المؤلفون: Lukas Grätz, Katharina Tropmann, Merlin Bresinsky, Christoph Müller, Günther Bernhardt, Steffen Pockes

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-3 (2021)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/e9afb80c8d6b4c9386fc717c1f34bab8

المؤلفون: Merlin Bresinsky

المساهمون: Journal of Medicinal Chemistry

مصطلحات موضوعية: Pharmacology + therapeutics, prescription drugs, Pharmakologie, Therapeutik, ddc:615, Biolumineszenz-Resonanzenergietransfer, BRET, Fluoreszenzligand, orphan GPCR, G protein-coupled receptor (GPCR), GPR3, fluorescence ligand, G-Protein gekoppelter Rezeptor, GPCR

Relation: https://doi.org/10.1021/acs.jmedchem.3c01707

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01707

المؤلفون: Merlin Bresinsky (10954861), Jessica M. Strasser (486124), Bernadette Vallaster (11908633), Peng Liu (120506), William M. McCue (11908636), Jessica Fuller (11908639), Alexander Hubmann (11908642), Gurpreet Singh (1291665), Kathryn M. Nelson (2032519), Matthew E. Cuellar (6424661), Carrie M. Wilmot (1864492), Barry C. Finzel (1484449), Karen H. Ashe (11908645), Michael A. Walters (486126), Steffen Pockes (1831753)

مصطلحات موضوعية: Biochemistry, Molecular Biology, Neuroscience, Pharmacology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, reversibly impairs cognitive, mediated cleavage product, like small molecules, 100 years ago, simple peptidic inhibitors, 35 pentapeptide inhibitors, vitro cleavage assay, recombinant tau mutants, cho (< b, casp2 binding site, selective casp2 probes, vivo studies, treat either, synaptic function, studies resulted, selective caspase, selected pentapeptides, potential approach, pharmacological tools, peptide acvdvad, overarching theory, nanomolar affinity, lead compounds

Relation: https://figshare.com/articles/journal_contribution/Structure-Based_Design_and_Biological_Evaluation_of_Novel_Caspase_2_Inhibitors_Based_on_the_Peptide_AcVDVAD-CHO_and_the_Caspase-2-Mediated_Tau_Cleavage_Sequence_YKPVD314/17884963

الاتاحة: https://doi.org/10.1021/acsptsci.1c00251.s001

المؤلفون: Katharina Tropmann (9183385), Merlin Bresinsky (10954861), Lisa Forster (649706), Denise Mönnich (10954864), Armin Buschauer (113026), Hans-Joachim Wittmann (1831759), Harald Hübner (1425337), Peter Gmeiner (217594), Steffen Pockes (1831753), Andrea Strasser (1714318)

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Neuroscience, Pharmacology, Evolutionary Biology, Immunology, Science Policy, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, dopamine D 2, affinity, D 3 R, residue, novel carbamoylguanidine-type ligands, D 2, subtype-selective histamine H 2 rec., H 2 R functions, H 2 R, Abolishing Dopamine D 2, CNS, Receptor

Relation: https://figshare.com/articles/journal_contribution/Abolishing_Dopamine_D_sub_2long_sub_D_sub_3_sub_Receptor_Affinity_of_Subtype-Selective_Carbamoylguanidine-Type_Histamine_H_sub_2_sub_Receptor_Agonists/14766148

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00692.s001

المؤلفون: Gurpreet Singh, Peng Liu, Katherine R. Yao, Jessica M. Strasser, Chris Hlynialuk, Kailee Leinonen-Wright, Peter J. Teravskis, Jessica M. Choquette, Junaid Ikramuddin, Merlin Bresinsky, Kathryn M. Nelson, Dezhi Liao, Karen H. Ashe, Michael A. Walters, Steffen Pockes

المصدر: ACS Chem Neurosci

مصطلحات موضوعية: Neurons, Physiology, Cognitive Neuroscience, Caspase 2, Mice, Transgenic, tau Proteins, Cell Biology, General Medicine, Synaptic Transmission, Biochemistry, Article, Rats, Disease Models, Animal, Mice, Tauopathies, Frontotemporal Dementia, Animals

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fcc59c4901a1d0ec5e5c27490609ec0
https://doi.org/10.1021/acschemneuro.2c00100

المؤلفون: Merlin Bresinsky, Jessica M. Strasser, Bernadette Vallaster, Peng Liu, William M. McCue, Jessica Fuller, Alexander Hubmann, Gurpreet Singh, Kathryn M. Nelson, Matthew E. Cuellar, Carrie M. Wilmot, Barry C. Finzel, Karen H. Ashe, Michael A. Walters, Steffen Pockes

