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1
المؤلفون: Lígia M. Saraiva, Martin J. Warren, Tanya Parkinson, Susanne Schroeder, Susana A.L. Lobo, M. J. Gardner, Marco A. M. Videira, Alan Scott, Michael John Palmer, Andy Lawrence, David Winpenny
المصدر: Molecular Microbiology. 97:472-487
مصطلحات موضوعية: chemistry.chemical_classification, Oxidase test, biology, digestive, oral, and skin physiology, Ferrochelatase, Microbiology, Coproporphyrinogen III, Cofactor, chemistry.chemical_compound, Enzyme, Biosynthesis, chemistry, Biochemistry, polycyclic compounds, biology.protein, Molecular Biology, Heme, Oxidative decarboxylation
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2
المؤلفون: Michael John Palmer, Andrew Simon Bell
المصدر: Expert Opinion on Therapeutic Patents. 21:1631-1641
مصطلحات موضوعية: Male, Sildenafil, Hypertension, Pulmonary, Avanafil, Pharmacology, Patents as Topic, chemistry.chemical_compound, Drug Delivery Systems, Erectile Dysfunction, Drug Discovery, Animals, Humans, Medicine, Cyclic Nucleotide Phosphodiesterases, Type 5, Mirodenafil, Udenafil, business.industry, General Medicine, Tadalafil, Clinical trial, Pyrimidines, chemistry, Vardenafil, Drug Design, cGMP-specific phosphodiesterase type 5, business, medicine.drug
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3
المؤلفون: Robert Hughes, Michael B. Tollefson, Michael John Palmer, Brad A. Acker, Brian R. Bond, Fox David Nathan Abraham, Ying Yu, E. J. Jacobsen, John K. Walker, Sandra K. Freeman
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:3120-3124
مصطلحات موضوعية: medicine.drug_mechanism_of_action, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Structure-Activity Relationship, Dogs, In vivo, Drug Discovery, medicine, Animals, Humans, Potency, Enzyme Inhibitors, Molecular Biology, Cyclic Nucleotide Phosphodiesterases, Type 5, chemistry.chemical_classification, Bicyclic molecule, biology, Organic Chemistry, Phosphodiesterase 5 Inhibitors, Pyrimidines, Enzyme, chemistry, Enzyme inhibitor, cGMP-specific phosphodiesterase type 5, Microsomes, Liver, biology.protein, Molecular Medicine, Phosphodiesterase 5 inhibitor
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4
المؤلفون: Brian R. Bond, Michael John Palmer, John K. Walker, Ying Yu, Michael B. Tollefson, Brad A. Acker, Fox David Nathan Abraham, Sandra K. Freeman, Eric Jon Jacobsen, Robert Hughes
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:3125-3128
مصطلحات موضوعية: Patch-Clamp Techniques, medicine.drug_mechanism_of_action, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Antihypertensive Agents, Cyclic Nucleotide Phosphodiesterases, Type 5, chemistry.chemical_classification, Bicyclic molecule, biology, Organic Chemistry, Phosphodiesterase 5 Inhibitors, In vitro, Rats, Pyrimidines, Enzyme, chemistry, Enzyme inhibitor, cGMP-specific phosphodiesterase type 5, Microsomes, Liver, Alkoxy group, biology.protein, Molecular Medicine, Phosphodiesterase 5 inhibitor
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5
المؤلفون: Maddux Todd Michael, Yvette M. Fobian, Alan G. Benson, Dafydd R. Owen, Brian R. Bond, Christopher Phillips, Brad A. Acker, E. Jon Jacobsen, Michael John Palmer, D. Joseph Rogier, John M. Molyneaux, Brent V. Mischke, John N. Freskos, Tracy J. Ringer, Andrew Simon Bell, Blevis-Bal Radhika M, Robert Hughes, David G. Brown, Steve E. Heasley, Joseph B. Moon, John K. Walker, Brown David L, William C. Stallings, Michael B. Tollefson, Alan MacInnes, Jerry W. Cubbage, Yung Yu, Margarita Rodriquez-Lens, Fox David Nathan Abraham
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:4088-4091
