المؤلفون: Kathrine Lundø, Oksana Dmytriyeva, Louise Spøhr, Eliana Goncalves-Alves, Jiayi Yao, Laia P. Blasco, Mette Trauelsen, Muthulakshmi Ponniah, Marc Severin, Albin Sandelin, Marie Kveiborg, Thue W. Schwartz, Stine F. Pedersen

المصدر: BMC Cancer, Vol 23, Iss 1, Pp 1-20 (2023)

مصطلحات موضوعية: HCAR1, Tumor microenvironment, Spheroid, EPHA7, PCDH7, Notch, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1471-2407

URL الوصول: https://doaj.org/article/4dce1bc40e524fe2bbe93834d25ecd0f

المؤلفون: Jacob Emil Petersen, Maria Hauge Pedersen, Oksana Dmytriyeva, Emilie Nellemose, Tulika Arora, Maja Storm Engelstoft, Wesley B. Asher, Jonathan A. Javitch, Thue W. Schwartz, Mette Trauelsen

المصدر: Molecular Metabolism, Vol 74, Iss , Pp 101757- (2023)

مصطلحات موضوعية: FFAR1, GPR40, Adenylate cyclase 2, GLP-1, ADCY2, Gq, Internal medicine, RC31-1245

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877823000911; https://doaj.org/toc/2212-8778

URL الوصول: https://doaj.org/article/a28f704e33e846e698b98299456a1403

المؤلفون: Silke Griepke, Mette Trauelsen, Michelle D. Nilsson, Jakob Hansen, Lasse B. Steffensen, Thue W. Schwartz, Daniel F. J. Ketelhuth

المصدر: Cells, Vol 12, Iss 21, p 2580 (2023)

مصطلحات موضوعية: atherosclerosis, inflammation, GPR91, SUCNR1, succinate, TCA, Cytology, QH573-671

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2073-4409/12/21/2580; https://doaj.org/toc/2073-4409

URL الوصول: https://doaj.org/article/3fd238d3f65b40cebedba2dd2d78c727

المؤلفون: Mette Trauelsen, Thomas K. Hiron, Da Lin, Jacob E. Petersen, Billy Breton, Anna Sofie Husted, Siv A. Hjorth, Asuka Inoue, Thomas M. Frimurer, Michel Bouvier, Chris A. O’Callaghan, Thue W. Schwartz

المصدر: Cell Reports, Vol 35, Iss 11, Pp 109246- (2021)

مصطلحات موضوعية: GPR91, SUCNR1, succinate, M2 macrophages, G protein, Gq signaling, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124721006112; https://doaj.org/toc/2211-1247

URL الوصول: https://doaj.org/article/e906e89d1b5e4aa098dfeafb3fbc142d

المؤلفون: Mette Trauelsen, Elisabeth Rexen Ulven, Siv A. Hjorth, Matjaz Brvar, Claudia Monaco, Thomas M. Frimurer, Thue W. Schwartz

المصدر: Molecular Metabolism, Vol 6, Iss 12, Pp 1585-1596 (2017)

مصطلحات موضوعية: Internal medicine, RC31-1245

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877817306348; https://doaj.org/toc/2212-8778

URL الوصول: https://doaj.org/article/f45b835b6bc0429090fa3e18fc5b7ec5

المؤلفون: Ahmed M. Abdelmoez, Oksana Dmytriyeva, Yasemin-Xiomara Zurke, Mette Trauelsen, Alesandra A. Marica, Mladen Savikj, Jonathon A. B. Smith, Claudia Monaco, Thue W. Schwartz, Anna Krook, Nicolas J. Pillon

المصدر: American Journal of Physiology-Endocrinology and Metabolism. 324:E289-E298

مصطلحات موضوعية: Physiology, Physiology (medical), Endocrinology, Diabetes and Metabolism

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e1041f588232278e92a8e087b55bd29c
https://doi.org/10.1152/ajpendo.00009.2023

المؤلفون: Maria J Forteza, Martin Berg, Andreas Edsfeldt, Jangming Sun, Roland Baumgartner, Ilona Kareinen, Felipe Beccaria Casagrande, Ulf Hedin, Song Zhang, Ivan Vuckovic, Petras P Dzeja, Konstantinos A Polyzos, Anton Gisterå, Mette Trauelsen, Thue W Schwartz, Lea Dib, Joerg Herrmann, Claudia Monaco, Ljubica Matic, Isabel Gonçalves, Daniel F J Ketelhuth

المصدر: Cardiovascular Research.

