المؤلفون: Derek M Erion, Amanda Lapworth, Paul A Amor, Guoyun Bai, Nicholas B Vera, Ronald W Clark, Qingyun Yan, Yimin Zhu, Trenton T Ross, Julie Purkal, Matthew Gorgoglione, Guodong Zhang, Vinicius Bonato, Levenia Baker, Nicole Barucci, Theresa D'Aquila, Alan Robertson, Robert J Aiello, Jiangli Yan, Jeff Trimmer, Timothy P Rolph, Jeffrey A Pfefferkorn

المصدر: PLoS ONE, Vol 9, Iss 5, p e97139 (2014)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC4032240?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/646e9e91d00f42f6a75e558c5e50e7cf

المؤلفون: Trenton T. Ross, Karyn L. Hamilton, Melissa A. Linden, Matthew Gorgoglione, William P. Esler, Benjamin F. Miller, Barry Braun, David A. Beebe

المصدر: Metabolism. 97:68-80

مصطلحات موضوعية: Blood Glucose, Male, 0301 basic medicine, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Rodentia, 030209 endocrinology & metabolism, Type 2 diabetes, Diabetes Mellitus, Experimental, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Sodium-Glucose Transporter 2, Physical Conditioning, Animal, Internal medicine, medicine, Animals, Insulin, Sodium-Glucose Transporter 2 Inhibitors, Glycemic, computer.programming_language, Canagliflozin, Exercise Tolerance, sed, business.industry, Body Weight, Area under the curve, Glucose Tolerance Test, medicine.disease, Streptozotocin, Metformin, Rats, Disease Models, Animal, Glucose, 030104 developmental biology, Diabetes Mellitus, Type 2, Sodium/Glucose Cotransporter 2, business, computer, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c081b3e40c2321fec844bb37d115150
https://doi.org/10.1016/j.metabol.2019.05.009

المؤلفون: John D. Knafels, David Price, Matthew Gorgoglione, Aaron C. Smith, Kevin D. Parris, Jemy A. Gutierrez, Magee Thomas Victor, Erik Alphie Lachapelle, Yan Weng, Edward L. Conn, Jeffrey A. Pfefferkorn, Jane M. Withka, Kim Huard, Matthew S. Dowling, Timothy A. Subashi, Trenton T. Ross, Benjamin A. Thuma, Kris A. Borzilleri, Paul A. Amor, Jeffrey S. Culp, Meihua Tu, Sylvie Perez, Jayvardhan Pandit, Andre Shavnya, Boris A. Chrunyk, Gang Xing, John D. Weaver, Yang Cong, Kay Ahn, David A. Beebe, Brian Raymer, Gregory J. Tesz, Steven B. Coffey

المصدر: Journal of Medicinal Chemistry. 60:7835-7849

مصطلحات موضوعية: Male, 0301 basic medicine, Pyridines, Pharmacology, Crystallography, X-Ray, 01 natural sciences, Fructokinases, Rats, Sprague-Dawley, Small Molecule Libraries, 03 medical and health sciences, Insulin resistance, In vivo, Drug Discovery, medicine, Animals, Humans, Transferase, Protein Kinase Inhibitors, chemistry.chemical_classification, 010405 organic chemistry, Chemistry, Metabolism, medicine.disease, Small molecule, Rats, 0104 chemical sciences, Molecular Docking Simulation, 030104 developmental biology, Fructose metabolism, Enzyme, Biochemistry, Drug Design, Molecular Medicine, Steatosis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b654213309542f5b2a14a9d23ebc4df8
https://doi.org/10.1021/acs.jmedchem.7b00947

المؤلفون: Zhenhong Li, James R. Gosset, Matthew Gorgoglione, Keith Riccardi, Li Di, Derek M. Erion, Janice A. Brown, Mark Niosi, Kim Huard

