المؤلفون: Alexej Dick, Megan E. Meuser, Simon Cocklin

المصدر: Biomolecules, Vol 12, Iss 5, p 695 (2022)

مصطلحات موضوعية: HIV-1 capsid protein, assembly, nuclear import factor recognition, CPSF-6, NUP-153, surface plasmon resonance, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2218-273X/12/5/695; https://doaj.org/toc/2218-273X

URL الوصول: https://doaj.org/article/341a47d54f424e9fabb8e9259737e804

المؤلفون: Eric Rossi, Megan E. Meuser, Camille J. Cunanan, Simon Cocklin

المصدر: Life, Vol 11, Iss 2, p 100 (2021)

مصطلحات موضوعية: HIV-1/AIDS, capsid, host proteins, post-entry events, assembly, virus-host interactions, Science

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2075-1729/11/2/100; https://doaj.org/toc/2075-1729

URL الوصول: https://doaj.org/article/db31db2d94d143bbafb41912ce0fda7c

المؤلفون: Rama Karadsheh, Megan E. Meuser, Simon Cocklin

المصدر: Molecules, Vol 25, Iss 6, p 1430 (2020)

مصطلحات موضوعية: hiv-1 entry inhibitor, metabolic stability, docking, antiviral, surface plasmon resonance, cyp p450, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1420-3049/25/6/1430; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/25ad9f9ad0884bc9984c0aa1789acc2c

المؤلفون: Megan E. Meuser, Michael B. Murphy, Adel A. Rashad, Simon Cocklin

المصدر: Proceedings, Vol 22, Iss 1, p 77 (2019)

مصطلحات موضوعية: bioisosteres, HIV-1 Env, antiviral, surface plasmon resonance, computer-aided drug design, General Works

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2504-3900/22/1/77; https://doaj.org/toc/2504-3900

URL الوصول: https://doaj.org/article/870c2bc27940483b8668c2517ee5eed0

المؤلفون: Megan E. Meuser, Adel A. Rashad, Gabriel Ozorowski, Alexej Dick, Andrew B. Ward, Simon Cocklin

المصدر: Molecules, Vol 24, Iss 8, p 1581 (2019)

مصطلحات موضوعية: bioisosteres, HIV-1 Env, antiviral, surface plasmon resonance, computer-aided drug design, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1420-3049/24/8/1581; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/88862b03cf994df28b6796baead59c2a

المؤلفون: Megan E. Meuser, Michael B. Murphy, Adel A. Rashad, Simon Cocklin

المصدر: Molecules, Vol 23, Iss 8, p 1940 (2018)

مصطلحات موضوعية: bioisosteres, HIV-1 Env, antiviral, surface plasmon resonance, computer-aided drug design, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: http://www.mdpi.com/1420-3049/23/8/1940; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/add00035b7d54bdf8beb1540a03fcd8d

المؤلفون: Megan E. Meuser (10344177), Poli Adi Narayana Reddy (10344180), Alexej Dick (8780288), Jean Marc Maurancy (10344183), Joseph M. Salvino (1265199), Simon Cocklin (2093152)

مصطلحات موضوعية: Biochemistry, Neuroscience, Physiology, Pharmacology, Cancer, Hematology, Infectious Diseases, Virology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, inhibitor PF -74, Multistep Computational Workflow Poor, stability, design CA compounds, HIV, PF -74, workflow, novel multistep computationally, immunodeficiency virus type, CA interprotomer pocket, PF -74 analogs

Relation: https://figshare.com/articles/journal_contribution/Rapid_Optimization_of_the_Metabolic_Stability_of_a_Human_Immunodeficiency_Virus_Type_1_Capsid_Inhibitor_Using_a_Multistep_Computational_Workflow/14262009

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c01810.s006

المؤلفون: Mehmet Berkmen, Marine Lénon, Guoping Ren, Megan E. Meuser, Patrick J. Loll, Paul Riggs, Na Ke

