المؤلفون: Mohamed Albadry, Jonas Küttner, Jan Grzegorzewski, Olaf Dirsch, Eva Kindler, Robert Klopfleisch, Vaclav Liska, Vladimira Moulisova, Sandra Nickel, Richard Palek, Jachym Rosendorf, Sylvia Saalfeld, Utz Settmacher, Hans-Michael Tautenhahn, Matthias König, Uta Dahmen

المصدر: Frontiers in Pharmacology, Vol 15 (2024)

مصطلحات موضوعية: liver lobular geometry, metabolic zonation, drug metabolism, cytochrome P450, glutamine synthetase, interspecies, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1404938/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/46affa48e26a429382b68c799c8fe292

المؤلفون: Albadry, Mohamed, Küttner, Jonas, Grzegorzewski, Jan, Dirsch, Olaf, Kindler, Eva, Klopfleisch, Robert, Liska, Vaclav, Moulisova, Vladimira, Nickel, Sandra, Palek, Richard, Rosendorf, Jachym, Saalfeld, Sylvia, Settmacher, Utz, Tautenhahn, Hans-Michael, König, Matthias, Dahmen, Uta

مصطلحات موضوعية: liver lobular geometry, metabolic zonation, drug metabolism, cytochrome P450, glutamine synthetase, interspecies, image analysis, 570 Biologie, 610 Medizin und Gesundheit, ddc:570, ddc:610

وصف الملف: application/pdf

Relation: http://edoc.hu-berlin.de/18452/29687; urn:nbn:de:kobv:11-110-18452/29687-7; http://dx.doi.org/10.18452/29070

الاتاحة: http://edoc.hu-berlin.de/18452/29687
https://nbn-resolving.org/urn:nbn:de:kobv:11-110-18452/29687-7
https://doi.org/10.18452/29070
https://doi.org/10.3389/fphar.2024.1404938

المؤلفون: Adebayo Michael, Adeola O, Ko, Sungjin, Tao, Junyan, Moghe, Akshata, Yang, Hong, Xu, Meng, Russell, Jacquelyn O, Pradhan-Sundd, Tirthadipa, Liu, Silvia, Singh, Sucha, Poddar, Minakshi, Monga, Jayvir S, Liu, Pin, Oertel, Michael, Ranganathan, Sarangarajan, Singhi, Aatur, Rebouissou, Sandra, Zucman-Rossi, Jessica, Ribback, Silvia, Calvisi, Diego, Qvartskhava, Natalia, Görg, Boris, Häussinger, Dieter, Chen, Xin, Monga, Satdarshan P

المصدر: Cell Metabolism. 29(5)

مصطلحات موضوعية: Chronic Liver Disease and Cirrhosis, Liver Cancer, Genetics, Liver Disease, Cancer, Digestive Diseases, Rare Diseases, Acetates, Animals, Carcinoma, Hepatocellular, Cell Line, Tumor, Cell Proliferation, Cell Survival, Child, Child, Preschool, Disease Models, Animal, Female, Glutamate-Ammonia Ligase, Glutamine, Hepatocytes, Humans, Infant, Liver Neoplasms, Male, Mechanistic Target of Rapamycin Complex 1, Mice, Mice, Inbred C57BL, Mice, Knockout, Mutation, Phenols, Retrospective Studies, Sirolimus, TOR Serine-Threonine Kinases, Transfection, Wnt Signaling Pathway, beta Catenin, Wnt, beta-catenin, glutamine synthetase, hepatocellular cancer, liver tumor, mTOR, metabolic zonation, personalized medicine, precision therapy, tumor metabolism, Biochemistry and Cell Biology, Medical Biochemistry and Metabolomics, Endocrinology & Metabolism

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/0fj4f3g6

المؤلفون: Ho, Harvey, Means, Shawn, Safaei, Soroush, Hunter, Peter John

المصدر: WIRES MECHANISMS OF DISEASE ; ISSN: 2692-9368

مصطلحات موضوعية: Technology and Engineering, Medicine and Health Sciences, circulation, computational model, liver, liver lobule, ARTERIAL BUFFER RESPONSE, INTRAHEPATIC PORTOSYSTEMIC SHUNT, BLOOD-FLOW, PARTIAL-HEPATECTOMY, METABOLIC ZONATION, B-VIRUS, HEMODYNAMICS, SYSTEMS, BILE

وصف الملف: application/pdf

Relation: https://biblio.ugent.be/publication/01HSCE4E7063FBYSBB9J249QKS; http://doi.org/10.1002/wsbm.1586; https://biblio.ugent.be/publication/01HSCE4E7063FBYSBB9J249QKS/file/01JAAQ4CD0JEKEMEQQ7AJ13QV8

