المؤلفون: Bingfa Sun, Dan Feng, Matthew Ling-Hon Chu, Inbar Fish, Silvia Lovera, Zara A. Sands, Sebastian Kelm, Anne Valade, Martyn Wood, Tom Ceska, Tong Sun Kobilka, Florence Lebon, Brian K. Kobilka

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/2dbb4259799647b08364c62567b2949b

المؤلفون: Wei Chen, Fan Yang, Carole Wang, Jatin Narula, Edward Pascua, Irene Ni, Sheng Ding, Xiaodi Deng, Matthew Ling-Hon Chu, Amber Pham, Xiaoyue Jiang, Kevin C. Lindquist, Patrick J. Doonan, Tom Van Blarcom, Yik Andy Yeung, Javier Chaparro-Riggers

المصدر: mAbs, Vol 13, Iss 1 (2021)

مصطلحات موضوعية: Bispecific engineering, cd3, t-cell engager, therapeutic window, Therapeutics. Pharmacology, RM1-950, Immunologic diseases. Allergy, RC581-607

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1942-0862; https://doaj.org/toc/1942-0870

URL الوصول: https://doaj.org/article/689b1a83bc0d495ead97d93c01362efb

المؤلفون: Pamela Zhang, Guang Huan Tu, Jie Wei, Pamela Santiago, Lance R. Larrabee, Sindy Liao-Chan, Tina Mistry, Matthew Ling-Hon Chu, Tao Sai, Kevin Lindquist, Hua Long, Javier Chaparro-Riggers, Shahram Salek-Ardakani, Yik Andy Yeung

المصدر: Cell Reports, Vol 27, Iss 11, Pp 3117-3123.e5 (2019)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124719306382; https://doaj.org/toc/2211-1247

URL الوصول: https://doaj.org/article/44cb539f22be4485ababb5654bc38b0f

المؤلفون: Ivana Djuretic, Dave Tsao, Yuanming Xu, Lucia Campos Carrascosa, Gabriel R. Starbeck-Miller, Valeska de Ruiter, Wenjing Yang, Javier Chaparro-Riggers, Zhouhong Ge, Changhua Ji, Tina Mistry, Jaap Kwekkeboom, Lidia Mosyak, John Zeytounian, Matthew Ling-Hon Chu, Renny Feldman, Lisanne Noordam, Eugenia Kraynov, Tzu-Hsuan Huang, Martin E. van Royen, Diamanda Rigas, Sherman M. Chin, Irene Ni, Dave Sprengers, Shih-Hsun Chen, Danielle Pappas, Kevin Lindquist, Michael Doukas, Patrick P.C. Boor, Joanne Verheij, Keith A. Ching, Magdalena Dorywalska, Luz Marina Londono, Joris I. Erdmann, Dirk J. Grünhagen, Laura Lin, Bing Kuang, Jan N. M. IJzermans, Yik Andy Yeung, James Patterson, Jie Guo, Salah Mahmoudi, Terrence Park, Pascal G. Doornebosch, Robert C Rickert

المساهمون: Gastroenterology & Hepatology, Pathology, Surgery

المصدر: Cancer Immunology Research, 9(10), 1141-1157. American Association for Cancer Research Inc.
Cancer immunology research, 9(10), 1141-1157. American Association for Cancer Research Inc.

مصطلحات موضوعية: Cancer Research, medicine.medical_treatment, T cell, Recombinant Fusion Proteins, Immunology, Programmed Cell Death 1 Receptor, Melanoma, Experimental, chemical and pharmacologic phenomena, CD8-Positive T-Lymphocytes, Protein Engineering, Mice, Lymphocytes, Tumor-Infiltrating, Cancer immunotherapy, SDG 3 - Good Health and Well-being, Cell Line, Tumor, medicine, Animals, Humans, Cytotoxicity, Interleukin-15, Mice, Inbred BALB C, biology, Chemistry, Immunotherapy, Fusion protein, Mice, Inbred C57BL, Disease Models, Animal, Cytokine, medicine.anatomical_structure, Colonic Neoplasms, biology.protein, Cancer research, Antibody, CD8

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::314114dc45d8eb706b8d4a6ebcec02a6
https://doi.org/10.1158/2326-6066.cir-21-0058

المؤلفون: Jennifer L Stamos, Matthew Ling-Hon Chu, Michael D Enos, Niket Shah, William I Weis

المصدر: eLife, Vol 3 (2014)

مصطلحات موضوعية: GSK-3, Wnt signaling, protein kinase, LRP6, Medicine, Science, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://elifesciences.org/articles/01998; https://doaj.org/toc/2050-084X