المصدر: Drug Metabolism and Disposition. 44:1633-1642

مصطلحات موضوعية: Pharmaceutical Science, In Vitro Techniques, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, Tandem Mass Spectrometry, In vivo, Animals, Humans, Bovine serum albumin, Cation Transport Proteins, Sodium Sulfate Cotransporter, Pharmacology, Symporters, biology, Chemistry, Biological activity, Transporter, Prodrug, In vitro, Culture Media, Rats, HEK293 Cells, Biochemistry, Cell culture, 030220 oncology & carcinogenesis, Hepatocytes, biology.protein, Intracellular, Chromatography, Liquid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc15d29bc763bc803d4c2d961ca04b87
https://doi.org/10.1124/dmd.116.071837

المؤلفون: Jeffrey A. Pfefferkorn, Matthew Gorgoglione, Scott M. Turner, Clare Buckeridge, Nicholas B. Vera, Marc K. Hellerstein, Annette M. Silvia, Gabriele E. Sonnenberg, Santos Carvajal-Gonzalez, Kathleen Biddle, Paul A. Amor, Raja K Sivamani, Lauren A Hassoun, David A. Griffith, Carine Beysen, Steven M. Watkins, Timothy P. Rolph, Julie Purkal, Mark Fitch, Gregory J. Tesz, William P. Esler, Frank J. Geoly, Suzana S. Bosanac

المصدر: Science translational medicine. 11(492)

مصطلحات موضوعية: 0301 basic medicine, Sebaceous gland, Adult, Male, medicine.medical_specialty, Adolescent, Swine, Human skin, 03 medical and health sciences, chemistry.chemical_compound, Squalene, Sebaceous Glands, Young Adult, 0302 clinical medicine, Internal medicine, Cricetinae, Acne Vulgaris, medicine, Animals, Humans, Enzyme Inhibitors, Rats, Wistar, Acne, Cells, Cultured, Triglycerides, integumentary system, Triglyceride, Cholesterol, Lipogenesis, Acetyl-CoA carboxylase, General Medicine, Middle Aged, medicine.disease, Malonyl Coenzyme A, Sebum, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, Swine, Miniature, Female, Acetyl-CoA Carboxylase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed755d8f32090787a27b2b7eaeec5c2b
https://pubmed.ncbi.nlm.nih.gov/31092695

المؤلفون: Michael Herr, Daniel P. Canterbury, Derek M. Erion, Janice A. Brown, Mark Niosi, Bhagyashree Khunte, Matthew Gorgoglione, Jaclyn Siderewicz, Jana Polivkova, Carmen N. Garcia-Irizarry, Nathan E. Genung, Adam M. Gilbert, Justin I. Montgomery, Daniel P. Uccello, Timothy P. Rolph, Adhiraj Lanba, Qifang Li, Nicholas B. Vera, Kentaro Futatsugi, Gary Erik Aspnes, Zhenhong Li, James R. Gosset, Kim Huard, Matthew Merrill Hayward, Shawn Cabral, Magee Thomas Victor, Julie Purkal, Kevin B. Bahnck

المصدر: Journal of Medicinal Chemistry. 59:1165-1175

مصطلحات موضوعية: Blood Glucose, Male, 0301 basic medicine, Pyridines, Malates, Mice, Obese, Pharmacology, Kidney, Phenylbutyrate, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, 03 medical and health sciences, Pharmacokinetics, In vivo, Drug Discovery, Animals, Humans, Citrates, Dose-Response Relationship, Drug, Molecular Structure, Symporters, Chemistry, Kidney metabolism, Biological Transport, Citrate transport, Phenylbutyrates, In vitro, Rats, Solute carrier family, Mice, Inbred C57BL, HEK293 Cells, 030104 developmental biology, Liver, Biochemistry, Symporter, Hepatocytes, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b4cd858c5eae974c53ce91c3e64131
https://doi.org/10.1021/acs.jmedchem.5b01752

المؤلفون: Sarah Apotheker, Khanh-Van Tran, Richard A. Perugini, Silvia Corvera, Olga Gealekman, Michael J. Thompson, Juerg R. Straubhaar, Kunal Gurav, Nina Guseva, Michael P. Czech, Matthew Gorgoglione, Celia Hartigan, Sarah M. Nicoloro