الاتاحة: https://biblio.ugent.be/publication/01HSCE4E7063FBYSBB9J249QKS
http://hdl.handle.net/1854/LU-01HSCE4E7063FBYSBB9J249QKS
https://doi.org/10.1002/wsbm.1586
https://biblio.ugent.be/publication/01HSCE4E7063FBYSBB9J249QKS/file/01JAAQ4CD0JEKEMEQQ7AJ13QV8

المؤلفون: Hassan, Reham, González, Daniela, Hobloss, Zaynab, Brackhagen, Lisa, Myllys, Maiju, Friebel, Adrian, Seddek, Abdel-latif, Marchan, Rosemarie, Cramer, Benedikt, Humpf, Hans-Ulrich, Hoehme, Stefan, Degen, Gisela H, Hengstler, Jan, Ghallab, Ahmed

المصدر: Archives of toxicology, 96(12):3349–3361

مصطلحات موضوعية: detoxification, metabolic zonation, mycotoxins, bioactivation, drug metabolism

Relation: https://repository.publisso.de/resource/frl:6438700; https://doi.org/10.1007/s00204-022-03395-y; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584869/; https://link.springer.com/article/10.1007/s00204-022-03395-y#Sec20

الاتاحة: https://repository.publisso.de/resource/frl:6438700
https://doi.org/10.1007/s00204-022-03395-y
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584869/
https://link.springer.com/article/10.1007/s00204-022-03395-y#Sec20

المؤلفون: Shigeyuki Kurosaki, Hayato Nakagawa, Yuki Hayata, Satoshi Kawamura, Yuki Matsushita, Tomoharu Yamada, Koji Uchino, Yoku Hayakawa, Nobumi Suzuki, Masahiro Hata, Mayo Tsuboi, Hiroto Kinoshita, Yasuo Tanaka, Takuma Nakatsuka, Yoshihiro Hirata, Keisuke Tateishi, Kazuhiko Koike

المصدر: JHEP Reports, Vol 3, Iss 4, Pp 100315- (2021)

مصطلحات موضوعية: Hepatocellular carcinoma, Liver regeneration, Metabolic dysfunction-associated fatty liver disease, Wnt/β-catenin signal, Metabolic zonation, Diseases of the digestive system. Gastroenterology, RC799-869

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589555921000914; https://doaj.org/toc/2589-5559

URL الوصول: https://doaj.org/article/eb6538ad7f884c609ff2050f2b466934

المؤلفون: Mohamed Albadry, Jonas Küttner, Jan Grzegorzewski, Olaf Dirsch, Eva Kindler, Robert Klopfleisch, Vaclav Liska, Vladimira Moulisova, Sandra Nickel, Richard Palek, Jachym Rosendorf, Sylvia Saalfeld, Utz Settmacher, Hans-Michael Tautenhahn, Matthias König, Uta Dahmen

مصطلحات موضوعية: Pharmacology, Basic Pharmacology, Clinical Pharmacology and Therapeutics, Clinical Pharmacy and Pharmacy Practice, Pharmaceutical Sciences, Pharmacogenomics, Toxicology (incl. Clinical Toxicology), Pharmacology and Pharmaceutical Sciences not elsewhere classified, liver lobular geometry, metabolic zonation, drug metabolism, cytochrome P450, glutamine synthetase, interspecies, image analysis

Relation: https://figshare.com/articles/dataset/DataSheet1_Cross-species_variability_in_lobular_geometry_and_cytochrome_P450_hepatic_zonation_insights_into_CYP1A2_CYP2D6_CYP2E1_and_CYP3A4_pdf/25834741

الاتاحة: https://doi.org/10.3389/fphar.2024.1404938.s001
https://figshare.com/articles/dataset/DataSheet1_Cross-species_variability_in_lobular_geometry_and_cytochrome_P450_hepatic_zonation_insights_into_CYP1A2_CYP2D6_CYP2E1_and_CYP3A4_pdf/25834741

المؤلفون: Nathan Carpentier, Luca Urbani, Peter Dubruel, Sandra Van Vlierberghe

المصدر: BIOMATERIALS SCIENCE

مصطلحات موضوعية: Chemistry, MICROPATTERNED SURFACES, PREDICTION, COCULTURE, KUPFFER CELLS, Biomedical Engineering, General Materials Science, HEPARG CELLS, PRIMARY HUMAN HEPATOCYTES, METABOLIC ZONATION, HEPG2 CELLS, STEM-CELLS, 3D

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c79f8b454510638fe0c2140f4748545
https://doi.org/10.1039/d2bm01646j

المؤلفون: Qvartskhava, Natalia, Lang, Philipp A., Görg, Boris, Pozdeev, Vitaly I., Ortiz, Marina Pascual, Lang, Karl S., Bidmon, Hans J., Lang, Elisabeth, Leibrock, Christina B., Herebian, Diran, Bode, Johannes G., Lang, Florian, Häussinger, Dieter

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2015 Apr . 112(17), 5521-5526.

