المؤلفون: Montes-de-Oca-García, Adrián, Perez-Bey, Alejandro, Velázquez-Díaz, Daniel, Corral-Pérez, Juan, Opazo-Díaz, Edgardo, Rebollo-Ramos, María, Gómez-Gallego, Félix, Cuenca-García, Magdalena, Casals, Cristina, Ponce-González, Jesús G.

المساهمون: Montes-de-Oca-García,A, Velázquez-Díaz,D, Corral-Pérez,J, Opazo-Díaz,E, Rebollo-Ramos,M, Casals,C, Ponce-González,JG MOVE-IT Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cadiz, Puerto Real, Spain. Montes-de-Oca-García,A, Perez-Bey,A, Cuenca-García,M, Ponce-González,JG Instituto de Investigación Biomédica de Cádiz (INiBICA), Hospital Uniersitario Puerta del Mar, Universidad de Cádiz, Cádiz, Spain. Perez-Bey,A, Cuenca-García,M GALENO Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cadiz, Puerto Real, Spain. Opazo-Díaz,E Department of Physical Therapy, Faculty of Medicine, University of Chile, Santiago, Chile. Gómez-Gallego,F Faculty of Health Sciences, International University of La Rioja, Logroño, Spain., This work was supported by the University of Cadiz Research Program under Grant PR2016-041 and PR2016-051.

مصطلحات موضوعية: Genetic association studies, Heart diseases, Lipid metabolism, Healthy lifestyle, Angiotensin-converting enzyme, Obesity, Estudios de asociación genética, Cardiopatías, Metabolismo de los lípidos, Estilo de vida saludable, Peptidil-Dipeptidasa A, Obesidad, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies, Medical Subject Headings::Anthropology, Education, Sociology and Social Phenomena::Human Activities::Exercise, Medical Subject Headings::Check Tags::Female, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Check Tags::Male, Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Exopeptidases::Dipeptidyl-Peptidases and Tripeptidyl-Peptidases::Peptidyl-Dipeptidase A, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic, Medical Subject Headings::Persons::Persons::Age Groups::Adult::Young Adult, Medical Subject Headings::Diseases::Cardiovascular Diseases::Heart Diseases, Medical Subject Headings::Diseases::Cardiovascular Diseases, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Genetic Association Studies, Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Lipid Metabolism, Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity

وصف الملف: application/pdf

Relation: https://www.mdpi.com/1660-4601/18/7/3443/htm; Montes-de-Oca-García A, Perez-Bey A, Velázquez-Díaz D, Corral-Pérez J, Opazo-Díaz E, Rebollo-Ramos M, et al. Influence of ACE Gene I/D Polymorphism on Cardiometabolic Risk, Maximal Fat Oxidation, Cardiorespiratory Fitness, Diet and Physical Activity in Young Adults. Int J Environ Res Public Health. 2021 Mar 26;18(7):3443; http://hdl.handle.net/10668/4471; PMC8036598

الاتاحة: http://hdl.handle.net/10668/4471
https://doi.org/10.3390/ijerph18073443

المؤلفون: Escudero-Contreras, Alejandro, López-Medina, Clementina, Collantes-Estévez, Eduardo, Ortega-Castro, Rafaela, Calvo-Gutiérrez, Jerusalem, Mena-Vázquez, Natalia, Panero-Lamothe, Blanca, Manzanares-Martín, Bárbara, Cáliz-Cáliz, Rafael, Jiménez-Morales, Alberto, Ruiz-Jiménez, Mayte, Font-Ugalde, Pilar

المساهمون: Escudero-Contreras,A, López-Medina,C, Collantes-Estévez,E, Ortega-Castro,R, Calvo-Gutiérrez,J, Font-Ugalde,P Rheumatology Department, Reina Sofia University Hospital, Cordoba, Spain. Escudero-Contreras,A, Manzanares-Martín,B, Font-Ugalde,P Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Cordoba, Spain. Escudero-Contreras,A, Font-Ugalde,P Medical and Surgical Sciences Department, University of Cordoba, Cordoba, Spain. Mena-Vázquez,N, Panero-Lamothe,B Institute of Biomedical Research from Malaga (IBIMA), Malaga, Spain. Mena-Vázquez,N, Panero-Lamothe,B Rheumatology Department, Regional University Hospital from Malaga, Malaga, Spain. Manzanares-Martín,B Immunology and Allergology Department, Reina Sofia University Hospital, Cordoba, Spain. Cáliz-Cáliz,R Rheumatology Department, Virgen de las Nieves University Hospital, Granada, Spain. Jiménez-Morales,A Pharmacy Department, Virgen de las Nieves University Hospital, Granada, Spain. Ruiz-Jiménez,M Medical Science Liaison Roche, Roche Farma, Madrid, Spain., This study was funded by an unrestricted grant from Roche Pharma and supported by “Red Andaluza para la Investigación de Enfermedades Reumáticas (RAIER)”.

مصطلحات موضوعية: Methotrexate, Rheumatoid arthritis, Genetics, Biomarkers, Metotrexato, Artritis reumatoide, Genética, Biomarcadores, Polimorfismo genético, Genetic polymorphisms, Genotype, Genotipo, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Pteridines::Pterins::Aminopterin::Methotrexate, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies::Retrospective Studies, Medical Subject Headings::Geographical Locations::Geographic Locations::Europe::Spain, Medical Subject Headings::Diseases::Musculoskeletal Diseases::Rheumatic Diseases::Arthritis, Rheumatoid, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype, Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleotides, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Clinical Trials as Topic::Multicenter Studies as Topic

وصف الملف: application/pdf

Relation: https://www.mdpi.com/2077-0383/10/18/4070/htm; Escudero-Contreras A, López-Medina C, Collantes-Estévez E, Ortega-Castro R, Calvo-Gutiérrez J, Mena-Vázquez N, et al. Genetic Polymorphisms of GGH and ABCC2 Are Associated with Methotrexate Intolerance in Patients with Rheumatoid Arthritis. J Clin Med. 2021 Sep 9;10(18):4070; http://hdl.handle.net/10668/3959; PMC8472669

الاتاحة: http://hdl.handle.net/10668/3959
https://doi.org/10.3390/jcm10184070

المؤلفون: Casares-Jimenez, Maria, Lopez-Lopez, Pedro, Caballero-Gomez, Javier, Frias, Mario, Perez-Hernando, Belen, Sunday Oluremi, Adeolu, Risalde, Maria A., Ruiz-Caceres, Inmaculada, Oladele Opaleye, Oluyinka, Garcia-Bocanegra, Ignacio, Rivero-Juarez, Antonio, Rivero, Antonio

المساهمون: Casares-Jimenez,M, Lopez-Lopez,P, Caballero-Gomez,J, Frias,M, Perez-Hernando,B, Sunday Oluremi,A, Risalde,MA, Ruiz-Caceres,I, Rivero-Juarez,A, Rivero,A Unidad de Enfermedades Infecciosas, Grupo de Virología Clínica y Zoonosis, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Reina Sofía, Universidad de Córdoba (UCO), Córdoba, Spain. Caballero-Gomez,J, Garcia-Bocanegra,I Grupo de Investigación en Sanidad Animal y Zoonosis (GISAZ), Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad de Córdoba (UCO), Córdoba, Spain. Sunday Oluremi,A, Oladele Opaleye,O Department of Medical Microbiology and Parasitology, Ladoke Akintola University of Technology, Ogbomoso, Nigeria. Risalde,MA Grupo de Investigación en Sanidad Animal y Zoonosis (GISAZ), Departamento de Anatomía y Anatomía Patológica Comparadas y Toxicología, Facultad de Veterinaria, Universidad de Córdoba (UCO), Córdoba, Spain., This work was supported by the Ministerio de Sanidad (RD12/0017/0012) integrated in the Plan Nacional de I + D + I and cofinanced by the ISCIII-Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER), Fundación para la Investigación en Salud (FIS) del Instituto Carlos III (PI19/00864). ARJ is the recipient of a Miguel Servet Research Contract by the Ministerio de Ciencia, Promoción y Universidades of Spain (CP18/00111). MF is the recipient of a Sara Borrell contract by the Ministerio de Ciencia, Promoción y Universidades of Spain (CD18/00091). JCG is supported by an FPU grant from the Spanish Ministry of Education, Culture and Sport (FPU17/01319). AR is the beneficiary of Contratos para la intensificación de la actividad investigadora en el Sistema Nacional de Salud by the Ministerio de Ciencia, Promoción y Universidades of Spain (INT20-00028). The funders did not play any role in the design, conclusions, or interpretation of the study.

