المؤلفون: Xu, Shuai¹ (AUTHOR) xsh4722@163.com, Jiang, Jialiu¹ (AUTHOR) jiangjialiu@126.com, Chang, Leilei¹ (AUTHOR) changlei198699@163.com, Zhang, Biao² (AUTHOR) biao.zhang@live.cn, Zhu, Xiaolei¹ (AUTHOR) zhuquelee@126.com, Niu, Fengnan² (AUTHOR) alison2009@126.com

المصدر: Orphanet Journal of Rare Diseases. 12/24/2024, Vol. 19 Issue 1, p1-15. 15p.

مصطلحات موضوعية: *MELAS syndrome, *PROTON magnetic resonance spectroscopy, *MEDICAL sciences, *CYTOCHROME oxidase, *NUCLEAR magnetic resonance spectroscopy

المؤلفون: Kawano, Yuri^1,2,3 (AUTHOR), Taniguchi, Akira^1,4 (AUTHOR), Narita, Yugo^1,4 (AUTHOR), Kagawa, Ken³ (AUTHOR), Harada, Tetsuro² (AUTHOR), Shindo, Akihiro¹ (AUTHOR) a-shindo@med.mie-u.ac.jp

المصدر: Case Reports in Neurology. Sep2024, Vol. 16 Issue 1, p288-293. 6p. 2 Illustrations.

مصطلحات موضوعية: *MELAS syndrome, *LACTIC acidosis, *MITOCHONDRIAL pathology, *COMPUTED tomography, *BLOOD flow, *ACETYLCHOLINESTERASE

المصدر: Phase 2b Randomized, Double-blind, Placebo-controlled Crossover Study Evaluating the Efficacy and Safety of Zagociguat in Participants with MELAS (PRIZM)

المؤلفون: National Center for Advancing Translational Sciences (NCATS), Children's National Research Institute

المصدر: Investigational Study of Glycerol Tributyrate in MELAS and LHON-Plus

المؤلفون: Nasello, Martina¹ (AUTHOR), Zancan, Valeria¹ (AUTHOR), Reniè, Roberta¹ (AUTHOR), Romano, Silvia¹ (AUTHOR), Buscarinu, Maria Chiara¹ (AUTHOR), Ristori, Giovanni^1,2 (AUTHOR), Salvetti, Marco^1,3 (AUTHOR) marco.salvetti@uniroma1.it, Bellucci, Gianmarco¹ (AUTHOR)

المصدر: Neurological Sciences. Aug2024, Vol. 45 Issue 8, p4067-4070. 4p.

مصطلحات موضوعية: *MELAS syndrome, *SPINOCEREBELLAR ataxia, *MYELIN, *NEUROLOGICAL disorders, *B cell receptors, *POSTVACCINAL encephalitis

المؤلفون: Sant'Anna‐Silva, Ana C. B.¹ (AUTHOR), Botton, Thomas¹ (AUTHOR), Rossi, Andrea² (AUTHOR), Dobner, Jochen² (AUTHOR), Bzioueche, Hanene¹ (AUTHOR), Thach, Nguyen² (AUTHOR), Blot, Lauriane¹ (AUTHOR), Pagnotta, Sophie³ (AUTHOR), Kleszczynski, Konrad⁴ (AUTHOR), Steinbrink, Kerstin⁴ (AUTHOR), Mazure, Nathalie M.¹ (AUTHOR), Rocchi, Stéphane¹ (AUTHOR), Krutmann, Jean^2,5 (AUTHOR), Passeron, Thierry^1,6 (AUTHOR) thierry.passeron@unice.fr, Tulic, Meri K.¹ (AUTHOR) meri.tulic@unice.fr

المصدر: Clinical & Translational Medicine. Aug2024, Vol. 14 Issue 8, p1-8. 8p.

مصطلحات موضوعية: *MELAS syndrome, *NUCLEAR factor E2 related factor, *MONONUCLEAR leukocytes, *INTERFERON regulatory factors, *MEDICAL ethics, *TYPE I interferons

المؤلفون: WEN Limin¹, LI Ran¹, HAO Yanlei¹, KONG Qingxia¹, XIA Min¹ xiaminyy1982@163.com

المصدر: Journal of Practical Medicine / Shiyong Yixue Zazhi. 7/10/2024, Vol. 40 Issue 13, p1885-1888. 4p.

