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1
المؤلفون: Stephen John Atkinson, Royston C. B. Copley, Matthew J Lindon, Rab K. Prinjha, Alex Preston, James Michael Woolven, Jonathan Thomas Seal, Chun-wa Chung, James Gray, Thomas George Christopher Hayhow, Laurie J. Gordon, Emmanuel Hubert Demont, Aylott Helen Elizabeth, Paola Grandi, Lee Andrew Harrison, Inmaculada Rioja, Robert J. Watson, Simon Taylor, Cassie Messenger, Ian D. Wall, Anne-Marie Michon, Darren Jason Mitchell, Paul Bamborough
المصدر: 'Journal of Medicinal Chemistry ', vol: 63, pages: 9093-9126 (2020)
مصطلحات موضوعية: Male, Stereochemistry, Protein domain, Anti-Inflammatory Agents, Administration, Oral, Cell Cycle Proteins, Molecular Dynamics Simulation, Crystallography, X-Ray, Ligands, Structure-Activity Relationship, Dogs, Protein Domains, In vivo, Drug Discovery, Animals, Humans, Structure–activity relationship, Rats, Wistar, Binding site, Binding Sites, Chemistry, Ligand, Hydrogen Bonding, Amides, Phenotype, Rats, Bromodomain, Molecular Medicine, Selectivity, Half-Life, Transcription Factors
وصف الملف: application/pdf
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2
المؤلفون: Peter D. Craggs, Darren Jason Mitchell, Rab K. Prinjha, Alex Preston, James Michael Woolven, Laurie J. Gordon, Simon Taylor, Paul Bamborough, Chun-wa Chung, Paola Grandi, James Gray, Francesco Rianjongdee, Matthew J Lindon, Anne-Marie Michon, Emma J. Jones, Inmaculada Rioja, Robert J. Watson, Ian D. Wall, Stephen John Atkinson, Emmanuel Hubert Demont, Jonathan Thomas Seal
المصدر: Journal of Medicinal Chemistry. 63:9070-9092
مصطلحات موضوعية: 0303 health sciences, Chemistry, Protein domain, Highly selective, 01 natural sciences, Phenotype, In vitro, 0104 chemical sciences, Cell biology, Bromodomain, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, In vivo, Drug Discovery, Molecular Medicine, Structure–activity relationship, Binding site, 030304 developmental biology
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3
المؤلفون: Patricia F Medeiros, Mythily Vimal, Vipulkumar Kantibhai Patel, John Evans, Neil R Carlson, Antonia J. Lewis, Paul Bamborough, Katherine L Jones, Jane E Smith, Michael O'Sullivan, Scott McCleary, Darren J. Mitchell, Heather Barnett, Chun-wa Chung, Gang Yao, Anthony W. J. Cooper, Rab K. Prinjha, Laurie Gordon, Mahnoor Mahmood, Peter D. Craggs, Isobel L Harada, Rino A Bit, Natalie Wellaway, Armelle Le Gall, Robert J. Watson, Tony W Dean, Dominique Amans, Ian D. Wall, Kayleigh A J Stafford, Dave Lugo, Matthew J Lindon, Rishi R Shah, David Jonathan Hirst, Chris Patten, Darren L Poole, Jack A Brown, Philip G Humphreys, Robert P Davis, Christopher Roland Wellaway, Pamela J Thomas
المصدر: Journal of Medicinal Chemistry. 63:714-746
مصطلحات موضوعية: Male, Models, Molecular, Benzimidazole, Lysine, Drug Evaluation, Preclinical, Computational biology, Crystallography, X-Ray, Small Molecule Libraries, Mice, chemistry.chemical_compound, In vivo, Histone tails, Drug Discovery, Leukocytes, Animals, Humans, Chemokine CCL2, Therapeutic strategy, Interleukin-6, Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Proteins, Drug Synergism, Epigenome, Small molecule, High-Throughput Screening Assays, Bromodomain, Molecular Medicine, Benzimidazoles, Protein Processing, Post-Translational
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4