URL الوصول: https://www.jstor.org/stable/26462590

المؤلفون: Tonon F., Giobbe G. G., Zambon A., Luni C., Gagliano O., FLOREANI, ALBERTO, Grassi G., ELVASSORE, NICOLA

المساهمون: Tonon, F., Giobbe, G. G., Zambon, A., Luni, C., Gagliano, O., Floreani, Alberto, Grassi, G., Elvassore, Nicola

مصطلحات موضوعية: metabolic zonation, liver, oxigen gradient, gene expression

وصف الملف: ELETTRONICO

Relation: info:eu-repo/semantics/altIdentifier/pmid/31537830; info:eu-repo/semantics/altIdentifier/wos/WOS:000486567800033; volume:9; issue:1; firstpage:"-"; lastpage:"-"; numberofpages:10; journal:SCIENTIFIC REPORTS; http://hdl.handle.net/11368/2951297; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85072382750; https://www.nature.com/articles/s41598-019-49412-6

الاتاحة: http://hdl.handle.net/11368/2951297
https://doi.org/10.1038/s41598-019-49412-6
https://www.nature.com/articles/s41598-019-49412-6

المؤلفون: Adebayo Michael, A., Ko, S., Tao, J., Moghe, A., Yang, H., Xu, M., Russell, J., Pradhan-Sundd, T., Liu, S., Singh, S., Poddar, M., Monga, J., Liu, P., Oertel, M., Ranganathan, S., Singhi, A., Rebouissou, S., Zucman-Rossi, J., Ribback, S., Calvisi, D., Qvartskhava, N., Görg, B., Häussinger, D., Chen, X., Monga, S.

المساهمون: Adebayo Michael, A., Ko, S., Tao, J., Moghe, A., Yang, H., Xu, M., Russell, J., Pradhan-Sundd, T., Liu, S., Singh, S., Poddar, M., Monga, J., Liu, P., Oertel, M., Ranganathan, S., Singhi, A., Rebouissou, S., Zucman-Rossi, J., Ribback, S., Calvisi, D., Qvartskhava, N., Görg, B., Häussinger, D., Chen, X., Monga, S.

مصطلحات موضوعية: beta-catenin, glutamine synthetase, hepatocellular cancer, liver tumor, metabolic zonation, mTOR, personalized medicine, precision therapy, tumor metabolism, Wnt

Relation: info:eu-repo/semantics/altIdentifier/wos/WOS:000467054100014; volume:29; issue:5; firstpage:1135; lastpage:1150.e1-e6; numberofpages:23; journal:CELL METABOLISM; http://hdl.handle.net/11388/224824; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85064172128; https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30002-6

الاتاحة: http://hdl.handle.net/11388/224824
https://doi.org/10.1016/j.cmet.2019.01.002
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30002-6

المؤلفون: Thomas Kietzmann

المصدر: International Journal of Molecular Sciences; Volume 20; Issue 9; Pages: 2347

مصطلحات موضوعية: ROS, antioxidants, antioxidative enzymes, matrix, diet, fibrosis, homeostasis, hypoxia, HIF, liver, metabolic zonation, metabolism, morphogen signaling, optimization, pathology, regulatory network, sinusoid, Hepatocytes

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Pathology, Diagnostics, and Therapeutics; https://dx.doi.org/10.3390/ijms20092347

الاتاحة: https://doi.org/10.3390/ijms20092347

المؤلفون: Nikolaus Berndt, Hermann-Georg Holzhütter

المصدر: Frontiers in Physiology, Vol 9 (2018)

مصطلحات موضوعية: metabolism, metabolic zonation, kinetic model, multiscale model, gene expression, Physiology, QP1-981

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphys.2018.01786/full; https://doaj.org/toc/1664-042X

URL الوصول: https://doaj.org/article/75482076d9e94431a3d49efd0c89ab42

المؤلفون: Berndt, Nikolaus, Holzhütter, Hermann-Georg

مصطلحات موضوعية: metabolism, metabolic zonation, kinetic model, multiscale model, gene expression, ddc:610

وصف الملف: application/pdf

Relation: https://refubium.fu-berlin.de/handle/fub188/24207; http://dx.doi.org/10.17169/refubium-1979

الاتاحة: https://refubium.fu-berlin.de/handle/fub188/24207
https://doi.org/10.17169/refubium-1979
https://doi.org/10.3389/fphys.2018.01786