مصطلحات موضوعية: *MELAS syndrome, *NUCLEAR DNA, *MITOCHONDRIAL DNA, *MITOCHONDRIA, *HETEROGENEITY

المؤلفون: Indelicato, Elisabetta^1,2,3 (AUTHOR), Schlieben, Lea D.^1,2 (AUTHOR), Stenton, Sarah L.^4,5 (AUTHOR), Boesch, Sylvia³ (AUTHOR), Skorvanek, Matej^6,7 (AUTHOR), Necpal, Jan^8,9 (AUTHOR), Jech, Robert¹⁰ (AUTHOR), Winkelmann, Juliane^1,2,11 (AUTHOR), Prokisch, Holger^1,2 (AUTHOR), Zech, Michael^1,2,12 (AUTHOR) michael.zech@mri.tum.de

المصدر: Journal of Neurology. Jul2024, Vol. 271 Issue 7, p4685-4692. 8p.

مصطلحات موضوعية: *MELAS syndrome, *MOVEMENT disorders, *DYSTONIA, *MITOCHONDRIA, *FOCAL dystonia, *MITOCHONDRIAL DNA, *FRIEDREICH'S ataxia

المؤلفون: Pui-Hung Ho¹ hopuihungmed@gmail.com, Li, Richard¹, Chi-Yeung Chu², Yip-Kan Tang, Kendrick², Chun-Kit Li², Man-Kwan Yip³, Wing-Tat Poon³, Wing-Ho Cheng, Stephen¹, Auyeung, M.¹, Cheung, C. M.¹

المصدر: Neurology Asia. 2024, Vol. 29 Issue 2, p465-470. 6p.

مصطلحات موضوعية: *MELAS syndrome, *LACTIC acidosis, *MAGNETIC resonance imaging, *BRAIN diseases, *MITOCHONDRIA, *MITOCHONDRIAL pathology

المصدر: A Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Oral TTI-0102 for Treatment of Patients With Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-like Episodes (MELAS)

المؤلفون: Du, Jixiang^1,2,3 (AUTHOR), Liu, Fuchen² (AUTHOR), Liu, Xihan⁴ (AUTHOR), Zhao, Dandan² (AUTHOR), Wang, Dongdong² (AUTHOR), Sun, Hongsheng^1,3 (AUTHOR), Yan, Chuanzhu^2,5,6 (AUTHOR) czyan@sdu.edu.cn, Zhao, Yuying² (AUTHOR) zyy72@126.com

المصدر: Journal of Translational Medicine. 5/13/2024, Vol. 22 Issue 1, p1-19. 19p.

مصطلحات موضوعية: *MELAS syndrome, *THYMIDINE, *NUCLEOSIDES, *MITOCHONDRIAL DNA, *NUCLEIC acids, *MITOCHONDRIAL proteins

المؤلفون: Barros, Camila D. S.¹ (AUTHOR) dantas.ca@hotmail.com, Coutinho, Aryane¹ (AUTHOR), Tengan, Celia H.¹ (AUTHOR) chtengan@unifesp.br

المصدر: International Journal of Molecular Sciences. Apr2024, Vol. 25 Issue 7, p3629. 12p.

مصطلحات موضوعية: *MELAS syndrome, *ARGININE, *DIETARY supplements, *LACTIC acidosis, *NITRIC oxide, *MITOCHONDRIAL DNA

المؤلفون: Zijun, Lin¹ (AUTHOR), Xu, Yi¹ (AUTHOR), Yujia, Yang¹ (AUTHOR), Zhiqiang, Xu¹ (AUTHOR) xzq881@163.com

المصدر: Clinical Case Reports. Mar2024, Vol. 12 Issue 3, p1-5. 5p.