URL الوصول: https://doaj.org/article/7c15a261e8bd48adb929dd7023bf8741

المؤلفون: Sebastian Kelm, Bingfa Sun, Inbar Fish, Matthew Ling-Hon Chu, Florence Lebon, Zara A. Sands, Martyn Wood, Dan Feng, Tong Sun Kobilka, Brian K. Kobilka, Silvia Lovera, Tom Ceska, Anne Valade

المصدر: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)

مصطلحات موضوعية: 0301 basic medicine, Agonist, Models, Molecular, medicine.drug_class, G protein, Protein Conformation, Science, General Physics and Astronomy, In Vitro Techniques, Molecular Dynamics Simulation, Crystallography, X-Ray, Ligands, Protein Engineering, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, 0302 clinical medicine, Dopamine receptor D1, Receptor pharmacology, In vivo, Dopamine, medicine, Extracellular, GTP-Binding Protein alpha Subunits, Gs, Humans, Receptor, Protein Structure, Quaternary, X-ray crystallography, Multidisciplinary, Binding Sites, Chemistry, Receptors, Dopamine D1, General Chemistry, Ligand (biochemistry), Recombinant Proteins, 030104 developmental biology, Biophysics, Structural biology, 030217 neurology & neurosurgery, medicine.drug, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b9b0b7a549f0537d2457a0993a82997
http://europepmc.org/articles/PMC8175458

المؤلفون: Amber Pham, Yik Andy Yeung, Javier Chaparro-Riggers, Carole Wang, Pascua Edward Derrick, Fan Yang, Patrick J. Doonan, Xiaoyue Jiang, Wei Chen, Irene Ni, Matthew Ling-Hon Chu, Jatin Narula, Kevin Lindquist, Xiaodi Deng, Sheng Ding, Tom Van Blarcom

المصدر: mAbs
article-version (VoR) Version of Record

مصطلحات موضوعية: CD3 Complex, Immunological Synapses, T cell, CD3, T-Lymphocytes, Immunology, Receptors, Antigen, T-Cell, Protein Engineering, Epitope, Bispecific engineering, Cell membrane, Antigen-Antibody Reactions, 03 medical and health sciences, Epitopes, 0302 clinical medicine, Immune system, Antigen, Report, Cell Line, Tumor, Antibodies, Bispecific, medicine, Immunology and Allergy, Animals, Humans, therapeutic window, B-Cell Maturation Antigen, 030304 developmental biology, t-cell engager, 0303 health sciences, Biological Products, Immunological synapse formation, biology, Chemistry, Antibody-Dependent Cell Cytotoxicity, cd3, Cell biology, Kinetics, medicine.anatomical_structure, fms-Like Tyrosine Kinase 3, 030220 oncology & carcinogenesis, Immunoglobulin G, biology.protein, Cytokines, Binding Sites, Antibody, Epitope Mapping

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b02862dd91a389a46e62c165e9a15789
http://europepmc.org/articles/PMC7889206

المؤلفون: Tong Sun Kobilka, Yan Zhang, William I. Weis, Michael J. Robertson, Matthew Ling-Hon Chu, Brian K. Kobilka, Toon Laermans, Hongli Hu, Somnath Dutta, Georgios Skiniotis, Jesper Mosolff Mathiesen, Dan Feng, Antoine Koehl, Jeffrey T. Tarrasch, Rasmus Fonseca, Jan Steyaert, Bingfa Sun

المساهمون: Structural Biology Brussels, Department of Bio-engineering Sciences

المصدر: Nature. 566:79-84

مصطلحات موضوعية: 0301 basic medicine, Agonist, Multidisciplinary, Chemistry, medicine.drug_class, Protein domain, Allosteric regulation, 3. Good health, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Membrane protein, general, Metabotropic glutamate receptor, Extracellular, Biophysics, medicine, Signal transduction, Receptor, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a235127f2470038cb83d480a3f2d7db2
https://doi.org/10.1038/s41586-019-0881-4

المؤلفون: Matthew Ling-Hon Chu, Jeffrey T. Tarrasch, Dan Feng, Qianhui Qu, Hongli Hu, Shane Li, Georgios Skiniotis, Brian K. Kobilka, Bingfa Sun, Yan Zhang, Tong Sun Kobilka

المصدر: Nature

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Protein domain, Glucagon-Like Peptide-1 Receptor, Article, 03 medical and health sciences, 0302 clinical medicine, Protein Domains, Glucagon-Like Peptide 1, GTP-Binding Protein alpha Subunits, Gs, Animals, 5-HT5A receptor, Receptor, Glucagon-like peptide 1 receptor, G protein-coupled receptor, G protein-coupled receptor kinase, Multidisciplinary, Chemistry, Cryoelectron Microscopy, Transmembrane protein, Cell biology, Transmembrane domain, 030104 developmental biology, Rabbits, hormones, hormone substitutes, and hormone antagonists, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f39ff2bc93cf8d85b35ccb9de8c2429d
http://europepmc.org/articles/PMC5587415