مصطلحات موضوعية: Hepatitis E virus, Wild boar, Pig, Genotype, Prevalence, One health, Virus de la hepatitis E, Sus scrofa, Cerdo doméstico, Genotipo, Prevalencia, Salud única, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Organisms::Eukaryota::Animals, Medical Subject Headings::Organisms::Viruses::Hepatitis Viruses::Hepatitis E virus, Medical Subject Headings::Geographical Locations::Geographic Locations::Antarctic Regions, Medical Subject Headings::Information Science::Information Science::Medical Informatics::Medical Informatics Applications::Information Systems::Databases as Topic::Databases, Factual::Databases, Chemical::Databases, Nucleic Acid, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Artiodactyla::Swine::Sus scrofa, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype, Medical Subject Headings::Geographical Locations::Geographic Locations::Asia, Medical Subject Headings::Information Science::Information Science::Data Collection::Vital Statistics::Morbidity::Prevalence

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Relation: https://www.sciencedirect.com/science/article/pii/S235277142100094X?via%3Dihub; Casares-Jimenez M, Lopez-Lopez P, Caballero-Gomez J, Frias M, Perez-Hernando B, Oluremi AS, et al. Global molecular diversity of Hepatitis E virus in wild boar and domestic pig. One Health. 2021 Aug 9;13:100304; http://hdl.handle.net/10668/4451; PMC8385159

الاتاحة: http://hdl.handle.net/10668/4451
https://doi.org/10.1016/j.onehlt.2021.100304

المؤلفون: Gámbaro, Fabiana, Pérez, Ana Belén, Agüera, Eduardo, Prot, Matthieu, Martínez-Martínez, Luis, Cabrerizo, María, Simon-Loriere, Etienne, Fernandez-Garcia, Maria Dolores

المساهمون: Gámbaro,F, Prot,M, Simon-Loriere,E Institut Pasteur, Paris, France. Pérez,AB, Agüera,E, Martínez-Martínez,L Hospital Universitario Reina Sofía, Córdoba, Spain. Pérez,AB, Martínez-Martínez,L, Fernandez-Garcia,MD Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain. Martínez-Martínez,L Universidad de Córdoba, Córdoba, Spain. Cabrerizo,M National Centre for Microbiology, Instituto de Salud Carlos III, Madrid, Spain. Cabrerizo,M CIBER de epidemiología y Salud Pública (CIBERESP), Madrid, Spain. Cabrerizo,M Red de Investigación Translacional en Infectología Pediátrica (RITIP), IdiPaz, Madrid, Spain., This work was funded by the Junta de Andalucía, Consejería de Salud y Familias (Project number PI-0216-2019) and by the Acción Estratégica en Salud Intramural (Project number PI20CIII/00005). MD Fernandez-Garcia received a Miguel Servet Research Contract (CP18/00067) from the Strategic Action in Health 2018 and funded by National Institute of Health Carlos III (ISCIII). ESL acknowledges funding from the INCEPTION programme (Investissements d’Avenir grant ANR-16-CONV-0005).

مصطلحات موضوعية: Genomics, Enterovirus, Meningitis, Spain, RNA, Genómica, España, ARN, Medical Subject Headings::Persons::Persons::Age Groups::Adolescent, Medical Subject Headings::Persons::Persons::Age Groups::Adult, Medical Subject Headings::Organisms::Viruses::RNA Viruses::Picornaviridae::Enterovirus::Enterovirus B, Human, Medical Subject Headings::Diseases::Virus Diseases::RNA Virus Infections::Picornaviridae Infections::Enterovirus Infections, Medical Subject Headings::Check Tags::Female, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Check Tags::Male, Medical Subject Headings::Diseases::Nervous System Diseases::Central Nervous System Diseases::Central Nervous System Infections::Meningitis::Meningitis, Aseptic, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phylogeny, Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Viral, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Sequence Analysis::Sequence Analysis, DNA, Medical Subject Headings::Geographical Locations::Geographic Locations::Europe::Spain, Medical Subject Headings::Persons::Persons::Age Groups::Adult::Young Adult, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome

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Relation: https://www.nature.com/articles/s41598-021-01053-4; Gámbaro F, Pérez AB, Agüera E, Prot M, Martínez-Martínez L, Cabrerizo M, et al. Genomic surveillance of enterovirus associated with aseptic meningitis cases in southern Spain, 2015-2018. Sci Rep. 2021 Nov 2;11(1):21523; http://hdl.handle.net/10668/3781; PMC8564535

الاتاحة: http://hdl.handle.net/10668/3781
https://doi.org/10.1038/s41598-021-01053-4

المؤلفون: Pozo-Agundo, Ana, Villaescusa, Nerea, Martorell-Marugán, Jordi, Soriano, Olga, Leyva, Socorro, Jódar-Reyes, Ana Belén, Botella, Luisa María, Carmona-Sáez, Pedro, Blanco, Francisco Javier

المساهمون: Pozo-Agundo,A, Villaescusa,N, Soriano,O, Blanco,FJ Department of Biochemistry and Molecular Biology (III) and Inmunology, School of Medicine, University of Granada, Granada, Spain. Pozo-Agundo,A, Blanco,FJ Centre for Biomedical Research, Biopathology and Regenerative Medicine Institute (IBIMER), University of Granada, Granada, Spain. Martorell-Marugán,J, Carmona-Sáez,P Bioinformatics Unit, Pfizer, Andalusian Government Centre of Genomics and Oncological Research (GENYO), University of Granada, Granada, Spain. Martorell-Marugán,J, Carmona-Sáez,P Department of Statistics and OR, University of Granada, Granada, Spain. Leyva,S San Cecilio Clinic Universitary Hospital, Granada, Spain. Jódar-Reyes,AB Biocolloid and Fluid Physics Group, Excellence Research Unit Modeling Nature (MNat), Department of Applied Physics, School of Sciences, University of Granada, Granada, Spain. Botella,LM Department of Molecular Biomedicine, Centro de Investigaciones Biológicas (CSIC), Madrid, Spain. Botella,LM Centro de Investigación Biomédica en Red, CIBERER, Instituto de Salud Carlos III, Madrid, Spain., This work was funded by the Spanish Program for Young Investigators of the Ministerio de Economía y Competitividad and Fondo Europeo de Desarrollo Regional (grant number SAF2015-74313JIN, MINECO/FEDER, UE) to FJB, and “Programa Operativo FEDER 2014–2020 and Consejería de Economía y Conocimiento de la Junta de Andalucía” (grant number B1-FQM-112-UGR18) to ABJR

مصطلحات موضوعية: Hereditary hemorrhagic telangiectasia, Liquid biopsy, Exosomes, MiRNAs, Arteriovenous malformations, Telangiectasia hemorrágica hereditaria, Biopsia líquida, Exosomas, MicroARNs, Malformaciones arteriovenosas, Medical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Antigens, Surface::Antigens, Differentiation::Antigens, CD, Medical Subject Headings::Diseases::Cardiovascular Diseases::Vascular Diseases::Arteriovenous Malformations, Medical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies, Medical Subject Headings::Anatomy::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Cytoplasmic Vesicles::Transport Vesicles::Exosomes, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Gene Expression Profiling, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Antisense Elements (Genetics)::RNA, Antisense::MicroRNAs, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation

وصف الملف: application/pdf; application/vnd.openxmlformats-officedocument.spreadsheetml.sheet

Relation: https://www.mdpi.com/1422-0067/22/17/9450/htm; Pozo-Agundo A, Villaescusa N, Martorell-Marugán J, Soriano O, Leyva S, Jódar-Reyes AB, et al. Identification of Exosomal MicroRNA Signature by Liquid Biopsy in Hereditary Hemorrhagic Telangiectasia Patients. Int J Mol Sci. 2021 Aug 31;22(17):9450; http://hdl.handle.net/10668/3979; PMC8431573

الاتاحة: http://hdl.handle.net/10668/3979
https://doi.org/10.3390/ijms22179450

المؤلفون: Rian, Kinza, Hidalgo, Marta R., Çubuk, Cankut, Falco, Matias M., Loucera, Carlos, Esteban-Medina, Marina, Alamo-Alvarez, Inmaculada, Peña-Chilet, María, Dopazo, Joaquín

