المؤلفون: Natalya A. Ortolano (10291721), Alejandra I. Romero-Morales (10291724), Megan L. Rasmussen (10291727), Caroline Bodnya (10291730), Leigh A. Kline (10291733), Piyush Joshi (6816557), Jon P. Connelly (10291736), Kristie L. Rose (744759), Shondra M. Pruett-Miller (10291739), Vivian Gama (10291742)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, CUL 9 protein levels, CUL 9, Cullin RING ligases, cell models CUL 9, APC, transcriptional regulation pathways, CRL, E 3 ubiquitin ligases, cell cycle regulator, ATP, CUL 9 substrates, FZR, Quantitative proteomic analysis, LC-MS, oxygen consumption rates, CUL 9 KO hPSCs, CUL 9 deletion, cell cycle progression, CUL 9 protein causes

Relation: https://figshare.com/articles/journal_contribution/S1_File_-/14202944

الاتاحة: https://doi.org/10.1371/journal.pone.0248000.s020

المؤلفون: Natalya A. Ortolano (10291721), Alejandra I. Romero-Morales (10291724), Megan L. Rasmussen (10291727), Caroline Bodnya (10291730), Leigh A. Kline (10291733), Piyush Joshi (6816557), Jon P. Connelly (10291736), Kristie L. Rose (744759), Shondra M. Pruett-Miller (10291739), Vivian Gama (10291742)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, CUL 9 protein levels, CUL 9, Cullin RING ligases, cell models CUL 9, APC, transcriptional regulation pathways, CRL, E 3 ubiquitin ligases, cell cycle regulator, ATP, CUL 9 substrates, FZR, Quantitative proteomic analysis, LC-MS, oxygen consumption rates, CUL 9 KO hPSCs, CUL 9 deletion, cell cycle progression, CUL 9 protein causes

Relation: https://figshare.com/articles/journal_contribution/S1_Raw_images_-/14202947

الاتاحة: https://doi.org/10.1371/journal.pone.0248000.s021

المؤلفون: Natalya A. Ortolano (10291721), Alejandra I. Romero-Morales (10291724), Megan L. Rasmussen (10291727), Caroline Bodnya (10291730), Leigh A. Kline (10291733), Piyush Joshi (6816557), Jon P. Connelly (10291736), Kristie L. Rose (744759), Shondra M. Pruett-Miller (10291739), Vivian Gama (10291742)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, CUL 9 protein levels, CUL 9, Cullin RING ligases, cell models CUL 9, APC, transcriptional regulation pathways, CRL, E 3 ubiquitin ligases, cell cycle regulator, ATP, CUL 9 substrates, FZR, Quantitative proteomic analysis, LC-MS, oxygen consumption rates, CUL 9 KO hPSCs, CUL 9 deletion, cell cycle progression, CUL 9 protein causes

Relation: https://figshare.com/articles/figure/All_cell_lines_used_in_this_study_have_normal_karyotypes_/14202890

الاتاحة: https://doi.org/10.1371/journal.pone.0248000.s002

المؤلفون: Natalya A. Ortolano (10291721), Alejandra I. Romero-Morales (10291724), Megan L. Rasmussen (10291727), Caroline Bodnya (10291730), Leigh A. Kline (10291733), Piyush Joshi (6816557), Jon P. Connelly (10291736), Kristie L. Rose (744759), Shondra M. Pruett-Miller (10291739), Vivian Gama (10291742)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, CUL 9 protein levels, CUL 9, Cullin RING ligases, cell models CUL 9, APC, transcriptional regulation pathways, CRL, E 3 ubiquitin ligases, cell cycle regulator, ATP, CUL 9 substrates, FZR, Quantitative proteomic analysis, LC-MS, oxygen consumption rates, CUL 9 KO hPSCs, CUL 9 deletion, cell cycle progression, CUL 9 protein causes

Relation: https://figshare.com/articles/figure/CUL9_KO_clones_have_varied_apoptotic_resistance_at_exposure_to_low_levels_of_DNA_damaging_agent_etoposide_/14202893

