المؤلفون: Hao Zhang (15339), John Ginn (6862658), Wenhu Zhan (6499577), Annie Leung (12901195), Yi J. Liu (12901192), Akinori Toita (5645645), Rei Okamoto (2007049), Tzu-Tshin Wong (6862661), Toshihiro Imaeda (346435), Ryoma Hara (2997180), Mayako Michino (1533277), Takafumi Yukawa (2271727), Sevil Chelebieva (14380648), Patrick K. Tumwebaze (6862670), Jeremie Vendome (4529773), Thijs Beuming (1649725), Kenjiro Sato (1600681), Kazuyoshi Aso (397284), Philip J. Rosenthal (47478), Roland A. Cooper (93076), Nigel Liverton (10070835), Michael Foley (90720), Peter T. Meinke (1730713), Carl F. Nathan (235509), Laura A. Kirkman (6694148), Gang Lin (824266)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Pharmacology, Cancer, Hematology, Chemical Sciences not elsewhere classified, tethered macrocyclic scaffold, humanized mouse model, enhanced metabolic stability, human constitutive proteasome, recently reported, promising strategy, plasmodium <, p5 groups, malarial activity, like properties, increasing reports, improved solubility, high selectivity, hepg2 cells, combination therapies, biphenyl ether

Relation: https://figshare.com/articles/journal_contribution/Structure_Activity_Relationship_Studies_of_Antimalarial_i_Plasmodium_i_Proteasome_Inhibitors_Part_II/21866155

الاتاحة: https://doi.org/10.1021/acs.jmedchem.2c01651.s002

المؤلفون: Makoto Fushimi (1714441), Hannes Buck (11133216), Melanie Balbach (3354395), Anna Gorovyy (11133219), Jacob Ferreira (11133222), Thomas Rossetti (11133225), Navpreet Kaur (3162048), Lonny R. Levin (7818410), Jochen Buck (53581), Jonathan Quast (11133228), Joop van den Heuvel (192614), Clemens Steegborn (117996), Efrat Finkin-Groner (2013025), Stacia Kargman (1436677), Mayako Michino (1533277), Michael A. Foley (1289370), Michael Miller (821), Nigel J. Liverton (1834777), David J. Huggins (243837), Peter T. Meinke (1730713)

مصطلحات موضوعية: Biochemistry, Microbiology, Molecular Biology, Neuroscience, Pharmacology, Biotechnology, Cancer, Hematology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, TDI -10229, exhibits mouse pharmacokinetic prop., sAC inhibitors, displays nanomolar inhibition, sAC inhibition, vivo tool compound, Orally Bioavailable Inhibitor, vivo interrogation, ADCY, Soluble Adenylyl Cyclase

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_TDI-10229_A_Potent_and_Orally_Bioavailable_Inhibitor_of_Soluble_Adenylyl_Cyclase_sAC_ADCY10_/14981295

الاتاحة: https://doi.org/10.1021/acsmedchemlett.1c00273.s001

المؤلفون: Hao Zhang (15339), Hao-Chi Hsu (3603950), Shoshanna C. Kahne (3808336), Ryoma Hara (2997180), Wenhu Zhan (6499577), Xiuju Jiang (182824), Kristin Burns-Huang (739692), Tierra Ouellette (6862652), Toshihiro Imaeda (346435), Rei Okamoto (2007049), Masanori Kawasaki (274320), Mayako Michino (1533277), Tzu-Tshin Wong (6862661), Akinori Toita (5645645), Takafumi Yukawa (2271727), Francesca Moraca (1948027), Jeremie Vendome (4529773), Priya Saha (10750110), Kenjiro Sato (1600681), Kazuyoshi Aso (397284), John Ginn (6862658), Peter T. Meinke (1730713), Michael Foley (90720), Carl F. Nathan (235509), K. Heran Darwin (10750113), Huilin Li (795365), Gang Lin (824266)

مصطلحات موضوعية: Biochemistry, Microbiology, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Infectious Diseases, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, Mycobacterium tuberculosis Proteaso., Mtb 20S, NR, TB, macrocycle 6, 6 dose dependently, Latent Mycobacterium tuberculosis, GFP

Relation: https://figshare.com/articles/journal_contribution/Macrocyclic_Peptides_that_Selectively_Inhibit_the_Mycobacterium_tuberculosis_Proteasome/14540844

