المؤلفون: Xiaoping Ye, Xiaohan Yang, Shengjun Wang, Yuan Yanqiu, Jia Wang, Meena Sachdeva, Jieyu Tang, Yu Qian, Cai Youyan, Jennifer A. Leeds, Wenhao Hu

المصدر: ACS Chemical Biology. 15:1826-1834

مصطلحات موضوعية: Methicillin-Resistant Staphylococcus aureus, 0301 basic medicine, medicine.drug_class, Antibiotics, Microbial Sensitivity Tests, medicine.disease_cause, 01 natural sciences, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Bacterial Proteins, 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase, Oxazines, Fatty Acid Synthase, Type II, medicine, Structure–activity relationship, Enzyme Inhibitors, Fatty acid synthesis, chemistry.chemical_classification, Molecular Structure, biology, 010405 organic chemistry, General Medicine, biology.organism_classification, Anti-Bacterial Agents, 0104 chemical sciences, 030104 developmental biology, Enzyme, chemistry, Mechanism of action, Staphylococcus aureus, Drug Design, Molecular Medicine, medicine.symptom, Antibacterial activity, Bacteria

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b9732f154bbf16b3f44f4448345513
https://doi.org/10.1021/acschembio.9b00982

المؤلفون: J. Mol Recognit, Lili Huang, Aaron K. Sato, Meena Sachdeva, Tony Fleming, Susan Townsend, Daniel T. Dransfield

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://www.dcu.ie/biotechnology/abg/pdfs/sue/Discovery of human antibodies against the C5aR target using phage display technology.pdf.

مصطلحات موضوعية: antibodies, phage display, GPCRs, C5aR

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.581.2116; http://www.dcu.ie/biotechnology/abg/pdfs/sue/Discovery of human antibodies against the C5aR target using phage display technology.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.581.2116
http://www.dcu.ie/biotechnology/abg/pdfs/sue/Discovery of human antibodies against the C5aR target using phage display technology.pdf

المؤلفون: Marcella Widya, David A. Six, Robert Lowell Simmons, Meena Sachdeva, Thomas Krucker, William D. Pasutti, Pramila Tamrakar

المصدر: ACS infectious diseases. 5(3)

مصطلحات موضوعية: 0301 basic medicine, Antibiotic drug, biology, medicine.drug_class, Chemistry, 030106 microbiology, Antibiotics, Solid Phase Extraction, Penetration (firestop), Tetracycline, biology.organism_classification, Mass Spectrometry, High-Throughput Screening Assays, 03 medical and health sciences, 030104 developmental biology, Infectious Diseases, medicine, Biophysics, Escherichia coli, Efflux, Bacteria

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944ce1b687e6466568a7f9330a1c14cd
https://pubmed.ncbi.nlm.nih.gov/30624052

المؤلفون: R Nau, K Kaye, M Sachdeva, M G Täuber, Roland Nau, T Keith Kaye, Meena Sachdeva, Eric R. Sande, Martin, G. Tauber

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://aac.asm.org/content/38/5/1186.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.424.8215; http://aac.asm.org/content/38/5/1186.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.424.8215
http://aac.asm.org/content/38/5/1186.full.pdf

المؤلفون: Jennifer A. Leeds, Alexey Ruzin, S. Whitney Barnes, Meena Sachdeva, Steve Mullin

المصدر: Journal of Antimicrobial Chemotherapy. 69:41-44

مصطلحات موضوعية: DNA, Bacterial, Microbiology (medical), DNA Mutational Analysis, Microbial Sensitivity Tests, Biology, medicine.disease_cause, Microbiology, Cell Wall, Vancomycin, Serial passage, Drug Resistance, Bacterial, medicine, Humans, Pharmacology (medical), Fidaxomicin, Selection, Genetic, Serial Passage, Gene, Pharmacology, Mutation, Clostridioides difficile, DNA-Directed RNA Polymerases, Sequence Analysis, DNA, Clostridium difficile, rpoB, Virology, Anti-Bacterial Agents, Thiazoles, Metronidazole, Aminoglycosides, Infectious Diseases, Genome, Bacterial, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98307eef92d87bb7ad1c2db7dc138ec
https://doi.org/10.1093/jac/dkt302

