المؤلفون: Longbin Liu (1261659), Peter D. Johnson (1655887), Michael E. Prime (2013466), Vinod Khetarpal (9187645), Christopher J. Brown (128374), Luca Anzillotti (8938853), Daniele Bertoglio (5467049), Xuemei Chen (14465), Samuel Coe (9187654), Randall Davis (2862278), Anthony P. Dickie (2882588), Simone Esposito (9187660), Elise Gadouleau (9187663), Paul R. Giles (3045201), Catherine Greenaway (9187672), James Haber (1621504), Christer Halldin (314522), Scott Haller (14295672), Sarah Hayes (8037875), Todd Herbst (9187678), Frank Herrmann (218163), Manuela Heßmann (373851), Ming Min Hsai (11236910), Yaser Khani (13020158), Adrian Kotey (1845754), Angelo Lembo (2388700), John E. Mangette (3896422), Gwendolyn A. Marriner (1400866), Richard W. Marston (2013460), Matthew R. Mills (2062672), Edith Monteagudo (2094247), Anton Forsberg-Morén (13020155), Sangram Nag (2153485), Laura Orsatti (272578), Christine Sandiego (14295675), Sabine Schaertl (2013472), Joanne Sproston (9187687), Steven Staelens (428999), Jack Tookey (14295678), Penelope A. Turner (2226844), Andrea Vecchi (839801), Maria Veneziano (2554966), Ignacio Muñoz-Sanjuan (1621456), Jonathan Bard (58130), Celia Dominguez (139255)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Neuroscience, Physiology, Pharmacology, Chemical Sciences not elsewhere classified, resulting pet ligand, rapid brain uptake, mutant huntingtin protein, 18 , 11 , strategically placed ring, two [< sup, f ]- signal, [< sup, vivo <, pyrimidine ring, pyridazinone ring, washout profile, methyl group, methoxy pendant, huntington ’, human testing, human primates, hd ), ethoxy group, alzheimer ’

Relation: https://figshare.com/articles/journal_contribution/Design_and_Evaluation_of_sup_18_sup_F_CHDI-650_as_a_Positron_Emission_Tomography_Ligand_to_Image_Mutant_Huntingtin_Aggregates/21774385

الاتاحة: https://doi.org/10.1021/acs.jmedchem.2c01585.s001

المؤلفون: Longbin Liu (1261659), Peter D. Johnson (1655887), Michael E. Prime (2013466), Vinod Khetarpal (9187645), Matthew R. Lee (1500754), Christopher J. Brown (128374), Xuemei Chen (14465), Daniel Clark-Frew (9187651), Samuel Coe (9187654), Mike Conlon (1228401), Randall Davis (2862278), Samantha Ensor (11236904), Simone Esposito (9187660), Anton Forsberg Moren (11236907), Xinjie Gai (9187666), Samantha Green (5755406), Catherine Greenaway (9187672), James Haber (1621504), Christer Halldin (314522), Sarah Hayes (8037875), Todd Herbst (9187678), Frank Herrmann (218163), Manuela Heßmann (373851), Ming Min Hsai (11236910), Adrian Kotey (1845754), John E. Mangette (3896422), Matthew R. Mills (2062672), Edith Monteagudo (2094247), Sangram Nag (2153485), Martina Nibbio (2939907), Laura Orsatti (272578), Sabine Schaertl (2013472), Christoph Scheich (4875), Joanne Sproston (9187687), Vladimir Stepanov (4676830), Katarina Varnäs (1408864), Andrea Varrone (436069), John Wityak (519927), Ladislav Mrzljak (1655863), Ignacio Munoz-Sanjuan (112471), Jonathan A. Bard (9187702), Celia Dominguez (139255)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Neuroscience, Pharmacology, HD mouse model, ligand, orthogonal biomarkers, pharmacologic interventions, Imaging Mutant Huntingtin Aggregates, Reduced Binding, PET Tracer Candidate, imaging biomarkers, nonhuman primate positron emission ., HD postmortem brain, binding, medium spiny neurons, mHTT aggregates, AD Pathological Proteins

Relation: https://figshare.com/articles/journal_contribution/_sup_11_sup_C_CHDI-626_a_PET_Tracer_Candidate_for_Imaging_Mutant_Huntingtin_Aggregates_with_Reduced_Binding_to_AD_Pathological_Proteins/15113468