المؤلفون: James M. Woolven, William J. Kerr, Chun-wa Chung, Bhumika Karamshi, Beata S. Wyspiańska, John Evans, Emmanuel Hubert Demont, Laurie Gordon, Matthew J Lindon, Peter E. Soden, Rob Willis, Leanne Cutler, Darren J. Mitchell, Christopher Roland Wellaway, Antonia J. Lewis, Robert J. Watson, Paul Bamborough, Simon Taylor, Inmaculada Rioja, Sharon G. Bernard, Rab K. Prinjha, Peter D. Craggs
مصطلحات موضوعية: Male, BRD4, medicine.drug_class, Anti-Inflammatory Agents, Cell Cycle Proteins, Molecular Dynamics Simulation, Quinolones, 01 natural sciences, Anti-inflammatory, BET inhibitor, 03 medical and health sciences, Mice, Protein Domains, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, QD, Epigenetics, Phylogeny, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Binding Sites, Small molecule, Phenotype, 0104 chemical sciences, Amino acid, Bromodomain, Cell biology, 010404 medicinal & biomolecular chemistry, chemistry, Drug Design, Leukocytes, Mononuclear, Molecular Medicine, Cytokines, Half-Life, Transcription Factors
وصف الملف: application/pdf
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5
المؤلفون: Peter Ernest Soden, Emma J. Roberts, Danette L. Daniels, Chun-wa Chung, Stephen John Atkinson, Paul Bamborough, Anne Marie Michon, Johanna Vappiani, Andrea C. Haynes, Massimo Petretich, Marcus Bantscheff, Miriam M. Yeung, Matthew J Bell, Sarah-Jane Dawson, Paola Grandi, Dane Vassiliadis, Simon Taylor, James Gray, Omer Gilan, Kathy Knezevic, Marjeta Urh, Matthew J Lindon, Marian L. Burr, Rab K. Prinjha, Alex Preston, Inmaculada Rioja, Mark A. Dawson, Gerard Drewes, Thilo Werner, Christopher Roland Wellaway, Emmanuel Hubert Demont, Anna K. Bassil, Nicola Harker, Thomas Gobbetti, Enid Y.N. Lam, David F. Tough, Vinod Kumar
المصدر: Science
مصطلحات موضوعية: Regulation of gene expression, Male, BRD4, Multidisciplinary, Chromatin binding, HEK 293 cells, Prostatic Neoplasms, Proteins, Biology, Article, Chromatin, Bromodomain, Protein Domains, Gene expression, Cancer research, Humans, Transcription factor
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6
المؤلفون: Nigel Deeks, Torquil I. Jack, Jonathan D. Goodacre, Martin Sims, Nigel J. Parr, Martin Brandt, Pamela Thomas, Kevin R. Page, Gordon Bruton, James H. Thorpe, Afjal Hussain Miah, Lena Shukla, Duncan S. Holmes, Matthew J Lindon, Leanne Cutler, Erica Christodoulou, David Jonathan Hirst
المصدر: Bioorganic & Medicinal Chemistry Letters. 30:127533
مصطلحات موضوعية: Indoles, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Chemistry, Pharmaceutical, Cellular Assay, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Combinatorial chemistry, METAP2, Rapid identification, Structure-Activity Relationship, Orally active, Molecular size, Drug Discovery, Humans, Methionyl Aminopeptidases, Molecular Medicine, Molecule, Distribution (pharmacology), Structure based, Enzyme Inhibitors, Molecular Biology
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7
المؤلفون: David Jonathan Hirst, Chun-wa Chung, Rab K. Prinjha, Stephen John Atkinson, Robert P. Law, Paul Bamborough, Allan J. B. Watson, Emmanuel Hubert Demont, Matthew J Lindon, Laurie J. Gordon
المصدر: Journal of medicinal chemistry. 61(10)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, BRD4, Protein Conformation, Quantitative Structure-Activity Relationship, Sequence Homology, chemical and pharmacologic phenomena, Cell Cycle Proteins, Plasma protein binding, Molecular Dynamics Simulation, Protein Serine-Threonine Kinases, 01 natural sciences, 03 medical and health sciences, Protein structure, Quinoxalines, Drug Discovery, Humans, Protein Interaction Domains and Motifs, Amino Acid Sequence, Binding Sites, biology, Molecular Structure, 010405 organic chemistry, Drug discovery, Chemistry, Nuclear Proteins, hemic and immune systems, Combinatorial chemistry, 0104 chemical sciences, Bromodomain, 030104 developmental biology, Histone, Acetylation, biology.protein, Molecular Medicine, Selectivity, Protein Binding, Transcription Factors
