المؤلفون: Florian Mayerthaler, Michael F.A. Finley, Tom A. Pfeifer, Albert A. Antolin

المصدر: ACS Chemical Biology. 14:567-578

مصطلحات موضوعية: Chemistry, Molecular Medicine, General Medicine, Biochemistry, Data science

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::05d18fa15995102a1c317a3843350cd3
https://doi.org/10.1021/acschembio.9b00169

المؤلفون: Teena M Varghese, Michael F.A. Finley, Samantha J Allen, Paul L. Dudas, Jonathan E Schneeweis

المصدر: SLAS discovery : advancing life sciences RD. 26(1)

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_treatment, Cell, Gene Expression, 010501 environmental sciences, 01 natural sciences, Biochemistry, Analytical Chemistry, 03 medical and health sciences, Genes, Reporter, Drug Discovery, medicine, Cytotoxic T cell, Humans, Luciferase, Viability assay, 0105 earth and related environmental sciences, biology, Chemistry, Small molecule, High-Throughput Screening Assays, 030104 developmental biology, medicine.anatomical_structure, Cytokine, Gene Expression Regulation, Cancer research, biology.protein, Interleukin-23 Subunit p19, Molecular Medicine, Phosphorylation, Antibody, Biotechnology, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a31d677e00fe1099053c8119e05f938
https://pubmed.ncbi.nlm.nih.gov/32484379

المؤلفون: Ning Qin, Michael F.A. Finley, Christopher M. Flores, Michael P. Neeper, Michael P. Winters, Michael R. Brandt, Wall Mark, Nalin L. Subasinghe, Raymond W. Colburn, Zhihua Sui, Craig R. Schneider, Mary Lou Lubin

المصدر: Bioorganic & Medicinal Chemistry Letters. 28:3780-3783

مصطلحات موضوعية: 010405 organic chemistry, Chemistry, Calcium channel, Organic Chemistry, Clinical Biochemistry, Patch clamp electrophysiology, Cell, Pharmaceutical Science, Pharmacology, N-type calcium channel, 010402 general chemistry, 01 natural sciences, Biochemistry, 0104 chemical sciences, medicine.anatomical_structure, Drug Discovery, Neuropathic pain, medicine, Molecular Medicine, Molecular Biology, Calcium influx

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::828824a0e64396bf3c9fd7b0be116b16
https://doi.org/10.1016/j.bmcl.2018.10.007

المؤلفون: Douglas C. Beshore, Stephen Day, Jason Cassaday, Michelle F. Homsher, Brian Squadroni, David Pechter, Michelle Smith, Lei Ma, Jeffrey D. Hermes, Elizabeth Mohammed, Michelle Hartnett, Paul Zuck, Michael F.A. Finley, Victor N. Uebele, Fredrick Monsma

المصدر: SLAS Discovery. 22:1060-1066

مصطلحات موضوعية: Agonist, Allosteric modulator, Chemistry, medicine.drug_class, Drug discovery, Allosteric regulation, Molecular Pharmacology, Ligand (biochemistry), Biochemistry, Analytical Chemistry, Muscarinic acetylcholine receptor, medicine, Biophysics, Molecular Medicine, Receptor, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4aa4a57a20f8bcde2680cb5a7bfd7c52
https://doi.org/10.1177/2472555217705373

المؤلفون: Michelle F. Homsher, Louis Locco, Shannon L. Stahler, Michael Weber, Jennifer E. Nothstein, Eleftheria N. Finger, Evelyn Boots, Mee Ra Heo, Amita Patel, Gregory O'Donnell, Alex Wolicki, Michael F.A. Finley, J. Christopher Culberson, Paul Zuck, Juncai Meng, Kenneth Roberts, David J. Bell, Peter S. Kutchukian, Gregory C. Adam, Carissa Quinn, Patrick Cocchiarella, Meir Glick, S. Alex May, Victor N. Uebele, Edward Hudak, Brian Squadroni, Daniel Riley, Andrew Rusinko, Kelli Solly, Michelle Hartnett, Dante A. Pertusi, Adam Amoss, Anthony Kreamer, Tara White, Anne Mai Wassermann

المصدر: SLAS Discovery. 22:995-1006

مصطلحات موضوعية: 0301 basic medicine, Prioritization, Engineering, Drug Evaluation, Preclinical, computer.software_genre, 01 natural sciences, Biochemistry, Analytical Chemistry, Machine Learning, User-Computer Interface, 03 medical and health sciences, Heuristics, Iterative and incremental development, Virtual screening, Drug discovery, business.industry, 0104 chemical sciences, Weighting, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, Cheminformatics, Benchmark (computing), Molecular Medicine, Data mining, business, computer, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561e5ff95861fbde45cdff3f2132d673
https://doi.org/10.1177/2472555217706058