الاتاحة: https://doi.org/10.1371/journal.pone.0248000.s003

المؤلفون: Natalya A. Ortolano (10291721), Alejandra I. Romero-Morales (10291724), Megan L. Rasmussen (10291727), Caroline Bodnya (10291730), Leigh A. Kline (10291733), Piyush Joshi (6816557), Jon P. Connelly (10291736), Kristie L. Rose (744759), Shondra M. Pruett-Miller (10291739), Vivian Gama (10291742)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, CUL 9 protein levels, CUL 9, Cullin RING ligases, cell models CUL 9, APC, transcriptional regulation pathways, CRL, E 3 ubiquitin ligases, cell cycle regulator, ATP, CUL 9 substrates, FZR, Quantitative proteomic analysis, LC-MS, oxygen consumption rates, CUL 9 KO hPSCs, CUL 9 deletion, cell cycle progression, CUL 9 protein causes

Relation: https://figshare.com/articles/figure/Design_and_analysis_of_CUL9_KO_hPSC_clones_/14202887

الاتاحة: https://doi.org/10.1371/journal.pone.0248000.s001

المؤلفون: Natalya A. Ortolano (10291721), Alejandra I. Romero-Morales (10291724), Megan L. Rasmussen (10291727), Caroline Bodnya (10291730), Leigh A. Kline (10291733), Piyush Joshi (6816557), Jon P. Connelly (10291736), Kristie L. Rose (744759), Shondra M. Pruett-Miller (10291739), Vivian Gama (10291742)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, CUL 9 protein levels, CUL 9, Cullin RING ligases, cell models CUL 9, APC, transcriptional regulation pathways, CRL, E 3 ubiquitin ligases, cell cycle regulator, ATP, CUL 9 substrates, FZR, Quantitative proteomic analysis, LC-MS, oxygen consumption rates, CUL 9 KO hPSCs, CUL 9 deletion, cell cycle progression, CUL 9 protein causes

Relation: https://figshare.com/articles/figure/CUL9_KO_cells_can_differentiate_to_NSCs_/14202899

الاتاحة: https://doi.org/10.1371/journal.pone.0248000.s005

المؤلفون: Natalya A. Ortolano (10291721), Alejandra I. Romero-Morales (10291724), Megan L. Rasmussen (10291727), Caroline Bodnya (10291730), Leigh A. Kline (10291733), Piyush Joshi (6816557), Jon P. Connelly (10291736), Kristie L. Rose (744759), Shondra M. Pruett-Miller (10291739), Vivian Gama (10291742)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, CUL 9 protein levels, CUL 9, Cullin RING ligases, cell models CUL 9, APC, transcriptional regulation pathways, CRL, E 3 ubiquitin ligases, cell cycle regulator, ATP, CUL 9 substrates, FZR, Quantitative proteomic analysis, LC-MS, oxygen consumption rates, CUL 9 KO hPSCs, CUL 9 deletion, cell cycle progression, CUL 9 protein causes

Relation: https://figshare.com/articles/figure/Deletion_of_CUL9_does_not_affect_cytochrome_i_c_i_levels_after_its_release_from_mitochondria_during_apoptosis_/14202896

الاتاحة: https://doi.org/10.1371/journal.pone.0248000.s004

المؤلفون: Natalya A. Ortolano (10291721), Alejandra I. Romero-Morales (10291724), Megan L. Rasmussen (10291727), Caroline Bodnya (10291730), Leigh A. Kline (10291733), Piyush Joshi (6816557), Jon P. Connelly (10291736), Kristie L. Rose (744759), Shondra M. Pruett-Miller (10291739), Vivian Gama (10291742)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, CUL 9 protein levels, CUL 9, Cullin RING ligases, cell models CUL 9, APC, transcriptional regulation pathways, CRL, E 3 ubiquitin ligases, cell cycle regulator, ATP, CUL 9 substrates, FZR, Quantitative proteomic analysis, LC-MS, oxygen consumption rates, CUL 9 KO hPSCs, CUL 9 deletion, cell cycle progression, CUL 9 protein causes

Relation: https://figshare.com/articles/figure/Significantly_enriched_gene_ontology_GO_terms_obtained_by_DAVID_functional_annotation_of_significantly_altered_proteins_/14202914