المصدر: ACS Pharmacol Transl Sci

مصطلحات موضوعية: Pharmacology, Pharmacology (medical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d23dbfa9d69eedac74f0ee60beb7c20
https://doi.org/10.1021/acsptsci.1c00251

المؤلفون: Ulrich Gergs, Carina Höring, Charlotte Fehse, Steffen Pockes, Maren Luise Büxel, Rebecca Schwarz, Uwe Kirchhefer, Margaréta Marušáková, Joachim Neumann, Britt Hofmann, Merlin Bresinsky, Aneta Čináková

المصدر: Journal of Pharmacology and Experimental Therapeutics. 379:223-234

مصطلحات موضوعية: Pharmacology, Ejection fraction, Contraction (grammar), business.industry, Antagonist, medicine.disease, Phospholamban, Histamine H2 receptor, In vivo, Heart failure, medicine, Molecular Medicine, Receptor, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3f2c0355e9482e1c32ea4d2630243ef8
https://doi.org/10.1124/jpet.121.000822

المؤلفون: Merlin Bresinsky, Lisa Forster, Steffen Pockes, Denise Mönnich, Andrea Strasser, Harald Hübner, Peter Gmeiner, Katharina Tropmann, Hans-Joachim Wittmann, Armin Buschauer

المصدر: Journal of Medicinal Chemistry. 64:8684-8709

مصطلحات موضوعية: 0303 health sciences, Chemistry, Central nervous system, Subtype selective, 01 natural sciences, Affinities, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, medicine.anatomical_structure, Histamine H2 receptor, Biochemistry, Docking (molecular), Dopamine receptor D3, Dopamine, Drug Discovery, medicine, Molecular Medicine, Receptor, 030304 developmental biology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::20985c185777957e7367ce5d19c04628
https://doi.org/10.1021/acs.jmedchem.1c00692

المؤلفون: Merlin Bresinsky, Jessica M. Strasser, Alexander Hubmann, Bernadette Vallaster, William M. McCue, Jessica Fuller, Gurpreet Singh, Kathryn M. Nelson, Matthew E. Cuellar, Barry C. Finzel, Karen H. Ashe, Michael A. Walters, Steffen Pockes

المصدر: Arch Pharm (Weinheim)

مصطلحات موضوعية: Alzheimer's disease, caspase‐2, caspase‐2 inhibitors, protein cleavage, tauopathies, Structure-Activity Relationship, 615 Pharmazie, Caspase 3, Drug Discovery, Proteolysis, Caspase 2, Pharmaceutical Science, Caspase Inhibitors, ddc:615, Article

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e68b4fd317071c944f65f1b4f880f97e
https://pubmed.ncbi.nlm.nih.gov/35642311

المؤلفون: Katharina, Tropmann, Merlin, Bresinsky, Lisa, Forster, Denise, Mönnich, Armin, Buschauer, Hans-Joachim, Wittmann, Harald, Hübner, Peter, Gmeiner, Steffen, Pockes, Andrea, Strasser

المصدر: Journal of medicinal chemistry. 64(12)

مصطلحات موضوعية: Binding Sites, Molecular Structure, Receptors, Dopamine D2, Guinea Pigs, Receptors, Dopamine D3, Guanidines, Rats, Histamine Agonists, Molecular Docking Simulation, Mice, Structure-Activity Relationship, Thiazoles, HEK293 Cells, Sf9 Cells, Animals, Humans, Receptors, Histamine H2

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::b3ce86b3c836f16c470ff3e0e1a65840
https://pubmed.ncbi.nlm.nih.gov/34110814

المؤلفون: Katharina Tropmann, Merlin Bresinsky, Lisa Forster, Denise Mönnich, Armin Buschauer, Hans-Joachim Wittmann, Harald Hübner, Peter Gmeiner, Steffen Pockes, Andrea Strasser

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Neuroscience, Pharmacology, Evolutionary Biology, Immunology, Science Policy, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, dopamine D 2, affinity, D 3 R, residue, novel carbamoylguanidine-type ligands, D 2, subtype-selective histamine H 2 rec, H 2 R functions, H 2 R, Abolishing Dopamine D 2, CNS, Receptor, socio, phil

Relation: https://doi.org/10.1021/acs.jmedchem.1c00692.s002

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00692.s002

المؤلفون: Sabrina, Biselli, Merlin, Bresinsky, Katharina, Tropmann, Lisa, Forster, Claudia, Honisch, Armin, Buschauer, Günther, Bernhardt, Steffen, Pockes