مصطلحات موضوعية: *MELAS syndrome, *DEAFNESS, *SENSORINEURAL hearing loss, *UBIQUINONES, *CEREBRAL infarction, *OLDER people

المصدر: A Phase 2a Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study in Individuals With Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS)

المؤلفون: National Institute of Neurological Disorders and Stroke (NINDS), University of South Florida, Columbia University

المساهمون: Fernando Scaglia, Professor

المصدر: Phase-1, Dose Finding and Safety Study on L- Citrulline Treatment of Nitric Oxide Deficiency in MELAS
El-Hattab AW, Emrick LT, Hsu JW, Chanprasert S, Almannai M, Craigen WJ, Jahoor F, Scaglia F. Impaired nitric oxide production in children with MELAS syndrome and the effect of arginine and citrulline supplementation. Mol Genet Metab. 2016 Apr;117(4):407-12. doi: 10.1016/j.ymgme.2016.01.010. Epub 2016 Jan 27.
El-Hattab AW, Almannai M, Scaglia F. MELAS. 2001 Feb 27 [updated 2018 Nov 29]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2025. Available from http://www.ncbi.nlm.nih.gov/books/NBK1233/
El-Hattab AW, Almannai M, Scaglia F. Arginine and citrulline for the treatment of MELAS syndrome. J Inborn Errors Metab Screen. 2017 Jan;5:10.1177/2326409817697399. doi: 10.1177/2326409817697399. Epub 2017 Mar 24.
El-Hattab AW, Emrick LT, Williamson KC, Craigen WJ, Scaglia F. The effect of citrulline and arginine supplementation on lactic acidemia in MELAS syndrome. Meta Gene. 2013 Oct 15;1:8-14. doi: 10.1016/j.mgene.2013.09.001. eCollection 2013 Dec.
Scaglia F, Northrop JL. The mitochondrial myopathy encephalopathy, lactic acidosis with stroke-like episodes (MELAS) syndrome: a review of treatment options. CNS Drugs. 2006;20(6):443-64. doi: 10.2165/00023210-200620060-00002. Erratum In: CNS Drugs. 2008;22(1):81.
Hirano M, Pavlakis SG. Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS): current concepts. J Child Neurol. 1994 Jan;9(1):4-13. doi: 10.1177/088307389400900102.
Noguchi T, Yoshiura T, Hiwatashi A, Togao O, Yamashita K, Nagao E, Shono T, Mizoguchi M, Nagata S, Sasaki T, Suzuki SO, Iwaki T, Kobayashi K, Mihara F, Honda H. Perfusion imaging of brain tumors using arterial spin-labeling: correlation with histopathologic vascular density. AJNR Am J Neuroradiol. 2008 Apr;29(4):688-93. doi: 10.3174/ajnr.A0903. Epub 2008 Jan 9.

المصدر: A Phase III, Randomised, Double-blind, Placebo-controlled, Parallel-group, Pivotal Trial to Assess the Efficacy and Safety of Sonlicromanol in Adult Subjects With a Genetically Confirmed Mitochondrial DNA tRNALeu(UUR) m.3243A>G Variant

المؤلفون: Gao, Rui, Gu, Lihua, Zuo, Wenchao, Wang, Pan

المصدر: Frontiers in Neurology; 2024, p1-7, 7p

مصطلحات موضوعية: MELAS syndrome, BIOMARKERS, MITOCHONDRIAL DNA, LACTIC acid, STATUS epilepticus

المؤلفون: McCully, Kevin K., Bossie, Hannah M., Kendall, Fran D.

المصدر: Muscles (2813-0413); Dec2024, Vol. 3 Issue 4, p393-403, 11p

مصطلحات موضوعية: NEAR infrared reflectance spectroscopy, FLEXOR muscles, MELAS syndrome, NEAR infrared spectroscopy, MUSCLE fatigue

المؤلفون: Chen, Lizhang¹ (AUTHOR), Lang, Hui¹ (AUTHOR), Abdulaziz, Ammar Taha Abdullah¹ (AUTHOR), Zhou, Muke¹ (AUTHOR) zmkeamail@126.com, He, Li¹ (AUTHOR) heli2003new@126.com

المصدر: Neurological Sciences. Jul2024, Vol. 45 Issue 7, p3535-3537. 3p.

مصطلحات موضوعية: *MELAS syndrome, *STROKE, *MEDICAL research, *NEUROLOGIC examination, *TRANSIENT ischemic attack, *ISCHEMIC stroke

Alternate Title: Migraine and mitochondrial diseases: Energy deficit in the brain.

المؤلفون: Hämmerl, Lucia¹ (AUTHOR), Kraya, Torsten^1,2 (AUTHOR) neurologie@sanktgeorg.de

المصدر: Der Nervenarzt. Feb2024, Vol. 95 Issue 2, p169-178. 10p.

مصطلحات موضوعية: *MELAS syndrome, *ENERGY metabolism, *MITOCHONDRIA, *BIOMARKERS, *HEADACHE