الاتاحة: https://doi.org/10.1371/journal.pone.0248000.s010

المؤلفون: Natalya A. Ortolano (10291721), Alejandra I. Romero-Morales (10291724), Megan L. Rasmussen (10291727), Caroline Bodnya (10291730), Leigh A. Kline (10291733), Piyush Joshi (6816557), Jon P. Connelly (10291736), Kristie L. Rose (744759), Shondra M. Pruett-Miller (10291739), Vivian Gama (10291742)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, CUL 9 protein levels, CUL 9, Cullin RING ligases, cell models CUL 9, APC, transcriptional regulation pathways, CRL, E 3 ubiquitin ligases, cell cycle regulator, ATP, CUL 9 substrates, FZR, Quantitative proteomic analysis, LC-MS, oxygen consumption rates, CUL 9 KO hPSCs, CUL 9 deletion, cell cycle progression, CUL 9 protein causes

Relation: https://figshare.com/articles/figure/S8_Fig_-/14202908

الاتاحة: https://doi.org/10.1371/journal.pone.0248000.s008

المؤلفون: Natalya A. Ortolano (10291721), Alejandra I. Romero-Morales (10291724), Megan L. Rasmussen (10291727), Caroline Bodnya (10291730), Leigh A. Kline (10291733), Piyush Joshi (6816557), Jon P. Connelly (10291736), Kristie L. Rose (744759), Shondra M. Pruett-Miller (10291739), Vivian Gama (10291742)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, CUL 9 protein levels, CUL 9, Cullin RING ligases, cell models CUL 9, APC, transcriptional regulation pathways, CRL, E 3 ubiquitin ligases, cell cycle regulator, ATP, CUL 9 substrates, FZR, Quantitative proteomic analysis, LC-MS, oxygen consumption rates, CUL 9 KO hPSCs, CUL 9 deletion, cell cycle progression, CUL 9 protein causes

Relation: https://figshare.com/articles/dataset/iTRAQ_hits_significantly_upregulated_in_CUL9_KO_hPSCs_/14202929

الاتاحة: https://doi.org/10.1371/journal.pone.0248000.s015

المؤلفون: Natalya A. Ortolano (10291721), Alejandra I. Romero-Morales (10291724), Megan L. Rasmussen (10291727), Caroline Bodnya (10291730), Leigh A. Kline (10291733), Piyush Joshi (6816557), Jon P. Connelly (10291736), Kristie L. Rose (744759), Shondra M. Pruett-Miller (10291739), Vivian Gama (10291742)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, CUL 9 protein levels, CUL 9, Cullin RING ligases, cell models CUL 9, APC, transcriptional regulation pathways, CRL, E 3 ubiquitin ligases, cell cycle regulator, ATP, CUL 9 substrates, FZR, Quantitative proteomic analysis, LC-MS, oxygen consumption rates, CUL 9 KO hPSCs, CUL 9 deletion, cell cycle progression, CUL 9 protein causes

Relation: https://figshare.com/articles/figure/Representative_histograms_showing_normalized_distribution_of_log_quantification_protein_ratios_for_A_WT_NSC_vs_WT_iPSC_B_Clone_1_vs_WT_iPSC_C_WT_NPC_vs_WT_NSC_and_D_Clone_1_NPC_vs_WT_NPC_/14202911

الاتاحة: https://doi.org/10.1371/journal.pone.0248000.s009

المؤلفون: Natalya A. Ortolano (10291721), Alejandra I. Romero-Morales (10291724), Megan L. Rasmussen (10291727), Caroline Bodnya (10291730), Leigh A. Kline (10291733), Piyush Joshi (6816557), Jon P. Connelly (10291736), Kristie L. Rose (744759), Shondra M. Pruett-Miller (10291739), Vivian Gama (10291742)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, CUL 9 protein levels, CUL 9, Cullin RING ligases, cell models CUL 9, APC, transcriptional regulation pathways, CRL, E 3 ubiquitin ligases, cell cycle regulator, ATP, CUL 9 substrates, FZR, Quantitative proteomic analysis, LC-MS, oxygen consumption rates, CUL 9 KO hPSCs, CUL 9 deletion, cell cycle progression, CUL 9 protein causes

Relation: https://figshare.com/articles/figure/CUL9_KO_hNPCs_have_expected_protein_levels_of_key_neuronal_transcription_factors_/14202917