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8
المؤلفون: Laurie J. Gordon, Matthew J Lindon, Nicholas C. O. Tomkinson, Chun-wa Chung, Isabelle Becher, Judit Molnar, Ka Hing Che, Paola Grandi, Andrew J. Bannister, David H. Drewry, Rab K. Prinjha, Antje Dittmann, Tony Kouzarides, Natalie Hope Theodoulou, Rino A. Bit, Philip G. Humphreys, Anne-Marie Michon, Samuel Robson, Gerard Drewes, Melanie Leveridge, Paul Bamborough
المصدر: 'Journal of Medicinal Chemistry ', vol: 59, pages: 1425-1439 (2016)
Theodoulou, N H, Bamborough, P, Bannister, A J, Becher, I, Bit, R A, Che, K H, Chung, C, Dittmann, A, Drewes, G, Drewry, D H, Gordon, L, Grandi, P, Leveridge, M, Lindon, M, Michon, A-M, Molnar, J, Robson, S C, Tomkinson, N C O, Kouzarides, T, Prinjha, R K & Humphreys, P G 2016, ' Discovery of I-BRD9, a selective cell active chemical probe for bromodomain containing protein 9 inhibition ', Journal of Medicinal Chemistry, vol. 59, no. 4, pp. 1425-1439 . https://doi.org/10.1021/acs.jmedchem.5b00256
J Med Chemمصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Lysine, Crystallography, X-Ray, Article, Cell Line, Small Molecule Libraries, 03 medical and health sciences, Protein acylation, Transcription (biology), Drug Discovery, Humans, Amino Acid Sequence, Gene, Binding Sites, biology, Chemistry, Biomedical Sciences, Molecular biology, Bromodomain, Chromatin, Cell biology, Molecular Docking Simulation, QD450, 030104 developmental biology, Histone, Acetylation, biology.protein, Molecular Medicine, Transcription Factors
وصف الملف: application/pdf
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9
المؤلفون: Chun-wa Chung, Paola Grandi, Mikhail M. Savitski, Matthew J Lindon, Rab K. Prinjha, Carsten Hopf, Thilo Werner, Marcus Bantscheff, Gitte Neubauer, Antje Dittmann, Maria Fälth Savitski, Gerard Drewes
المصدر: ACS Chemical Biology; Vol 9
مصطلحات موضوعية: Models, Molecular, BRD4, Morpholines, chemical and pharmacologic phenomena, Cell Cycle Proteins, Biology, Protein Serine-Threonine Kinases, Crystallography, X-Ray, Biochemistry, Piperazines, Cell Line, chemistry.chemical_compound, Humans, LY294002, Enzyme Inhibitors, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Kinase, Nuclear Proteins, RNA-Binding Proteins, hemic and immune systems, General Medicine, Cell cycle, 3. Good health, Bromodomain, HEK293 Cells, chemistry, Chromones, Molecular Medicine, Pharmacophore, Transcription Factors
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10
المؤلفون: Laurie J. Gordon, Paola Grandi, Chun-wa Chung, Katherine Louise Jones, Colin J. Suckling, Jameed Hussain, Matthew J Lindon, David F. Tough, Philip G. Humphreys, Thomas George Christopher Hayhow, Jessica F. Renaux, Paul Bamborough, Peter D. Craggs, Rab K. Prinjha, Anne-Marie Michon
المصدر: Journal of medicinal chemistry. 60(2)
مصطلحات موضوعية: 0301 basic medicine, Cell Membrane Permeability, Protein domain, Cell, 01 natural sciences, 03 medical and health sciences, Mice, Structure-Activity Relationship, Piperidines, Protein Domains, Transcription (biology), Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, p300-CBP Transcription Factors, CREB-binding protein, Histone Acetyltransferases, biology, 010405 organic chemistry, Chemistry, Membranes, Artificial, Stereoisomerism, 0104 chemical sciences, Cell biology, Bromodomain, Pyridazines, enzymes and coenzymes (carbohydrates), 030104 developmental biology, medicine.anatomical_structure, PCAF, Biochemistry, Viral replication, Molecular Probes, biology.protein, Molecular Medicine
