المؤلفون: Weisheng Zheng, Mengchen Pu, Xiaorong Li, Zhaolan Du, Sutong Jin, Xingshuai Li, Jielong Zhou, Yingsheng Zhang

المصدر: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/f58d81d234f3424aa5c1fb263f083383

المؤلفون: Mengchen Pu, Kaiyang Cheng, Xiaorong Li, Yucui Xin, Lanying Wei, Sutong Jin, Weisheng Zheng, Gongxin Peng, Qihong Tang, Jielong Zhou, Yingsheng Zhang

المصدر: Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 5099-5110 (2023)

مصطلحات موضوعية: Synthetic lethality, GNN, Deep learning, Cell specific target identification, Multi-omics, Biotechnology, TP248.13-248.65

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2001037023003641; https://doaj.org/toc/2001-0370

URL الوصول: https://doaj.org/article/308c4c25a7454031a4c2093276b0154b

المؤلفون: Mengchen Pu, Zhijie Xu, Yao Peng, Yaguang Hou, Dongsheng Liu, Yang Wang, Haiguang Liu, Gaojie Song, Zhi-Jie Liu

المصدر: Protein & Cell, Vol 9, Iss 7, Pp 659-663 (2017)

مصطلحات موضوعية: Cytology, QH573-671, Animal biochemistry, QP501-801

وصف الملف: electronic resource

Relation: http://link.springer.com/article/10.1007/s13238-017-0482-7; https://doaj.org/toc/1674-800X; https://doaj.org/toc/1674-8018

URL الوصول: https://doaj.org/article/b4c6ec03e3654691a39a4066320b17b2

المؤلفون: Liming Zhao, Mengchen Pu, Huting Wang, Xiangyu Ma, Yingsheng J. Zhang

المصدر: Journal of Chemical Information and Modeling. 62:4420-4426

مصطلحات موضوعية: Machine Learning, Drug Design, General Chemical Engineering, Static Electricity, General Chemistry, Library and Information Sciences, Ligands, Computer Science Applications

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf92637990975f49d628f1ffed09461
https://doi.org/10.1021/acs.jcim.2c00616

المؤلفون: Lanying Wei, Yucui Xin, Mengchen Pu, Yingsheng Zhang

المصدر: Life Science Alliance; Feb2024, Vol. 7 Issue 2, p1-14, 14p

المؤلفون: Weisheng Zheng, Mengchen Pu, Xiaorong Li, Sutong Jin, Xingshuai Li, Jielong Zhou, Yingsheng Zhang

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f7be19a3e15826bfb8aa262f34def99a
https://doi.org/10.1101/2022.09.29.510207

المؤلفون: Mengchen Pu, Biao Fu, Yingsheng J. Zhang

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ab8cde1d5f9c3dc92d57e3b1025d05a1
https://doi.org/10.1101/2022.07.25.501404

المؤلفون: Chongyun Cheng, Miaomiao Liu, Xiaoqin Gao, Dong Wu, Mengchen Pu, Jun Ma, Ronald J. Quinn, Zhicheng Xiao, Zhijie Liu

المصدر: ACS omega. 7(16)

مصطلحات موضوعية: General Chemical Engineering, General Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11cdfbd5b8f685eb741de03b869026ae
https://pubmed.ncbi.nlm.nih.gov/35559183

المؤلفون: Mengchen PU, Biao Fu, Yingsheng John Zhang

المصدر: SSRN Electronic Journal.

مصطلحات موضوعية: History, Polymers and Plastics, Business and International Management, Industrial and Manufacturing Engineering

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::cec232ca466de423a9e3d38655c5729b
https://doi.org/10.2139/ssrn.4197391

المؤلفون: H. Eric Xu, Lu Yang, Petr Popov, Raymond C. Stevens, Fei Xu, Mengchen Pu, Yuanzheng He, Yuxiang Chen, Kelly Suino-Powell, Shaowei Dong, Kaleeckal G. Harikumar, Yiran Wu, Parker W. de Waal, Laurence J. Miller, Zachary J. DeBruine, Yu Guo, Karsten Melcher, Vsevolod Katritch, Wenqing Shui, Gye Won Han, Shifan Yang, Saheem A. Zaidi, Suwen Zhao, Bingjie Zhang, Ting-Hai Xu

المصدر: Nature. 560:666-670

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Frizzled, Binding Sites, Multidisciplinary, Chemistry, Protein domain, Dishevelled Proteins, Wnt signaling pathway, Molecular Dynamics Simulation, Crystallography, X-Ray, Ligands, Ligand (biochemistry), Frizzled Receptors, Transmembrane protein, 03 medical and health sciences, Transmembrane domain, 030104 developmental biology, Protein Domains, Biophysics, Humans, Cysteine, Binding site, Wnt Signaling Pathway, G protein-coupled receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ed5dfc01d5e9660808fe7b27e5b98b
https://doi.org/10.1038/s41586-018-0447-x