الاتاحة: https://doi.org/10.1371/journal.pone.0248000.s011

المؤلفون: Natalya A. Ortolano (10291721), Alejandra I. Romero-Morales (10291724), Megan L. Rasmussen (10291727), Caroline Bodnya (10291730), Leigh A. Kline (10291733), Piyush Joshi (6816557), Jon P. Connelly (10291736), Kristie L. Rose (744759), Shondra M. Pruett-Miller (10291739), Vivian Gama (10291742)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, CUL 9 protein levels, CUL 9, Cullin RING ligases, cell models CUL 9, APC, transcriptional regulation pathways, CRL, E 3 ubiquitin ligases, cell cycle regulator, ATP, CUL 9 substrates, FZR, Quantitative proteomic analysis, LC-MS, oxygen consumption rates, CUL 9 KO hPSCs, CUL 9 deletion, cell cycle progression, CUL 9 protein causes

Relation: https://figshare.com/articles/dataset/Proteins_present_in_endogenous_CUL9_immunoprecipitation_from_hNPC_lysate_as_determined_by_LC-MS_MS_/14202926

الاتاحة: https://doi.org/10.1371/journal.pone.0248000.s014

المؤلفون: Natalya A. Ortolano (10291721), Alejandra I. Romero-Morales (10291724), Megan L. Rasmussen (10291727), Caroline Bodnya (10291730), Leigh A. Kline (10291733), Piyush Joshi (6816557), Jon P. Connelly (10291736), Kristie L. Rose (744759), Shondra M. Pruett-Miller (10291739), Vivian Gama (10291742)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, CUL 9 protein levels, CUL 9, Cullin RING ligases, cell models CUL 9, APC, transcriptional regulation pathways, CRL, E 3 ubiquitin ligases, cell cycle regulator, ATP, CUL 9 substrates, FZR, Quantitative proteomic analysis, LC-MS, oxygen consumption rates, CUL 9 KO hPSCs, CUL 9 deletion, cell cycle progression, CUL 9 protein causes

Relation: https://figshare.com/articles/figure/CUL9_KO_hPSCs_and_hNPCs_display_normal_metabolic_profile_/14202971

الاتاحة: https://doi.org/10.1371/journal.pone.0248000.g008

المؤلفون: Natalya A. Ortolano (10291721), Alejandra I. Romero-Morales (10291724), Megan L. Rasmussen (10291727), Caroline Bodnya (10291730), Leigh A. Kline (10291733), Piyush Joshi (6816557), Jon P. Connelly (10291736), Kristie L. Rose (744759), Shondra M. Pruett-Miller (10291739), Vivian Gama (10291742)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, CUL 9 protein levels, CUL 9, Cullin RING ligases, cell models CUL 9, APC, transcriptional regulation pathways, CRL, E 3 ubiquitin ligases, cell cycle regulator, ATP, CUL 9 substrates, FZR, Quantitative proteomic analysis, LC-MS, oxygen consumption rates, CUL 9 KO hPSCs, CUL 9 deletion, cell cycle progression, CUL 9 protein causes

Relation: https://figshare.com/articles/figure/CUL9_KO_hPSCs_normally_express_key_pluripotency_genes_/14202950

الاتاحة: https://doi.org/10.1371/journal.pone.0248000.g001

المؤلفون: Natalya A. Ortolano (10291721), Alejandra I. Romero-Morales (10291724), Megan L. Rasmussen (10291727), Caroline Bodnya (10291730), Leigh A. Kline (10291733), Piyush Joshi (6816557), Jon P. Connelly (10291736), Kristie L. Rose (744759), Shondra M. Pruett-Miller (10291739), Vivian Gama (10291742)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, CUL 9 protein levels, CUL 9, Cullin RING ligases, cell models CUL 9, APC, transcriptional regulation pathways, CRL, E 3 ubiquitin ligases, cell cycle regulator, ATP, CUL 9 substrates, FZR, Quantitative proteomic analysis, LC-MS, oxygen consumption rates, CUL 9 KO hPSCs, CUL 9 deletion, cell cycle progression, CUL 9 protein causes

Relation: https://figshare.com/articles/dataset/iTRAQ_hits_significantly_downregulated_in_CUL9_KO_NPCs_/14202938