المساهمون: Rian,K, Çubuk,C, Falco,MM, Loucera,C, Esteban-Medina,M, Alamo-Alvarez,I, Peña-Chilet,M, Dopazo,J Clinical Bioinformatics Area, Fundación Progreso y Salud (FPS), Hospital Virgen del Rocío, Sevilla, Spain. Rian,K Laboratory of Innovative Technologies (LTI), National School of Applied Sciences in Tangier, UAE, Morocco. Hidalgo,MR Bioinformatics and Biostatistics Unit, Centro de Investigación Príncipe Felipe (CIPF), Valencia, Spain. Falco,MM, Dopazo,J Bioinformatics in RareDiseases (BiER), Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Sevilla, Spain. Loucera,C, Dopazo,J Computational Systems Medicine. Institute of Biomedicine of Seville (IBiS), Sevilla, Spain. Dopazo,J Functional Genomics Node (INB-ELIXIR-es), Sevilla, Spain., This work is supported by grants SAF2017-88908-R from the Spanish Ministry of Economy and Competitiveness and PT17/0009/0006 and PI20/01305 from the ISCIII, both co-funded with European Regional Development Funds (ERDF) as well as H2020 Programme of the European Union grants Marie Curie Inno vative Training Network ‘‘Machine Learning Frontiers in Precision Medicine” (MLFPM) (GA 813533) and ‘‘ELIXIR-EXCELERATE fast track ELIXIR implementation and drive early user exploitation across the life sciences” (GA 676559) to JD. Funding for open access charge: from the Spanish Ministry of Economy and Competitive ness / SAF2017-88908-R

مصطلحات موضوعية: Signaling pathway, Mathematical modelling, Transcriptomic, Causality, Mutations, Sistema de señalización, Causalidad, Mutación, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression::Transcription, Genetic::Transcriptome, Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::Genomics, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotype, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation, Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Signal Transduction, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype

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Relation: https://www.sciencedirect.com/science/article/pii/S2001037021002038; Rian K, Hidalgo MR, Çubuk C, Falco MM, Loucera C, Esteban-Medina M, et al. Genome-scale mechanistic modeling of signaling pathways made easy: A bioconductor/cytoscape/web server framework for the analysis of omic data. Comput Struct Biotechnol J. 2021 May 15;19:2968-2978; http://hdl.handle.net/10668/3908; PMC8170118

الاتاحة: http://hdl.handle.net/10668/3908
https://doi.org/10.1016/j.csbj.2021.05.022

المؤلفون: Cañibano-Hernández, Alberto, Valdes-Sanchez, Lourdes, Garcia-Delgado, Ana B., Ponte-Zúñiga, Beatriz, Diaz-Corrales, Francisco J., de la Cerda, Berta

المساهمون: Cañibano-Hernández,A, Valdes-Sanchez,L, Garcia-Delgado,AB, Diaz-Corrales,FJ, de la Cerda,B Department of Regeneration and Cell Therapy, Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER), Seville, Spain. Ponte-Zúñiga,B University Hospital Virgen Macarena, RETICS Oftared, Carlos III Institute of Health (Spain), Ministry of Health RD16/0008/0010, Seville, Spain., This work was supported by Andalusian Ministry of Health, Equality and Social Policies (PI-0099-2018).

مصطلحات موضوعية: Retinal dystrophies, Mutations, Macular dystrophy, Cell line, CRB1 gene, Genotype, Distrofias retinianas, Mutación, Degeneración macular, Línea celular, Genotipo, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation, and Proteins::Proteins::Nerve Tissue Proteins, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Pedigree, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotype, Medical Subject Headings::Anatomy::Cells::Stem Cells::Pluripotent Stem Cells::Induced Pluripotent Stem Cells, Medical Subject Headings::Diseases::Eye Diseases::Retinal Diseases::Retinal Degeneration::Macular Degeneration, Medical Subject Headings::Diseases::Eye Diseases::Retinal Diseases::Retinal Degeneration::Retinal Dystrophies, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Alleles, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype, Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line, and Proteins::Proteins::Eye Proteins

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Relation: https://www.sciencedirect.com/science/article/pii/S1873506121001471; Cañibano-Hernández A, Valdes-Sanchez L, Garcia-Delgado AB, Ponte-Zúñiga B, Diaz-Corrales FJ, de la Cerda B. Generation of the human iPSC line ESi082-A from a patient with macular dystrophy associated to mutations in the CRB1 gene. Stem Cell Res. 2021 May;53:102301.; http://hdl.handle.net/10668/4158

الاتاحة: http://hdl.handle.net/10668/4158
https://doi.org/10.1016/j.scr.2021.102301

المؤلفون: Boughanem, Hatim, Bandera-Merchán, Borja, Hernández-Alonso, Pablo, Moreno-Morales, Noelia, Tinahones, Francisco José, Lozano, José, Morcillo, Sonsoles, Macias-Gonzalez, Manuel

المساهمون: Boughanem,H Instituto de Investigación Biomédica de Málaga (IBIMA), Facultad de Ciencias, Universidad de Málaga, Málaga, Spain. Bandera-Merchán,B, Hernández-Alonso,P, Tinahones,FJ, Morcillo,S, Macias-Gonzalez,M Unidad de Gestión Clínica de Endocrinología y Nutrición del Hospital Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Málaga, Spain. Hernández-Alonso,P, Macias-Gonzalez,M Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición, CIBERObn, Madrid, Spain. Hernández-Alonso,P Human Nutrition Unit, Faculty of Medicine and Health Sciences, Sant Joan Hospital, Institut d’Investigació Sanitària Pere Virgili, Rovira i Virgili University, Reus, Spain. Moreno-Morales,N Department of Physiotherapy, School of Health Sciences, University of Malaga-Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain. Lozano,J Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias, Universidad de Málaga, Málaga, Spain., This study was supported by the “Centros de Investigación En Red” (CIBER, CB06/03/0018) of the “Instituto de Salud Carlos III” (ISCIII) and grants from ISCIII (PI18/01399, PI15/01350), grants from the Ministry of Economy and Competitiveness (SAF2010-20203) and co-financed by the European Regional Development Fund (FEDER). MMG was the recipient of the Nicolas Monardes Programme from the “Servicio Andaluz de Salud, Junta de Andalucia”, Spain (RC-0001-2018 and C-0029-2023). PHA is supported by a postdoctoral fellowship (Juan de la Cierva-Formación, FJCI-2017-32205). S.M. was the recipient of the Nicolas Monardes Program from the “Servicio Andaluz de Salud, Junta de Andalucía”, Spain (C-0050-2017).

مصطلحات موضوعية: rs3813627, APOA1, APOA2, HDL, BMI, SNP, Body mass index, Genotype, Single nucleotide polymorphism, High density lipoprotein, Apolipoprotein type 1, Apolipoprotein type 2, Índice de masa corporal, Genotipo, Polimorfismo de nucleótido simple, Lipoproteínas HDL, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Anthropometry::Body Weights and Measures::Body Mass Index, Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weight::Overweight, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Odds Ratio, Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Computational Biology, Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Motivation::Goals, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype, Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides

وصف الملف: application/pdf

Relation: https://www.mdpi.com/2227-9059/8/3/44/htm; Boughanem H, Bandera-Merchán B, Hernández-Alonso P, Moreno-Morales N, Tinahones FJ, Lozano J, et al. Association between the APOA2 rs3813627 Single Nucleotide Polymorphism and HDL and APOA1 Levels Through BMI. Biomedicines. 2020 Feb 27;8(3):44; http://hdl.handle.net/10668/4167; PMC7148512

الاتاحة: http://hdl.handle.net/10668/4167
https://doi.org/10.3390/biomedicines8030044

المؤلفون: De-Ugarte, Laura, Caro-Molina, Enrique, Rodríguez-Sanz, Maria, García-Pérez, Miguel Angel, Olmos, José M, Sosa-Henríquez, Manuel, Pérez-Cano, Ramón, Gómez-Alonso, Carlos, Del Rio, Luis, Mateo-Agudo, Jesús, Blázquez-Cabrera, José Antonio, González-Macías, Jesús, Del Pino-Montes, Javier, Muñoz-Torres, Manuel, Diaz-Curiel, Manuel, Malouf, Jorge, Cano, Antonio, Pérez-Castrillon, José Luis, Nogues, Xavier, Garcia-Giralt, Natalia, Diez-Perez, Adolfo