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11
المؤلفون: Hongtao Lu, Feng Ren, David Jonathan Hirst, John D. Elliott, Xichen Lin, Linbo Luan, Taylor B. Guo, Yonghui Wang, Chengyong Li, Ting Yang, Heng Xu, Haibo Zhang, Matthew J Lindon, Wei Zhang, Yan Xu, Jia-Ning Xiang, Han Fangbin, Yonggang Zhao
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:2456-2459
مصطلحات موضوعية: Chemistry, Stereochemistry, Sphingosine-1-phosphate receptor, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Combinatorial chemistry, chemistry.chemical_compound, Drug Discovery, Molecular Medicine, Sphingosine-1-phosphate, Receptor, Selectivity, Molecular Biology
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12
المؤلفون: Victoria J. Barrett, Feng Wang, Christopher Browning, Matthew J Lindon, Henry M. Sarau, James A. Fornwald, Andy J. Harker, Guido Hartmann, Jeffery K. Kerns, David P. Andrew, Graeme Irvine Stevenson, Ashley Paul Hancock, Victoria Vinader, Michael L. Moore, James J. Foley, Jian Jin, Parvathi Rao, Anthony J. Jurewicz, Helen E. Connor, Dwight M. Morrow, Kristen E. Belmonte, Yonghui Wang, Ralph A. Rivero, Cuc Nguyen
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:1722-1725
مصطلحات موضوعية: ERG1 Potassium Channel, Stereochemistry, High-throughput screening, Clinical Biochemistry, Drug Evaluation, Preclinical, Human immunodeficiency virus (HIV), Pharmaceutical Science, CHO Cells, Computational biology, Protein Serine-Threonine Kinases, medicine.disease_cause, Biochemistry, Chemical synthesis, Myotonin-Protein Kinase, Receptors, CCR8, Structure-Activity Relationship, Cricetulus, Th2 Cells, Cricetinae, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Computer Simulation, Molecular Biology, Oxazolidinones, Chemistry, Organic Chemistry, Ether-A-Go-Go Potassium Channels, Chemotaxis, Leukocyte, Lung disease, Molecular Medicine, Indicators and Reagents, Receptors, Chemokine
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13
المؤلفون: Rab K. Prinjha, Inmaculada Rioja, David F. Tough, Matthew J Lindon, Huw D. Lewis
المصدر: British Journal of Pharmacology.
مصطلحات موضوعية: Pharmacology, Genetics, Human disease, Protein family, Drug discovery, Disease, Computational biology, Epigenetics, Biology, Gene, Function (biology), Epigenesis
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14
المصدر: British journal of pharmacology. 171(22)
مصطلحات موضوعية: Histone Demethylases, Protein-Arginine N-Methyltransferases, Hydrolases, Drug Discovery, Humans, Reviews, Histone-Lysine N-Methyltransferase, Histone Deacetylases, Epigenesis, Genetic, Histone Acetyltransferases
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15Academic Journal
المؤلفون: Luke Henderson, Matthew J Lindon, Michael C Willis
مصطلحات موضوعية: Chemical sciences, Inorganic chemistry, Organic chemistry, Uncategorised value
Relation: http://hdl.handle.net/10779/DRO/DU:26367757.v1; https://figshare.com/articles/journal_contribution/ChemInform_Abstract_Palladium_Catalyzed_Tandem_Alkenyl_and_Aryl_C_N_Bond_Formation_A_Cascade_N_Annulation_Route_to_4_5_6_and_7_Chloroindoles_/26367757
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16