الاتاحة: https://doi.org/10.1371/journal.pone.0248000.s018

المؤلفون: Natalya A. Ortolano (10291721), Alejandra I. Romero-Morales (10291724), Megan L. Rasmussen (10291727), Caroline Bodnya (10291730), Leigh A. Kline (10291733), Piyush Joshi (6816557), Jon P. Connelly (10291736), Kristie L. Rose (744759), Shondra M. Pruett-Miller (10291739), Vivian Gama (10291742)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, CUL 9 protein levels, CUL 9, Cullin RING ligases, cell models CUL 9, APC, transcriptional regulation pathways, CRL, E 3 ubiquitin ligases, cell cycle regulator, ATP, CUL 9 substrates, FZR, Quantitative proteomic analysis, LC-MS, oxygen consumption rates, CUL 9 KO hPSCs, CUL 9 deletion, cell cycle progression, CUL 9 protein causes

Relation: https://figshare.com/articles/figure/CUL9_interacts_with_several_subunits_of_the_APC_C_/14202959

الاتاحة: https://doi.org/10.1371/journal.pone.0248000.g004

المؤلفون: Natalya A. Ortolano (10291721), Alejandra I. Romero-Morales (10291724), Megan L. Rasmussen (10291727), Caroline Bodnya (10291730), Leigh A. Kline (10291733), Piyush Joshi (6816557), Jon P. Connelly (10291736), Kristie L. Rose (744759), Shondra M. Pruett-Miller (10291739), Vivian Gama (10291742)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, CUL 9 protein levels, CUL 9, Cullin RING ligases, cell models CUL 9, APC, transcriptional regulation pathways, CRL, E 3 ubiquitin ligases, cell cycle regulator, ATP, CUL 9 substrates, FZR, Quantitative proteomic analysis, LC-MS, oxygen consumption rates, CUL 9 KO hPSCs, CUL 9 deletion, cell cycle progression, CUL 9 protein causes

Relation: https://figshare.com/articles/figure/EBs_and_neural_rosettes_derived_from_CUL9_KO_clones_display_abnormalities_/14202956

الاتاحة: https://doi.org/10.1371/journal.pone.0248000.g003

المؤلفون: Natalya A. Ortolano (10291721), Alejandra I. Romero-Morales (10291724), Megan L. Rasmussen (10291727), Caroline Bodnya (10291730), Leigh A. Kline (10291733), Piyush Joshi (6816557), Jon P. Connelly (10291736), Kristie L. Rose (744759), Shondra M. Pruett-Miller (10291739), Vivian Gama (10291742)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, CUL 9 protein levels, CUL 9, Cullin RING ligases, cell models CUL 9, APC, transcriptional regulation pathways, CRL, E 3 ubiquitin ligases, cell cycle regulator, ATP, CUL 9 substrates, FZR, Quantitative proteomic analysis, LC-MS, oxygen consumption rates, CUL 9 KO hPSCs, CUL 9 deletion, cell cycle progression, CUL 9 protein causes

Relation: https://figshare.com/articles/figure/CUL9_KO_clones_differentiate_to_hNPCs_and_early_born_cortical_neurons_/14202953

الاتاحة: https://doi.org/10.1371/journal.pone.0248000.g002

المؤلفون: Natalya A. Ortolano (10291721), Alejandra I. Romero-Morales (10291724), Megan L. Rasmussen (10291727), Caroline Bodnya (10291730), Leigh A. Kline (10291733), Piyush Joshi (6816557), Jon P. Connelly (10291736), Kristie L. Rose (744759), Shondra M. Pruett-Miller (10291739), Vivian Gama (10291742)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, CUL 9 protein levels, CUL 9, Cullin RING ligases, cell models CUL 9, APC, transcriptional regulation pathways, CRL, E 3 ubiquitin ligases, cell cycle regulator, ATP, CUL 9 substrates, FZR, Quantitative proteomic analysis, LC-MS, oxygen consumption rates, CUL 9 KO hPSCs, CUL 9 deletion, cell cycle progression, CUL 9 protein causes

Relation: https://figshare.com/articles/figure/CUL9_KO_cells_have_significantly_altered_levels_of_key_proteins_in_metabolism_as_determined_by_iTRAQ_/14202968

الاتاحة: https://doi.org/10.1371/journal.pone.0248000.g007