مصطلحات موضوعية: medicine.drug_mechanism_of_action, Phosphodiesterase Inhibitors, Stereochemistry, Chemistry, Pharmaceutical, Clinical Biochemistry, Pharmaceutical Science, Crystallographic data, Crystallography, X-Ray, Biochemistry, Chemical synthesis, QH301, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, 3',5'-Cyclic-GMP Phosphodiesterases, Catalytic Domain, Drug Discovery, Hydrolase, medicine, Animals, Humans, QD, Molecular Biology, Cyclic Nucleotide Phosphodiesterases, Type 5, chemistry.chemical_classification, Cyclic Nucleotide Phosphodiesterases, Type 6, biology, Bicyclic molecule, Phosphoric Diester Hydrolases, Chemistry, Organic Chemistry, Hydrogen-Ion Concentration, Phosphodiesterase 5 Inhibitors, Protein Structure, Tertiary, Rats, Enzyme, Enzyme inhibitor, Drug Design, Pyrazines, biology.protein, Lactam, Molecular Medicine, Phosphodiesterase 5 inhibitor
وصف الملف: application/pdf
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6
المؤلفون: Michael Scott Visser, Michael P. DeNinno, Melissa P. Andrews, Andrew Simon Bell, Michael John Palmer, Nan Eshelby, Cynthia Eller-Zarbo, John B. Etienne, Yue Chen, E. Michael Gibbs, William J. Zavadoski, Li J. Yu, Dianna E. Moore
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:2537-2541
مصطلحات موضوعية: Phosphodiesterase Inhibitors, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Permeability, Inhibitory Concentration 50, Structure-Activity Relationship, Oral administration, Catalytic Domain, Drug Discovery, Diabetes Mellitus, Humans, Hypoglycemic Agents, Structure–activity relationship, Inhibitory concentration 50, Cyclic GMP, Molecular Biology, biology, Chemistry, Organic Chemistry, Phosphoric Diester Hydrolases, Highly selective, Hypoglycemia, Bioavailability, Models, Chemical, 3',5'-Cyclic-AMP Phosphodiesterases, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine
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7
المؤلفون: Michael John Palmer
المصدر: Expert Opinion on Therapeutic Patents. 19:575-592
مصطلحات موضوعية: Endothelin Receptor Antagonists, Pharmacology, Endothelin Antagonists, medicine.medical_specialty, Phosphodiesterase Inhibitors, business.industry, Hypertension, Pulmonary, Patent literature, Enzyme Activators, Treatment options, General Medicine, medicine.disease, Pulmonary hypertension, Patents as Topic, Drug Design, Drug Discovery, Prostaglandins, medicine, Animals, Humans, Enzyme Inhibitors, Intensive care medicine, business
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8
المؤلفون: James R. Gosset, Wendy Petit, Nicola Clear, David S. Reynolds, Pierre-Philippe Saintot, Kelly Conlon, Sonia Roberts, Jennifer C. Gardiner, Paul Alan Glossop, Susie Collins, Kevin Beaumont, Michael Postlethwaite, Wendy J. Winchester, Michael John Palmer, Sophie Glatt, Tomomi Matsuura, Andrews Mark David, Katrina Gore
المصدر: The Journal of pharmacology and experimental therapeutics. 351(2)
مصطلحات موضوعية: Male, Guinea Pigs, Pain, TRPM Cation Channels, Pharmacology, Body Temperature, Transient receptor potential channel, Double-Blind Method, In vivo, Membrane Transport Modulators, medicine, TRPM8, Animals, Humans, Rats, Wistar, Cross-Over Studies, Chemistry, Cold pressor test, Antagonist, Hypothermia, Rats, Cold Temperature, HEK293 Cells, Molecular Medicine, Cold sensitivity, medicine.symptom, Oxycodone, medicine.drug
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9
المؤلفون: Michael John Palmer, David C. Pryde
المصدر: Orphan Drugs and Rare Diseases
مصطلحات موضوعية: Tafamidis, Ruxolitinib, Idursulfase, business.industry, Hunter syndrome, Disease, Pharmacology, Eculizumab, medicine.disease, Bioinformatics, Orphan drug, chemistry.chemical_compound, chemistry, medicine, business, Rare disease, medicine.drug
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10
المؤلفون: Michael John Palmer, Timothy N. C. Wells
المصدر: Neglected Diseases and Drug Discovery
مصطلحات موضوعية: biology, business.industry, viruses, Yellow fever, virus diseases, biology.organism_classification, medicine.disease, Virology, Microbiology, Dengue fever, Flavivirus, Diarrhea, Lower respiratory tract infection, parasitic diseases, Medicine, Helminths, medicine.symptom, business, Malaria, Schistosoma
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11