المساهمون: De-Ugarte,L, Caro-Molina,E, Rodríguez-Sanz,M, Nogues,X, Garcia-Giralt,N, Diez-Perez,A IMIM (Hospital del Mar Medical Research Institute), Universitat Autònoma de Barcelona, CIBERFES, RETICEF (ISCIII), Barcelona, Spain. García-Pérez,MA Department of Genetics and Institute of Health Research INCLIVA, University of Valencia, Valencia, Spain. Olmos,JM Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla-IDIVAL/Hospital de Torrelavega, Universidad de Cantabria. RETICEF, Santander, Spain. Sosa-Henríquez,M Unidad Metabólica Ósea, Hospital Universitario Insular, Universidad de Las Palmas de Gran Canaria, Canarias, Spain. Pérez-Cano,R Departamento de Medicina (USE), UGC Medicina Interna, Hospital Universitario Virgen Macarena, Seville, Spain. Gómez-Alonso,C Servicio de Metabolismo Óseo y Mineral, Hospital Universitario Central de Asturias, Oviedo, Spain. Del Rio,L CETIR Grup Mèdic, RETICEF, Barcelona, Spain. Mateo-Agudo,J Servicio COT, Hospital Universitario Miguel Servet, Zaragoza, Spain. Blázquez-Cabrera,JA Servicio de Medicina Interna, Complejo Hospitalario Universitario de Albacete, Albacete, Spain. González-Macías,J Departamento de Medicina Interna, H. Marqués de Valdecilla, Universidad de Cantabria, IDIVAL, RETICEF, Santander, Spain. del Pino-Montes,J Servicio de Reumatología. Hospital Universitario de Salamanca, RETICEF (ISCIII), IBSAL (Biomedical Research Institute of Salamanca), Salamanca, Spain. Muñoz-Torres,M UGC Endocrinologia y Nutrición. Hospital Universitario San Cecilio. Granada, RETICEF, Ibs, Granada, Spain. Diaz-Curiel,M Unidad de Enfermedades Metabólicas Óseas. Servicio de Medicina Interna. Fundacion Jimenez Diaz, Madrid, Spain. Malouf,J Hospital de la Santa Creu I Sant Pau. Institut d’Investigació Biomèdica Sant Pau, Barcelona, Spain. Cano,A Department of Pediatrics, Obstetrics and Gynecology, University of Valencia, INCLIVA, Valencia, Spain. Pérez-Castrillon,JL Hospital Universitario Río Hortega, Valladolid, Spain., This work was supported by RETICEF (RD12/0043/0022), CIBERFES (CB16/10/00245) and the Grant FIS PI10/01537, PI12/02775, PI12/02582, and PI13/00116 (Carlos III Health Institute, Science and Innovation Ministry), FIS and Grants from the Generalitat de Catalunya (DIUE 2014 SGR 775), “664367/FOCUS” project (EU Health Programme, 2014–2020) and FEDER funds have supported this study.

مصطلحات موضوعية: Alelos, Densidad ósea, Enfermedades óseas, Cuello femoral, Fracturas de cadera, Genotipo, Humanos, MicroARNs, Osteoblastos, Fracturas osteoporóticas, Fenotipo, Polimorfismo de nucleótido simple, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Alleles, Medical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Bone Density, Medical Subject Headings::Diseases::Musculoskeletal Diseases::Bone Diseases, Cancellous Bone, Medical Subject Headings::Anatomy::Musculoskeletal System::Skeleton::Bone and Bones::Bones of Lower Extremity::Leg Bones::Femur::Femur Neck, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype, Medical Subject Headings::Diseases::Wounds and Injuries::Fractures, Bone::Hip Fractures, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Antisense Elements (Genetics)::RNA, Antisense::MicroRNAs, Medical Subject Headings::Anatomy::Cells::Connective Tissue Cells::Osteoblasts, Bone::Osteoporotic Fractures, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotype, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism

وصف الملف: application/pdf

Relation: https://www.nature.com/articles/s41598-017-00641-7; De-Ugarte L, Caro-Molina E, Rodríguez-Sanz M, García-Pérez MA, Olmos JM, Sosa-Henríquez M et al.SNPs in bone-related miRNAs are associated with the osteoporotic phenotype. Sci Rep. 2017 Mar 31;7(1):516.; http://hdl.handle.net/10668/2644; PMC5391928

الاتاحة: http://hdl.handle.net/10668/2644
https://doi.org/10.1038/s41598-017-00641-7

المؤلفون: Dávila-Fajardo, Cristina Lucía, Sánchez-Ramos, Jesús, Diaz- Villamarín, Xando, Martínez-González, Luis Javier, Toledo Frías, Pablo, Martínez Huertas, Susana, Burillo Gómez, Francisco, Caballero Borrego, Juan, Bautista Pavés, Alicia, Marín Guzmán, Mª Carmen, Ramirez Hernández, José Antonio, Correa Vilches, Concepción, Cabeza Barrera, Jose

المساهمون: Dávila-Fajardo,CL, Diaz- Villamarín,X, Ramirez Hernández,JA, Cabeza Barrera,J Department of Clinical Pharmacy, Granada University Hospital. Sánchez-Ramos,J, Toledo Frías,P, Martínez Huertas,S, Burillo Gómez,F, Caballero Borrego,J, Bautista Pavés,A, Marín Guzmán,MC, Correa Vilches,C Department of Cardiology, Granada University Hospital. Dávila-Fajardo,CL, Cabeza Barrera,J, Sánchez-Ramos,J, Correa Vilches,C Institute for Biomedical Research, ibs., Granada, Spain. Martínez-González,LJ Genomics Unit, Centre for Genomics and Oncological Research (GENYO), Pfizer-University of Granada-Andalusian Regional Government, Health Sciences Technology Park, Granada, Spain., This work was supported by Ministry of Health of Government of Andalusia, Grant number: PI-057/2012.

مصطلحات موضوعية: Clinical trial protocol, Protocolos clínicos, Formularios de consentimiento, Citocromos, Estudios de seguimiento, Genotipo, Hemorragia, Glicoproteínas p, Intervención coronaria percutánea, Tamaño de la muestra, Tomografía computarizada por rayos x, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Clinical Protocols, Medical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Data Collection::Records as Topic::Consent Forms, Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Cytochromes, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studies, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype, Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Hemorrhage, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::ATP-Binding Cassette Transporters::P-Glycoproteins, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Cardiovascular Surgical Procedures::Vascular Surgical Procedures::Endovascular Procedures::Percutaneous Coronary Intervention, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Sample Size, Diagnostic and Therapeutic Techniques and Equipment::Equipment and Supplies::Prostheses and Implants::Stents, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Tomography::Tomography

وصف الملف: application/pdf; application/msword

Relation: http://www.sciencedirect.com/science/article/pii/S2352340916307806; Dávila-Fajardo CL, Sánchez-Ramos J, Díaz Villamarín X, Martínez-González LJ, Toledo Frías P, Martínez Huertas S et al. The study protocol for a non-randomized controlled clinical trial using a genotype-guided strategy in a dataset of patients who undergone percutaneous coronary intervention with stent. Data Brief. 2017, Feb ;10:518-524; http://hdl.handle.net/10668/2611; PMC5199189

الاتاحة: http://hdl.handle.net/10668/2611
https://doi.org/10.1016/j.dib.2016.12.019

المؤلفون: López-Mejías, Raquel, Corrales, Alfonso, Vicente, Esther, Robustillo-Villarino, Montserrat, González-Juanatey, Carlos, Llorca, Javier, Genre, Fernanda, Remuzgo-Martínez, Sara, Dierssen-Sotos, Trinidad, Miranda-Filloy, José A, Ramírez Huaranga, Marco A, Pina, Trinitario, Blanco, Ricardo, Alegre-Sancho, Juan J, Raya, Enrique, Mijares, Verónica, Ubilla, Begoña, Ferraz-Amaro, Iván, Gómez-Vaquero, Carmen, Balsa, Alejandro, López-Longo, Francisco J, Carreira, Patricia, González-Álvaro, Isidoro, Ocejo-Vinyals, J Gonzalo, Rodríguez-Rodríguez, Luis, Fernández-Gutiérrez, Benjamín, Castañeda, Santos, Martín, Javier, González-Gay, Miguel A

المساهمون: López-Mejías,R, Corrales,A, Genre,F, Remuzgo-Martínez,S, Pina,T, Blanco,R, Mijares,V, Ubilla,B, González-Gay,MA Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Department, IDIVAL, Santander, Spain. Vicente,E, González-Álvaro,I, Castañeda,S Rheumatology Department, Hospital Universitario la Princesa, IIS-IP, Madrid, Spain. Robustillo-Villarino,M, Alegre-Sancho,JJ Rheumatology Department, Hospital Universitario Doctor Peset, Valencia, Spain. González-Juanatey,C Cardiology Department, Hospital Lucus Augusti, Lugo, Spain. Llorca,J, Dierssen-Sotos,T Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain. Miranda-Filloy,JA Division of Rheumatology, Hospital Universitario Lucus Augusti, Lugo, Spain. Ramírez Huaranga,MA Rheumatology Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain. Raya,E Rheumatology Department, Hospital Clínico San Cecilio, Granada, Spain. Ferraz-Amaro,I Rheumatology Division, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain. Gómez-Vaquero,C Department of Rheumatology, Hospital Universitario Bellvitge, Barcelona, Spain. Balsa,A Department of Rheumatology, Hospital Universitario La Paz, Madrid, Spain. López-Longo,FJ Department of Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain. Carreira,P Department of Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain. Ocejo-Vinyals,JG Immunology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain. Rodríguez-Rodríguez,L, Fernández-Gutiérrez,B Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain. Martín,J Instituto de Parasitología y Biomedicina ‘López-Neyra’, CSIC, PTS Granada, Granada, Spain. González-Gay,MA School of Medicine, University of Cantabria, Santander, Spain. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

