المؤلفون: Holovach, Serhii, Poroshyn, Illia, Melnykov, Kostiantyn P., Liashuk, Oleksandr S., Pariiska, Olena O., Kolotilov, Sergey V., Rozhenko, Alexander B., Volochnyuk, Dmytro M., Grygorenko, Oleksandr O.

المساهمون: Enamine, Ministry of Education and Science of Ukraine

المصدر: ACS Organic & Inorganic Au ; volume 4, issue 4, page 424-431 ; ISSN 2694-247X 2694-247X

الاتاحة: http://dx.doi.org/10.1021/acsorginorgau.4c00028
https://pubs.acs.org/doi/pdf/10.1021/acsorginorgau.4c00028

المؤلفون: Melnykov, Kostiantyn P., Liashuk, Oleksandr S., Smyrnov, Oleh, Lesyk, Dmytro, Holota, Yuliia, Borysko, Petro, Yakubovskyi, Viktor, Grygorenko, Oleksandr O.

المساهمون: Enamine Ltd

المصدر: Journal of Fluorine Chemistry ; volume 281, page 110384 ; ISSN 0022-1139

الاتاحة: https://doi.org/10.1016/j.jfluchem.2024.110384
https://api.elsevier.com/content/article/PII:S0022113924001441?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0022113924001441?httpAccept=text/plain

المؤلفون: Liashuk, Oleksandr S., Fedinchyk, Anastasiya, Melnykov, Kostiantyn P., Herasymchuk, Maksym, Alieksieieva, Diana, Lesyk, Dmytro, Bas, Yuliia P., Keda, Tetiana Ye., Yatsymyrskiy, Andriy V., Holota, Yuliia, Borysko, Petro, Yarmolchuk, Volodymyr S., Grygorenko, Oleksandr O.

المصدر: Chemistry - A European Journal; Dec2024, Vol. 30 Issue 72, p1-9, 9p

مصطلحات موضوعية: DRUG discovery, ORGANIC chemistry, CHEMICAL stability, PHARMACEUTICAL chemistry, BIOISOSTERES

المؤلفون: Melnykov, Kostiantyn P.^1,2 (AUTHOR), Liashuk, Oleksandr S.^1,2 (AUTHOR), Holovach, Serhii^1,3 (AUTHOR), Shatnia, Valeriia^1,4 (AUTHOR), Horbenko, Artur^1,5 (AUTHOR), Lesyk, Dmytro^2,6 (AUTHOR), Melnyk, Varvara⁶ (AUTHOR), Skrypnik, Daniil⁶ (AUTHOR), Beshtynarska, Anna⁶ (AUTHOR), Borysko, Petro⁶ (AUTHOR), Viniichuk, Oleksandr^1,2 (AUTHOR), Grygorenko, Oleksandr O.^1,2 (AUTHOR) gregor@univ.kiev.ua

المصدر: Chemistry - A European Journal. Dec2024, p1. 8p. 7 Illustrations.

مصطلحات موضوعية: *DRUG discovery, *CARBOXYLIC acids, *KINASE inhibitors, *BIOISOSTERES, *MOIETIES (Chemistry)

المؤلفون: Holovach, Serhii M., Melnykov, Kostiantyn P., Poluektova, Maryna S., Rozhenko, Oleksandr B., Grygorenko, Oleksandr O.

المصدر: Journal of Organic and Pharmaceutical Chemistry; Vol. 21 No. 3 (2023); 11-16 ; Журнал органической и фармацевтической химии; Том 21 № 3 (2023); 11-16 ; Журнал органічної та фармацевтичної хімії; Том 21 № 3 (2023); 11-16 ; 2518-1548 ; 2308-8303

مصطلحات موضوعية: cycloalkanes, fluorine, Levin’s anomeric amide, “Nitrogen deletion”, reductive amination, циклоалкани, Флуор, аномерний амід Левіна, «видалення Нітрогену», відновне амінування

وصف الملف: application/pdf

Relation: https://ophcj.nuph.edu.ua/article/view/278321/280939; https://ophcj.nuph.edu.ua/article/view/278321/280940; https://ophcj.nuph.edu.ua/article/view/278321

الاتاحة: https://ophcj.nuph.edu.ua/article/view/278321
https://doi.org/10.24959/ophcj.23.278321

المؤلفون: Moroz, Bohdan, Melnykov, Kostiantyn P., Holovach, Serhii, Filatov, Andrey A., Raievskyi, Oleksii, Platonov, Maksym, Liashuk, Oleksandr, Volochnyuk, Dmytro M., Grygorenko, Oleksandr O.

