire, Ramzi F. Sweis, Huan-Qiu Li, Marina A. Pliushchev, Zhiqin Ji, Paul L. Richardson, Maricel Torrent, Bailin Shaw, Richard F. Clark, Michael L. Curtin, Justin D. Dietrich, Clarissa G. Jakob, Chaohong Sun, Sujatha Selvaraju, Haizhong Zhu, Hongyu Zhao, Michael R. Michaelides
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:1576-1583
مصطلحات موضوعية: 0301 basic medicine, Pyrrolidines, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Stereoisomerism, macromolecular substances, Plasma protein binding, Ligands, Biochemistry, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Mouse xenograft, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, PRC2 complex, Molecular Biology, Indole test, Sulfonamides, biology, Novel protein, Chemistry, Organic Chemistry, Polycomb Repressive Complex 2, Xenograft Model Antitumor Assays, 030104 developmental biology, 030220 oncology & carcinogenesis, Microsomes, Liver, biology.protein, Molecular Medicine, PRC2, Protein Binding
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5
المؤلفون: Nirupama B. Soni, Anil Vasudevan, Jun Guo, Marina A. Pliushchev, Julie L. Wilsbacher, H. Robin Heyman, Michael R. Michaelides, Kathy Sarris, Bryan K. Sorensen, Richard F. Clark, Noah Tu, Min Cheng, George Doherty, Alla Korepanova, Anurupa Shrestha, Michael L. Curtin, Mikkel Algire, Badagnani Ilaria, Kenton L. Longenecker, Chris Tse, Diana Raich, Woller Kevin R, Robin R. Frey, Violeta L. Marin, Gary G. Chiang, T. Matthew Hansen, Ana L. Aguirre, F. Greg Buchanan, Peter Kovar, David Maag, Dong Cheng, Paul L. Richardson, Ramzi F. Sweis
المصدر: Bioorganicmedicinal chemistry letters. 27(15)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Clinical Biochemistry, Nicotinamide phosphoribosyltransferase, Pharmaceutical Science, Antineoplastic Agents, Isoindoles, Crystallography, X-Ray, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Cell Line, Tumor, Neoplasms, Drug Discovery, Structure–activity relationship, Animals, Humans, Urea, Enzyme Inhibitors, Nicotinamide Phosphoribosyltransferase, Molecular Biology, Cell Proliferation, Antitumor activity, Drug discovery, Cell growth, Organic Chemistry, Substrate (chemistry), Isoindoline, 030104 developmental biology, chemistry, Molecular Medicine, Cytokines
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6
المؤلفون: Alla Korepanova, Danli L. Towne, F. Gregory Buchanan, Jun Guo, Stormy L. Koeniger, Diana Raich, Yan Shi, Michael L. Curtin, Gary G. Chiang, Bryan K. Sorensen, Yupeng He, Hua Tang, Vivek C. Abraham, H. Robin Heyman, Richard F. Clark, Kenton L. Longenecker, Saul H. Rosenberg, Paul L. Richardson, Badagnani Ilaria, Wenqing Gao, Julie L. Wilsbacher, Peter Kovar, David Maag, Samuel A.J. Trammell, Dong Cheng, T. Matthew Hansen, Shaun M. McLoughlin, Chris Tse, Min Cheng, Steven Cepa, Michael R. Michaelides, Sujatha Selvaraju, Charles Brenner
المصدر: Molecular cancer therapeutics. 16(7)
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, DNA Repair, Nicotinamide phosphoribosyltransferase, 03 medical and health sciences, chemistry.chemical_compound, Enzyme activator, Mice, 0302 clinical medicine, Adenosine Triphosphate, In vivo, Animals, Humans, Calcium Signaling, Enzyme Inhibitors, Nicotinamide Phosphoribosyltransferase, chemistry.chemical_classification, Nicotinamide, Chemistry, HCT116 Cells, NAD, Xenograft Model Antitumor Assays, Enzyme Activation, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Enzyme, Oncology, Biochemistry, 030220 oncology & carcinogenesis, Cancer cell, Cytokines, NAD+ kinase, Colorectal Neoplasms, Adenosine triphosphate
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7
المؤلفون: Kenneth M. Comess, Steven Kennedy, Donald J. Osterling, Michael L. Curtin, Masoud Vedadi, Ramzi F. Sweis, Guillermo Senisterra, Mikkel Algire, Evelyne Lima-Fernandes, Dalia Barsyte-Lovejoy, Justin D. Dietrich, William N. Pappano, Bailin Shaw, David Maag, Dong Cheng, Cheryl H. Arrowsmith, Fengling Li, Marina A. Pliushchev, Kelly L Klinge, Jun Guo, Chaohong Sun, Andrew M. Petros, Gary G. Chiang, Magdalena M. Szewczyk, Huan-Qiu Li, Maricel Torrent, Scott Galasinski, Sujatha Selvaraju, Yupeng He, David Lindley, Clarissa G. Jakob, Sanjay C. Panchal, Wenqing Gao, Lance J Bigelow, Haizhong Zhu, Fritz G. Buchanan, Qin Wu
