المؤلفون: Mark Stewart (1269330), Carla Rodriguez-Watson (10319057), Adem Albayrak (6525617), Julius Asubonteng (10319060), Andrew Belli (10319063), Thomas Brown (4994990), Kelly Cho (289664), Ritankar Das (5356424), Elizabeth Eldridge (10319066), Nicolle Gatto (10319069), Alice Gelman (10319072), Hanna Gerlovin (9347041), Stuart L. Goldberg (9239394), Eric Hansen (2337007), Jonathan Hirsch (10319075), Yuk-Lam Ho (7010873), Andrew Ip (9239310), Monika Izano (10319078), Jason Jones (194533), Amy C. Justice (9185633), Reyna Klesh (10319081), Seth Kuranz (10319084), Carson Lam (10319087), Qingqing Mao (10319090), Samson Mataraso (10195103), Robertino Mera (10319093), Daniel C. Posner (10319096), Jeremy A. Rassen (10319099), Anna Siefkas (10195106), Andrew Schrag (10319102), Georgia Tourassi (8828105), Andrew Weckstein (10319105), Frank Wolf (10319108), Amar Bhat (322700), Susan Winckler (10319111), Ellen V. Sigal (10319114), Jeff Allen (4021046)

مصطلحات موضوعية: Medicine, Pharmacology, Biotechnology, Cancer, Science Policy, Mental Health, Infectious Diseases, Virology, FDA, COVID -19 patients Background, COVID -19 patients, COVID -19, EHR, COVID -19 Evidence Accelerator, combination, health systems research, hydroxychloroquine, data, COVID -19 pandemic, propensity score methods, azithromycin, Methods Electronic health record

Relation: https://figshare.com/articles/journal_contribution/S1_File_-/14232419

الاتاحة: https://doi.org/10.1371/journal.pone.0248128.s001

المؤلفون: Mark Stewart (1269330), Carla Rodriguez-Watson (10319057), Adem Albayrak (6525617), Julius Asubonteng (10319060), Andrew Belli (10319063), Thomas Brown (4994990), Kelly Cho (289664), Ritankar Das (5356424), Elizabeth Eldridge (10319066), Nicolle Gatto (10319069), Alice Gelman (10319072), Hanna Gerlovin (9347041), Stuart L. Goldberg (9239394), Eric Hansen (2337007), Jonathan Hirsch (10319075), Yuk-Lam Ho (7010873), Andrew Ip (9239310), Monika Izano (10319078), Jason Jones (194533), Amy C. Justice (9185633), Reyna Klesh (10319081), Seth Kuranz (10319084), Carson Lam (10319087), Qingqing Mao (10319090), Samson Mataraso (10195103), Robertino Mera (10319093), Daniel C. Posner (10319096), Jeremy A. Rassen (10319099), Anna Siefkas (10195106), Andrew Schrag (10319102), Georgia Tourassi (8828105), Andrew Weckstein (10319105), Frank Wolf (10319108), Amar Bhat (322700), Susan Winckler (10319111), Ellen V. Sigal (10319114), Jeff Allen (4021046)

مصطلحات موضوعية: Medicine, Pharmacology, Biotechnology, Cancer, Science Policy, Mental Health, Infectious Diseases, Virology, FDA, COVID -19 patients Background, COVID -19 patients, COVID -19, EHR, COVID -19 Evidence Accelerator, combination, health systems research, hydroxychloroquine, data, COVID -19 pandemic, propensity score methods, azithromycin, Methods Electronic health record

Relation: https://figshare.com/articles/figure/Study_diagram_/14232425

الاتاحة: https://doi.org/10.1371/journal.pone.0248128.g002

المؤلفون: Mark Stewart (1269330), Carla Rodriguez-Watson (10319057), Adem Albayrak (6525617), Julius Asubonteng (10319060), Andrew Belli (10319063), Thomas Brown (4994990), Kelly Cho (289664), Ritankar Das (5356424), Elizabeth Eldridge (10319066), Nicolle Gatto (10319069), Alice Gelman (10319072), Hanna Gerlovin (9347041), Stuart L. Goldberg (9239394), Eric Hansen (2337007), Jonathan Hirsch (10319075), Yuk-Lam Ho (7010873), Andrew Ip (9239310), Monika Izano (10319078), Jason Jones (194533), Amy C. Justice (9185633), Reyna Klesh (10319081), Seth Kuranz (10319084), Carson Lam (10319087), Qingqing Mao (10319090), Samson Mataraso (10195103), Robertino Mera (10319093), Daniel C. Posner (10319096), Jeremy A. Rassen (10319099), Anna Siefkas (10195106), Andrew Schrag (10319102), Georgia Tourassi (8828105), Andrew Weckstein (10319105), Frank Wolf (10319108), Amar Bhat (322700), Susan Winckler (10319111), Ellen V. Sigal (10319114), Jeff Allen (4021046)