مصطلحات موضوعية: Artritis reumatoide, Aterosclerosis, Enfermedades cardiovasculares, Grosor intima-media carotídeo, Enfermedad de la arteria coronaria, Genotipo, Humanos, Polimorfismo genético, Estados Unidos, Europa (Continente), Medical Subject Headings::Diseases::Musculoskeletal Diseases::Rheumatic Diseases::Arthritis, Rheumatoid, Medical Subject Headings::Diseases::Cardiovascular Diseases::Vascular Diseases::Arterial Occlusive Diseases::Arteriosclerosis::Atherosclerosis, Medical Subject Headings::Diseases::Cardiovascular Diseases, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Ultrasonography::Carotid Intima-Media Thickness, Medical Subject Headings::Diseases::Cardiovascular Diseases::Heart Diseases::Myocardial Ischemia::Coronary Disease::Coronary Artery Disease, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic, Medical Subject Headings::Geographical Locations::Geographic Locations::Americas::North America::United States, Medical Subject Headings::Geographical Locations::Geographic Locations::Europe

وصف الملف: application/pdf

Relation: http://www.nature.com/articles/srep40303#abstract; López-Mejías R, Corrales A, Vicente E, Robustillo-Villarino M, González-Juanatey C, Llorca J, et al. Influence of coronary artery disease and subcClinical atherosclerosis related polymorphisms on the risk of atherosclerosis in rheumatoid arthritis. Sci Rep. 2017; 7:40303; http://hdl.handle.net/10668/2632; PMC5216400

الاتاحة: http://hdl.handle.net/10668/2632
https://doi.org/10.1038/srep40303

المؤلفون: Moreno-Fernández, R D, Pérez-Martín, M, Castilla-Ortega, E, Rosell Del Valle, C, García-Fernández, M I, Chun, J, Estivill-Torrús, G, Rodríguez de Fonseca, F, Santín, L J, Pedraza, C

المساهمون: Moreno-Fernández ,RD, Rosell del Valle,C, Santín,LJ, Pedraza,C Departamento de Psicobiología y Metodología de las CC, Facultad de Psicología, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Málaga, Spain. Pérez-Martín,M Departamento de Biología Celular, Genética y Fisiología, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Málaga, Spain. Castilla-Ortega,E, Rodríguez de Fonseca,F Unidad de Gestión Clínica de Salud Mental, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Málaga, Spain. García-Fernández,MI Departamento de Fisiología y Medicina Deportiva, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Málaga, Spain. Chun,J Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA. Estivill-Torrús,G Unidad de Gestión Clínica de Neurociencias, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitarios de Málaga, Málaga, Spain., This research was funded by the Andalusian Ministry of Economy, Innovation, Science and Employment (SEJ1863 to CP and CTS-643 to GE-T) and of Health (Nicolas Monardes programme, to GE-T), the Spanish Ministry of Economy and Competitiveness (PSI2013-44901-P to LJS and CP). Author EC-O. holds a Sara Borrell’ research contract from the National System of Health, ISC-III (Grant Number: CD12/00455). Author RDM-F holds a Grant of the Spanish Ministry of Education, Culture and Sports (FPU14/01610). Author CRdV holds a Grant of the Andalusian Ministry of Economy, Innovation, Science and Employment (FPDI 2010).

مصطلحات موضوعية: Animales, Antidepresivos, Ansiedad, Encéfalo, Depresión, Endofenotipos, Genotipo, Humanos, Lisofosfolípidos, Ratones, Ratones noqueados, Modelos animales, Trastornos del humor, Pánico, Pronóstico, Receptores del ácido lisofosfatídico, Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Neurobehavioral Manifestations::Anhedonia, Medical Subject Headings::Organisms::Eukaryota::Animals, Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Central Nervous System Agents::Psychotropic Drugs::Antidepressive Agents, Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Emotions::Anxiety, Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain, Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::Depression, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotype::Endophenotypes, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Chemicals and Drugs::Lipids::Membrane Lipids::Phospholipids::Glycerophosphates::Phosphatidic Acids::Lysophospholipids, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice, Medical Subject Headings::Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Genetically Modified::Mice, Transgenic::Mice

وصف الملف: application/pdf; application/msword

Relation: http://www.nature.com/tp/journal/v7/n4/abs/tp201724a.html; Moreno-Fernández RD, Pérez-Martín M, Castilla-Ortega E, Rosell del Valle C, García-Fernández MI, Chun J, et al. maLPA1-null mice as an endophenotype of anxious depression. Transl Psychiatry. 2017;7(4):e1077.; http://hdl.handle.net/10668/2670; PMC5416683

الاتاحة: http://hdl.handle.net/10668/2670
https://doi.org/10.1038/tp.2017.24

المؤلفون: García Castaño, Alejandro, Pérez de Nanclares, Gustavo, Madariaga, Leire, Aguirre, Mireia, Madrid, Álvaro, Chocrón, Sara, Nadal, Inmaculada, Navarro, Mercedes, Lucas, Elena, Fijo, Julia, Espino, Mar, Espitaletta, Zilac, García Nieto, Víctor, Barajas de Frutos, David, Loza, Reyner, Pintos, Guillem, Castaño, Luis, Ariceta, Gema

المساهمون: RenalTube Group, García Castaño,A, Pérez de Nanclares,G, Castaño,L BioCruces Health Research Institute, Ciberer, Cruces University Hospital, Bizkaia, Spain. Madariaga,L, Aguirre,M Pediatric Nephrology, Cruces University Hospital, Bizkaia, Spain. Madariaga,L, Castaño,L Department of Pediatrics, School of Medicine and Odontology, University of Basque Country UPV/EHU, Bizkaia, Spain. Madrid,A, Chocrón,S, Ariceta,G Pediatric Nephrology, Vall d’Hebron University Hospital, Universitat Autonoma, Barcelona, Spain. Nadal,I Pediatric Nephrology, Virgen del Camino Hospital, Pamplona, Spain. Navarro,M Pediatric Nephrology, La Paz University Hospital, Madrid, Spain. Lucas,E Pediatrics, Manises Hospital, Valencia, Spain. Fijo,J Pediatric Nephrology, Virgen del Rocío Hospital, Sevilla, Spain. Espino,M Pediatric Nephrology, Fundación Alcorcón University Hospital, Madrid, Spain. Espitaletta,Z San Ignacio University Hospital, Bogotá, Colombia. García Nieto,V Pediatric Nephrology, Nuestra Señora de Candelaria University Hospital, Tenerife, Canarias, Spain. Barajas de Frutos,D Pediatric Nephrology, Virgen de las Nieves Hospital, Granada, Spain. Loza,R Nephrology Unit, Cayetano Heredia University, Cayetano Heredia Hospital, Lima, Peru. Pintos,G Germans Trias i Pujol University Hospital, Badalona, Spain. Castaño,L BioCruces Health Research Institute, Ciberer, Cruces University Hospital, Bizkaia, Spain, Department of Pediatrics, School of Medicine and Odontology, University of Basque Country UPV/EHU, Bizkaia, Spain, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain.