المصدر: Nature chemical biology. 13(4)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Cell Survival, Protein subunit, Allosteric regulation, Antineoplastic Agents, macromolecular substances, Protein–protein interaction, 03 medical and health sciences, Histone H3, Structure-Activity Relationship, 0302 clinical medicine, Cell Line, Tumor, Tumor Cells, Cultured, Gene silencing, Humans, Epigenetics, Molecular Biology, Cell Proliferation, chemistry.chemical_classification, Sulfonamides, biology, Dose-Response Relationship, Drug, Molecular Structure, Polycomb Repressive Complex 2, Cell Biology, 030104 developmental biology, Enzyme, Biochemistry, chemistry, 030220 oncology & carcinogenesis, Indans, biology.protein, Drug Screening Assays, Antitumor, PRC2, Protein Binding
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8
المؤلفون: Patrick A. Marcotte, Jun Guo, Michael R. Michaelides, Steven K. Davidsen, David R. Reuter, Junling Li, Yanping Luo, Lori J. Pease, Chris Tse, Terrance J. Magoc, Ru-Qi Wei, Paul Tapang, Eric F. Johnson, Cherrie K. Donawho, Zehan Chen, Amanda M. Olson, Donald J. Osterling, Daniel H. Albert, Michael L. Curtin, Keith B. Glaser, Jennifer J. Bouska, Mai H. Bui, Robin R. Frey
المصدر: Journal of Pharmacology and Experimental Therapeutics. 343:617-627
مصطلحات موضوعية: Male, Time Factors, Aminopyridines, Antineoplastic Agents, Mice, SCID, Protein Serine-Threonine Kinases, Histones, Mice, chemistry.chemical_compound, Growth factor receptor, Aurora Kinases, Cell Line, Tumor, Human Umbilical Vein Endothelial Cells, Animals, Aurora Kinase B, Humans, Receptors, Platelet-Derived Growth Factor, Pharmacology, Mice, Inbred BALB C, Leukemia, Experimental, Dose-Response Relationship, Drug, Molecular Structure, biology, Phenylurea Compounds, Autophosphorylation, Xenograft Model Antitumor Assays, Molecular biology, Vascular endothelial growth factor, Vascular endothelial growth factor A, Receptors, Vascular Endothelial Growth Factor, src-Family Kinases, chemistry, NIH 3T3 Cells, biology.protein, Molecular Medicine, Female, Tyrosine kinase, Platelet-derived growth factor receptor, Proto-oncogene tyrosine-protein kinase Src
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9
المؤلفون: Melinda Yates, Lori J. Pease, Patrick A. Marcotte, Jennifer J. Bouska, Niru B. Soni, Daniel H. Albert, Robin R. Frey, Steven K. Davidsen, Michael L. Curtin, Keith B. Glaser, Michael R. Michaelides, Peter J. Dandliker, Asma A Ahmed, Paul Rafferty, Kent D. Stewart, Maria D Moskey, Candace Black-Schaefer, Peter F. Bousquet, H. Robin Heyman, George A. Cunha
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:1246-1249
مصطلحات موضوعية: Models, Molecular, Thienopyridine, Pyridines, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, Animals, Edema, Urea, Structure–activity relationship, Kinase activity, Molecular Biology, Uterine Diseases, chemistry.chemical_classification, Estradiol, Kinase, Organic Chemistry, Biological activity, Kinase insert domain receptor, Vascular Endothelial Growth Factor Receptor-2, Disease Models, Animal, Enzyme, chemistry, Molecular Medicine, Female
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10
المؤلفون: Teresa Barlozzari, Shannon S Arries, Keith B. Glaser, Michael L. Curtin, Lori J. Pease, Patrick A. Marcotte, Robin R. Frey, Daniel H. Albert, Neil Wishart, George A. Cunha, Yan Guo, Jennifer J. Bouska, Lee D. Arnold, Jun Guo, Michael R. Michaelides, Kennan C. Marsh, Steven K. Davidsen, Joy Bauch, Asma A Ahmed, Peter F. Bousquet, Maria D Moskey, Paul Tapang, Kent D. Stewart, Yujia Dai, Zhiqin Ji, Vincent S. Stoll, Junling Li
المصدر: Journal of Medicinal Chemistry. 48:6066-6083