المصدر: Protein Sci

مصطلحات موضوعية: Lysis, medicine.drug_class, Recombinant Fusion Proteins, Full‐Length Papers, Crystallography, X-Ray, medicine.disease_cause, Monoclonal antibody, Biochemistry, Maltose-Binding Proteins, Epitope, Epitopes, 03 medical and health sciences, Maltose-binding protein, Affinity chromatography, Escherichia coli, medicine, Molecular Biology, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, biology, Chemistry, Escherichia coli Proteins, 030302 biochemistry & molecular biology, Amino acid, biology.protein, Antibody

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a30a3c6c4709caa6b91c02f0e0ec2c59
https://doi.org/10.1002/pro.4088

المؤلفون: Jean Marc Maurancy, Joseph M. Salvino, Simon Cocklin, Megan E. Meuser, Alexej Dick, Poli Adi Narayana Reddy

المصدر: Journal of Medicinal Chemistry. 64:3747-3766

مصطلحات موضوعية: 0303 health sciences, Chemistry, Human immunodeficiency virus (HIV), Computational biology, Metabolic stability, medicine.disease_cause, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Workflow, Capsid, health services administration, Drug Discovery, medicine, Molecular Medicine, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::91ca7515ca418e15cd3dcf1ce70cb953
https://doi.org/10.1021/acs.jmedchem.0c01810

المؤلفون: Megan E Meuser

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::53b30ea2811b222570737138502954a7
https://doi.org/10.17918/00000924

المؤلفون: Megan E. Meuser, Eric Rossi, Simon Cocklin, Camille J Cunanan

المصدر: Life, Vol 11, Iss 100, p 100 (2021)
Life

مصطلحات موضوعية: 0301 basic medicine, assembly, viruses, 030106 microbiology, Human immunodeficiency virus (HIV), host proteins, Review, medicine.disease_cause, Genome, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, medicine, capsid, post-entry events, lcsh:Science, Ecology, Evolution, Behavior and Systematics, virus-host interactions, HIV-1/AIDS, Chemistry, Paleontology, Signal transducing adaptor protein, BICD2, restriction factors, Reverse transcriptase, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Capsid, Space and Planetary Science, lcsh:Q, Nucleus, FEZ1

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f804de452cb2f27ea5ca634ac60703c3
https://www.mdpi.com/2075-1729/11/2/100

المؤلفون: Srinivasulu Cherukupalli, Xiao Ding, Chin Ho Chen, Kuo Hsiung Lee, Simon Cocklin, Alexej Dick, Dongwei Kang, Ping Gao, Lin Sun, Megan E. Meuser, Peng Zhan, Waleed A. Zalloum, Shujing Xu, Tianguang Huang, Xinyong Liu, Christophe Pannecouque, Erik De Clercq

المصدر: J Med Chem

مصطلحات موضوعية: Male, Anti-HIV Agents, Phenylalanine, Population, PROTEIN, Context (language use), Chemistry, Medicinal, Virus Replication, 01 natural sciences, Article, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, 03 medical and health sciences, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Potency, Moiety, PEPTIDE, Pharmacology & Pharmacy, education, 030304 developmental biology, EC50, Sulfonamides, 0303 health sciences, education.field_of_study, Science & Technology, Molecular Structure, Chemistry, 0104 chemical sciences, Bioavailability, 010404 medicinal & biomolecular chemistry, Mechanism of action, Biochemistry, Capsid, Drug Design, DISCOVERY, HIV-2, REPLICATION, HIV-1, Microsomes, Liver, Molecular Medicine, Capsid Proteins, Female, medicine.symptom, Life Sciences & Biomedicine

وصف الملف: Print-Electronic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2781e3b2b8f910c3ef736a6003330040
https://lirias.kuleuven.be/handle/123456789/685205

المؤلفون: Megan E. Meuser, Erik De Clercq, Xiao Ding, Tianguang Huang, Xinyong Liu, Waleed A. Zalloum, Dang Ding, Peng Zhan, Christophe Pannecouque, Simon Cocklin, Xiangyi Jiang, Shenghua Gao, Alexej Dick, Yucen Tao, Lin Sun, Shujing Xu, Xujie Zhang, Srinivasulu Cherukupalli, Dongwei Kang