المؤلفون: Lili Huang, Aaron K. Sato, Daniel T. Dransfield, Susan Townsend, Tony J. Fleming, Meena Sachdeva

المصدر: Journal of Molecular Recognition. 18:327-333

مصطلحات موضوعية: Phage display, medicine.drug_class, Molecular Sequence Data, Monoclonal antibody, Immunoglobulin G, Immunoglobulin Fab Fragments, Peptide Library, Structural Biology, medicine, Humans, Amino Acid Sequence, Peptide library, Receptor, Anaphylatoxin C5a, Molecular Biology, Peptide sequence, biology, Membrane Proteins, Cell Differentiation, U937 Cells, Molecular biology, Receptors, Complement, Biochemistry, Biotinylation, biology.protein, Antibody

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149d5cf59614939ad0e5e852ec252585
https://doi.org/10.1002/jmr.735

المؤلفون: Mary Devlin, Daniel J. Sexton, Charles R. Wescott, Robert C. Lander, David M. Hilbert, Viktor Roschke, Meena Sachdeva, Andrew E. Nixon, Marko Delic, James P. Beltzer, Tony J. Fleming

المصدر: Journal of Molecular Recognition. 18:94-102

مصطلحات موضوعية: Phage display, Sequence analysis, Transmembrane Activator and CAML Interactor Protein, Amino Acid Motifs, Fluorescence Polarization, Peptide, Biology, Receptors, Tumor Necrosis Factor, Ruthenium, Conserved sequence, Affinity maturation, Peptide Library, Structural Biology, B-Cell Activating Factor, Protein Interaction Mapping, medicine, Humans, Disulfides, Peptide library, Receptor, Molecular Biology, Conserved Sequence, B cell, chemistry.chemical_classification, Tumor Necrosis Factor-alpha, Membrane Proteins, Molecular biology, medicine.anatomical_structure, chemistry, Biological Assay, Peptides

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::673dac75d1f4d69d4cd59affd327c295
https://doi.org/10.1002/jmr.722

المؤلفون: Meena Sachdeva, Jennifer A. Leeds

مصطلحات موضوعية: medicine.drug_class, Antibiotics, Clostridium difficile toxin A, Microbial Sensitivity Tests, Biology, medicine.disease_cause, Microbiology, Vancomycin, Metronidazole, medicine, Pharmacology (medical), Fidaxomicin, Mechanisms of Action: Physiological Effects, Pharmacology, Toxin, Clostridioides difficile, Clostridium difficile, Thiazoles, Infectious Diseases, Aminoglycosides, Mechanism of action, medicine.symptom, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a7ba562c4b24c36dc5c01860ebf9288
https://europepmc.org/articles/PMC4335859/

المؤلفون: Jennifer A. Leeds, Meena Sachdeva, JoAnne Dzink-Fox, Matthew J. LaMarche, Steve Mullin

المصدر: Antimicrobial agents and chemotherapy. 56(8)

مصطلحات موضوعية: Mutant, Peptide Chain Elongation, Translational, Clostridium difficile toxin A, Microbial Sensitivity Tests, Peptide Elongation Factor Tu, Bacterial genetics, Microbiology, Drug Resistance, Bacterial, medicine, Humans, Pharmacology (medical), Experimental Therapeutics, Enterocolitis, Pseudomembranous, Pharmacology, Binding Sites, biology, Clostridioides difficile, Clostridium difficile, Antimicrobial, biology.organism_classification, Anti-Bacterial Agents, Protein Structure, Tertiary, Thiazoles, Infectious Diseases, Mechanism of action, medicine.symptom, Antibacterial activity, Bacteria

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9544a21c5ba5762cca207d67dd89516b
https://pubmed.ncbi.nlm.nih.gov/22644023