مصطلحات موضوعية: Medicine, Pharmacology, Biotechnology, Cancer, Science Policy, Mental Health, Infectious Diseases, Virology, FDA, COVID -19 patients Background, COVID -19 patients, COVID -19, EHR, COVID -19 Evidence Accelerator, combination, health systems research, hydroxychloroquine, data, COVID -19 pandemic, propensity score methods, azithromycin, Methods Electronic health record

Relation: https://figshare.com/articles/figure/Age_distribution_by_treatment_group_/14232428

الاتاحة: https://doi.org/10.1371/journal.pone.0248128.g003

المؤلفون: Mark Stewart (1269330), Carla Rodriguez-Watson (10319057), Adem Albayrak (6525617), Julius Asubonteng (10319060), Andrew Belli (10319063), Thomas Brown (4994990), Kelly Cho (289664), Ritankar Das (5356424), Elizabeth Eldridge (10319066), Nicolle Gatto (10319069), Alice Gelman (10319072), Hanna Gerlovin (9347041), Stuart L. Goldberg (9239394), Eric Hansen (2337007), Jonathan Hirsch (10319075), Yuk-Lam Ho (7010873), Andrew Ip (9239310), Monika Izano (10319078), Jason Jones (194533), Amy C. Justice (9185633), Reyna Klesh (10319081), Seth Kuranz (10319084), Carson Lam (10319087), Qingqing Mao (10319090), Samson Mataraso (10195103), Robertino Mera (10319093), Daniel C. Posner (10319096), Jeremy A. Rassen (10319099), Anna Siefkas (10195106), Andrew Schrag (10319102), Georgia Tourassi (8828105), Andrew Weckstein (10319105), Frank Wolf (10319108), Amar Bhat (322700), Susan Winckler (10319111), Ellen V. Sigal (10319114), Jeff Allen (4021046)

مصطلحات موضوعية: Medicine, Pharmacology, Biotechnology, Cancer, Science Policy, Mental Health, Infectious Diseases, Virology, FDA, COVID -19 patients Background, COVID -19 patients, COVID -19, EHR, COVID -19 Evidence Accelerator, combination, health systems research, hydroxychloroquine, data, COVID -19 pandemic, propensity score methods, azithromycin, Methods Electronic health record

Relation: https://figshare.com/articles/dataset/Characteristics_of_participating_data_sources_and_populations_/14232437

الاتاحة: https://doi.org/10.1371/journal.pone.0248128.t001

المؤلفون: Mark Stewart (1269330), Carla Rodriguez-Watson (10319057), Adem Albayrak (6525617), Julius Asubonteng (10319060), Andrew Belli (10319063), Thomas Brown (4994990), Kelly Cho (289664), Ritankar Das (5356424), Elizabeth Eldridge (10319066), Nicolle Gatto (10319069), Alice Gelman (10319072), Hanna Gerlovin (9347041), Stuart L. Goldberg (9239394), Eric Hansen (2337007), Jonathan Hirsch (10319075), Yuk-Lam Ho (7010873), Andrew Ip (9239310), Monika Izano (10319078), Jason Jones (194533), Amy C. Justice (9185633), Reyna Klesh (10319081), Seth Kuranz (10319084), Carson Lam (10319087), Qingqing Mao (10319090), Samson Mataraso (10195103), Robertino Mera (10319093), Daniel C. Posner (10319096), Jeremy A. Rassen (10319099), Anna Siefkas (10195106), Andrew Schrag (10319102), Georgia Tourassi (8828105), Andrew Weckstein (10319105), Frank Wolf (10319108), Amar Bhat (322700), Susan Winckler (10319111), Ellen V. Sigal (10319114), Jeff Allen (4021046)