مصطلحات موضوعية: Alcalosis, Alelos, Síndrome de bartter, Canales de cloruro, Deshidratación, Exones, Genotipo, Humanos, Hipercalciuria, Hipopotasemia, Intrones, Nefrocalcinosis, Polidipsia, Reacción en cadena de la polimerasa, Remisión y consulta, Eliminación de secuencia, Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Acid-Base Imbalance::Alkalosis, Medical Subject Headings::Diseases::Endocrine System Diseases::Adrenal Gland Diseases::Adrenocortical Hyperfunction::Hyperaldosteronism::Bartter Syndrome, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Membrane Transport Proteins::Ion Channels::Chloride Channels, Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Water-Electrolyte Imbalance::Dehydration, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Gene Components::Exons, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Urological Manifestations::Hypercalciuria, Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Water-Electrolyte Imbalance::Hypokalemia, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::DNA, Intergenic::Introns

وصف الملف: application/pdf; application/msword

Relation: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0173581#abstract0; García Castaño A, Pérez de Nanclares G, Madariaga L3, Aguirre M, Madrid Á, Chocrón S,et al.Poor phenotype-genotype association in a large series of patients with Type III Bartter syndrome. PLoS One. 2017 Mar 13;12(3):e0173581.; http://hdl.handle.net/10668/2629; PMC5348002

الاتاحة: http://hdl.handle.net/10668/2629
https://doi.org/10.1371/journal.pone.0173581

المؤلفون: Bravo-Gil, Nereida, Méndez-Vidal, Cristina, Romero-Pérez, Laura, González-Del Pozo, María, Rodríguez-de la Rúa, Enrique, Dopazo, Joaquín, Borrego, Salud, Antiñolo, Guillermo

المساهمون: Bravo-Gil,N, Méndez-Vidal,C, Romero-Pérez,L, González-Del Pozo,M, Borrego,S, Antiñolo,G Department of Genetics, Reproduction and Fetal Medicine, Institute of Biomedicine of Seville, University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain. Bravo-Gil,N, Dopazo,J, Antiñolo,G Centre for Biomedical Network Research on Rare Diseases (CIBERER), Spain. Rodríguez-de la Rúa,E Department of Ophthalmology, University Hospital Virgen Macarena, Seville, Spain. Dopazo,J Computational Genomics Department, Centro de Investigación Príncipe Felipe (CIPF).Functional Genomics Node, (INB) at CIPF, Valencia, Spain., This work was supported by the Instituto de Salud Carlos III (ISCIII), Spanish Ministry of Economy and Competitiveness, Spain (PI11-02923), CIBERER ACCI, CDTI FEDER-Innterconecta (EXP00052887/ITC-20111037), Regional Ministry of Economy, Innovation, Science and Employment of the Autonomous Government of Andalusia (CTS-1664) and the Foundation Ramon Areces (CIVP16A1856). The CIBERER is an initiative of the ISCIII, Spanish Ministry of Economy and Competitiveness. NB-G is supported by fellowship FI12/00545 from ISCIII.

مصطلحات موضوعية: Exoma, Estudios de asociación genética, Asesoramiento genético, Heterogeneidad genética, Genotipo, Fenotipo, Distrofias retinianas, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Exome, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Genetic Association Studies, Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::Genetics, Medical::Genetic Counseling, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Genetic Heterogeneity, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Sequence Analysis::High-Throughput Nucleotide Sequencing, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotype, Medical Subject Headings::Diseases::Eye Diseases::Retinal Diseases::Retinal Degeneration::Retinal Dystrophies

وصف الملف: application/pdf

Relation: http://www.nature.com/articles/srep23910; Bravo-Gil N, Méndez-Vidal C, Romero-Pérez L, González-Del Pozo M, Rodríguez-de la Rúa E, Dopazo J, et al. Improving the management of Inherited Retinal Dystrophies by targeted sequencing of a population-specific gene panel. Sci Rep. 2016, 6:23910; http://hdl.handle.net/10668/2265; PMC4817143

الاتاحة: http://hdl.handle.net/10668/2265
https://doi.org/10.1038/srep23910

المؤلفون: Pérez-Parra, Santiago, Chueca, Natalia, Álvarez, Marta, Pasquau, Juan, Omar, Mohamed, Collado, Antonio, Vinuesa, David, Lozano, Ana B, Yebra, Gonzalo, García, Federico

المساهمون: Pérez-Parra,S, Chueca,N, Álvarez,M, García,F Servicio de Microbiología Clínica, Hospital Universitario San Cecilio, Complejo Hospitalario e Instituto de Investigación IBS, Granada, Spain. Pasquau,J Servicio de Infecciosas, Hospital Virgen de las Nieves, Granada, Spain. Omar,M Servicio de Infecciosas, Hospital Ciudad de Jaén, Jaén, Spain. Collado,A Servicio de Medicina Interna, Hospital de Torrecárdenas, Almería, Spain. Vinuesa,D Servicio de Infecciosas, Hospital Universitario San Cecilio, Granada, Spain. Lozano,AB Servicio de Infecciosas, Hospital de Poniente, Almería, Spain. Yebra,G Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, United Kingdom., Funded by National Plan of I+D+i (RD12/0017/006), Health institute Carlos III(ISCIII), PI12/01053 (General Ministry of Evaluation and European Fund of Regional Development-FEDER), granted to FGG. Ministry of Health of Andalusia (AC-0082-2013), granted to FGG.

مصطلحات موضوعية: Linfocitos T CD4-positivos, Ciudades, Análisis por conglomerados, Epidemias, Genotipo, Infecciones por VIH, VIH-1, Homosexualidad masculina, Péptido hidrolasas, Filogeografía, Probabilidad, ADN polimerasa dirigida por ARN, España, Teorema de bayes, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Bayes Theorem, Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::T-Lymphocytes::CD4-Positive T-Lymphocytes, Medical Subject Headings::Geographicals::Geographic Locations::Cities, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Cluster Analysis, Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Disease Outbreaks::Epidemics, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype, Medical Subject Headings::Diseases::Virus Diseases::RNA Virus Infections::Retroviridae Infections::Lentivirus Infections::HIV Infections, Medical Subject Headings::Organisms::Viruses::RNA Viruses::Retroviridae::Lentivirus::Lentiviruses, Primate::HIV, Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Sexual Behavior::Sexuality::Homosexuality::Homosexuality, Male, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Check Tags::Male, Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases

وصف الملف: application/pdf; application/postscript

Relation: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0168099; Pérez-Parra S, Chueca N, Álvarez M, Pasquau J, Omar M, Collado A, et al. Phylodynamic and Phylogeographic Profiles of Subtype B HIV-1 Epidemics in South Spain. PLoS ONE. 2016; 11(12):e0168099; http://hdl.handle.net/10668/2599; PMC5176287

الاتاحة: http://hdl.handle.net/10668/2599
https://doi.org/10.1371/journal.pone.0168099

المؤلفون: Stephens, Camilla, Moreno-Casares, Antonia, López-Nevot, Miguel-Ángel, García-Cortés, Miren, Medina-Cáliz, Inmaculada, Hallal, Hacibe, Soriano, German, Roman, Eva, Ruiz-Cabello, Francisco, Romero-Gomez, Manuel, Lucena, M Isabel, Andrade, Raúl J

المساهمون: Stephens,C, García-Cortés,M, Medina-Cáliz,I, Lucena,MI, Andrade,RJ Unidad de Gestión Clínica de Aparato Digestivo, Servicio de Farmacología Clínica, Instituto de Investigación Biomédica de Málaga, Hospital Universitario Virgen de la Victoria, Universidad de Málaga, CIBERehd, Málaga, Spain. Moreno-Casares,A, López-Nevot,MA Unidad de Gestión Clínica de Laboratorio, Departamento de Bioquímica y Biología Molecular III/Inmunología, Instituto de Investigación Biosanitario de Granada, Complejo Hospitalario de Granada, Universidad de Granada, Granada, Spain. Hallal,H, Ruiz-Cabello,F Servicio de Aparato Digestivo, Hospital Morales Meseguer, Murcia, Spain. Soriano,G, Roman,E Servicio de Gastroenterología, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, CIBERehd, Barcelona, Spain. Roman,E Escola Universitària d’Infermeria-Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain. Romero-Gomez,M Unidad de Gestión Clínica de Aparato Digestivo Intercentros, Hospitales Universitarios Virgen Macarena-Virgen del Rocio, CIBERehd, Seville, Spain., The present study has been supported by grants of the Instituto de Salud Carlos III co-founded by Fondo Europeo de Desarrollo Regional – FEDER (contract numbers: PI12/00378, SAS-PI-0239/2012, AC-0073-2013) and by the Agencia Española del Medicamento. CIBERehd is funded by Instituto de Salud Carlos III.