المؤلفون: Zara A. Sands, Florence Lebon, Matthew Ling-Hon Chu, Tong Sun Kobilka, Joël Mercier, Priti Bachhawat, Tom Ceska, Brian K. Kobilka, Martyn Wood, Bingfa Sun

المصدر: Proceedings of the National Academy of Sciences. 114:2066-2071

مصطلحات موضوعية: 0301 basic medicine, Multidisciplinary, Chemistry, Ligand, Stereochemistry, Allosteric regulation, Antagonist, Adenosine A2A receptor, Crystal structure, Adenosine, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, medicine, Tyrosine, Receptor, 030217 neurology & neurosurgery, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e5111950850a954b0b1feb0b2564e766
https://doi.org/10.1073/pnas.1621423114

المؤلفون: Bingfa, Sun, Priti, Bachhawat, Matthew Ling-Hon, Chu, Martyn, Wood, Tom, Ceska, Zara A, Sands, Joel, Mercier, Florence, Lebon, Tong Sun, Kobilka, Brian K, Kobilka

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 114(8)

مصطلحات موضوعية: Receptor, Adenosine A2A, Triazines, Parkinson Disease, Spodoptera, Triazoles, Biological Sciences, Crystallography, X-Ray, Ligands, Receptors, N-Methyl-D-Aspartate, Adenosine A2 Receptor Antagonists, Protein Structure, Tertiary, Antiparkinson Agents, Sf9 Cells, Animals, Humans, Tyrosine, Allosteric Site

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::2c85aad0b6af316eccea2c03ae6b2fed
https://pubmed.ncbi.nlm.nih.gov/28167788

المؤلفون: Dan Feng, Jesper Mosolff Mathiesen, Michael J. Robertson, Antoine Koehl, Tong Sun Kobilka, Brian K. Kobilka, Matthew Ling-Hon Chu, Jeffrey T. Tarrasch, Yan Zhang, Georgios Skiniotis, William I. Weis, Somnath Dutta, Hongli Hu, Toon Laeremans, Rasmus Fonseca, Jan Steyaert, Bingfa Sun

المصدر: Nature. 567:E10-E10

مصطلحات موضوعية: 0301 basic medicine, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Multidisciplinary, Metabotropic glutamate receptor, business.industry, 030220 oncology & carcinogenesis, Published Erratum, Medicine, business, Neuroscience

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::31c6b7d85627dcf756a41d63e67641ce
https://doi.org/10.1038/s41586-019-0983-z

المؤلفون: Matthew Ling-Hon Chu, David Williams, Olga S. Fedorova, Kenneth T. Douglas, Mike Cherry, Leonard M. G. Chavas, João Neres, Patrick A. Eyers, Zhaolei Lang, Lydia Tabernero

المصدر: Biochemistry. 49:1689-1701

مصطلحات موضوعية: Anthracenes, Molecular Structure, MAP kinase kinase kinase, biology, Cyclin-dependent kinase 4, Cyclin-dependent kinase 2, Cell Cycle Proteins, Protein Serine-Threonine Kinases, Protein-Tyrosine Kinases, Mitogen-activated protein kinase kinase, Crystallography, X-Ray, Biochemistry, Protein Structure, Secondary, MAP2K7, Cell biology, Spectrometry, Fluorescence, Mitotic spindle assembly checkpoint, Catalytic Domain, biology.protein, Humans, Spectrophotometry, Ultraviolet, Cyclin-dependent kinase 9, Protein kinase A, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d47a8c82d258b62df5865e24f9a68fc8
https://doi.org/10.1021/bi901970c

المؤلفون: Paul J. Scutt, Colin R. Bignell, Patrick A. Eyers, David Williams, Matthew Ling-Hon Chu, Mike Cherry, Dominic A. Sloane

المصدر: Journal of Biological Chemistry. 284:15880-15893

مصطلحات موضوعية: DNA, Complementary, DNA Mutational Analysis, Aurora inhibitor, Aurora B kinase, Mitosis, Protein Serine-Threonine Kinases, Biology, Biochemistry, PLK1, Piperazines, MAP2K7, Aurora Kinases, Aurora Kinase B, Humans, Kinome, Enzyme Inhibitors, Molecular Biology, Binding Sites, Mechanisms of Signal Transduction, Polo kinase, Cell Biology, Cell biology, Kinetics, enzymes and coenzymes (carbohydrates), Pyrimidines, Imatinib mesylate, Mutagenesis, Benzamides, Imatinib Mesylate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6476963271ae555101562669ac2b011c
https://doi.org/10.1074/jbc.m109.005694

المؤلفون: Matthew Ling-Hon Chu, William I. Weis, Niket Shah, Michael D Enos, Jennifer L. Stamos