مصطلحات موضوعية: Medicine, Pharmacology, Biotechnology, Cancer, Science Policy, Mental Health, Infectious Diseases, Virology, FDA, COVID -19 patients Background, COVID -19 patients, COVID -19, EHR, COVID -19 Evidence Accelerator, combination, health systems research, hydroxychloroquine, data, COVID -19 pandemic, propensity score methods, azithromycin, Methods Electronic health record

Relation: https://figshare.com/articles/dataset/Adjusted_hazard_ratios_for_each_treatment_group_/14232458

الاتاحة: https://doi.org/10.1371/journal.pone.0248128.t008

المؤلفون: Mark Stewart (1269330), Carla Rodriguez-Watson (10319057), Adem Albayrak (6525617), Julius Asubonteng (10319060), Andrew Belli (10319063), Thomas Brown (4994990), Kelly Cho (289664), Ritankar Das (5356424), Elizabeth Eldridge (10319066), Nicolle Gatto (10319069), Alice Gelman (10319072), Hanna Gerlovin (9347041), Stuart L. Goldberg (9239394), Eric Hansen (2337007), Jonathan Hirsch (10319075), Yuk-Lam Ho (7010873), Andrew Ip (9239310), Monika Izano (10319078), Jason Jones (194533), Amy C. Justice (9185633), Reyna Klesh (10319081), Seth Kuranz (10319084), Carson Lam (10319087), Qingqing Mao (10319090), Samson Mataraso (10195103), Robertino Mera (10319093), Daniel C. Posner (10319096), Jeremy A. Rassen (10319099), Anna Siefkas (10195106), Andrew Schrag (10319102), Georgia Tourassi (8828105), Andrew Weckstein (10319105), Frank Wolf (10319108), Amar Bhat (322700), Susan Winckler (10319111), Ellen V. Sigal (10319114), Jeff Allen (4021046)

مصطلحات موضوعية: Medicine, Pharmacology, Biotechnology, Cancer, Science Policy, Mental Health, Infectious Diseases, Virology, FDA, COVID -19 patients Background, COVID -19 patients, COVID -19, EHR, COVID -19 Evidence Accelerator, combination, health systems research, hydroxychloroquine, data, COVID -19 pandemic, propensity score methods, azithromycin, Methods Electronic health record

Relation: https://figshare.com/articles/figure/Partner_map_for_HCQ_analysis_/14232422

الاتاحة: https://doi.org/10.1371/journal.pone.0248128.g001

المؤلفون: Mark Stewart (1269330), Carla Rodriguez-Watson (10319057), Adem Albayrak (6525617), Julius Asubonteng (10319060), Andrew Belli (10319063), Thomas Brown (4994990), Kelly Cho (289664), Ritankar Das (5356424), Elizabeth Eldridge (10319066), Nicolle Gatto (10319069), Alice Gelman (10319072), Hanna Gerlovin (9347041), Stuart L. Goldberg (9239394), Eric Hansen (2337007), Jonathan Hirsch (10319075), Yuk-Lam Ho (7010873), Andrew Ip (9239310), Monika Izano (10319078), Jason Jones (194533), Amy C. Justice (9185633), Reyna Klesh (10319081), Seth Kuranz (10319084), Carson Lam (10319087), Qingqing Mao (10319090), Samson Mataraso (10195103), Robertino Mera (10319093), Daniel C. Posner (10319096), Jeremy A. Rassen (10319099), Anna Siefkas (10195106), Andrew Schrag (10319102), Georgia Tourassi (8828105), Andrew Weckstein (10319105), Frank Wolf (10319108), Amar Bhat (322700), Susan Winckler (10319111), Ellen V. Sigal (10319114), Jeff Allen (4021046)

مصطلحات موضوعية: Medicine, Pharmacology, Biotechnology, Cancer, Science Policy, Mental Health, Infectious Diseases, Virology, FDA, COVID -19 patients Background, COVID -19 patients, COVID -19, EHR, COVID -19 Evidence Accelerator, combination, health systems research, hydroxychloroquine, data, COVID -19 pandemic, propensity score methods, azithromycin, Methods Electronic health record

Relation: https://figshare.com/articles/figure/Sex_distribution_by_treatment_group_/14232431