المؤلفون: Jo-Hao Ho, Spyros P. Nikas, Zhi-Jie Liu, Tian Hua, Yiran Wu, Anisha Korde, Haiguang Liu, Kiran Vemuri, Mengchen Pu, Gye Won Han, Kang Ding, Raymond C. Stevens, Alexandros Makriyannis, Shan Jiang, Xuanxuan Li, Laura M. Bohn, Michael A. Hanson, Suwen Zhao, Robert B. Laprairie, Lu Qu

المصدر: Nature. 547:468-471

مصطلحات موضوعية: 0301 basic medicine, Agonist, Multidisciplinary, Cannabinoid receptor, Stereochemistry, medicine.drug_class, Chemistry, medicine.medical_treatment, Partial agonist, Endocannabinoid system, 03 medical and health sciences, 030104 developmental biology, mental disorders, Synthetic cannabinoids, medicine, Biophysics, lipids (amino acids, peptides, and proteins), Cannabinoid, Binding site, Receptor, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1abe7846e336c006ee8283d9de174651
https://doi.org/10.1038/nature23272

المؤلفون: Eugene S. Vysotski, Pavel V. Natashin, Zhi-Jie Liu, Natalia P. Malikova, Mengchen Pu, Fengfeng Niu, Ludmila Burakova

المصدر: Journal of Photochemistry and Photobiology B: Biology. 154:57-66

مصطلحات موضوعية: Light, Inorganic chemistry, Biophysics, Aequorin, Photoprotein, chemistry.chemical_element, Molecular Dynamics Simulation, Calcium, Crystallography, X-Ray, Serine, chemistry.chemical_compound, Coelenterazine, Animals, Bioluminescence, Magnesium, Radiology, Nuclear Medicine and imaging, Amino Acid Sequence, Protein Precursors, Magnesium ion, Thermostability, Ions, Binding Sites, Radiation, Radiological and Ultrasound Technology, biology, Ctenophora, Protein Structure, Tertiary, Kinetics, Luminescent Proteins, Crystallography, chemistry, Luminescent Measurements, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a8e406e5fc07c0774afc86fb23c2fb
https://doi.org/10.1016/j.jphotobiol.2015.11.012

المؤلفون: Tian, Hua, Kiran, Vemuri, Spyros P, Nikas, Robert B, Laprairie, Yiran, Wu, Lu, Qu, Mengchen, Pu, Anisha, Korde, Shan, Jiang, Jo-Hao, Ho, Gye Won, Han, Kang, Ding, Xuanxuan, Li, Haiguang, Liu, Michael A, Hanson, Suwen, Zhao, Laura M, Bohn, Alexandros, Makriyannis, Raymond C, Stevens, Zhi-Jie, Liu

المصدر: Nature. 547(7664)

مصطلحات موضوعية: Cannabinoid Receptor Agonists, Binding Sites, Protein Conformation, Crystallography, X-Ray, Ligands, Heterotrimeric GTP-Binding Proteins, Article, Molecular Docking Simulation, Receptor, Cannabinoid, CB1, mental disorders, Humans, Droperidol, Dronabinol, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::00ed6b768c0cfb689311fec2809062a8
https://pubmed.ncbi.nlm.nih.gov/28678776

المؤلفون: Jie Yang, Yurong Da, Yanping Zhu, Gong-Hong Wei, Yanqing Liu, Qiang Shao, Jinan Wang, Wei Ding, Li-Wei Hung, Fengfeng Niu, Mengchen Pu, Genhong Cheng, Zhi-Jie Liu, Songying Ouyang, Yongfang Zhao, Zhi Yao, Jing Li, Jose Pindado Rodriguez

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 113(46)

مصطلحات موضوعية: 0301 basic medicine, Conformational change, HMG-box, Protein Conformation, Biology, Molecular Dynamics Simulation, 03 medical and health sciences, chemistry.chemical_compound, parasitic diseases, Transcriptional regulation, Escherichia coli, Genetics, Multidisciplinary, Innate immune system, Binding Sites, integumentary system, DNA, respiratory system, Biological Sciences, In vitro, Cell biology, DNA binding site, 030104 developmental biology, chemistry, Mutation, Mutagenesis, Site-Directed, Phosphorylation, Protein Multimerization, Crystallization, STAT6 Transcription Factor, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ead8ebefa75aa6e336f23c20b9cfe3c
https://pubmed.ncbi.nlm.nih.gov/27803324

المؤلفون: Juan P. Garrahan, Mengchen Pu, Jonathan D. Hirst

المصدر: Chemical Physics Letters. 515:283-289

مصطلحات موضوعية: Molecular dynamics, Solvent models, Chemistry, General Physics and Astronomy, Statistical physics, Physical and Theoretical Chemistry, Molecular mechanics, Force field (chemistry), Computational physics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b955aebc86db81957d326c36f1b7c5b5
https://doi.org/10.1016/j.cplett.2011.09.026