المصدر: Eur J Med Chem

مصطلحات موضوعية: Anti-HIV Agents, Phenylalanine, Capsid inhibitor, PROTEIN, Chemistry, Medicinal, Microbial Sensitivity Tests, Virus Replication, Article, law.invention, Structure-Activity Relationship, chemistry.chemical_compound, law, Drug Discovery, medicine, Humans, Moiety, Pharmacology & Pharmacy, Benzothiazoles, Binding site, Pharmacology, Indole test, Science & Technology, ROLES, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, General Medicine, Benzothiazole, chemistry, Biochemistry, Mechanism of action, DISCOVERY, Drug Design, REPLICATION, HIV-1, Microsomes, Liver, Recombinant DNA, Capsid Proteins, Metabolic stability, medicine.symptom, Life Sciences & Biomedicine, Lead compound

وصف الملف: Print-Electronic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::588d03d3b2c05879dc0a2d52e359a007
https://doi.org/10.1016/j.ejmech.2021.113903

المؤلفون: Waleed A. Zalloum, Peng Zhan, Erik De Clercq, Xujie Zhang, Megan E. Meuser, Christophe Pannecouque, Alexej Dick, Lin Sun, Xinyong Liu, Xiao Ding, Dongwei Kang, Tianguang Huang, Xiangyi Jiang, Simon Cocklin, Yucen Tao, Srinivasulu Cherukupalli, Shujing Xu

المصدر: Eur J Med Chem

مصطلحات موضوعية: Anti-HIV Agents, Stereochemistry, Phenylalanine, Dimer, Microbial Sensitivity Tests, Molecular Dynamics Simulation, Random hexamer, Article, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Humans, Pharmacology, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, General Medicine, Surface Plasmon Resonance, Monomer, chemistry, Capsid, Drug Design, HIV-1, Microsomes, Liver, Microsome, Lipinski's rule of five, Capsid Proteins, Dimerization, Linker

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ac2fc579b9564255b742a5f8a09a6b
https://doi.org/10.1016/j.ejmech.2021.113848

المؤلفون: Beth A. Bouchard, Megan E. Meuser, Jacqueline M. Gertz

المصدر: Cytometry Part A. 91:713-720

مصطلحات موضوعية: 0301 basic medicine, Histology, medicine.diagnostic_test, Cell division, Megakaryocyte differentiation, Cell, Cell Biology, Biology, Molecular biology, Pathology and Forensic Medicine, Flow cytometry, Cell biology, Cell membrane, 03 medical and health sciences, 030104 developmental biology, medicine.anatomical_structure, Megakaryocyte, medicine, Endomitotic cell cycle, Cytometry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5554da3a72ba64b7bbc0bd0f28c7d456
https://doi.org/10.1002/cyto.a.23161

المؤلفون: Ruifang Jia, Xiangyi Jiang, Dongwei Kang, Gaochan Wu, Waleed A. Zalloum, Peng Zhan, Megan E. Meuser, Lanlan Jing, Lin Sun, Chin Ho Chen, Simon Cocklin, Alexej Dick, Xinyong Liu, Kuo Hsiung Lee

المصدر: RSC advances. 9(50)

مصطلحات موضوعية: chemistry.chemical_classification, 1,2,3-Triazole, Stereochemistry, General Chemical Engineering, Alkyne, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Affinities, Cycloaddition, Article, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Capsid, Azide, Surface plasmon resonance, 0210 nano-technology, Lead compound

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aafcd987782d7f54b3e83b79c3ae253
https://pubmed.ncbi.nlm.nih.gov/32089839

المؤلفون: Waleed A. Zalloum, Simon Cocklin, Megan E. Meuser, Kuo Hsiung Lee, Tianguang Huang, Alexej Dick, Ping Gao, Chin Ho Chen, Lin Sun, Peng Zhan, Xinyong Liu, Xiao Ding