المؤلفون: Qingming Zhu, Bushell Simon, Stacey Tiamfook, JoAnne Dzink-Fox, Michael A. Patane, Jason T. Brewer, Deborah Palestrant, Elin M. Rann, Matthew J. LaMarche, Meena Sachdeva, Anna Trzasko, Lewis Whitehead, Jennifer A. Leeds, Steve Mullin, Janetta Dewhurst, Lac Lee, Wanlin Yan, David McKenney, Gabriel G. Gamber, Jian Ding, Aregahegn Yifru, Adam Amaral, Jian Shao, Donghui Yu, Gejing Deng, Kwangho Lee, Troy Lister, Colin P. Osborne, Akash Jain

المصدر: Journal of medicinal chemistry. 55(5)

مصطلحات موضوعية: Male, Models, Molecular, Toxic megacolon, Staphylococcus aureus, medicine.drug_class, Streptococcus pyogenes, Antibiotics, Microbial Sensitivity Tests, Biology, Peptide Elongation Factor Tu, Crystallography, X-Ray, Microbiology, Rats, Sprague-Dawley, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Clostridium, Pharmacokinetics, Cricetinae, Drug Discovery, medicine, Animals, Enterocolitis, Pseudomembranous, Natural product, Mesocricetus, Molecular Structure, Clostridioides difficile, Escherichia coli Proteins, Water, Clostridium difficile, medicine.disease, biology.organism_classification, Anti-Bacterial Agents, Rats, Diarrhea, Thiazoles, chemistry, Solubility, Molecular Medicine, Female, medicine.symptom, Antibacterial activity, Enterococcus

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384c1bda3979597c478a8efdea5840cb
https://pubmed.ncbi.nlm.nih.gov/22315981

المؤلفون: Henry F. Chambers, C J Hackbarth, Meena Sachdeva

المصدر: Biochemical Journal. 301:139-144

مصطلحات موضوعية: Staphylococcus aureus, Penicillin binding proteins, Penicillin Resistance, Penicillins, Muramoylpentapeptide Carboxypeptidase, medicine.disease_cause, Binding, Competitive, Biochemistry, Microbiology, Muramoylpentapeptide carboxypeptidase, Antibiotic resistance, Bacterial Proteins, polycyclic compounds, medicine, Penicillin-Binding Proteins, Molecular Biology, Antibacterial agent, biology, Membrane Proteins, Cell Biology, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, Penicillin, Kinetics, Hexosyltransferases, Peptidyl Transferases, bacteria, Penicillin binding, Carrier Proteins, Bacteria, Research Article, Protein Binding, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0418e114d1eb5929d3cb8eaad208045
https://doi.org/10.1042/bj3010139

المؤلفون: Jennifer A. Leeds, Eric Gangl, Georg Neckermann, Jason T. Brewer, Julie Goldovitz, JoAnne Dzink-Fox, Bushell Simon, Akash Jain, Stacey Tiamfook, Deborah Palestrant, Michael A. Patane, Lewis Whitehead, Elin M. Rann, Steve Mullin, Colin Osborne, Matthew J. LaMarche, Kerri Amaral, Janetta Dewhurst, Jian Shao, Donghui Yu, Meena Sachdeva

المصدر: Journal of medicinal chemistry. 54(23)

مصطلحات موضوعية: Male, Models, Molecular, Carboxylic Acids, Molecular Conformation, Stereoisomerism, Microbial Sensitivity Tests, Crystallography, X-Ray, Gram-Positive Bacteria, Peptides, Cyclic, Rats, Sprague-Dawley, chemistry.chemical_compound, Mice, Structure-Activity Relationship, In vivo, Amide, Sepsis, Drug Discovery, Drug Resistance, Bacterial, Organic chemistry, Structure–activity relationship, Animals, Solubility, Gram-Positive Bacterial Infections, Natural product, Chemistry, Combinatorial chemistry, Anti-Bacterial Agents, Rats, Thiazoles, Area Under Curve, Mutation, Molecular Medicine, Chemical stability, Female, Antibacterial activity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::917eae7075592660485c48aaf879a366
https://pubmed.ncbi.nlm.nih.gov/21999529