مصطلحات موضوعية: Models, Molecular, Platelet-derived growth factor, Antineoplastic Agents, Mice, SCID, Receptor tyrosine kinase, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Adenosine Triphosphate, Growth factor receptor, Drug Discovery, Animals, Edema, Humans, Urea, Receptors, Platelet-Derived Growth Factor, Phosphorylation, Mice, Inbred BALB C, Estradiol, biology, Uterus, Vascular Endothelial Growth Factor Receptor-2, Xenograft Model Antitumor Assays, Vascular endothelial growth factor, Pyrimidines, chemistry, Biochemistry, Enzyme inhibitor, NIH 3T3 Cells, biology.protein, Molecular Medicine, Female, Signal transduction, Platelet-derived growth factor receptor
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المؤلفون: Michael L. Curtin, Keith B. Glaser
المصدر: Current Medicinal Chemistry. 10:2373-2392
مصطلحات موضوعية: Mice, Nude, Antineoplastic Agents, In Vitro Techniques, Hydroxamic Acids, Biochemistry, Histone Deacetylases, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Humans, Structure–activity relationship, Enzyme Inhibitors, Pharmacology, chemistry.chemical_classification, Gene knockdown, Hydroxamic acid, biology, Organic Chemistry, Small molecule, Histone Deacetylase Inhibitors, Enzyme, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, HT1080, Histone deacetylase, Drug Screening Assays, Antitumor, Cell Division
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12
المؤلفون: Douglas H. Steinman, Keith B. Glaser, Carol K. Wada, Lori J. Pease, Robin R. Frey, Jun Guo, Michael R. Michaelides, Steven K. Davidsen, Jennifer J. Bouska, Yan Guo, Anil Vasudevan, H. Robin Heyman, Junling Li, Patrick A. Marcotte, Zhiqin Ji, Michael L. Curtin
المصدر: Bioorganic & Medicinal Chemistry Letters. 13:3909-3913
مصطلحات موضوعية: medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Structure-Activity Relationship, Heterocyclic Compounds, Drug Discovery, medicine, Enzyme Inhibitors, Cytotoxicity, Molecular Biology, chemistry.chemical_classification, Histone deacetylase 5, biology, Histone deacetylase 2, Organic Chemistry, Histone acetyltransferase, Ketones, Histone Deacetylase Inhibitors, Kinetics, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Histone deacetylase
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13
المؤلفون: Carol K. Wada, Lori J. Pease, Keith B. Glaser, Robert B. Garland, Steven K. Davidsen, Robin R. Frey, Michael L. Curtin, Junling Li, Jennifer J. Bouska, Michael R. Michaelides, Patrick A. Marcotte, Shannon S. Murphy
المصدر: Bioorganic & Medicinal Chemistry Letters. 12:3443-3447
مصطلحات موضوعية: Hydrocarbons, Fluorinated, Stereochemistry, Fibrosarcoma, Blotting, Western, Clinical Biochemistry, Pharmaceutical Science, Breast Neoplasms, Biochemistry, Histones, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Tumor Cells, Cultured, Humans, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, Trifluoromethyl, biology, Chemistry, Cell growth, Cell Cycle, Organic Chemistry, Acetylation, Histone acetyltransferase, Ketones, Histone Deacetylase Inhibitors, Histone, Enzyme inhibitor, biology.protein, Molecular Medicine, Histone deacetylase
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14
المؤلفون: Yupeng, He, Sujatha, Selvaraju, Michael L, Curtin, Clarissa G, Jakob, Haizhong, Zhu, Kenneth M, Comess, Bailin, Shaw, Juliana, The, Evelyne, Lima-Fernandes, Magdalena M, Szewczyk, Dong, Cheng, Kelly L, Klinge, Huan-Qiu, Li, Marina, Pliushchev, Mikkel A, Algire, David, Maag, Jun, Guo, Justin, Dietrich, Sanjay C, Panchal, Andrew M, Petros, Ramzi F, Sweis, Maricel, Torrent, Lance J, Bigelow, Guillermo, Senisterra, Fengling, Li, Steven, Kennedy, Qin, Wu, Donald J, Osterling, David J, Lindley, Wenqing, Gao, Scott, Galasinski, Dalia, Barsyte-Lovejoy, Masoud, Vedadi, Fritz G, Buchanan, Cheryl H, Arrowsmith, Gary G, Chiang, Chaohong, Sun, William N, Pappano
المصدر: Nature Chemical Biology. 13:922-922
مصطلحات موضوعية: Cell Biology, Molecular Biology
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15
المؤلفون: Douglas W. Morgan, Jennifer J. Bouska, H. Robin Heyman, Patrick A. Marcotte, Yujia Dai, Steven K. Davidsen, Carole L. Goodfellow, Carol K. Wada, Daniel H. Albert, Jamie R. Stacey, Robert B. Garland, Douglas H. Steinman, Paul Tapang, Alan S. Florjancic, Michael L. Curtin, James H. Holms, Yan Guo, Michael R. Michaelides, Ildiko Elmore