المصدر: European journal of medicinal chemistry. 214

مصطلحات موضوعية: Structure-Activity Relationship, HEK293 Cells, Dose-Response Relationship, Drug, Molecular Structure, Dopamine Agonists, Guinea Pigs, Receptors, Dopamine D3, Animals, Humans, Receptors, Histamine H2, Ligands, Guanidines, Cells, Cultured

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::8c7f3075ae184a4df75d07fe4ff8ca6f
https://pubmed.ncbi.nlm.nih.gov/33548637

المؤلفون: Katarzyna, Szczepańska, Steffen, Pockes, Sabina, Podlewska, Carina, Höring, Kamil, Mika, Gniewomir, Latacz, Marek, Bednarski, Agata, Siwek, Tadeusz, Karcz, Martin, Nagl, Merlin, Bresinsky, Denise, Mönnich, Ulla, Seibel, Kamil J, Kuder, Magdalena, Kotańska, Holger, Stark, Sigurd, Elz, Katarzyna, Kieć-Kononowicz

المصدر: European journal of medicinal chemistry. 213

مصطلحات موضوعية: Models, Molecular, Dose-Response Relationship, Drug, Body Weight, Imidazoles, Regulatory Sequences, Nucleic Acid, Ligands, Structure-Activity Relationship, Piperidines, Animals, Humans, Receptors, Histamine H3, Female, Anti-Obesity Agents, Rats, Wistar, Piperazine, Histamine H3 Antagonists, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::714d1f27b2325a285b137f0d7134bbec
https://pubmed.ncbi.nlm.nih.gov/33261900

المؤلفون: Lukas, Grätz, Katharina, Tropmann, Merlin, Bresinsky, Christoph, Müller, Günther, Bernhardt, Steffen, Pockes

المصدر: Scientific Reports

مصطلحات موضوعية: HEK293 Cells, Cell Survival, DNA, Recombinant, Fluorescence Resonance Energy Transfer, Humans, Nanotechnology, Receptors, Histamine H2, Ligands, Author Correction, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::01b3e2af5ae6cbbb88829ab12277e9fb
https://pubmed.ncbi.nlm.nih.gov/34103640

المؤلفون: Agata Siwek, Katarzyna Szczepańska, Magdalena Kotańska, Marek Bednarski, Katarzyna Kieć-Kononowicz, Martin Nagl, Holger Stark, Tadeusz Karcz, Gniewomir Latacz, Steffen Pockes, Ulla Seibel, Merlin Bresinsky, Carina Höring, Kamil Kuder, Sabina Podlewska, Denise Mönnich, Sigurd Elz, Kamil Mika

المصدر: European Journal of Medicinal Chemistry. 213:113041

مصطلحات موضوعية: Pharmacology, 0303 health sciences, Molecular model, Intrinsic activity, 010405 organic chemistry, Stereochemistry, Chemistry, Organic Chemistry, General Medicine, 01 natural sciences, 0104 chemical sciences, 03 medical and health sciences, chemistry.chemical_compound, Piperazine, Ciproxifan, Drug Discovery, medicine, Moiety, Piperidine, Histamine H3 receptor, Selectivity, 030304 developmental biology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fca7f022cdc2d7e2d9a511b84fc0bc9
https://doi.org/10.1016/j.ejmech.2020.113041

المؤلفون: Merlin Bresinsky, Aida Shahraki, Peter Kolb, Steffen Pockes, Hannes Schihada

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Molecular Biology, Neuroscience, Pharmacology, Biotechnology, Immunology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, similar submicromolar affinities, potential drug target, pharmacologically attractive ogpcrs, future drugs acting, distinct mode compared, closely related receptors, 355 ), bound, pharmacological assays hampers, orphan g protein, novel binding assay, time binding studies, based binding studies, fluorescent af64394 analogues, 45 , potent gpr3 ligand, potent ligand, coincubation studies, pharmacological manipulation, orphan class

Relation: https://figshare.com/articles/journal_contribution/Development_of_Fluorescent_AF64394_Analogues_Enables_Real-Time_Binding_Studies_for_the_Orphan_Class_A_GPCR_GPR3/24470843

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01707.s001
https://figshare.com/articles/journal_contribution/Development_of_Fluorescent_AF64394_Analogues_Enables_Real-Time_Binding_Studies_for_the_Orphan_Class_A_GPCR_GPR3/24470843