المساهمون: Ministry of Education and Science of Ukraine, Enamine

المصدر: Journal of Fluorine Chemistry ; volume 272, page 110215 ; ISSN 0022-1139

الاتاحة: http://dx.doi.org/10.1016/j.jfluchem.2023.110215
https://api.elsevier.com/content/article/PII:S0022113923001306?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0022113923001306?httpAccept=text/plain

المؤلفون: Bondarenko, Semen S., Fedorchenko, Anatolii M., Druzhenko, Tetiana V., Melnykov, Kostiantyn P., Volovenko, Yulian M., Volochnyuk, Dmytro M., Ryabukhin, Serhiy V.

المصدر: Synthesis; Nov2024, Vol. 56 Issue 22, p3431-3442, 12p

مصطلحات موضوعية: NUCLEOPHILIC substitution reactions, SERENDIPITY, QUINOLINE, ACIDS

المؤلفون: Grygorenko, Oleksandr O, Melnykov, Kostiantyn P

المصدر: Future Medicinal Chemistry; 2024, Vol. 16 Issue 14, p1375-1378, 4p

المؤلفون: Smyrnov, Oleh K., Melnykov, Kostiantyn P., Pashenko, Olexandr Ye., Volochnyuk, Dmytro M., Ryabukhin, Serhiy V.

المصدر: Organic Letters; 6/7/2024, Vol. 26 Issue 22, p4808-4812, 5p

المؤلفون: Semeno, Volodymyr V., Vasylchenko, Vadym O., Fesun, Ihor M., Ruzhylo, Liudmyla Yu., Kipriianov, Mykhailo O., Melnykov, Kostiantyn P., Skreminskyi, Artem, Iminov, Rustam, Mykhailiuk, Pavel, Vashchenko, Bohdan V., Grygorenko, Oleksandr O.

المساهمون: Enamine, Ministry of Education and Science of Ukraine, HORIZON EUROPE European Research Council

المصدر: Chemistry – A European Journal ; volume 30, issue 12 ; ISSN 0947-6539 1521-3765

الاتاحة: http://dx.doi.org/10.1002/chem.202303859

المؤلفون: Bondarenko, Semen, Fedorchenko, Anatolii, Druzhenko, Tetiana, Melnykov, Kostiantyn P., Volovenko, Yulian M., Volochnyuk, Dmitriy M, Ryabukhin, Serhiy V.

المساهمون: Ministry of Education and Science of Ukraine

المصدر: Synthesis ; ISSN 0039-7881 1437-210X

الاتاحة: http://dx.doi.org/10.1055/a-2382-4428
http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-2382-4428.pdf

المؤلفون: Loskutov, Oleg A., Melnykov, Kostiantyn P., Ryabukhin, Serhiy V., Rusanov, Eduard B., Chaikovsky, Illya A., Khavryuchenko, Oleksiy V., Dziuba, Dmytro O., Volochnyuk, Dmytro M.

المصدر: Chemistry of Heterocyclic Compounds ; volume 60, issue 1-2, page 83-91 ; ISSN 0009-3122 1573-8353

الاتاحة: http://dx.doi.org/10.1007/s10593-024-03297-0
https://link.springer.com/content/pdf/10.1007/s10593-024-03297-0.pdf
https://link.springer.com/article/10.1007/s10593-024-03297-0/fulltext.html

المؤلفون: Kihakh, Serhii^1,2 (AUTHOR), Melnykov, Kostiantyn P.^1,2 (AUTHOR), Bilenko, Vitalii^1,2 (AUTHOR), Trofymchuk, Serhii¹ (AUTHOR), Liashuk, Oleksandr S.^1,2 (AUTHOR), Grygorenko, Oleksandr O.^1,2 (AUTHOR) gregor@univ.kiev.ua

المصدر: European Journal of Organic Chemistry. 1/8/2024, Vol. 27 Issue 2, p1-16. 16p.

مصطلحات موضوعية: *DRUG discovery, *PIPERIDINE, *ALKANES, *TRANSFORMATION groups, *BICYCLIC compounds, *DIAMINES

المؤلفون: Smyrnov, Oleh^1,2 (AUTHOR), Melnykov, Kostiantyn P.^1,2 (AUTHOR), Semeno, Volodymyr^1,2 (AUTHOR), Liashuk, Oleksandr S.^1,2 (AUTHOR), Grygorenko, Oleksandr O.^1,2 (AUTHOR) gregor@univ.kiev.ua

المصدر: European Journal of Organic Chemistry. 1/2/2024, Vol. 27 Issue 1, p1-6. 6p.