المصدر: eLife, Vol 3 (2014)
eLife

مصطلحات موضوعية: LRP6, Protein Conformation, QH301-705.5, Science, Molecular Sequence Data, macromolecular substances, Biology, Crystallography, X-Ray, Biochemistry, Catalysis, General Biochemistry, Genetics and Molecular Biology, Substrate Specificity, Glycogen Synthase Kinase 3, 03 medical and health sciences, GSK-3, Animals, Humans, Amino Acid Sequence, human, Phosphorylation, Biology (General), Receptor, Protein kinase A, 030304 developmental biology, 0303 health sciences, Sequence Homology, Amino Acid, General Immunology and Microbiology, General Neuroscience, 030302 biochemistry & molecular biology, Wnt signaling pathway, protein kinase, General Medicine, Biophysics and Structural Biology, Wnt signaling, 3. Good health, A-site, Medicine, Signal transduction, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a188b88d2e8ad3a0e6ea4b1b762dec0
https://doi.org/10.7554/elife.01998

المؤلفون: Michael D Enos, William I. Weis, Niket Shah, Jennifer L. Stamos, Matthew Ling-Hon Chu

مصطلحات موضوعية: Terminal (electronics), GSK-3, Chemistry, Wnt signaling pathway, LRP6, Phosphorylation, Receptor, Cell biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::132cc77268b4983f69f64e23930939f5
https://doi.org/10.7554/elife.01998.015

المؤلفون: Matthew Ling-Hon Chu, Arie Abo, Denise Tran, Victoria E. Ahn, William I. Weis, Hee Jung Choi

مصطلحات موضوعية: 0303 health sciences, Frizzled, Wnt signaling pathway, LRP6, LRP5, Cell Biology, Biology, General Biochemistry, Genetics and Molecular Biology, Article, Cell biology, 03 medical and health sciences, 0302 clinical medicine, Protein structure, DKK1, Ectodomain, Binding site, Molecular Biology, 030217 neurology & neurosurgery, 030304 developmental biology, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a4d3394db71c4019c48785f4183ad5
https://europepmc.org/articles/PMC3215855/

المؤلفون: Hannah Johnson, Patrick A. Eyers, Simon J. Gaskell, Edward A. McKenzie, Matthew Ling-Hon Chu, Rebecca K. Tyler

المصدر: The Biochemical journal. 417(1)

مصطلحات موضوعية: Models, Molecular, Molecular Sequence Data, Mitosis, Cell Cycle Proteins, macromolecular substances, Biology, Protein Serine-Threonine Kinases, Biochemistry, Protein Structure, Secondary, Tandem Mass Spectrometry, Catalytic Domain, Humans, Amino Acid Sequence, Phosphorylation, Protein kinase A, Molecular Biology, Metaphase, Centrosome, Sequence Homology, Amino Acid, Kinase, Autophosphorylation, Cell Biology, Protein-Tyrosine Kinases, Molecular biology, Cell biology, Phosphoprotein, Mutation, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e47fc08f85f7dece8c9b9d821667a750
https://pubmed.ncbi.nlm.nih.gov/18680479

المؤلفون: Patrick A. Eyers, Matthew Ling-Hon Chu, Lydia Tabernero, Leonard M. G. Chavas, Kenneth T. Douglas

المصدر: The Journal of biological chemistry. 283(31)

مصطلحات موضوعية: Molecular Conformation, Antineoplastic Agents, Cell Cycle Proteins, Biology, Protein Serine-Threonine Kinases, Crystallography, X-Ray, Biochemistry, Binding, Competitive, Adenosine Triphosphate, Catalytic Domain, Humans, Integrin-linked kinase, Enzyme Inhibitors, Phosphorylation, Protein kinase A, Molecular Biology, Mitosis, Anthracenes, Binding Sites, Kinase, Rational design, Cell Biology, Cell cycle, Protein-Tyrosine Kinases, Small molecule, Cell biology, Protein Structure, Tertiary, Cyclin-dependent kinase complex, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbdd4dce8bef53409182f9f1af91a885
https://pubmed.ncbi.nlm.nih.gov/18480048

المؤلفون: Bingfa Sun, Bachhawat, Priti, Matthew Ling-Hon Chu, Tong Sun Kobilka, Kobilka, Brian K., Wood, Martyn, Ceska, Tom, Sands, Zara A., Mercier, Joel, Lebon, Florence

المصدر: Proceedings of the National Academy of Sciences of the United States of America; 2/21/2017, Vol. 114 Issue 8, p2066-2071, 6p

مصطلحات موضوعية: ADENOSINES, ALLOSTERIC regulation, DRUG therapy for Parkinson's disease, PARKINSON'S disease treatment, PARKINSON'S disease diagnosis, G protein coupled receptors