مصطلحات موضوعية: Physiology, Physiology (medical), Cardiology and Cardiovascular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::fc4e5f7d56c6c5f4fc76b3882b6a3d5e
https://doi.org/10.1093/cvr/cvad038

المؤلفون: Michael Lückmann, Mette Trauelsen, Marie A Bentsen, Tinne AD Nissen, Joao Martins, Zohreh Fallah, Mads M Nygaard, Elena Papaleo, Kresten Lindorff-Larsen, Thue W Schwartz, Thomas M Frimurer

مصطلحات موضوعية: Uncategorized, Uncategorised value, allosteric modulator, molecular dynamics, GPCR, virtual screening, free fatty acid receptor 1

Relation: 2134/14307749.v1; https://figshare.com/articles/journal_contribution/Molecular_dynamics-guided_discovery_of_an_ago-allosteric_modulator_for_GPR40_FFAR1/14307749

الاتاحة: https://figshare.com/articles/journal_contribution/Molecular_dynamics-guided_discovery_of_an_ago-allosteric_modulator_for_GPR40_FFAR1/14307749

المؤلفون: Xiao Tang, Elin Rönnberg, Jesper Säfholm, Madhuranayaki Thulasingam, Mette Trauelsen, Thue W. Schwartz, Craig E. Wheelock, Sven‐Erik Dahlén, Gunnar Nilsson, Jesper Z. Haeggström

المصدر: Tang, X, Rönnberg, E, Säfholm, J, Thulasingam, M, Trauelsen, M, Schwartz, T W, Wheelock, C E, Dahlén, S E, Nilsson, G & Haeggström, J Z 2022, ' Activation of succinate receptor 1 boosts human mast cell reactivity and allergic bronchoconstriction ', Allergy: European Journal of Allergy and Clinical Immunology, vol. 77, no. 9, pp. 2677-2687 . https://doi.org/10.1111/all.15245

مصطلحات موضوعية: Inflammation, Respiratory Medicine and Allergy, Bronchoconstriction, Guinea Pigs, Immunology, Succinates, Immunoglobulin E, succinate, Asthma, SUCNR1, eicosanoid, Hypersensitivity, Animals, Humans, Immunology and Allergy, mast cell hyper-reactivity, Mast Cells, allergic bronchoconstriction, Lungmedicin och allergi

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b5783ec2ddc0e3f8c3ae38faff6fc6
https://doi.org/10.1111/all.15245

المؤلفون: Aslihan Shenol, Michael Lückmann, Mette Trauelsen, Matteo Lambrughi, Matteo Tiberti, Elena Papaleo, Thomas Michael Frimurer, Thue W. Schwartz

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f151710d0a997db00565a4be9f617c09
https://doi.org/10.2139/ssrn.4416988

المؤلفون: Kathrine Lundø, Oksana Dmytriyeva, Louise Spøhr, Eliana Goncalves-Alves, Jiayi Yao, Laia P. Blasco, Mette Trauelsen, Muthulakshmi Ponniah, Marc Severin, Albin Sandelin, Marie Kveiborg, Thue W. Schwartz, Stine F. Pedersen

مصطلحات موضوعية: Biophysics, Microbiology, Cell Biology, Genetics, Molecular Biology, Pharmacology, Developmental Biology, Cancer, Hematology, Plant Biology, Computational Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, HCAR1, Tumor microenvironment, Spheroid, EPHA7, PCDH7, Notch, Extracellular matrix, Metabolite GPCR

Relation: https://figshare.com/articles/dataset/Additional_file_1_of_Lactate_receptor_GPR81_drives_breast_cancer_growth_and_invasiveness_through_regulation_of_ECM_properties_and_Notch_ligand_DLL4/24628097

الاتاحة: https://doi.org/10.6084/m9.figshare.24628097.v1
https://figshare.com/articles/dataset/Additional_file_1_of_Lactate_receptor_GPR81_drives_breast_cancer_growth_and_invasiveness_through_regulation_of_ECM_properties_and_Notch_ligand_DLL4/24628097

المؤلفون: Nailin Li, Mette Trauelsen, Xiao Tang, David Fuchs, Jesper Z. Haeggström, Shuai Tan, Thue W. Schwartz, Craig E. Wheelock

المصدر: Tang, X, Fuchs, D, Tan, S, Trauelsen, M, Schwartz, T W, Wheelock, C E, Li, N & Haeggstrom, J Z 2020, ' Activation of metabolite receptor GPR91 promotes platelet aggregation and transcellular biosynthesis of leukotriene C 4 ', Journal of Thrombosis and Haemostasis, vol. 18, no. 4, pp. 976-984 . https://doi.org/10.1111/jth.14734

مصطلحات موضوعية: biology, Leukotriene C4, GPR91, Chemistry, Thromboxane, Hematology, Lipid signaling, 030204 cardiovascular system & hematology, succinate, antiplatelet therapy, eicosanoids, Cell biology, Proinflammatory cytokine, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Phospholipase A2, platelet aggregation, biology.protein, lipids (amino acids, peptides, and proteins), Platelet, Arachidonic acid, Platelet activation