مصطلحات موضوعية: *PHARMACEUTICAL chemistry, *DRUG discovery, *AMINES, *DOSAGE forms of drugs, *CHEMICAL synthesis, *RING formation (Chemistry)

المؤلفون: Smyrnov, Oleh K.^1,2 (AUTHOR), Melnykov, Kostiantyn P.^1,2 (AUTHOR), Rusanov, Eduard B.³ (AUTHOR), Suikov, Sergey Yu.³ (AUTHOR), Pashenko, Olexandr E.^1,2,3 (AUTHOR), Fokin, Andrey A.^4,5 (AUTHOR), Volochnyuk, Dmytro M.^1,2,3 (AUTHOR) d.volochnyuk@enamine.net, Ryabukhin, Serhiy V.^1,2,3 (AUTHOR) s.ryabukhin@enamine.net

المصدر: Chemistry - A European Journal. Dec2023, Vol. 29 Issue 70, p1-11. 11p.

مصطلحات موضوعية: *DIMETHYL sulfate, *ETHANES, *RING formation (Chemistry), *STEREOCHEMISTRY, *ACID derivatives, *RADICAL anions

المؤلفون: Melnykov, Kostiantyn P., Artemenko, Artem N., Ivanenko, Bohdan O., Sokolenko, Yevhenii M., Nosik, Pavel S., Ostapchuk, Eugeniy N., Grygorenko, Oleksandr O., Volochnyuk, Dmitriy M., Ryabukhin, Sergey V.

المصدر: ACS Omega ; volume 4, issue 4, page 7498-7515 ; ISSN 2470-1343 2470-1343

الاتاحة: http://dx.doi.org/10.1021/acsomega.9b00896
http://pubs.acs.org/doi/pdf/10.1021/acsomega.9b00896
https://pubs.acs.org/doi/pdf/10.1021/acsomega.9b00896