المؤلفون: JoAnn Dzink-Fox, Deborah Palestrant, Akash Jain, Bushell Simon, Meena Sachdeva, Jason T. Brewer, Stacey Tiamfook, Maria-Dawn Lilly, Eric Gangl, Lewis Whitehead, Alejandra Raimondi, Srijan Ranjitkar, Michael A. Patane, Matthew J. LaMarche, Steve Mullin, Elin M. Rann, Lac Lee, Georg Neckermann, Kari Manni, Jennifer A. Leeds, Janetta Dewhurst, Jian Shao, Colin Osborne, Donghui Yu, Gejing Deng

المصدر: Antimicrobial agents and chemotherapy. 55(11)

مصطلحات موضوعية: Methicillin-Resistant Staphylococcus aureus, medicine.drug_class, Cell Survival, Antibiotics, Mutant, Microbial Sensitivity Tests, Biology, Peptide Elongation Factor Tu, medicine.disease_cause, Staphylococcal infections, Peptides, Cyclic, Microbiology, Cell Line, chemistry.chemical_compound, Mice, Aminothiazole, In vivo, medicine, Animals, Humans, Pharmacology (medical), Experimental Therapeutics, Pharmacology, Molecular Structure, Hep G2 Cells, Staphylococcal Infections, medicine.disease, Methicillin-resistant Staphylococcus aureus, In vitro, Anti-Bacterial Agents, Thiazoles, Infectious Diseases, chemistry, Staphylococcus aureus, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dacc6276d0efb008e92187e85d6546f5
https://pubmed.ncbi.nlm.nih.gov/21825297

المؤلفون: Keith W. Miller, Katie J. Simmons, Jennifer A. Leeds, Colin W. G. Fishwick, Simon G. Patching, Ian Chopra, Meena Sachdeva, Joe De Los Angeles, Colin J. Dunsmore, Peter J. F. Henderson, William J. Stubbings, Katy L. Blake

المصدر: The Journal of antimicrobial chemotherapy. 65(12)

مصطلحات موضوعية: Microbiology (medical), Staphylococcus aureus, Microbial Sensitivity Tests, Peptidoglycan, Biology, medicine.disease_cause, chemistry.chemical_compound, Lactones, Structure-Activity Relationship, Mura, Bacterial Proteins, medicine, Escherichia coli, Transferase, Humans, Pharmacology (medical), Enzyme Inhibitors, Mode of action, Pharmacology, chemistry.chemical_classification, Alkyl and Aryl Transferases, Anti-Bacterial Agents, High-Throughput Screening Assays, Infectious Diseases, Enzyme, chemistry, Biochemistry, Docking (molecular), Cysteine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cecfa9ad5118ed6ca04c1e713dfdaa6
https://pubmed.ncbi.nlm.nih.gov/20861142

المؤلفون: Hansruedi Loetscher, Martin G. Täuber, Werner Lesslauer, Stephen L. Kennedy, Meena Sachdeva

المصدر: Journal of Infectious Diseases. 166:1045-1050

مصطلحات موضوعية: Cell Line, Meningitis, Bacterial, Proinflammatory cytokine, Cerebrospinal fluid, Escherichia coli, medicine, Animals, Immunology and Allergy, Receptor, Cytotoxicity, Cerebrospinal Fluid, Neurons, Cell Death, L-Lactate Dehydrogenase, Meningitis, Pneumococcal, Tumor Necrosis Factor-alpha, business.industry, medicine.disease, Recombinant Proteins, Pneumococcal infections, Streptococcus pneumoniae, Infectious Diseases, Toxicity, Immunology, Tumor necrosis factor alpha, Rabbits, business, Meningitis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45828adae838a0a63d7799fcdc0aa51e
https://doi.org/10.1093/infdis/166.5.1045