المصدر: Journal of Medicinal Chemistry. 45:219-232
مصطلحات موضوعية: Matrix metalloproteinase inhibitor, Stereochemistry, Administration, Oral, Biological Availability, Antineoplastic Agents, Ether, Matrix Metalloproteinase Inhibitors, Matrix metalloproteinase, Hydroxylamines, Chemical synthesis, Cell Line, Sulfone, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Structure–activity relationship, Protease Inhibitors, Hydroxamic acid, Formamides, biology, Tumor Necrosis Factor-alpha, Metalloendopeptidases, Xenograft Model Antitumor Assays, Macaca fascicularis, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine
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المؤلفون: Douglas W. Morgan, H. Robin Heyman, Michael R. Michaelides, Jamie R. Stacey, Patrick A. Marcotte, Yan Guo, Steven K. Davidsen, Michael L. Curtin, Carole L. Goodfellow, Joseph F. Dellaria, Daniel H. Albert, Jane Gong, James H. Holms, Terrance J. Magoc, Jennifer J. Bouska, Ildiko B. Elmore, Carol K. Wada
المصدر: Bioorganic & Medicinal Chemistry Letters. 11:1553-1556
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Antineoplastic Agents, Ether, Matrix Metalloproteinase Inhibitors, Hydroxamic Acids, Biochemistry, Chemical synthesis, Inhibitory Concentration 50, chemistry.chemical_compound, Pharmacokinetics, Oral administration, Drug Discovery, Animals, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Hydroxamic acid, biology, Organic Chemistry, Bioavailability, Macaca fascicularis, Enzyme, chemistry, Enzyme inhibitor, Injections, Intravenous, biology.protein, Molecular Medicine, Half-Life
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17
المؤلفون: Michael R. Michaelides, Michael L. Curtin
المصدر: Current Pharmaceutical Design. 5:787-819
مصطلحات موضوعية: Pharmacology, Drug Discovery
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18
المؤلفون: Steven K. Davidsen, Patrick A. Marcotte, Terrance J. Magoc, James H. Holms, Zhiwen Guan, Robert B. Garland, Douglas H. Steinman, Douglas W. Morgan, Daniel H. Albert, Carol K. Wada, Yan Guo, H. Robin Heyman, Michael L. Curtin, George S. Sheppard, Ildiko Elmore
المصدر: Journal of Enzyme Inhibition. 14:425-435
مصطلحات موضوعية: Carboxypeptidases A, Swine, Matrix metalloproteinase inhibitor, Thermolysin, Angiotensin-Converting Enzyme Inhibitors, Carboxypeptidases, Matrix Metalloproteinase Inhibitors, Matrix metalloproteinase, Hydroxamic Acids, Biochemistry, Aminopeptidase, Inhibitory Concentration 50, Leucyl Aminopeptidase, Bacterial Proteins, Animals, Protease Inhibitors, Neprilysin, chemistry.chemical_classification, biology, Metalloendopeptidases, Angiotensin-converting enzyme, Carboxypeptidase, Rats, Amino acid, Zinc, chemistry, biology.protein, Molecular Medicine, Cattle, Rabbits
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19
المؤلفون: Michael L Curtin
المصدر: Expert Opinion on Therapeutic Patents. 8:703-711
مصطلحات موضوعية: Pharmacology, Crohn's disease, Platelet-activating factor, biology, business.industry, Septic shock, Antagonist, Inflammation, General Medicine, medicine.disease, Bioinformatics, Inflammatory bowel disease, chemistry.chemical_compound, chemistry, Drug Discovery, Arachidonate 5-lipoxygenase, Immunology, medicine, biology.protein, medicine.symptom, business, Reperfusion injury
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20
المؤلفون: Conway Rg, H. R. Heyman, Denissen Jf, George S. Sheppard, George M. Carrera, Douglas W. Morgan, T. J. Magoc, Daniel H. Albert, Lianhong Xu, Florjancic As, Steven K. Davidsen, Michael L. Curtin, Robert B. Garland, Douglas H. Steinman, Paul Tapang, Luo G, Rhein Da, James B. Summers, Trautmann Ja, Kennan C. Marsh
المصدر: Journal of Medicinal Chemistry. 41:74-95
مصطلحات موضوعية: Indole test, Imidazopyridine, chemistry.chemical_compound, Platelet-activating factor, chemistry, Bicyclic molecule, Stereochemistry, Drug Discovery, Antagonist, Molecular Medicine, Moiety, Chemical synthesis, Lead compound