الاتاحة: https://doi.org/10.1371/journal.pone.0248128.g004

المؤلفون: Mark Stewart (1269330), Carla Rodriguez-Watson (10319057), Adem Albayrak (6525617), Julius Asubonteng (10319060), Andrew Belli (10319063), Thomas Brown (4994990), Kelly Cho (289664), Ritankar Das (5356424), Elizabeth Eldridge (10319066), Nicolle Gatto (10319069), Alice Gelman (10319072), Hanna Gerlovin (9347041), Stuart L. Goldberg (9239394), Eric Hansen (2337007), Jonathan Hirsch (10319075), Yuk-Lam Ho (7010873), Andrew Ip (9239310), Monika Izano (10319078), Jason Jones (194533), Amy C. Justice (9185633), Reyna Klesh (10319081), Seth Kuranz (10319084), Carson Lam (10319087), Qingqing Mao (10319090), Samson Mataraso (10195103), Robertino Mera (10319093), Daniel C. Posner (10319096), Jeremy A. Rassen (10319099), Anna Siefkas (10195106), Andrew Schrag (10319102), Georgia Tourassi (8828105), Andrew Weckstein (10319105), Frank Wolf (10319108), Amar Bhat (322700), Susan Winckler (10319111), Ellen V. Sigal (10319114), Jeff Allen (4021046)

مصطلحات موضوعية: Medicine, Pharmacology, Biotechnology, Cancer, Science Policy, Mental Health, Infectious Diseases, Virology, FDA, COVID -19 patients Background, COVID -19 patients, COVID -19, EHR, COVID -19 Evidence Accelerator, combination, health systems research, hydroxychloroquine, data, COVID -19 pandemic, propensity score methods, azithromycin, Methods Electronic health record

Relation: https://figshare.com/articles/figure/Race_distribution_by_treatment_group_/14232434

الاتاحة: https://doi.org/10.1371/journal.pone.0248128.g005

المؤلفون: Mark Stewart (1269330), Carla Rodriguez-Watson (10319057), Adem Albayrak (6525617), Julius Asubonteng (10319060), Andrew Belli (10319063), Thomas Brown (4994990), Kelly Cho (289664), Ritankar Das (5356424), Elizabeth Eldridge (10319066), Nicolle Gatto (10319069), Alice Gelman (10319072), Hanna Gerlovin (9347041), Stuart L. Goldberg (9239394), Eric Hansen (2337007), Jonathan Hirsch (10319075), Yuk-Lam Ho (7010873), Andrew Ip (9239310), Monika Izano (10319078), Jason Jones (194533), Amy C. Justice (9185633), Reyna Klesh (10319081), Seth Kuranz (10319084), Carson Lam (10319087), Qingqing Mao (10319090), Samson Mataraso (10195103), Robertino Mera (10319093), Daniel C. Posner (10319096), Jeremy A. Rassen (10319099), Anna Siefkas (10195106), Andrew Schrag (10319102), Georgia Tourassi (8828105), Andrew Weckstein (10319105), Frank Wolf (10319108), Amar Bhat (322700), Susan Winckler (10319111), Ellen V. Sigal (10319114), Jeff Allen (4021046)

مصطلحات موضوعية: Medicine, Pharmacology, Biotechnology, Cancer, Science Policy, Mental Health, Infectious Diseases, Virology, FDA, COVID -19 patients Background, COVID -19 patients, COVID -19, EHR, COVID -19 Evidence Accelerator, combination, health systems research, hydroxychloroquine, data, COVID -19 pandemic, propensity score methods, azithromycin, Methods Electronic health record

Relation: https://figshare.com/articles/dataset/Covariates_reported_by_each_group_/14232440

الاتاحة: https://doi.org/10.1371/journal.pone.0248128.t002

المؤلفون: Mark Stewart (1269330), Carla Rodriguez-Watson (10319057), Adem Albayrak (6525617), Julius Asubonteng (10319060), Andrew Belli (10319063), Thomas Brown (4994990), Kelly Cho (289664), Ritankar Das (5356424), Elizabeth Eldridge (10319066), Nicolle Gatto (10319069), Alice Gelman (10319072), Hanna Gerlovin (9347041), Stuart L. Goldberg (9239394), Eric Hansen (2337007), Jonathan Hirsch (10319075), Yuk-Lam Ho (7010873), Andrew Ip (9239310), Monika Izano (10319078), Jason Jones (194533), Amy C. Justice (9185633), Reyna Klesh (10319081), Seth Kuranz (10319084), Carson Lam (10319087), Qingqing Mao (10319090), Samson Mataraso (10195103), Robertino Mera (10319093), Daniel C. Posner (10319096), Jeremy A. Rassen (10319099), Anna Siefkas (10195106), Andrew Schrag (10319102), Georgia Tourassi (8828105), Andrew Weckstein (10319105), Frank Wolf (10319108), Amar Bhat (322700), Susan Winckler (10319111), Ellen V. Sigal (10319114), Jeff Allen (4021046)