المؤلفون: Boby, Melissa L, Fearon, Daren, Ferla, Matteo, Filep, Mihajlo, Koekemoer, Lizbé, Robinson, Matthew C, Chodera, John D, Lee, Alpha A, London, Nir, von Delft, Annette, von Delft, Frank, Achdout, Hagit, Aimon, Anthony, Alonzi, Dominic S, Arbon, Robert, Aschenbrenner, Jasmin C, Balcomb, Blake H, Bar-David, Elad, Barr, Haim, Ben-Shmuel, Amir, Bennett, James, Bilenko, Vitaliy A, Borden, Bruce, Boulet, Pascale, Bowman, Gregory R, Brewitz, Lennart, Brun, Juliane, Bvnbs, Sarma, Calmiano, Mark, Carbery, Anna, Carney, Daniel W, Cattermole, Emma, Chang, Edcon, Chernyshenko, Eugene, Clyde, Austin, Coffland, Joseph E, Cohen, Galit, Cole, Jason C, Contini, Alessandro, Cox, Lisa, Croll, Tristan Ian, Cvitkovic, Milan, De Jonghe, Steven, Dias, Alex, Donckers, Kim, Dotson, David L, Douangamath, Alice, Duberstein, Shirly, Dudgeon, Tim, Dunnett, Louise E, Eastman, Peter, Erez, Noam, Eyermann, Charles J, Fairhead, Michael, Fate, Gwen, Fedorov, Oleg, Fernandes, Rafaela S, Ferrins, Lori, Foster, Richard, Foster, Holly, Fraisse, Laurent, Gabizon, Ronen, García-Sastre, Adolfo, Gawriljuk, Victor O, Gehrtz, Paul, Gileadi, Carina, Giroud, Charline, Glass, William G, Glen, Robert C, Glinert, Itai, Godoy, Andre S, Gorichko, Marian, Gorrie-Stone, Tyler, Griffen, Ed J, Haneef, Amna, Hassell Hart, Storm, Heer, Jag, Henry, Michael, Hill, Michelle, Horrell, Sam, Huang, Qiu Yu Judy, Huliak, Victor D, Hurley, Matthew F D, Israely, Tomer, Jajack, Andrew, Jansen, Jitske, Jnoff, Eric, Jochmans, Dirk, John, Tobias, Kaminow, Benjamin, Kang, Lulu, Kantsadi, Anastassia L, Kenny, Peter W, Kiappes, J L, Kinakh, Serhii O, Kovar, Boris, Krojer, Tobias, La, Van Ngoc Thuy, Laghnimi-Hahn, Sophie, Lefker, Bruce A, Levy, Haim, Lithgo, Ryan M, Logvinenko, Ivan G, Lukacik, Petra, Macdonald, Hannah Bruce, MacLean, Elizabeth M, Makower, Laetitia L, Malla, Tika R, Marples, Peter G, Matviiuk, Tatiana, McCorkindale, Willam, McGovern, Briana L, Melamed, Sharon, Melnykov, Kostiantyn P, Michurin, Oleg, Miesen, Pascal, Mikolajek, Halina, Milne, Bruce F, Minh, David, Morris, Aaron, Morris, Garrett M, Morwitzer, Melody Jane, Moustakas, Demetri, Mowbray, Charles E, Nakamura, Aline M, Neto, Jose Brandao, Neyts, Johan, Nguyen, Luong, Noske, Gabriela D, Oleinikovas, Vladas, Oliva, Glaucius, Overheul, Gijs J, Owen, C David, Pai, Ruby, Pan, Jin, Paran, Nir, Payne, Alexander Matthew, Perry, Benjamin, Pingle, Maneesh, Pinjari, Jakir, Politi, Boaz, Powell, Ailsa, Pšenák, Vladimír, Pulido, Iván, Puni, Reut, Rangel, Victor L, Reddi, Rambabu N, Rees, Paul, Reid, St Patrick, Reid, Lauren, Resnick, Efrat, Ripka, Emily Grace, Robinson, Ralph P, Rodriguez-Guerra, Jaime, Rosales, Romel, Rufa, Dominic A, Saar, Kadi, Saikatendu, Kumar Singh, Salah, Eidarus, Schaller, David, Scheen, Jenke, Schiffer, Celia A, Schofield, Christopher J, Shafeev, Mikhail, Shaikh, Aarif, Shaqra, Ala M, Shi, Jiye, Shurrush, Khriesto, Singh, Sukrit, Sittner, Assa, Sjö, Peter, Skyner, Rachael, Smalley, Adam, Smeets, Bart, Smilova, Mihaela D, Solmesky, Leonardo J, Spencer, John, Strain-Damerell, Claire, Swamy, Vishwanath, Tamir, Hadas, Taylor, Jenny C, Tennant, Rachael E, Thompson, Warren, Thompson, Andrew, Tomásio, Susana, Tomlinson, Charles W E, Tsurupa, Igor S, Tumber, Anthony, Vakonakis, Ioannis, van Rij, Ronald P, Vangeel, Laura, Varghese, Finny S, Vaschetto, Mariana, Vitner, Einat B, Voelz, Vincent, Volkamer, Andrea, Walsh, Martin A, Ward, Walter, Weatherall, Charlie, Weiss, Shay, White, Kris M, Wild, Conor Francis, Witt, Karolina D, Wittmann, Matthew, Wright, Nathan, Yahalom-Ronen, Yfat, Yilmaz, Nese Kurt, Zaidmann, Daniel, Zhang, Ivy, Zidane, Hadeer, Zitzmann, Nicole, Zvornicanin, Sarah N

المساهمون: Biochemistry and Molecular Biotechnology, Morningside Graduate School of Biomedical Sciences, Schiffer Lab, Qiu Yu Judy Huang