المؤلفون: Henry F. Chambers, Steve Kennedy, Meena Sachdeva

المصدر: Journal of Infectious Diseases. 162:705-710

مصطلحات موضوعية: Staphylococcus aureus, Imipenem, Penicillin binding proteins, medicine.drug_class, Penicillin Resistance, Antibiotics, Muramoylpentapeptide Carboxypeptidase, medicine.disease_cause, Microbiology, Nafcillin, Methicillin, Bacterial Proteins, Multienzyme Complexes, Ampicillin, polycyclic compounds, medicine, Animals, Penicillin-Binding Proteins, Ticarcillin, Immunology and Allergy, Chemistry, Endocarditis, Bacterial, Sulbactam, Staphylococcal Infections, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, Methicillin-resistant Staphylococcus aureus, Anti-Bacterial Agents, Disease Models, Animal, Infectious Diseases, Hexosyltransferases, Peptidyl Transferases, Rabbits, Carrier Proteins, Acyltransferases, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c128b4a7a2e2dbbca714e58c122ae7
https://doi.org/10.1093/infdis/162.3.705

المؤلفون: Henry F. Chambers, Meena Sachdeva

المصدر: Journal of Infectious Diseases. 161:1170-1176

مصطلحات موضوعية: Staphylococcus aureus, Penicillin binding proteins, medicine.drug_class, Penicillin Resistance, Antibiotics, Microbial Sensitivity Tests, Muramoylpentapeptide Carboxypeptidase, medicine.disease_cause, Binding, Competitive, Microbiology, Methicillin, chemistry.chemical_compound, Bacterial Proteins, polycyclic compounds, medicine, Penicillin-Binding Proteins, Immunology and Allergy, Least-Squares Analysis, Staphylococcus aureus delta toxin, Strain (chemistry), biology, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, Methicillin-resistant Staphylococcus aureus, Anti-Bacterial Agents, Infectious Diseases, Hexosyltransferases, chemistry, Peptidyl Transferases, Regression Analysis, bacteria, Growth inhibition, Carrier Proteins, Bacteria, Densitometry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b85c442098aa2415105ef2f3cf96b1a1
https://doi.org/10.1093/infdis/161.6.1170

المؤلفون: Brian Storrie, Robert R Pool, Meena Sachdeva, Karen M Maurey, Constance Oliver

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/97/28/J_Cell_Biol_1984_Jan_1_98(1)_108-115.tar.gz

وصف الملف: application/zip

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.280.4484

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.280.4484

المؤلفون: C J Hackbarth, Meena Sachdeva, Y W Francis Lam, Joan Kapusnik-Uner, John G. Gambertoglio, Merle A. Sande

المصدر: Clinical pharmacology and therapeutics. 47(5)

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, medicine.drug_class, Urology, Renal function, Urine, Glycopeptide antibiotic, Kidney, chemistry.chemical_compound, Pharmacokinetics, Internal medicine, medicine, Humans, Pharmacology (medical), Infusions, Intravenous, Antibacterial agent, Pharmacology, Creatinine, Teicoplanin, business.industry, Glycopeptides, Middle Aged, Glycopeptide, Anti-Bacterial Agents, Endocrinology, chemistry, Kidney Diseases, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79bde76ca101cba3acac64506b3c3485
https://pubmed.ncbi.nlm.nih.gov/2140543

المؤلفون: Ronald J. Dworkin, Jay H. Tureen, Merle A. Sande, Stephen L. Kennedy, Meena Sachdeva

المصدر: The Journal of clinical investigation. 85(2)

مصطلحات موضوعية: Intracranial Pressure, business.industry, Blood Pressure, General Medicine, Carbon Dioxide, medicine.disease, Cerebral circulation, Blood pressure, Cerebral blood flow, Anesthesia, Cerebrovascular Circulation, Streptococcal Infections, Medicine, Animals, Homeostasis, Autoregulation, Meningitis, Rabbits, Cerebral perfusion pressure, business, Intracranial pressure, circulatory and respiratory physiology, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ebc57f428d5972bb116c82bcc09820
https://pubmed.ncbi.nlm.nih.gov/2105342