المؤلفون: Bharti Gajera, Albert Rauch, Paul Zuck, Sylvie Jezequel-Sur, Michael F.A. Finley, Jason Cassaday, Jeffrey D. Hermes, Victor N. Uebele, Brian Squadroni

المصدر: SLAS Technology. 22:195-205

مصطلحات موضوعية: Automation, Laboratory, 0301 basic medicine, Engineering, Dose-Response Relationship, Drug, business.industry, High-throughput screening, Drug Evaluation, Preclinical, Titrimetry, Computational biology, 01 natural sciences, High-Throughput Screening Assays, Receptors, G-Protein-Coupled, 0104 chemical sciences, Computer Science Applications, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Medical Laboratory Technology, 030104 developmental biology, Fully automated, Humans, Titration, business, Cells, Cultured, Simulation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::061a421fab1301d8c06fa8e561b2e973
https://doi.org/10.1177/2211068216679805

المؤلفون: James I. Fells, Michael F.A. Finley, Wen Feng, Graeme L. Fraser, Xi Ai, Adam B. Weinglass, Ying Lei, Hamid R. Hoveyda, Michelle R. Machacek

المصدر: Bioorganic & Medicinal Chemistry Letters. 30:127460

مصطلحات موضوعية: Nearest neighbor search, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Receptors, Cell Surface, Computational biology, Ligands, 01 natural sciences, Biochemistry, Structure-Activity Relationship, Statistical quality, Drug Discovery, Humans, Molecular Biology, Virtual screening, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Organic Chemistry, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, HEK293 Cells, Docking (molecular), Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f64bf151e360bb047749463a394c80
https://doi.org/10.1016/j.bmcl.2020.127460

المؤلفون: M. Katharine Holloway, Michael T. Rudd, Michael F.A. Finley, Darrell A. Henze, Kelli Solly, Eric N. Johnson, Rebecca Klein

المصدر: SLAS Discovery. 20:708-719

مصطلحات موضوعية: Automation, Laboratory, Dose-Response Relationship, Drug, High-throughput screening, Glutamate receptor, Reproducibility of Results, Kainate receptor, Pharmacology, Biology, Receptors, N-Methyl-D-Aspartate, Biochemistry, Cell Line, High-Throughput Screening Assays, Analytical Chemistry, Small Molecule Libraries, Electrophysiology, Receptors, Kainic Acid, Drug Discovery, Humans, Molecular Medicine, Receptor, PAR-1, Receptor, Plate reader, Biotechnology, Ionotropic effect

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b23729d0c20b165e295ab2d1b90a41c7
https://doi.org/10.1177/1087057115570580

المؤلفون: Kelly-Ann S. Schlegel, Peter S. Kutchukian, Lee Warren, Sophie Parmentier-Batteur, Jason Cassaday, Victor N. Uebele, Brian C. Magliaro, Brian Squadroni, Danielle M. Hurzy, Eric N. Johnson, J. Chris Culberson, Gregory O'Donnell, Adam Amoss, Fiona Thomson, Michael F.A. Finley, Paul Zuck, Andrew J. Cooke, Danette Pascarella, Jeffrey D. Hermes

مصطلحات موضوعية: 0301 basic medicine, Amino Acid Transport System y+, Synaptic cleft, Central nervous system, Hippocampus, CHO Cells, Biology, Biochemistry, Machine Learning, 03 medical and health sciences, Glutamatergic, Cricetulus, 0302 clinical medicine, Cricetinae, medicine, Animals, Humans, Receptor, Bayes Theorem, Transporter, General Medicine, High-Throughput Screening Assays, 030104 developmental biology, medicine.anatomical_structure, nervous system, Glycine, Molecular Medicine, NMDA receptor, Neuroscience, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ee89032dec0bd4c1bf64d0fea584c0
https://eprints.gla.ac.uk/146530/1/146530.pdf

المؤلفون: Matthew Lombardo, Eric N. Johnson, John Cummings, Jerry Di Salvo, Thomas Roussel, James R. Tata, Melissa Kirkland, Michael A. Plotkin, Christopher Joseph Sinz, Feroze Ujjainwalla, Dennis Leung, Dorina Trusca, Joel Mane, Taro E. Akiyama, Alejandro Crespo, Mary Ann Powles, Kate Bender, Michael F.A. Finley, Joanna Pols, Candice Alleyne, Michele Pachanski, Andrew D. Howard, Wayne M. Geissler, Ying Lei, Bahanu Habulihaz, Victor N. Uebele, Clare London, Maria Madeira