المصدر: Science (New York, N.Y.) ; 382 ; 6671 ; eabo7201 ; United States

Relation: Science; https://doi.org/10.1126/science.abo7201; Boby ML, Fearon D, Ferla M, Filep M, Koekemoer L, Robinson MC; COVID Moonshot Consortium‡; Chodera JD, Lee AA, London N, von Delft A, von Delft F, Achdout H, Aimon A, Alonzi DS, Arbon R, Aschenbrenner JC, Balcomb BH, Bar-David E, Barr H, Ben-Shmuel A, Bennett J, Bilenko VA, Borden B, Boulet P, Bowman GR, Brewitz L, Brun J, Bvnbs S, Calmiano M, Carbery A, Carney DW, Cattermole E, Chang E, Chernyshenko E, Clyde A, Coffland JE, Cohen G, Cole JC, Contini A, Cox L, Croll TI, Cvitkovic M, De Jonghe S, Dias A, Donckers K, Dotson DL, Douangamath A, Duberstein S, Dudgeon T, Dunnett LE, Eastman P, Erez N, Eyermann CJ, Fairhead M, Fate G, Fedorov O, Fernandes RS, Ferrins L, Foster R, Foster H, Fraisse L, Gabizon R, García-Sastre A, Gawriljuk VO, Gehrtz P, Gileadi C, Giroud C, Glass WG, Glen RC, Glinert I, Godoy AS, Gorichko M, Gorrie-Stone T, Griffen EJ, Haneef A, Hassell Hart S, Heer J, Henry M, Hill M, Horrell S, Huang QYJ, Huliak VD, Hurley MFD, Israely T, Jajack A, Jansen J, Jnoff E, Jochmans D, John T, Kaminow B, Kang L, Kantsadi AL, Kenny PW, Kiappes JL, Kinakh SO, Kovar B, Krojer T, La VNT, Laghnimi-Hahn S, Lefker BA, Levy H, Lithgo RM, Logvinenko IG, Lukacik P, Macdonald HB, MacLean EM, Makower LL, Malla TR, Marples PG, Matviiuk T, McCorkindale W, McGovern BL, Melamed S, Melnykov KP, Michurin O, Miesen P, Mikolajek H, Milne BF, Minh D, Morris A, Morris GM, Morwitzer MJ, Moustakas D, Mowbray CE, Nakamura AM, Neto JB, Neyts J, Nguyen L, Noske GD, Oleinikovas V, Oliva G, Overheul GJ, Owen CD, Pai R, Pan J, Paran N, Payne AM, Perry B, Pingle M, Pinjari J, Politi B, Powell A, Pšenák V, Pulido I, Puni R, Rangel VL, Reddi RN, Rees P, Reid SP, Reid L, Resnick E, Ripka EG, Robinson RP, Rodriguez-Guerra J, Rosales R, Rufa DA, Saar K, Saikatendu KS, Salah E, Schaller D, Scheen J, Schiffer CA, Schofield CJ, Shafeev M, Shaikh A, Shaqra AM, Shi J, Shurrush K, Singh S, Sittner A, Sjö P, Skyner R, Smalley A, Smeets B, Smilova MD, Solmesky LJ, Spencer J, Strain-Damerell C, Swamy V, Tamir H, Taylor JC, Tennant RE, Thompson W, Thompson A, Tomásio S, Tomlinson CWE, Tsurupa IS, Tumber A, Vakonakis I, van Rij RP, Vangeel L, Varghese FS, Vaschetto M, Vitner EB, Voelz V, Volkamer A, Walsh MA, Ward W, Weatherall C, Weiss S, White KM, Wild CF, Witt KD, Wittmann M, Wright N, Yahalom-Ronen Y, Yilmaz NK, Zaidmann D, Zhang I, Zidane H, Zitzmann N, Zvornicanin SN. Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors. Science. 2023 Nov 10;382(6671):eabo7201. doi:10.1126/science.abo7201. Epub 2023 Nov 10. PMID: 37943932.; http://hdl.handle.net/20.500.14038/52849; Science (New York, N.Y.)

الاتاحة: https://doi.org/10.1126/science.abo7201
https://hdl.handle.net/20.500.14038/52849

المؤلفون: Melnykov, Kostiantyn P., Nazar, Kostiantyn, Smyrnov, Oleh, Skreminskyi, Artem, Pavlenko, Serhii, Klymenko‐Ulianov, Oleksii, Shishkina, Svitlana, Volochnyuk, Dmitriy M., Grygorenko, Oleksandr O.

المساهمون: Enamine, Ministry of Education and Science of Ukraine

المصدر: Chemistry – A European Journal ; volume 29, issue 47 ; ISSN 0947-6539 1521-3765

الاتاحة: http://dx.doi.org/10.1002/chem.202301383

المؤلفون: Kihakh, Serhii, Melnykov, Kostiantyn P., Bilenko, Vitalii, Trofymchuk, Serhii, Liashuk, Oleksandr S., Grygorenko, Oleksandr O.

المصدر: European Journal of Organic Chemistry ; volume 27, issue 2 ; ISSN 1434-193X 1099-0690

الاتاحة: http://dx.doi.org/10.1002/ejoc.202301228

المؤلفون: Smyrnov, Oleh K., Melnykov, Kostiantyn P., Rusanov, Eduard B., Suikov, Sergey Yu., Pashenko, Olexandr E., Fokin, Andrey A., Volochnyuk, Dmytro M., Ryabukhin, Serhiy V.

المصدر: Chemistry – A European Journal ; volume 29, issue 70 ; ISSN 0947-6539 1521-3765

الاتاحة: http://dx.doi.org/10.1002/chem.202303728