المؤلفون: Michael John Palmer, Keith James
المصدر: Bioorganic & Medicinal Chemistry Letters. 3:825-830
مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Cleavage (embryo), Biochemistry, Potassium thioacetate, chemistry.chemical_compound, chemistry, Nucleophile, Drug Discovery, Thiol, Molecular Medicine, Neutral Endopeptidase 24.11, Molecular Biology
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12
المؤلفون: Michael John Palmer, Andrew Simon Bell
المصدر: Accounts in Drug Discovery ISBN: 9781849731263
مصطلحات موضوعية: Sildenafil, business.industry, Male erectile dysfunction, Pharmacology, medicine.disease, Pulmonary hypertension, chemistry.chemical_compound, Safety profile, Long acting, chemistry, Pharmacokinetics, medicine, Dosing, Pharmacophore, business
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13
المؤلفون: Brad A. Acker, Michael John Palmer, Brian R. Bond, E. J. Jacobsen, Fox David Nathan Abraham, Robert Hughes, John K. Walker, Ying Yu, Michael B. Tollefson, Sandra K. Freeman
المصدر: ChemInform. 41
مصطلحات موضوعية: Stereochemistry, Chemistry, cGMP-specific phosphodiesterase type 5, General Medicine
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14
المؤلفون: John C. Danilewicz, Michael John Palmer, Hannah Vuong
المصدر: ChemInform. 25
مصطلحات موضوعية: Serine, Chemistry, Stereochemistry, Phase (matter), General Medicine, Alkylation
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15
المؤلفون: Michael John Palmer, M. E. Mahler
المصدر: ChemInform. 28
مصطلحات موضوعية: chemistry.chemical_compound, Protease, chemistry, Stereochemistry, medicine.medical_treatment, medicine, Human immunodeficiency virus (HIV), General Medicine, medicine.disease_cause, Octane
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16
المؤلفون: Michael John Palmer
مصطلحات موضوعية: Structural biology, Drug target, Antagonist, Computational biology, Pharmacophore, Biology, Pharmacology, Receptor, Endothelin receptor, G protein-coupled receptor
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17
المصدر: Current topics in medicinal chemistry. 7(4)
مصطلحات موضوعية: Cyclic Nucleotide Phosphodiesterases, Type 5, Ligand efficiency, Molecular Structure, Sildenafil, Phosphodiesterase Inhibitors, Male erectile dysfunction, General Medicine, Memory retention, Pharmacology, Highly selective, Crystallography, X-Ray, chemistry.chemical_compound, Structure-Activity Relationship, chemistry, 3',5'-Cyclic-GMP Phosphodiesterases, cGMP-specific phosphodiesterase type 5, Drug Design, Drug Discovery, Dosing, Enhanced selectivity
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18
المؤلفون: R. Horton, Ismail C. Noyan, Michael John Palmer, Harry R. Bickford
المصدر: 1991 Proceedings 41st Electronic Components & Technology Conference.
مصطلحات موضوعية: Surface-mount technology, Engineering, Dip soldering, business.industry, Soldering, Process integration, Metallurgy, Mechanical engineering, Process window, Tape-automated bonding, Wave soldering, business, Corrosion
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19
المؤلفون: Ieuan O. Roberts, Kevin Whitby, Mike Westby, Darren Stead, Claire Bru, David John Bull, Richard A. Bissell, Edward J. Murray, Chris Pickford, Michael John Palmer, David C. Blakemore, Wai-Yee Cheung, Iain Gardner, Christopher P. Ashcroft, David C. Pryde, Rob Webster, Hannah Vuong, Jennifer Morton, Scott L. Butler
المصدر: MedChemComm. 4:709
مصطلحات موضوعية: Pharmacology, biology, Organic Chemistry, Pharmaceutical Science, Biochemistry, Virology, Integrase, Pharmacokinetics, MicroDose, Drug Discovery, biology.protein, HIV Integrase Inhibitors, Molecular Medicine, Potency
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20
المؤلفون: John C. Danilewicz, Hannah Vuong, Michael John Palmer
المصدر: Synlett. 1994:171-172
مصطلحات موضوعية: Serine, chemistry.chemical_compound, Chemistry, Phase (matter), Organic Chemistry, Alkylation, Aliphatic compound, Medicinal chemistry, Dichloromethane