المصدر: Eur J Med Chem

مصطلحات موضوعية: Anti-HIV Agents, Phenylalanine, Microbial Sensitivity Tests, Random hexamer, Molecular Dynamics Simulation, Virus Replication, 01 natural sciences, Article, law.invention, 03 medical and health sciences, Structure-Activity Relationship, law, Cell Line, Tumor, Drug Discovery, medicine, Humans, 030304 developmental biology, Pharmacology, 0303 health sciences, biology, Molecular Structure, 010405 organic chemistry, Chemistry, Ligand binding assay, Organic Chemistry, Active site, General Medicine, Triazoles, Reverse transcriptase, 0104 chemical sciences, Mechanism of action, Viral replication, Biochemistry, Drug Design, biology.protein, Recombinant DNA, HIV-1, Microsomes, Liver, Capsid Proteins, medicine.symptom, Nuclear transport, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7d6c309f8ac439afc739ea6ee30e761
https://europepmc.org/articles/PMC7053825/

المؤلفون: Simon Cocklin, Adel A. Rashad, Michael B. Murphy, Megan E. Meuser

المصدر: Molecules, Vol 23, Iss 8, p 1940 (2018)
Molecules
Volume 23
Issue 8
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Proceedings, Vol 22, Iss 1, p 77 (2019)

مصطلحات موضوعية: 0301 basic medicine, 0209 industrial biotechnology, Human immunodeficiency virus (HIV), Pharmaceutical Science, 02 engineering and technology, HIV Envelope Protein gp120, medicine.disease_cause, 01 natural sciences, Piperazines, Analytical Chemistry, law.invention, HIV-1 Env, 020901 industrial engineering & automation, law, Drug Discovery, Moiety, Surface plasmon resonance, computer-aided drug design, Chemistry, env Gene Products, Human Immunodeficiency Virus, antiviral, 3. Good health, Molecular Docking Simulation, Biochemistry, Chemistry (miscellaneous), Recombinant DNA, Molecular Medicine, surface plasmon resonance, Protein Binding, medicine.drug, Anti-HIV Agents, Cell Survival, lcsh:A, Article, Cell Line, lcsh:QD241-441, Structure-Activity Relationship, 03 medical and health sciences, lcsh:Organic chemistry, medicine, bioisosteres, Humans, Potency, Pyrroles, Physical and Theoretical Chemistry, 010401 analytical chemistry, Organic Chemistry, Triazoles, Virus Internalization, Off rate, Chemical space, 0104 chemical sciences, Entry inhibitor, Kinetics, 030104 developmental biology, Drug Design, HIV-1, lcsh:General Works, Protein Multimerization

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a43c44123018c00f45ba8c5b5fcc7d1
http://www.mdpi.com/1420-3049/23/8/1940

المؤلفون: Kuo Hsiung Lee, Megan E. Meuser, Fangfang Zhang, Gaochan Wu, Ye Tian, Chin Ho Chen, Peng Zhan, Lanlan Jing, Dongwei Kang, Simon Cocklin, Xinyong Liu, Waleed A. Zalloum

المصدر: European journal of medicinal chemistry. 158

مصطلحات موضوعية: 0301 basic medicine, Anti-HIV Agents, Phenylalanine, HIV Infections, Molecular Dynamics Simulation, 01 natural sciences, Article, law.invention, Small Molecule Libraries, 03 medical and health sciences, chemistry.chemical_compound, Capsid, law, Drug Discovery, Potency, Humans, Surface plasmon resonance, EC50, Pharmacology, 010405 organic chemistry, Chemistry, Organic Chemistry, General Medicine, Small molecule, 0104 chemical sciences, 030104 developmental biology, Biochemistry, Recombinant DNA, Click chemistry, HIV-1, Click Chemistry, Lead compound

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679263cd0fe677c59dd905cc3bbeeb1a
https://pubmed.ncbi.nlm.nih.gov/30243152