مصطلحات موضوعية: Hepatotoxicity, Drug-induced liver injury, Pharmacogenetics, Immune response, HLA, Receptor/ligand, Amoxicilina, Enfermedades autoinmunes, Ácido clavulánico, Enfermedad hepática inducida por drogas, Epítopos, Variación genética, Genotipo, Antígenos HLA, Haplotipos, Humanos, Células asesinas naturales, Ligandos, Subgrupos linfocitarios, Neoplasias, Seudogenes, Receptores KIR, Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams::Penicillins::Penicillin G::Ampicillin::Amoxicillin, Medical Subject Headings::Diseases::Immune System Diseases::Autoimmune Diseases, Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams::Clavulanic Acids::Clavulanic Acid, Medical Subject Headings::Diseases::Substance-Related Disorders::Poisoning::Drug-Induced Liver Injury, Medical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Epitopes, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype, Medical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Antigens

وصف الملف: application/pdf

Relation: http://journal.frontiersin.org/article/10.3389/fphar.2016.00280/full; Stephens C, Moreno-Casares A, López-Nevot MÁ, García-Cortés M, Medina-Cáliz I, Hallal H, et al. Killer Immunoglobulin-Like Receptor Profiles Are not Associated with Risk of Amoxicillin-Clavulanate-Induced Liver Injury in Spanish Patients. Front Pharmacol. 2016; 7:280; http://hdl.handle.net/10668/2563; PMC4999432

الاتاحة: http://hdl.handle.net/10668/2563
https://doi.org/10.3389/fphar.2016.00280

المؤلفون: Chueca, Natalia, Rivadulla, Isidro, Lovatti, Rubén, Reina, Gabriel, Blanco, Ana, Fernandez-Caballero, Jose Angel, Cardeñoso, Laura, Rodriguez-Granjer, Javier, Fernandez-Alonso, Miriam, Aguilera, Antonio, Alvarez, Marta, Galán, Juan Carlos, García, Federico

المساهمون: Chueca,N, Fernandez-Caballero,JA, Alvarez,M, García,F Servicio de Microbiología, Complejo Hospitalario Universitario Granada, Hospital San Cecilio. Instituto de Investigación Biosanitaria IBS, Granada, Spain. Rivadulla,I Departamento de Microbiología y Parasitología USC. Servicio de Microbiología Hospital Conxo-CHUS Santiago de Compostela, A Coruña, Spain. Lovatti,R, Galán,JC Servicio de Microbiología, Hospital Ramón y Cajal. Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain. CIBER en Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. Reina,G, Fernandez-Alonso,M Servicio de Microbiología, Clínica Universidad de Navarra. Navarra Institute for Health Research (IdiSNA), Pamplona, Spain. Blanco,A, Cardeñoso,L Servicio de Microbiología, Hospital la Princesa, Madrid, Spain. Rodriguez-Granjer,J Servicio de Microbiología, Complejo Hospitalario Universitario Granada, Hospital Virgen de las Nieves, Granada, Spain., This work was supported in part by grants from Fondo de Investigación Sanitaria (PI12/01053, PI15/00713), RD12/0017/006 (Plan Nacional de I+D +I and Fondo Europeo de Desarrollo RegionalFEDER), and PI-0411-2014, Fundación Progreso y salud, Junta de Andalucía. Federico García has received a research extension grant from the Programa de Intensificación de la Actividad de Investigación del Servicio Andaluz de Salud.

مصطلحات موضوعية: Antivirales, Genotipo, Técnicas de genotipaje, Hepacivirus, España, Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Antiviral Agents, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Genotyping Techniques, Medical Subject Headings::Organisms::Viruses::Hepatitis Viruses::Hepacivirus, Medical Subject Headings::Geographicals::Geographic Locations::Europe::Spain

وصف الملف: application/pdf

Relation: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153754; Chueca N, Rivadulla I, Lovatti R, Reina G, Blanco A, Fernandez-Caballero JA, et al. Using NS5B Sequencing for Hepatitis C Virus Genotyping Reveals Discordances with Commercial Platforms. PLoS ONE. 2016; 11(4):e0153754; http://hdl.handle.net/10668/2322; PMC4838212

الاتاحة: http://hdl.handle.net/10668/2322
https://doi.org/10.1371/journal.pone.0153754

المؤلفون: Ortiz-Fernández, Lourdes, Carmona, Francisco-David, Montes-Cano, Marco-Antonio, García-Lozano, José-Raúl, Conde-Jaldón, Marta, Ortego-Centeno, Norberto, Castillo, María Jesús, Espinosa, Gerard, Graña-Gil, Genaro, Sánchez-Bursón, Juan, Juliá, María Rosa, Solans, Roser, Blanco, Ricardo, Barnosi-Marín, Ana-Celia, Gómez de la Torre, Ricardo, Fanlo, Patricia, Rodríguez-Carballeira, Mónica, Rodríguez-Rodríguez, Luis, Camps, Teresa, Castañeda, Santos, Alegre-Sancho, Juan-Jose, Martín, Javier, González-Escribano, María Francisca

المساهمون: Ortiz-Fernández,L, Montes-Cano,MA, García-Lozano,JR, Conde-Jaldón,M, González-Escribano,MF Department of Immunology, Hospital Universitario Virgen del Rocío (IBiS, CSIC, US), Sevilla, Spain. Carmona,FD, Martín,J Instituto de Parasitología y Biomedicina “López-Neyra”, CSIC, Granada, Spain. Ortego-Centeno,N Department of Internal Medicine, Hospital Clínico San Cecilio, Granada, Spain. Castillo,MJ Department of Internal Medicine, Hospital Universitario Virgen del Rocío, Sevilla, Spain. Espinosa,G Department Autoimmune Diseases, Hospital Universitari Clínic, Barcelona, Spain. Graña-Gil,G Department of Rheumatology, Complejo Hospitalario Universitario A Coruña, A Coruña, Spain. Sánchez-Bursón,J Department of Rheumatology, Hospital Universitario de Valme, Sevilla, Spain. Juliá,MR Department of Immunology, Hospital Universitari Son Espases, Palma de Mallorca, Spain. Solans,R Department of Internal Medicine, Autoimmune Systemic Diseases Unit, Hospital Vall d’Hebron, Universidad Autonoma de Barcelona, Barcelona, Spain. Blanco,R Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain. Barnosi-Marín,AC Department of Internal Medicine, Complejo Hospitalario Torrecárdenas, Almería, Spain. Gómez de la Torre,R Department of Internal Medicine, Hospital Universitario Central de Asturias, Asturias, Spain. Fanlo,P Department of Internal Medicine, Hospital Virgen del Camino, Pamplona, Spain. Rodríguez-Carballeira,M Deparment of Internal Medicine, Hospital Universitari Mútua Terrassa, Terrassa, Spain. Rodríguez-Rodríguez,L Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain. Camps,T Department of Internal Medicine, Hospital Regional Universitario de Málaga, Málaga, Spain. Castañeda,S Department of Rheumatology, Hospital de la Princesa, IIS-Princesa, Madrid, Spain. Alegre-Sancho,JJ Department of Rheumatology, Hospital Universitario Doctor Peset, Valencia, Spain., This work was supported by Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III (ISCIII, 13/01118), Fondos FEDER and Plan Andaluz de Investigación (CTS-0197). LOF is the recipient of a fellowship (ISCIII, FI11/00547) and FDC was funded by the RETICS Program (RIER, ISCIII, RD12/0009/0013).

مصطلحات موضوعية: Alelos, Aminoácidos, Síndrome de Behçet, Genes clase I del complejo de histocompatibilidad (MHC), Genotipo, Antígenos HLA-B, Modelos logísticos, España, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Alleles, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Amino Acids, Medical Subject Headings::Diseases::Stomatognathic Diseases::Mouth Diseases::Behcet Syndrome, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Major Histocompatibility Complex::Genes, MHC Class I, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::Histocompatibility Antigens Class I::HLA-B Antigens, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Logistic Models, Medical Subject Headings::Geographicals::Geographic Locations::Europe::Spain

وصف الملف: application/pdf; image/tiff; application/vnd.ms-excel

Relation: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0161305#abstract0; Ortiz-Fernández L, Carmona FD, Montes-Cano MA, García-Lozano JR, Conde-Jaldón M, Ortego-Centeno N, et al. Genetic Analysis with the Immunochip Platform in Behçet Disease. Identification of Residues Associated in the HLA Class I Region and New Susceptibility Loci. PLoS ONE. 2016; 11(8):e0161305; http://hdl.handle.net/10668/2469; PMC4993481

الاتاحة: http://hdl.handle.net/10668/2469
https://doi.org/10.1371/journal.pone.0161305