المصدر: Bioorganicmedicinal chemistry letters. 27(5)

مصطلحات موضوعية: Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Mechanism based, GPR120, Biochemistry, chemistry.chemical_compound, Propanoic acid, chemistry, Drug Discovery, Molecular Medicine, Benzofuran, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15bdf4d7ae8e579647d40689c42f33e
https://pubmed.ncbi.nlm.nih.gov/27815121

المؤلفون: Christopher Joseph Sinz, Feroze Ujjainwalla, Joel Mane, Eric N. Johnson, John Cummings, Jerry Di Salvo, Michele Pachanski, Michael A. Plotkin, Joanna Pols, Taro E. Akiyama, Andrew D. Howard, Matthew Lombardo, James R. Tata, Maria Madeira, Ying Lei, Wayne M. Geissler, Victor N. Uebele, Michael F.A. Finley, Clare London, Candice Alleyne, Thomas Roussel, Kate Bender, Dennis Leung, Bahanu Habulihaz, Mary Ann Powles, Melissa Kirkland, Dorina Trusca, Alejandro Crespo

المصدر: Bioorganicmedicinal chemistry letters. 26(23)

مصطلحات موضوعية: 0301 basic medicine, Blood Glucose, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Pharmacology, 01 natural sciences, Biochemistry, Receptors, G-Protein-Coupled, 03 medical and health sciences, chemistry.chemical_compound, Mice, Pharmacokinetics, In vivo, Free fatty acid receptor 1, Drug Discovery, Potency, Animals, Humans, Hypoglycemic Agents, Benzofuran, Molecular Biology, Benzofurans, chemistry.chemical_classification, 010405 organic chemistry, Organic Chemistry, Fatty acid, GPR120, 0104 chemical sciences, High-Throughput Screening Assays, 030104 developmental biology, Propanoic acid, chemistry, Diabetes Mellitus, Type 2, Molecular Medicine, Propionates

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a693b676faad583895d0ff2ed06132a4
https://pubmed.ncbi.nlm.nih.gov/28169160

المؤلفون: Michael R. Brandt, Michael F.A. Finley, Ning Qin, Michael P. Winters, Craig R. Schneider, Mary Lou Lubin, Michael P. Neeper, Nalin L. Subasinghe, Zhihua Sui, Raymond W. Colburn, Christopher M. Flores, Wall Mark

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:4080-4083

مصطلحات موضوعية: Patch-Clamp Techniques, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, N-type calcium channel, Biochemistry, omega-Conotoxins, Cell Line, Structure-Activity Relationship, Calcium Channels, N-Type, Piperidines, In vivo, Drug Discovery, medicine, Animals, Humans, Potency, Molecular Biology, Analgesics, Ziconotide, Chemistry, Calcium channel, Organic Chemistry, Chronic pain, Metabolic stability, Calcium Channel Blockers, medicine.disease, High-Throughput Screening Assays, Rats, Neuropathic pain, Neuralgia, Pyrazoles, Molecular Medicine, Chronic Pain, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a6e83fd1b4246ea39226f0f164e5f44
https://doi.org/10.1016/j.bmcl.2012.04.075

المؤلفون: Yi Liu, Michael F.A. Finley, Mary Lou Lubin, Ning Qin, Michael P. Neeper, Christopher M. Flores, Edward J. Beck

المصدر: ASSAY and Drug Development Technologies. 8:685-694

مصطلحات موضوعية: Patch-Clamp Techniques, Calcitonin Gene-Related Peptide, Presynaptic Terminals, Pain, Pharmacology, omega-Conotoxins, Cell Line, Small Molecule Libraries, Calcium Channels, N-Type, Dorsal root ganglion, Ganglia, Spinal, Drug Discovery, Calcium flux, medicine, Animals, Humans, Patch clamp, Ion channel, Neurons, Analgesics, Ziconotide, Voltage-dependent calcium channel, Chemistry, Calcium channel, Calcium Channel Blockers, High-Throughput Screening Assays, Rats, Electrophysiology, HEK293 Cells, medicine.anatomical_structure, Spinal Cord, Luminescent Measurements, Molecular Medicine, Neuroscience, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021e926842b8366d4a8742a010cc48f2
https://doi.org/10.1089/adt.2010.0311

المؤلفون: Antonella Converso, Greg O’Donnell, Jixin Wang, Ming-Tain Lai, Kelli Solly, Wei Lemaire, Michael F.A. Finley, Mark E. Layton, Michelle K. Clements, Richard L. Kraus, Donnette D. Staas, Jason Cassaday, Tony Kreamer, Xinnian Li, Sean P. Cook, Chris Daley