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00296.s001

المؤلفون: Hao Zhang (15339), John Ginn (6862658), Wenhu Zhan (6499577), Annie Leung (12901195), Yi J. Liu (12901192), Akinori Toita (5645645), Rei Okamoto (2007049), Tzu-Tshin Wong (6862661), Toshihiro Imaeda (346435), Ryoma Hara (2997180), Mayako Michino (1533277), Takafumi Yukawa (2271727), Sevil Chelebieva (14380648), Patrick K. Tumwebaze (6862670), Jeremie Vendome (4529773), Thijs Beuming (1649725), Kenjiro Sato (1600681), Kazuyoshi Aso (397284), Philip J. Rosenthal (47478), Roland A. Cooper (93076), Nigel Liverton (10070835), Michael Foley (90720), Peter T. Meinke (1730713), Carl F. Nathan (235509), Laura A. Kirkman (6694148), Gang Lin (824266)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Pharmacology, Cancer, Hematology, Chemical Sciences not elsewhere classified, tethered macrocyclic scaffold, humanized mouse model, enhanced metabolic stability, human constitutive proteasome, recently reported, promising strategy, plasmodium <, p5 groups, malarial activity, like properties, increasing reports, improved solubility, high selectivity, hepg2 cells, combination therapies, biphenyl ether

Relation: https://figshare.com/articles/dataset/Structure_Activity_Relationship_Studies_of_Antimalarial_i_Plasmodium_i_Proteasome_Inhibitors_Part_II/21866152

الاتاحة: https://doi.org/10.1021/acs.jmedchem.2c01651.s001

المؤلفون: Hao Zhang (15339), Hao-Chi Hsu (3603950), Shoshanna C. Kahne (3808336), Ryoma Hara (2997180), Wenhu Zhan (6499577), Xiuju Jiang (182824), Kristin Burns-Huang (739692), Tierra Ouellette (6862652), Toshihiro Imaeda (346435), Rei Okamoto (2007049), Masanori Kawasaki (274320), Mayako Michino (1533277), Tzu-Tshin Wong (6862661), Akinori Toita (5645645), Takafumi Yukawa (2271727), Francesca Moraca (1948027), Jeremie Vendome (4529773), Priya Saha (10750110), Kenjiro Sato (1600681), Kazuyoshi Aso (397284), John Ginn (6862658), Peter T. Meinke (1730713), Michael Foley (90720), Carl F. Nathan (235509), K. Heran Darwin (10750113), Huilin Li (795365), Gang Lin (824266)

مصطلحات موضوعية: Biochemistry, Microbiology, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Infectious Diseases, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, Mycobacterium tuberculosis Proteaso., Mtb 20S, NR, TB, macrocycle 6, 6 dose dependently, Latent Mycobacterium tuberculosis, GFP

Relation: https://figshare.com/articles/dataset/Macrocyclic_Peptides_that_Selectively_Inhibit_the_Mycobacterium_tuberculosis_Proteasome/14540847

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00296.s002

المؤلفون: Hao Zhang (15339), Hao-Chi Hsu (3603950), Shoshanna C. Kahne (3808336), Ryoma Hara (2997180), Wenhu Zhan (6499577), Xiuju Jiang (182824), Kristin Burns-Huang (739692), Tierra Ouellette (6862652), Toshihiro Imaeda (346435), Rei Okamoto (2007049), Masanori Kawasaki (274320), Mayako Michino (1533277), Tzu-Tshin Wong (6862661), Akinori Toita (5645645), Takafumi Yukawa (2271727), Francesca Moraca (1948027), Jeremie Vendome (4529773), Priya Saha (10750110), Kenjiro Sato (1600681), Kazuyoshi Aso (397284), John Ginn (6862658), Peter T. Meinke (1730713), Michael Foley (90720), Carl F. Nathan (235509), K. Heran Darwin (10750113), Huilin Li (795365), Gang Lin (824266)

مصطلحات موضوعية: Biochemistry, Microbiology, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Infectious Diseases, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, Mycobacterium tuberculosis Proteaso., Mtb 20S, NR, TB, macrocycle 6, 6 dose dependently, Latent Mycobacterium tuberculosis, GFP

Relation: https://figshare.com/articles/dataset/Macrocyclic_Peptides_that_Selectively_Inhibit_the_Mycobacterium_tuberculosis_Proteasome/14540850

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00296.s003