المؤلفون: López-Mejías, Raquel, Genre, Fernanda, Remuzgo-Martínez, Sara, González-Juanatey, Carlos, Robustillo-Villarino, Montserrat, Llorca, Javier, Corrales, Alfonso, Vicente, Esther, Miranda-Filloy, José A, Magro, César, Tejera-Segura, Beatriz, Ramírez Huaranga, Marco A, Pina, Trinitario, Blanco, Ricardo, Alegre-Sancho, Juan J, Raya, Enrique, Mijares, Verónica, Ubilla, Begoña, Mínguez Sánchez, María D, Gómez-Vaquero, Carmen, Balsa, Alejandro, Pascual-Salcedo, Dora, López-Longo, Francisco J, Carreira, Patricia, González-Álvaro, Isidoro, Rodríguez-Rodríguez, Luis, Fernández-Gutiérrez, Benjamín, Ferraz-Amaro, Iván, Castañeda, Santos, Martín, Javier, González-Gay, Miguel A

المساهمون: López-Mejías,R, Remuzgo-Martínez,S, Genre,F, Corrales,A, Pina,T, Blanco,R, Mijares,V, Ubilla,B, González-Gay,MA Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Division of Rheumatology, IDIVAL, Santander, Spain. González-Juanatey,C Cardiology Department, Hospital Lucus Augusti, Lugo, Spain. Robustillo-Villarino,M, Alegre-Sancho,JJ Division of Rheumatology, Hospital Universitario Doctor Peset, Valencia, Spain. Llorca,J Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain. Vicente,E, González-Álvaro,I, Castañeda,S Division of Rheumatology, Hospital Universitario la Princesa, IIS-IPrincesa, Madrid, Spain. Miranda-Filloy,JA Rheumatology Department, Hospital Universitario Lucus Augusti, Lugo, Spain. Magro,C, Raya,E Division of Rheumatology, Hospital Clínico San Cecilio, Granada, Spain. Tejera-Segura,B, Ferraz-Amaro,I Rheumatology Division, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain. Ramírez Huaranga,MA, Mínguez Sánchez,MD Rheumatology Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain. Gómez-Vaquero,C Department of Rheumatology, Hospital Universitario Bellvitge, Barcelona, Spain. Balsa,A, Pascual-Salcedo,D Department of Rheumatology, Hospital Universitario La Paz, Madrid, Spain. López-Longo,FJ Department of Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain. Carreira,P Department of Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain. Rodríguez-Rodríguez,L, Fernández-Gutiérrez,B Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain. Martín,J Institute of Parasitology and Biomedicine López-Neyra, IPBLN-CSIC, Granada, Spain. González-Gay,MA School of Medicine, University of Cantabria, Santander, Spain. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., The present work was financed by European Union FEDER funds and “Fondo de Investigación Sanitaria” (grants PI12/00060 and PI15/00525) and RETICS Programs RD12/0009 from “Instituto Carlos III de Salud” (Health Ministry, Spain) and in part by grants from the European IMI BTCure Program.

مصطلحات موضوعية: Artritis reumatoide, Aterosclerosis, Proteína c-reactiva, Grosor intima-media carotídeo, Genotipo, Humanos, Polimorfismo genético, Medical Subject Headings::Diseases::Musculoskeletal Diseases::Rheumatic Diseases::Arthritis, Rheumatoid, Medical Subject Headings::Diseases::Cardiovascular Diseases::Vascular Diseases::Arterial Occlusive Diseases::Arteriosclerosis::Atherosclerosis, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Albumins::C-Reactive Protein, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Ultrasonography::Carotid Intima-Media Thickness, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic

وصف الملف: application/pdf

Relation: http://www.nature.com/articles/srep31979; López-Mejías R, Genre F, Remuzgo-Martínez S, González-Juanatey C, Robustillo-Villarino M, Llorca J, et al. Influence of elevated-CRP level-related polymorphisms in non-rheumatic Caucasians on the risk of subclinical atherosclerosis and cardiovascular disease in rheumatoid arthritis. Sci Rep. 2016; 6:31979; http://hdl.handle.net/10668/2474; PMC4989194

الاتاحة: http://hdl.handle.net/10668/2474
https://doi.org/10.1038/srep31979

المؤلفون: Lupiañez, Carmen B, Villaescusa, María T, Carvalho, Agostinho, Springer, Jan, Lackner, Michaela, Sánchez-Maldonado, José M, Canet, Luz M, Cunha, Cristina, Segura-Catena, Juana, Alcazar-Fuoli, Laura, Solano, Carlos, Fianchi, Luana, Pagano, Livio, Potenza, Leonardo, Aguado, José M, Luppi, Mario, Cuenca-Estrella, Manuel, Lass-Flörl, Cornelia, Einsele, Hermann, Vázquez, Lourdes, Ríos-Tamayo, Rafael, Loeffler, Jurgen, Jurado, Manuel, Sainz, Juan

المساهمون: PCRAGA Study Group, Lupiañez,CB, Sánchez-Maldonado,JM, Canet,LM, Segura-Catena,J, Ríos-Tamayo,R, Jurado,M, Sainz,J Genomic Oncology Area, GENYO, Center for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government,Granada, Spain. Lupiañez,CB, Sainz,J Hematology Department, Virgen de las Nieves University Hospital, Granada, Spain. Villaescusa,M, Vázquez,L Hematology Department, University Hospital of Salamanca, Salamanca, Spain. Villaescusa,MT Hematology Department, Jiménez Díaz Foundation, Madrid, Spain. Carvalho,A, Cunha,C Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho. 6ICVS/3B's - PT Government Associate Laboratory, Braga, Portugal. Springer,J, Einsele,H, Loeffler,J Universitätsklinikum Würzburg, Klinik II, Würzburg, Germany. Lackner,M, Lass-Flörl,C Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria. Alcazar-Fuoli,L: Cuenca-Estrella,M Mycology Reference Laboratory, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain. Solano,C Hematology Department, Clinic University Hospital of Valencia, Valencia, Spain. Fianchi,L, Pagano,L Istituto di Ematologia, Università Cattolica del S. Cuore, Rome, Italy. Potenza,L, Luppi,M Istituto di Ematologia, Università Cattolica del S. Cuore, Rome, Italy. Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, AOU Policlinico, Modena, Italy. Aguado,JM Unit of Infectious Diseases, University Hospital 12 de Octubre, Research Institute of Hospital 12 de Octubre (i+12), Madrid., This study was supported by grants PI12/02688 from Fondo de Investigaciones Sanitarias (Instituto de Salud Carlos III, Madrid, Spain), the ERA-NET PathoGenoMics (03159000A, Ministerio de Ciencia e Innovación PIM2010EPA-00756, Madrid, Spain), the Collaborative Research Center / Transregio 124 FungiNet, the Austrian Science Fundation (FWF I-656-B09), the Fundação para a Ciência e Tecnologia (FCT), cofunded by Programa Operacional Regional do Norte (ON.2—O Novo Norte), the Quadro de Referência Estratégico Nacional (QREN) through the Fundo Europeu de Desenvolvimento Regional (FEDER) and the Projeto Estratégico – LA 26 – 2013–2014 (PEst-C/SAU/LA0026/2013). Agostinho Carvalho and Cristina Cunha were supported by the Fundação para a Ciência e Tecnologia (FCT), Portugal (IF/00735/2014 and SFRH/BPD/96176/2013, respectively).The PCRAGA trial was supported by an unrestricted grant from Pfizer. This study was also supported by Astellas Pharma Inc. and a donation from Consuelo González Moreno, an acute myeloid leukemia survivor.

مصطلحات موضوعية: Aspergilosis, Susceptibilidad a enfermedades, Marcadores genéticos, Genotipo, Haplotipos, Trasplante de células madre hematopoyéticas, Humanos, Nucleótidos, Infecciones oportunistas, Polimorfismo de nucleótido simple, Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Mycoses::Hyalohyphomycosis::Aspergillosis, Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Susceptibility, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotype::Genetic Markers, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype::Haplotypes, Medical Subject Headings::Organisms::Eukaryota::Fungi::Mitosporic Fungi::Aspergillus, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Transplantation::Cell Transplantation::Stem Cell Transplantation::Hematopoietic Stem Cell Transplantation, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Chemicals and Drugs::Carbohydrates::Glycosides::Nucleotides, Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Opportunistic Infections, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide

وصف الملف: application/pdf; image/jpeg; application/vnd.oasis.opendocument.text

Relation: http://journal.frontiersin.org/article/10.3389/fmicb.2016.01243/full#h1; Lupiañez CB, Villaescusa MT, Carvalho A, Springer J, Lackner M, Sánchez-Maldonado JM, et al. Common Genetic Polymorphisms within NFκB-Related Genes and the Risk of Developing Invasive Aspergillosis. Front Microbiol. 2016; 7:1243; http://hdl.handle.net/10668/2541; PMC4982195

الاتاحة: http://hdl.handle.net/10668/2541
https://doi.org/10.3389/fmicb.2016.01243