مصطلحات موضوعية: Medicine, Pharmacology, Biotechnology, Cancer, Science Policy, Mental Health, Infectious Diseases, Virology, FDA, COVID -19 patients Background, COVID -19 patients, COVID -19, EHR, COVID -19 Evidence Accelerator, combination, health systems research, hydroxychloroquine, data, COVID -19 pandemic, propensity score methods, azithromycin, Methods Electronic health record

Relation: https://figshare.com/articles/dataset/Summary_of_outcome_definitions_across_groups_/14232443

الاتاحة: https://doi.org/10.1371/journal.pone.0248128.t003

المؤلفون: Mark Stewart (1269330), Carla Rodriguez-Watson (10319057), Adem Albayrak (6525617), Julius Asubonteng (10319060), Andrew Belli (10319063), Thomas Brown (4994990), Kelly Cho (289664), Ritankar Das (5356424), Elizabeth Eldridge (10319066), Nicolle Gatto (10319069), Alice Gelman (10319072), Hanna Gerlovin (9347041), Stuart L. Goldberg (9239394), Eric Hansen (2337007), Jonathan Hirsch (10319075), Yuk-Lam Ho (7010873), Andrew Ip (9239310), Monika Izano (10319078), Jason Jones (194533), Amy C. Justice (9185633), Reyna Klesh (10319081), Seth Kuranz (10319084), Carson Lam (10319087), Qingqing Mao (10319090), Samson Mataraso (10195103), Robertino Mera (10319093), Daniel C. Posner (10319096), Jeremy A. Rassen (10319099), Anna Siefkas (10195106), Andrew Schrag (10319102), Georgia Tourassi (8828105), Andrew Weckstein (10319105), Frank Wolf (10319108), Amar Bhat (322700), Susan Winckler (10319111), Ellen V. Sigal (10319114), Jeff Allen (4021046)

مصطلحات موضوعية: Medicine, Pharmacology, Biotechnology, Cancer, Science Policy, Mental Health, Infectious Diseases, Virology, FDA, COVID -19 patients Background, COVID -19 patients, COVID -19, EHR, COVID -19 Evidence Accelerator, combination, health systems research, hydroxychloroquine, data, COVID -19 pandemic, propensity score methods, azithromycin, Methods Electronic health record

Relation: https://figshare.com/articles/dataset/Key_definitions_and_methodology_/14232446

الاتاحة: https://doi.org/10.1371/journal.pone.0248128.t004

المؤلفون: Mark Stewart (1269330), Carla Rodriguez-Watson (10319057), Adem Albayrak (6525617), Julius Asubonteng (10319060), Andrew Belli (10319063), Thomas Brown (4994990), Kelly Cho (289664), Ritankar Das (5356424), Elizabeth Eldridge (10319066), Nicolle Gatto (10319069), Alice Gelman (10319072), Hanna Gerlovin (9347041), Stuart L. Goldberg (9239394), Eric Hansen (2337007), Jonathan Hirsch (10319075), Yuk-Lam Ho (7010873), Andrew Ip (9239310), Monika Izano (10319078), Jason Jones (194533), Amy C. Justice (9185633), Reyna Klesh (10319081), Seth Kuranz (10319084), Carson Lam (10319087), Qingqing Mao (10319090), Samson Mataraso (10195103), Robertino Mera (10319093), Daniel C. Posner (10319096), Jeremy A. Rassen (10319099), Anna Siefkas (10195106), Andrew Schrag (10319102), Georgia Tourassi (8828105), Andrew Weckstein (10319105), Frank Wolf (10319108), Amar Bhat (322700), Susan Winckler (10319111), Ellen V. Sigal (10319114), Jeff Allen (4021046)