المؤلفون: Mengchen Pu, Cornelius Gati, Vadim Cherezov, Benjamin Stauch, Gye Won Han, Raymond C. Stevens, Andrii Ishchenko, Wei Liu, Alexander Batyuk, Andrew Aquila, Yun Zhao, Mark S. Hunter, Sébastien Boutet, Mengning Liang, Uwe Weierstall, Petr Popov, Garrett Nelson, Vsevolod Katritch, Lorenzo Galli, Chufeng Li, Ming-Yue Lee, Zhi-Jie Liu, Daniel James, John C. H. Spence, Thomas A. White, Anton Barty, Petra Fromme

المصدر: Science Advances
Science advances 2(9), e1600292 (2016). doi:10.1126/sciadv.1600292

مصطلحات موضوعية: 0301 basic medicine, Diffraction, serial femtosecond crystallography, Materials science, Phase (waves), Nanotechnology, Phase problem, law.invention, 03 medical and health sciences, 0302 clinical medicine, GPCR, law, Structural Biology, de novo structure, Physics::Atomic and Molecular Clusters, Research Articles, Quantitative Biology::Biomolecules, Multidisciplinary, Crystallography, Quantitative Biology::Molecular Networks, Resolution (electron density), Free-electron laser, SciAdv r-articles, SAD, x-ray free electron laser, Laser, Quantitative Biology::Quantitative Methods, 030104 developmental biology, Chemical physics, sulfur, Femtosecond, native phasing, Physics::Accelerator Physics, ddc:500, Structure factor, lipidic cubic phase, protein, 030217 neurology & neurosurgery, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98cc19de46bb640bb066b1d39e213e0f
https://pubmed.ncbi.nlm.nih.gov/27679816

المؤلفون: Suwen Zhao, Raymond C. Stevens, Walden E. Bjørn-Yoshimoto, Lu Qu, Xi Ping Huang, Jianjun Cheng, Vsevolod Katritch, Kang Ding, Michael A. Hanson, Zhi-Jie Liu, Anders A. Jensen, Petr Popov, Yao Peng, Mengchen Pu, Ling Shen, Daniel Wacker, Louise F. Nikolajsen, John D. McCorvy, Shuguang Yuan, Gye Won Han, Tao Che, Katherine Lansu, David E. Gloriam, Bryan L. Roth, Kasper Harpsøe, Yiran Wu

المصدر: Cell. 172:719-730.e14

مصطلحات موضوعية: 0301 basic medicine, Agonist, Drug discovery, medicine.drug_class, Ritanserin, Computational biology, Biology, General Biochemistry, Genetics and Molecular Biology, 5-HT2C receptor, 03 medical and health sciences, 030104 developmental biology, medicine, Functional selectivity, Inverse agonist, Receptor, G protein-coupled receptor, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::418cf9a8ea70063f82dd0b1e4db975b9
https://doi.org/10.1016/j.cell.2018.01.001

المؤلفون: Robert B. Laprairie, Lu Qu, Mengchen Pu, Qiang Zhao, Nikolai Zvonok, Laura M. Bohn, Irina Kufareva, Suwen Zhao, Alexandros Makriyannis, Raymond C. Stevens, Han Zhou, Jo-Hao Ho, Michael A. Hanson, Kiran Vemuri, Zhi-Jie Liu, Tian Hua, Shanshan Li, Edward L. Stahl, Anisha Korde, Gye Won Han, Wenqing Shui, Yiran Wu, Beili Wu

المصدر: Cell. 167:750-762.e14

مصطلحات موضوعية: Protein Conformation, alpha-Helical, 0301 basic medicine, Cannabinoid receptor, Receptors, Drug, Morpholines, Biology, Pharmacology, Crystallography, X-Ray, Ligands, Article, General Biochemistry, Genetics and Molecular Biology, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Receptor, Cannabinoid, CB1, Rimonabant, mental disorders, Synthetic cannabinoids, medicine, Cannabinoid receptor type 2, Humans, Inverse agonist, Dronabinol, Receptors, Cannabinoid, Cannabinoid Receptor Antagonists, Cannabis, G protein-coupled receptor, Binding Sites, Molecular Structure, Cannabinoids, musculoskeletal, neural, and ocular physiology, Antagonist, food and beverages, Endocannabinoid system, 030104 developmental biology, nervous system, Drug Design, Pyrazoles, lipids (amino acids, peptides, and proteins), 030217 neurology & neurosurgery, Endocannabinoids, Protein Binding, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e44e73f0dd1c47961cb400767ceb6ef9
https://doi.org/10.1016/j.cell.2016.10.004

المؤلفون: Fengfeng Niu¹, Mengchen Pu¹, Yanping Zhu¹, Wei Ding¹, Yanqing Liu¹, Yongfang Zhao¹, Jing Li^1,2, Songying Ouyang^1,3, Zhi-Jie Liu^1,4,5,6, Rodriguez, Jose Pindado³, Genhong Cheng³, Jinan Wang⁷, Qiang Shao⁷, Li-Wei Hung⁷, Yurong Da⁴, Zhi Yao⁴, Jie Yang⁴, Gong-Hong Wei⁷

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 11/15/2016, Vol. 113 Issue 46, p13015-13020. 6p.

مصطلحات موضوعية: *DNA, *STAT proteins, *CRYSTAL structure, *X-ray scattering, *MOLECULAR dynamics