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450f51bf626591af213b072c93534f69
https://doi.org/10.1111/jth.14734

المؤلفون: Thue W. Schwartz, Mette Trauelsen, Sally Winther

المصدر: Cell Metabolism. 33:1276-1278

مصطلحات موضوعية: Physiology, Metabolite, Inflammation, Cell Biology, Metabolism, medicine.disease, Phenotype, Cell biology, Citric acid cycle, chemistry.chemical_compound, chemistry, Fibrosis, Extracellular, medicine, medicine.symptom, Receptor, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::fc6d31b7c811d5e1af86e5fb65167a45
https://doi.org/10.1016/j.cmet.2021.06.009

المؤلفون: Thue W. Schwartz, Mette Trauelsen, Kathrine Lundø, Stine F. Pedersen

المصدر: Larsen, K L, Trauelsen, M, Pedersen, S H F & Schwartz, T W 2020, ' Why Warburg Works : Lactate Controls Immune Evasion through GPR81 ', Cell Metabolism, vol. 31, no. 4, pp. 666–668 . https://doi.org/10.1016/j.cmet.2020.03.001

مصطلحات موضوعية: 0301 basic medicine, Stromal cell, Physiology, Antigen-Presenting Cells, Breast Neoplasms, GPR81, Biology, Receptors, G-Protein-Coupled, 03 medical and health sciences, Paracrine signalling, 0302 clinical medicine, Immune system, Tumor Microenvironment, Humans, Lactic Acid, Autocrine signalling, Molecular Biology, Immune Evasion, Cell Biology, Metabolism, Evasion (ethics), 3. Good health, 030104 developmental biology, Cancer cell, Cancer research, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7de02a8919f9a115685cb21e46b2071
https://pubmed.ncbi.nlm.nih.gov/32071396

المؤلفون: Line Ørsted Bielefeldt, Mette Trauelsen, Elisabeth Rexen Ulven, Matjaz Brvar, Lisa K. I. Jensen, Michael Lückmann, Thue W. Schwartz, Thomas M. Frimurer

المصدر: Scientific Reports, Vol 8, Iss 1, Pp 1-18 (2018)
Rexen Ulven, E, Trauelsen, M, Brvar, M, Lückmann, M, Bielefeldt, L, Jensen, L K I, Schwartz, T W & Frimurer, T M 2018, ' Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1 ', Scientific Reports, vol. 8, 10010 . https://doi.org/10.1038/s41598-018-28263-7
Scientific Reports
Rexen Ulven, E, Trauelsen, M, Brvar, M, Lückmann, M, Bielefeldt, L Ø, Jensen, L K I, Schwartz, T W & Frimurer, T M 2018, ' Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1 ', Scientific Reports, vol. 8, no. 1, 10010, pp. 1-18 . https://doi.org/10.1038/s41598-018-28263-7

مصطلحات موضوعية: 0301 basic medicine, Agonist, medicine.drug_class, Metabolite, Succinic Acid, Adipose tissue, lcsh:Medicine, Crystallography, X-Ray, Article, Receptors, G-Protein-Coupled, 03 medical and health sciences, chemistry.chemical_compound, Mice, Receptors, Purinergic P2Y1, Structure-Activity Relationship, medicine, Succinate receptor 1, Potency, Animals, Humans, Receptor, lcsh:Science, Kidney, Multidisciplinary, lcsh:R, In vitro toxicology, 030104 developmental biology, medicine.anatomical_structure, Biochemistry, chemistry, lcsh:Q

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f5703255d281374c7fefe07cc8d7a33
http://link.springer.com/article/10.1038/s41598-018-28263-7

المؤلفون: Michael Lückmann, Mette Trauelsen, Thue W. Schwartz, Thomas M. Frimurer

المصدر: Current opinion in cell biology. 63

مصطلحات موضوعية: 0303 health sciences, Metabolite, Cell, Transporter, Cell Biology, Biology, Ligands, Receptors, G-Protein-Coupled, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine.anatomical_structure, chemistry, Biochemistry, Free fatty acid receptor 1, medicine, Extracellular, Humans, Lipid bilayer, Receptor, 030217 neurology & neurosurgery, 030304 developmental biology, G protein-coupled receptor, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c6264064222985c5fa968f2b370927
https://pubmed.ncbi.nlm.nih.gov/31951921

المؤلفون: Zohreh Fallah, Michael Lückmann, Thue W. Schwartz, João M. Martins, Thomas M. Frimurer, Mette Trauelsen, Marie A. Bentsen, Kresten Lindorff-Larsen, Elena Papaleo, Tinne A.D. Nissen, Mads Nygaard

