المؤلفون: Ling Wang, Jiongjie He, Lianghong Wu, Xueqin Wu, Baocheng Hao, Shengyi Wang, Dongan Cui

المصدر: Veterinary Sciences, Vol 10, Iss 615, p 615 (2023)

مصطلحات موضوعية: herbal remedy, Guixiong Yimu San, safety assessment, maximum-tolerated dose (MTD), oral toxicity, Veterinary medicine, SF600-1100

Relation: https://www.mdpi.com/2306-7381/10/10/615; https://doaj.org/toc/2306-7381; https://doaj.org/article/47141ee124d54b748c87b6a155832835

الاتاحة: https://doi.org/10.3390/vetsci10100615
https://doaj.org/article/47141ee124d54b748c87b6a155832835

المؤلفون: Keying Ye, Xiaobin Yang, Ying Ji, Min Wang

المصدر: Statistical Theory and Related Fields, Vol 5, Iss 4, Pp 288-302 (2021)

مصطلحات موضوعية: bayesian methods, continual reassessment method (crm), drug dose finding, markov chain monte carlo (mcmc) method, maximum tolerated dose (mtd), phase i clinical trial, toxicity responses, Probabilities. Mathematical statistics, QA273-280

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2475-4269; https://doaj.org/toc/2475-4277

URL الوصول: https://doaj.org/article/c9ffb3309b4647258b9d871dcf07a614

المؤلفون: Bagri, P.¹, Kumar, V., Singh, P.

المصدر: Journal Of Veterinary Pharmacology And Toxicology 19(1):31-34. 2020

المؤلفون: L. D. Burgoon, Christopher J. Borgert, C. Fuentes

المصدر: Archives of Toxicology

مصطلحات موضوعية: Blood level, Toxicology study design, Maximum Tolerated Dose, Health, Toxicology and Mutagenesis, Kinetic Maximum Dose (KMD), Toxicology, Regulatory Toxicology, Hazardous Substances, Toxicology studies, Toxicity Tests, Medicine, Animals, Humans, Pharmacokinetics, Human safety, Dose-Response Relationship, Drug, business.industry, Chemical toxicity, General Medicine, Environmental Exposure, Hazard, Maximum Tolerated Dose (MTD), Chemical hazard, Toxicokinetics, Regulatory toxicology, Risk analysis (engineering), Maximum dose, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c9f784015dd26b6b262ae5631009254
http://europepmc.org/articles/PMC8536606

المصدر: Environmental Health Perspectives, 1994 Dec 01. 102, 13-22.

URL الوصول: https://www.jstor.org/stable/4641169

المؤلفون: Zhang, Tianshu

المساهمون: Zang, Yong, Han, Yan, Liu, Ziyue

مصطلحات موضوعية: Phase I clinical trial, 3+3 design, maximum tolerated dose (MTD), dose-limiting toxicity (DLT)

وصف الملف: application/pdf

Relation: https://hdl.handle.net/1805/42019

الاتاحة: https://hdl.handle.net/1805/42019

المؤلفون: Jane A. Foster, Lisa Genore, Rianne Hastie Adams, Toni Lui, Annie Dupuis, Jessica Brian, Dina Odrobina, Sharon Smile, Evdokia Anagnostou, Deepali Mankad, Lucia Capano

المصدر: Molecular Autism, Vol 9, Iss 1, Pp 1-14 (2018)
Molecular Autism

مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_specialty, Efficacy, Maximum tolerated dose (MTD), Pilot Projects, Neutropenia, Placebo, lcsh:RC346-429, law.invention, 03 medical and health sciences, Physiological effects of drugs, 0302 clinical medicine, Developmental Neuroscience, Randomized controlled trial, law, Internal medicine, Medicine, Humans, Autistic Disorder, Autism spectrum disorder, Adverse effect, Prospective cohort study, Child, Molecular Biology, lcsh:Neurology. Diseases of the nervous system, Inflammation, Pioglitazone, business.industry, Research, medicine.disease, 3. Good health, Clinical trial, Treatment, Psychiatry and Mental health, 030104 developmental biology, Safety profile, Cytokines, Female, Drug therapy, business, 030217 neurology & neurosurgery, Developmental Biology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e27c325c960000d92f4d188d8e161613
http://link.springer.com/article/10.1186/s13229-018-0241-5