المصدر: Circulation. 123:186-194

مصطلحات موضوعية: Adult, medicine.medical_specialty, Intra-Abdominal Fat, Angiogenesis, Adipose tissue macrophages, Gastric Bypass, Subcutaneous Fat, Neovascularization, Physiologic, Adipose tissue, White adipose tissue, Article, Body Mass Index, Neovascularization, Physiology (medical), Internal medicine, medicine, Angiopoietin-Like Protein 4, Humans, Obesity, Matrigel, Neovascularization, Pathologic, business.industry, Middle Aged, Endocrinology, medicine.anatomical_structure, Insulin Resistance, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Angiopoietins, Subcutaneous tissue

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f43eb6fcf1ae834713da9dc8fc514484
https://doi.org/10.1161/circulationaha.110.970145

المؤلفون: Matthew Gorgoglione, Keith Riccardi, James R. Gosset, Cecile Vernochet, Mark Niosi, Adhiraj Lanba, Daniel P. Uccello, Li Di, Magee Thomas Victor, Yimin Zhu, Nathan E. Genung, Jeffrey A. Pfefferkorn, David Pirman, Gary Erik Aspnes, Nicholas B. Vera, Yingjiang Zhou, David Hepworth, Timothy P. Rolph, Michael Herr, Derek M. Erion, Janice A. Brown, Shawn Cabral, Jessica E. C. Jones, Paula M. Loria, Kim Huard, Kentaro Futatsugi, Qingyun Yan, Angela Wolford

المصدر: Scientific Reports

مصطلحات موضوعية: Ion Transport, Multidisciplinary, Symporters, Sodium, Cell, chemistry.chemical_element, Citrate transport, Biology, Metabolic intermediate, Article, Citric Acid, In vitro, HEK293 Cells, medicine.anatomical_structure, chemistry, Biochemistry, In vivo, medicine, Extracellular, Humans, Glycolysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7d2a93bec78fd0437c878b51d1bec85

المؤلفون: Timothy P. Rolph, Jiangli Yan, Levenia Baker, Alan Robertson, Vinicius Bonato, Jeffrey A. Pfefferkorn, Paul A. Amor, Jeff K. Trimmer, Theresa D’Aquila, Guoyun Bai, Derek M. Erion, Qingyun Yan, Yimin Zhu, Nicole Barucci, Matthew Gorgoglione, Nicholas B. Vera, Ronald W. Clark, Julie Purkal, Robert J. Aiello, Amanda L. Lapworth, Trenton T. Ross, Guodong Zhang

المصدر: PLoS ONE, Vol 9, Iss 5, p e97139 (2014)
PLoS ONE

مصطلحات موضوعية: Male, Physiology, medicine.medical_treatment, lcsh:Medicine, Biochemistry, Endocrinology, Non-alcoholic Fatty Liver Disease, Integrative Physiology, Drug Discovery, Glucokinase, Medicine and Health Sciences, Glucose homeostasis, lcsh:Science, Mammals, Multidisciplinary, Systems Biology, Fatty liver, Imidazoles, Animal Models, Lipids, Liver, Research Design, Organ Specificity, Vertebrates, Carbohydrate Metabolism, Anatomy, Research Article, Biotechnology, medicine.medical_specialty, Drug Research and Development, Clinical Research Design, Enzyme Activators, Endocrine System, Hypoglycemia, Carbohydrate metabolism, Biology, Research and Analysis Methods, Rodents, Diabetes Mellitus, Experimental, Model Organisms, Internal medicine, Diabetes mellitus, medicine, Animals, Animal Models of Disease, Diabetic Endocrinology, Pharmacology, Insulin, lcsh:R, Organisms, Nicotinic Acids, Biology and Life Sciences, medicine.disease, Lipid Metabolism, Rats, Metabolism, Glucose, Small Molecules, Hyperglycemia, Animal Studies, Hepatocytes, lcsh:Q, Steatosis, Energy Metabolism, Physiological Processes

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393ea8ae1d1d8d29924dda2ab8dfedf2
http://europepmc.org/articles/PMC4032240?pdf=render