مصطلحات موضوعية: Medicine, Pharmacology, Biotechnology, Cancer, Science Policy, Mental Health, Infectious Diseases, Virology, FDA, COVID -19 patients Background, COVID -19 patients, COVID -19, EHR, COVID -19 Evidence Accelerator, combination, health systems research, hydroxychloroquine, data, COVID -19 pandemic, propensity score methods, azithromycin, Methods Electronic health record

Relation: https://figshare.com/articles/dataset/Summary_of_comorbidities_across_groups_/14232449

الاتاحة: https://doi.org/10.1371/journal.pone.0248128.t005

المؤلفون: Mark Stewart (1269330), Carla Rodriguez-Watson (10319057), Adem Albayrak (6525617), Julius Asubonteng (10319060), Andrew Belli (10319063), Thomas Brown (4994990), Kelly Cho (289664), Ritankar Das (5356424), Elizabeth Eldridge (10319066), Nicolle Gatto (10319069), Alice Gelman (10319072), Hanna Gerlovin (9347041), Stuart L. Goldberg (9239394), Eric Hansen (2337007), Jonathan Hirsch (10319075), Yuk-Lam Ho (7010873), Andrew Ip (9239310), Monika Izano (10319078), Jason Jones (194533), Amy C. Justice (9185633), Reyna Klesh (10319081), Seth Kuranz (10319084), Carson Lam (10319087), Qingqing Mao (10319090), Samson Mataraso (10195103), Robertino Mera (10319093), Daniel C. Posner (10319096), Jeremy A. Rassen (10319099), Anna Siefkas (10195106), Andrew Schrag (10319102), Georgia Tourassi (8828105), Andrew Weckstein (10319105), Frank Wolf (10319108), Amar Bhat (322700), Susan Winckler (10319111), Ellen V. Sigal (10319114), Jeff Allen (4021046)

مصطلحات موضوعية: Medicine, Pharmacology, Biotechnology, Cancer, Science Policy, Mental Health, Infectious Diseases, Virology, FDA, COVID -19 patients Background, COVID -19 patients, COVID -19, EHR, COVID -19 Evidence Accelerator, combination, health systems research, hydroxychloroquine, data, COVID -19 pandemic, propensity score methods, azithromycin, Methods Electronic health record

Relation: https://figshare.com/articles/dataset/Frequency_of_adverse_events_across_each_treatment_group_/14232452

الاتاحة: https://doi.org/10.1371/journal.pone.0248128.t006

المؤلفون: Mark Stewart (1269330), Carla Rodriguez-Watson (10319057), Adem Albayrak (6525617), Julius Asubonteng (10319060), Andrew Belli (10319063), Thomas Brown (4994990), Kelly Cho (289664), Ritankar Das (5356424), Elizabeth Eldridge (10319066), Nicolle Gatto (10319069), Alice Gelman (10319072), Hanna Gerlovin (9347041), Stuart L. Goldberg (9239394), Eric Hansen (2337007), Jonathan Hirsch (10319075), Yuk-Lam Ho (7010873), Andrew Ip (9239310), Monika Izano (10319078), Jason Jones (194533), Amy C. Justice (9185633), Reyna Klesh (10319081), Seth Kuranz (10319084), Carson Lam (10319087), Qingqing Mao (10319090), Samson Mataraso (10195103), Robertino Mera (10319093), Daniel C. Posner (10319096), Jeremy A. Rassen (10319099), Anna Siefkas (10195106), Andrew Schrag (10319102), Georgia Tourassi (8828105), Andrew Weckstein (10319105), Frank Wolf (10319108), Amar Bhat (322700), Susan Winckler (10319111), Ellen V. Sigal (10319114), Jeff Allen (4021046)

مصطلحات موضوعية: Medicine, Pharmacology, Biotechnology, Cancer, Science Policy, Mental Health, Infectious Diseases, Virology, FDA, COVID -19 patients Background, COVID -19 patients, COVID -19, EHR, COVID -19 Evidence Accelerator, combination, health systems research, hydroxychloroquine, data, COVID -19 pandemic, propensity score methods, azithromycin, Methods Electronic health record

Relation: https://figshare.com/articles/dataset/Frequencies_of_outcome_for_each_treatment_group_/14232455

الاتاحة: https://doi.org/10.1371/journal.pone.0248128.t007