المؤلفون: Michael C. Willis, Matthew J Lindon, Luke C. Henderson
المصدر: ChemInform. 42
مصطلحات موضوعية: chemistry.chemical_compound, Annulation, Tandem, Cascade, Chemistry, Aryl, Intramolecular force, chemistry.chemical_element, General Medicine, Medicinal chemistry, Amination, Catalysis, Palladium
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17
المؤلفون: Matthew J Lindon, Michael C. Willis, Luke C. Henderson
المصدر: TETRAHEDRON. 66(33)
مصطلحات موضوعية: Annulation, Intramolecular reaction, Aryl, Organic Chemistry, chemistry.chemical_element, Biochemistry, Medicinal chemistry, chemistry.chemical_compound, chemistry, Cascade reaction, Nucleophile, Intramolecular force, Drug Discovery, Organic chemistry, Amination, Palladium
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18Academic Journal
المؤلفون: Philip G. Humphreys (1357530), Stephen J. Atkinson (1297362), Paul Bamborough (1343466), Rino A. Bit (1357536), Chun-wa Chung (1343454), Peter D. Craggs (7180412), Leanne Cutler (1738141), Rob Davis (9204195), Alan Ferrie (11920186), GangLi Gong (11920189), Laurie J. Gordon (1343442), Matthew Gray (2402251), Lee A. Harrison (2160145), Thomas G. Hayhow (3624884), Andrea Haynes (1399255), Nick Henley (11920192), David J. Hirst (1399282), Ian D. Holyer (11920195), Matthew J. Lindon (8232792), Cerys Lovatt (11920198), David Lugo (2803279), Scott McCleary (8232795), Judit Molnar (1357521), Qendresa Osmani (11920201), Chris Patten (8232804), Alex Preston (9105252), Inmaculada Rioja (8539), Jonathan T. Seal (2119816), Nicholas Smithers (487233), Fenglai Sun (11920204), Dalin Tang (835554), Simon Taylor (441637), Natalie H. Theodoulou (1508650), Clare Thomas (7943747), Robert J. Watson (1343463), Christopher R. Wellaway (7148462), Linrong Zhu (11920207), Nicholas C. O. Tomkinson (7417448), Rab K. Prinjha (449759)
مصطلحات موضوعية: Biochemistry, Medicine, Molecular Biology, Pharmacology, Biotechnology, Sociology, Immunology, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, potency agnostic analysis, orally bioavailable tetrahydroquinoline, medicinal chemistry strategy, bet567 (< b, appropriate lipophilicity space, oncology clinical trials, bromodomain oral candidate, bet candidate inhibitor, bet candidate, ‑ bet567, work describes, ultimately delivered, small group, sar knowledge, n <, mouse models, lysine group, human disease, histone tails, higher probability
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19
المؤلفون: Jingjun Li, Jie Luo, Zhong Zhong, Guofeng Meng, Jing Zhao, Sharon Wu, Hong Lin, Rab K. Prinjha, Hongkang Mei, Jing Ma, David F. Tough, Inmaculada Rioja, Matthew J Lindon, Xiaohong Xu, Jamie Wang
المصدر: Stem Cell Research, Vol 17, Iss 2, Pp 212-221 (2016)
مصطلحات موضوعية: 0301 basic medicine, JQ-1, BRD4, Chromosomal Proteins, Non-Histone, Neurogenesis, Biology, Bioinformatics, I-BET, 03 medical and health sciences, Mice, Directed differentiation, Neural Stem Cells, medicine, Fluorescence Resonance Energy Transfer, Animals, Neural progenitor cells, Progenitor cell, RNA, Small Interfering, lcsh:QH301-705.5, Cells, Cultured, Gliogenesis, Cell Proliferation, Medicine(all), Nuclear Proteins, Cell Differentiation, Cell Biology, General Medicine, Azepines, Triazoles, Immunohistochemistry, Neural stem cell, Cell biology, Bromodomain, 030104 developmental biology, medicine.anatomical_structure, Phenotype, lcsh:Biology (General), RNA Interference, Epigenetics, Neuron, Small molecule inhibitor, Transcriptome, BET bromodomain, Developmental Biology, Transcription Factors