المصدر: Journal of biomolecular screening. 21(5)

مصطلحات موضوعية: 0301 basic medicine, Pain, Nav1.5, Pharmacology, 01 natural sciences, Biochemistry, Analytical Chemistry, Membrane Potentials, NAV1.5 Voltage-Gated Sodium Channel, 03 medical and health sciences, Paroxysmal extreme pain disorder, medicine, Humans, Molecular Targeted Therapy, Membrane potential, Neurons, biology, Chemistry, Sodium channel, NAV1.7 Voltage-Gated Sodium Channel, Area under the curve, Rectum, medicine.disease, 0104 chemical sciences, High-Throughput Screening Assays, 010404 medicinal & biomolecular chemistry, Electrophysiology, Kinetics, 030104 developmental biology, NAV1, Neuropathic pain, biology.protein, Molecular Medicine, Neuralgia, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e333e0768a580b7c4fb09601f949b433
https://pubmed.ncbi.nlm.nih.gov/26861708

المؤلفون: Ning Qin, Mary Lou Lubin, Michael R. Brandt, Edward J. Beck, Zhihua Sui, Christopher M. Flores, Michael P. Winters, Yi Liu, Michael P. Neeper, Michael F.A. Finley, Wall Mark, Nalin L. Subasinghe

المصدر: Bioorganicmedicinal chemistry letters. 24(9)

مصطلحات موضوعية: Chemistry, Stereochemistry, Calcium channel, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, N-type calcium channel, Calcium Channel Blockers, Biochemistry, Rats, Structure-Activity Relationship, Calcium Channels, N-Type, Drug Discovery, Microsomes, Liver, Molecular Medicine, Animals, Humans, Pyrazoles, Chronic Pain, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ec7ef54f1ffc10974d794a05d211f0
https://pubmed.ncbi.nlm.nih.gov/24726802

المؤلفون: Yi Liu, Mary Lou Lubin, Christopher M. Flores, Michael P. Winters, Michael F.A. Finley, Wall Mark, Ning Qin, Nalin L. Subasinghe, Michael R. Brandt, Michael P. Neeper, Zhihua Sui, Edward J. Beck

المصدر: Bioorganicmedicinal chemistry letters. 24(9)

مصطلحات موضوعية: Analgesics, Series (mathematics), Chemistry, Stereochemistry, Calcium channel, Organic Chemistry, Clinical Biochemistry, Chronic pain, Pharmaceutical Science, Pain, N-type calcium channel, medicine.disease, Calcium Channel Blockers, Biochemistry, Combinatorial chemistry, Rats, Calcium Channels, N-Type, In vivo, Drug Discovery, medicine, Microsomes, Liver, Molecular Medicine, Animals, Pyrazoles, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24b71083cf3a7f61a88d50c7768be61d
https://pubmed.ncbi.nlm.nih.gov/24726803

المؤلفون: Laurent Leclercq, Brian D. Klein, Robert Iannucci, Michael H. Parker, Ning Qin, Yifang Huang, Smith-Swintosky Virginia L, David F. McComsey, Michael F.A. Finley, Ewa Malatynska, Allen B. Reitz, Michael E. Milewski, Mary Lou Lubin, Bruce E. Maryanoff, H. Steve White, Mark Herb, Filip Cuyckens, Yi Liu, Douglas E. Brenneman

المصدر: Journal of medicinal chemistry. 52(23)

مصطلحات موضوعية: Male, Stereochemistry, medicine.medical_treatment, Drug Evaluation, Preclinical, Thiophenes, Chemical synthesis, Carbonic Anhydrase II, Cell Line, Epilepsy, chemistry.chemical_compound, Mice, Pharmacokinetics, Oral administration, Drug Discovery, medicine, Animals, Humans, IC50, Sulfamide, Clinical Trials as Topic, Sulfonamides, Bicyclic molecule, Chemistry, medicine.disease, Amides, Rats, Anticonvulsant, Molecular Medicine, Anticonvulsants, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c23965975217c54526da2173fe275e9c
https://pubmed.ncbi.nlm.nih.gov/19388676

المؤلفون: Michael F.A. Finley, Mary Lou Lubin, Michael P. Neeper, Edward Beck, Yi Liu, Christopher M. Flores, Ning Qin

المصدر: Assay & Drug Development Technologies; Dec2010, Vol. 8 Issue 6, p685-694, 10p

مصطلحات موضوعية: BIOLOGICAL assay, CALCIUM antagonists, CALCIUM channels, ANALGESICS, OPIOIDS, INTRACTABLE pain, ELECTROPHYSIOLOGY, NEURONS