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00667.s002

المؤلفون: Longbin Liu (1261659), Peter D. Johnson (1655887), Michael E. Prime (2013466), Vinod Khetarpal (9187645), Christopher J. Brown (128374), Luca Anzillotti (8938853), Daniele Bertoglio (5467049), Xuemei Chen (14465), Samuel Coe (9187654), Randall Davis (2862278), Anthony P. Dickie (2882588), Simone Esposito (9187660), Elise Gadouleau (9187663), Paul R. Giles (3045201), Catherine Greenaway (9187672), James Haber (1621504), Christer Halldin (314522), Scott Haller (14295672), Sarah Hayes (8037875), Todd Herbst (9187678), Frank Herrmann (218163), Manuela Heßmann (373851), Ming Min Hsai (11236910), Yaser Khani (13020158), Adrian Kotey (1845754), Angelo Lembo (2388700), John E. Mangette (3896422), Gwendolyn A. Marriner (1400866), Richard W. Marston (2013460), Matthew R. Mills (2062672), Edith Monteagudo (2094247), Anton Forsberg-Morén (13020155), Sangram Nag (2153485), Laura Orsatti (272578), Christine Sandiego (14295675), Sabine Schaertl (2013472), Joanne Sproston (9187687), Steven Staelens (428999), Jack Tookey (14295678), Penelope A. Turner (2226844), Andrea Vecchi (839801), Maria Veneziano (2554966), Ignacio Muñoz-Sanjuan (1621456), Jonathan Bard (58130), Celia Dominguez (139255)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Neuroscience, Physiology, Pharmacology, Chemical Sciences not elsewhere classified, resulting pet ligand, rapid brain uptake, mutant huntingtin protein, 18 , 11 , strategically placed ring, two [< sup, f ]- signal, [< sup, vivo <, pyrimidine ring, pyridazinone ring, washout profile, methyl group, methoxy pendant, huntington ’, human testing, human primates, hd ), ethoxy group, alzheimer ’

Relation: https://figshare.com/articles/dataset/Design_and_Evaluation_of_sup_18_sup_F_CHDI-650_as_a_Positron_Emission_Tomography_Ligand_to_Image_Mutant_Huntingtin_Aggregates/21774388

الاتاحة: https://doi.org/10.1021/acs.jmedchem.2c01585.s002

المؤلفون: Longbin Liu (1261659), Peter D. Johnson (1655887), Michael E. Prime (2013466), Vinod Khetarpal (9187645), Matthew R. Lee (1500754), Christopher J. Brown (128374), Xuemei Chen (14465), Daniel Clark-Frew (9187651), Samuel Coe (9187654), Mike Conlon (1228401), Randall Davis (2862278), Samantha Ensor (11236904), Simone Esposito (9187660), Anton Forsberg Moren (11236907), Xinjie Gai (9187666), Samantha Green (5755406), Catherine Greenaway (9187672), James Haber (1621504), Christer Halldin (314522), Sarah Hayes (8037875), Todd Herbst (9187678), Frank Herrmann (218163), Manuela Heßmann (373851), Ming Min Hsai (11236910), Adrian Kotey (1845754), John E. Mangette (3896422), Matthew R. Mills (2062672), Edith Monteagudo (2094247), Sangram Nag (2153485), Martina Nibbio (2939907), Laura Orsatti (272578), Sabine Schaertl (2013472), Christoph Scheich (4875), Joanne Sproston (9187687), Vladimir Stepanov (4676830), Katarina Varnäs (1408864), Andrea Varrone (436069), John Wityak (519927), Ladislav Mrzljak (1655863), Ignacio Munoz-Sanjuan (112471), Jonathan A. Bard (9187702), Celia Dominguez (139255)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Neuroscience, Pharmacology, HD mouse model, ligand, orthogonal biomarkers, pharmacologic interventions, Imaging Mutant Huntingtin Aggregates, Reduced Binding, PET Tracer Candidate, imaging biomarkers, nonhuman primate positron emission ., HD postmortem brain, binding, medium spiny neurons, mHTT aggregates, AD Pathological Proteins

Relation: https://figshare.com/articles/dataset/_sup_11_sup_C_CHDI-626_a_PET_Tracer_Candidate_for_Imaging_Mutant_Huntingtin_Aggregates_with_Reduced_Binding_to_AD_Pathological_Proteins/15113465

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00667.s001