المؤلفون: Andre ́ Rogatko, Mourad Tighiouart, Pulak Ghosh, Brani Vidakovic, Phase I Cancer Clinical Trials

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://www.mdanderson.org/education-and-research/departments-programs-and-labs/departments-and-divisions/division-of-quantitative-sciences/pdf/branividakovic.pdf.

مصطلحات موضوعية: Dose referred as, Maximum Tolerated Dose (MTD, Working Dose, Target Dose, Recommended Phase II Dose (RPTD). 4Phase I Clinical Trials (Contnd

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.501.1897; http://www.mdanderson.org/education-and-research/departments-programs-and-labs/departments-and-divisions/division-of-quantitative-sciences/pdf/branividakovic.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.501.1897
http://www.mdanderson.org/education-and-research/departments-programs-and-labs/departments-and-divisions/division-of-quantitative-sciences/pdf/branividakovic.pdf

المؤلفون: Rall, David P.

المصدر: Environmental Health Perspectives, 1995 Sep 01. 103, 173-175.

URL الوصول: https://www.jstor.org/stable/3432370

المؤلفون: Peter Stei, Fiona Sewell, Deborah Ockert, Helen Palmer, Marija Popovic, Elizabeth Donald, Sophie Kervyn, Wendy Roosen, Vicente Nogues, Linda Allais, Jean-Luc Delongeas, Matthias Festag, Kevin Somers, Ankie Schoenmakers, Kathryn Chapman, Sally Robinson, Claudia Stark

المصدر: Regulatory Toxicology and Pharmacology. 67:27-38

مصطلحات موضوعية: Primates, medicine.medical_specialty, Evidence-based practice, Drug Industry, Drug-Related Side Effects and Adverse Reactions, Maximum Tolerated Dose, Maximum tolerated dose (MTD), Toxicology, Body weight, 3Rs, Non-human primates (NHPs), Dogs, Weight Loss, Toxicity Tests, Acute, medicine, Animals, Humans, Short term toxicity, Operations management, Dosing, Regulatory toxicology, Adverse effect, Intensive care medicine, business.industry, Body weight loss (BWL), Body Weight, General Medicine, Refinement, Preclinical, Rats, Term (time), Maximum tolerated dose, Toxicity, Short term toxicity study, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f68b6a65df8c912a87ad9e918ce987cf
https://doi.org/10.1016/j.yrtph.2013.04.003

المؤلفون: Carla Kurkjian, Ofir Moreno, Wendy Levin, Manish R. Patel, Howard A. Burris, Shubham Pant, Johanna C. Bendell, Jeffrey R. Infante, Suzanne F. Jones, Kathleen N. Moore, Vanessa Esquibel

المصدر: Cancer

مصطلحات موضوعية: Adult, Male, Cancer Research, medicine.medical_specialty, Maximum Tolerated Dose, medicine.medical_treatment, Urology, Cmax, maximum tolerated dose (MTD), Antineoplastic Agents, Young Adult, Therapeutic index, Pharmacokinetics, first-in-human, Neoplasms, medicine, Humans, Tissue Distribution, ME-344, refractory solid tumors, Adverse effect, Infusions, Intravenous, Aged, Neoplasm Staging, Aged, 80 and over, Chemotherapy, Dose-Response Relationship, Drug, business.industry, Cancer, Common Terminology Criteria for Adverse Events, Original Articles, Middle Aged, medicine.disease, Prognosis, Isoflavones, mitochondrial inhibitor, Surgery, Mitochondria, Oncology, Tolerability, phase 1, Female, Safety, business, Follow-Up Studies

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d706c05d9ceb943426a1153f5f6799
https://pubmed.ncbi.nlm.nih.gov/25411085