المصدر: Proceedings of the National Academy of Sciences of the United States of America
Lückmann, M, Trauelsen, M, Bentsen, M A, Nissen, T A D, Martins, J, Fallah, Z, Nygaard, M M, Papaleo, E, Lindorff-Larsen, K, Schwartz, T W & Frimurer, T M 2019, ' Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1 ', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 14, pp. 7123-7128 . https://doi.org/10.1073/pnas.1811066116

مصطلحات موضوعية: 0301 basic medicine, Agonist, Allosteric modulator, medicine.drug_class, Protein Conformation, Allosteric regulation, Molecular Dynamics Simulation, Crystallography, X-Ray, Ligands, Receptors, G-Protein-Coupled, 03 medical and health sciences, 0302 clinical medicine, GPCR, Allosteric Regulation, Free fatty acid receptor 1, medicine, Humans, Sulfones, G protein-coupled receptor, Benzofurans, Pharmacology, Virtual screening, Multidisciplinary, Binding Sites, Drug discovery, Chemistry, allosteric modulator, Biological Sciences, free fatty acid receptor 1, virtual screening, molecular dynamics, Molecular Docking Simulation, Transmembrane domain, 030104 developmental biology, Mutation, Biophysics, 030217 neurology & neurosurgery, Allosteric Site, Protein Binding

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46256fae054e249a146227b4e4c4a330
https://pubmed.ncbi.nlm.nih.gov/30872479

المؤلفون: Mette Trauelsen, Michael Lückmann, Thue W. Schwartz, Thomas M. Frimurer

المصدر: Nature Communications

مصطلحات موضوعية: 0301 basic medicine, endocrine system, medicine.medical_specialty, Physiology, medicine.medical_treatment, Article, Receptors, G-Protein-Coupled, Islets of Langerhans, 03 medical and health sciences, Free fatty acid receptor 1, Islet cells, Internal medicine, Hydroxyeicosatetraenoic Acids, Insulin Secretion, medicine, Insulin, Receptor, Insulin secretion, Autocrine signalling, Molecular Biology, chemistry.chemical_classification, Hydroxyeicosatetraenoic acid, Fatty acid, Cell Biology, Glucose, 030104 developmental biology, Endocrinology, chemistry, cardiovascular system, lipids (amino acids, peptides, and proteins)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3340d186d64e6427596e1273794fd9
https://doi.org/10.1016/j.cmet.2018.01.006

المؤلفون: Mette Trauelsen, Siv A. Hjorth, Thue W. Schwartz, Anna Sofie Husted, Olga Rudenko

المصدر: Cell metabolism. 25(4)

مصطلحات موضوعية: 0301 basic medicine, Cell signaling, Physiology, Metabolite, Enteroendocrine Cells, Enteroendocrine cell, Nutrient sensing, Biology, Ligands, Receptors, G-Protein-Coupled, 03 medical and health sciences, Paracrine signalling, chemistry.chemical_compound, 0302 clinical medicine, Extracellular, Animals, Humans, Autocrine signalling, Molecular Biology, Cell Biology, Gastrointestinal Microbiome, 030104 developmental biology, Biochemistry, chemistry, Metabolome, 030217 neurology & neurosurgery, Hormone, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15f2e028642526b772867d0275070668
https://pubmed.ncbi.nlm.nih.gov/28380372

المؤلفون: Michala Prause, Nils Billestrup, Thomas Mandrup-Poulsen, Joachim Størling, Adriana Ibarra Urizar, Lukas Adrian Berchtold, Mette Trauelsen

المصدر: Molecular and cellular endocrinology. 420

مصطلحات موضوعية: 0301 basic medicine, STAT3 Transcription Factor, TRAF2, p38 mitogen-activated protein kinases, medicine.medical_treatment, Interleukin-1beta, Nitric Oxide Synthase Type II, Apoptosis, Biology, Biochemistry, Cell Line, 03 medical and health sciences, Interferon-gamma, Mice, Necrosis, Endocrinology, Cell surface receptor, Insulin-Secreting Cells, medicine, Animals, Humans, Phosphorylation, Rats, Wistar, Molecular Biology, Kinase, Pancreatic islets, JNK Mitogen-Activated Protein Kinases, TNF Receptor-Associated Factor 2, Cell biology, Up-Regulation, Enzyme Activation, 030104 developmental biology, medicine.anatomical_structure, Cytokine, Caspases, Gene Knockdown Techniques, Immunology, Tumor necrosis factor alpha, Inflammation Mediators, Reactive Oxygen Species

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::255a9a65d493e6243a67a6231d4ff9f2
https://pubmed.ncbi.nlm.nih.gov/26610752