المؤلفون: Reham Hassan, Daniela González, Zaynab Hobloss, Lisa Brackhagen, Maiju Myllys, Adrian Friebel, Abdel-latif Seddek, Rosemarie Marchan, Benedikt Cramer, Hans-Ulrich Humpf, Stefan Hoehme, Gisela H. Degen, Jan G. Hengstler, Ahmed Ghallab

المصدر: Archives of toxicology, 96(12):3349–3361

مصطلحات موضوعية: Health, Toxicology and Mutagenesis, Liver Diseases, Alanine Transaminase, General Medicine, Mycotoxins, Toxicology, detoxification, metabolic zonation, mycotoxins, bioactivation, drug metabolism, Mice, Lipocalin-2, Cytochrome P-450 Enzyme System, Animals, Aspartate Aminotransferases, Chemical and Drug Induced Liver Injury, Carbon Tetrachloride, Biomarkers, Acetaminophen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::535c8130fa41c939044dd67befa2dc5b
https://pubmed.ncbi.nlm.nih.gov/36227364

المصدر: Biochemical Pharmacology. 201

مصطلحات موضوعية: NITROGEN-METABOLISM, DIGITONIN COLLAGENASE PERFUSION, Amino acid transport, SPLANCHNIC BED UTILIZATION, Gluconeogenesis, RAT-LIVER, Amino acid signalling, Liver, SYSTEM-A, GLUTAMINE-SYNTHETASE, HEPATOCELLULAR-CARCINOMA, SKELETAL-MUSCLE, Hepatocyte, MESSENGER-RNA, Metabolic zonation, mTORC1, GENE-EXPRESSION

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od________83::bee9af1d1cfc1beb558d46c864298de1
https://cris.maastrichtuniversity.nl/en/publications/e8114ef6-51c7-43f5-94af-43a0fbe93e76

المؤلفون: Coen C, Paulusma, Wouter H, Lamers, Stefan, Broer, Stan F J, van de Graaf

المصدر: Biochemical Pharmacology. 201

مصطلحات موضوعية: Pharmacology, NITROGEN-METABOLISM, DIGITONIN COLLAGENASE PERFUSION, Amino acid transport, SPLANCHNIC BED UTILIZATION, Gluconeogenesis, RAT-LIVER, Biological Transport, Amino acid signalling, Biochemistry, Liver, SYSTEM-A, GLUTAMINE-SYNTHETASE, HEPATOCELLULAR-CARCINOMA, SKELETAL-MUSCLE, Hepatocyte, Amino Acids, MESSENGER-RNA, Metabolic zonation, mTORC1, Amino Acids, Branched-Chain, Signal Transduction, GENE-EXPRESSION

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed685f43efff859ccc3304134168fef5
https://doi.org/10.1016/j.bcp.2022.115074

المؤلفون: Kietzmann, T. (Thomas)

مصطلحات موضوعية: Antioxidants, Antioxidative enzymes, Diet, Fibrosis, HIF, Hepatocytes, Homeostasis, Hypoxia, Liver, Matrix, Metabolic zonation, Metabolism, Morphogen signaling, Optimization, Pathology, ROS, Regulatory network, Sinusoid

وصف الملف: application/pdf

Relation: info:eu-repo/semantics/altIdentifier/pissn/2213-2317; info:eu-repo/semantics/altIdentifier/eissn/2213-2317

الاتاحة: http://urn.fi/urn:nbn:fi-fe201702271869

المؤلفون: Jana Schleicher, Uta Dahmen, Reinhard Guthke, Stefan Schuster

مصطلحات موضوعية: Bioinformatics, Systems Biology, Biological Mathematics, nonalcoholic fatty liver diseases, liver metabolism, metabolic zonation, steatosis, fatty acid uptake

Relation: https://figshare.com/articles/journal_contribution/Supplementary_Material_from_Zonation_of_hepatic_fat_accumulation_insights_from_mathematical_modelling_of_nutrient_gradients_and_fatty_acid_uptake/5281138

الاتاحة: https://doi.org/10.6084/m9.figshare.5281138.v1
https://figshare.com/articles/journal_contribution/Supplementary_Material_from_Zonation_of_hepatic_fat_accumulation_insights_from_mathematical_modelling_of_nutrient_gradients_and_fatty_acid_uptake/5281138

المؤلفون: Patricia Aspichueta, Silvia Pérez, Begoña Ochoa, Olatz Fresnedo

المصدر: Journal of Lipid Research, Vol 46, Iss 5, Pp 1017-1026 (2005)

مصطلحات موضوعية: Gram-negative bacterial sepsis, liver metabolic zonation, lipid metabolism, apolipoprotein expression, very low density lipoprotein, Biochemistry, QD415-436

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520339857; https://doaj.org/toc/0022-2275

URL الوصول: https://doaj.org/article/df5d6f1c1e874b79b99925411bec84bf