مصطلحات موضوعية: Oncology, medicine.medical_specialty, business.industry, continual reassessment method (CRM), maximum tolerated dose (MTD), Phase i trials, partial ordering, Dose finding, Phase I trials, Internal medicine, biomarker, Medicine, Biomarker (medicine), business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2659865fe1f1a3e98c43534f6eb68e7c

المؤلفون: Cui, Ye

المصدر: Mathematics Dissertations

مصطلحات موضوعية: Clinical trial design, Phase I, Phase II, Maximum tolerated dose (MTD), Adaptive design, Personalized MTD, Covariate effect, Two-stage design, Success rate, Trial efficiency

وصف الملف: application/pdf

Relation: https://scholarworks.gsu.edu/math_diss/15; https://scholarworks.gsu.edu/context/math_diss/article/1013/viewcontent/Cui_Ye_201305_phd_7_1_1.pdf

الاتاحة: https://scholarworks.gsu.edu/math_diss/15
https://doi.org/10.57709/4139254
https://scholarworks.gsu.edu/context/math_diss/article/1013/viewcontent/Cui_Ye_201305_phd_7_1_1.pdf

المؤلفون: Ranjana Advani, Bert L. Lum, George A. Fisher, Joanne Halsey, Richard S. Geary, Jon T. Holmlund, T. Jesse Kwoh, F. Andrew Dorr, Branimir I. Sikic

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://med.stanford.edu/labs/branimir_sikic/PDF/Advani_R_2.pdf.

مصطلحات موضوعية: Key words, Antisense therapy, protein kinase C, phase I trial, pharmacokinetics, pharmacodynamics. Summary Purpose, Aphase I study was performed to determine the maximum tolerated dose (MTD, safety profile and pharmacology

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.383.8326; http://med.stanford.edu/labs/branimir_sikic/PDF/Advani_R_2.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.383.8326
http://med.stanford.edu/labs/branimir_sikic/PDF/Advani_R_2.pdf

المؤلفون: Darrell D. Sumner, James T. Stevens

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/a0/c7/Environ_Health_Perspect_1994_Dec_102(Suppl_11)_13-22.tar.gz

مصطلحات موضوعية: Key words, hazard, maximum tolerated dose (MTD, dose-response, pharmacokinetics, nonlinear kinetics, modeling, risk assessment, logic

وصف الملف: application/zip

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.277.3515

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.277.3515

المؤلفون: Jack Lippes, Ernest E. McConnell, Roger G. Growe, Michael I. Luster, Joseph K. Haseman, Errol Zeiger

المصدر: Regulatory Toxicology and Pharmacology. (3):371-378

مصطلحات موضوعية: Drug, Male, Maximum Tolerated Dose, media_common.quotation_subject, Chemistry, Pharmaceutical, Endometriosis, Maximum tolerated dose (MTD), Inflammation, Pharmacology, Methylcellulose, Toxicology, Risk Assessment, Rats, Sprague-Dawley, Mice, Species Specificity, medicine, Contraceptive Agents, Female, Bioassay, Animals, Humans, Reproductive system, Mode of action, Chronic toxicity, media_common, Biological relevance, Drug Carriers, Dose-Response Relationship, Drug, business.industry, Uterus, Cancer, General Medicine, Chronic inflammation, medicine.disease, Carcinogenicity bioassay (CaBio), Cell Transformation, Neoplastic, Contraception, Quinacrine, Toxicity, Chronic Disease, Uterine Neoplasms, Female, medicine.symptom, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79cd2856c45436bbd38d210e21f19860

المؤلفون: Cui, Ye

المصدر: Mathematics Dissertations.

مصطلحات موضوعية: Clinical trial design, Phase I, Phase II, Maximum tolerated dose (MTD), Adaptive design, Personalized MTD, Covariate effect, Two-stage design, Success rate, Trial efficiency

وصف الملف: application/pdf

الاتاحة: http://digitalarchive.gsu.edu/math_diss/15
http://digitalarchive.gsu.edu/cgi/viewcontent.cgi?article=1013&context=math_diss