المؤلفون: Kimberly J. Hassett, Kerry E. Benenato, Eric Jacquinet, Aisha Lee, Angela Woods, Olga Yuzhakov, Sunny Himansu, Jessica Deterling, Benjamin M. Geilich, Tatiana Ketova, Cosmin Mihai, Andy Lynn, Iain McFadyen, Melissa J. Moore, Joseph J. Senn, Matthew G. Stanton, Örn Almarsson, Giuseppe Ciaramella, Luis A. Brito

المصدر: Molecular Therapy: Nucleic Acids, Vol 15, Iss , Pp 1-11 (2019)

مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253119300174; https://doaj.org/toc/2162-2531

URL الوصول: https://doaj.org/article/a67efab35a6f4ecb83f57432db8444c0

المؤلفون: Aisha Lee, Kerry Benenato, Angela Woods, Cosmin Mihai, Luis Brito, Andy Lynn, Matthew G. Stanton, Orn Almarsson, Kimberly J. Hassett, Benjamin M. Geilich, Olga Yuzhakov, Sunny Himansu, Melissa J. Moore, Jessica Deterling, Joseph J. Senn, Tatiana Ketova, Iain Mcfadyen, Eric Jacquinet, Giuseppe Ciaramella

المصدر: Molecular Therapy: Nucleic Acids, Vol 15, Iss, Pp 1-11 (2019)
Molecular Therapy. Nucleic Acids

مصطلحات موضوعية: 0301 basic medicine, LNP, mRNA, formulation, immunogenicity, Pharmacology, Article, lipids, 03 medical and health sciences, 0302 clinical medicine, Immune system, Drug Discovery, Medicine, Potency, tolerability, intramuscular, Messenger RNA, Innate immune system, business.industry, Immunogenicity, lcsh:RM1-950, Rodent model, vaccines, 030104 developmental biology, lcsh:Therapeutics. Pharmacology, Tolerability, 030220 oncology & carcinogenesis, Molecular Medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f88cbdbd52e2ec8195489fa0016d36ed
http://www.sciencedirect.com/science/article/pii/S2162253119300174

المؤلفون: Matthew G. Stanton, Sanjeev Munshi, Ian W. Davies, Kaleen Konrad Childers, Michael Hutton, Lee Warren, Mansuo Hayashi, Anna A. Zabierek, Alan B. Northrup, Alexander A. Szewczak, Hugh Nuthall, Andrew M. Haidle, Ben Munoz, Dapeng Chen, Hua-Poo Su, Yongquan Hou, Jason D. Katz, Andreas Harsch, Michael D. Altman, James P. Jewell

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:114-120

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Pyrimidinones, Computational biology, Protein Serine-Threonine Kinases, Crystallography, X-Ray, Biochemistry, Cell Line, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Alzheimer Disease, Drug Discovery, Humans, Pyrroles, Protein Kinase Inhibitors, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Isoindoline, 030104 developmental biology, Drug Design, Molecular Medicine, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20493003f7f8446544809a814383d0f7
https://doi.org/10.1016/j.bmcl.2016.08.068

المؤلفون: Andrew M. Haidle, Alan B. Northrup, Alexander A. Szewczak, Lee Warren, Jason D. Katz, James P. Jewell, Mansuo Hayashi, Hugh Nuthall, Andreas Harsch, Michael D. Altman, Ian W. Davies, Dapeng Chen, Kaleen Konrad Childers, Michael Hutton, Anna A. Zabierek, Matthew G. Stanton, Yongquan Hou, Ben Munoz

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:109-113

مصطلحات موضوعية: 0301 basic medicine, Clinical Biochemistry, Pharmaceutical Science, Pyrimidinones, Computational biology, Protein Serine-Threonine Kinases, Pharmacology, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, Alzheimer Disease, Drug Discovery, Animals, Humans, Pyrroles, Protein Kinase Inhibitors, Molecular Biology, Ligand efficiency, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Rats, Isoenzymes, 030104 developmental biology, Go/no go, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fc8536570d3d5135b8796086271560b
https://doi.org/10.1016/j.bmcl.2016.08.066

المؤلفون: Laura Sepp-Lorenzino, Hangchun Zhang, Yi Pei, South Victoria J, Steven L. Colletti, Wonsuk Chang, Daniel Zewge, Matthew G. Stanton, Jillian DiMuzio, Edward C. Sherer, Craig A. Parish, Erin N. Guidry, Walter Strapps

المصدر: Bioorganic & Medicinal Chemistry Letters. 26:4513-4517

مصطلحات موضوعية: 0301 basic medicine, Small interfering RNA, Clinical Biochemistry, Trans-acting siRNA, Pharmaceutical Science, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, RNA interference, Drug Discovery, Humans, Gene silencing, Gene Silencing, RNA, Messenger, RNA, Small Interfering, Molecular Biology, beta Catenin, Gene knockdown, Oligonucleotide, Chemistry, Organic Chemistry, Molecular biology, Cell biology, RNA silencing, HEK293 Cells, 030104 developmental biology, 030220 oncology & carcinogenesis, Nucleic acid, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb6c3475fdb99d790963e0ba52d5e60
https://doi.org/10.1016/j.bmcl.2016.07.064

المؤلفون: Iain Mcfadyen, Kerry Benenato, Cosmin Mihai, Andy Lynn, Timothy Salerno, Matthew G. Stanton, Alex Bulychev, E. Sathyajith Kumarasinghe, Orn Almarsson, Tatiana Ketova, Joyce Chan, Staci Sabnis, Joseph J. Senn

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Primates, Messenger RNA, Endosome, Delivery vehicle, Chemistry, Repeat dose, Lipids, Rats, 03 medical and health sciences, 030104 developmental biology, Tolerability, Pharmacokinetics, Drug Discovery, Genetics, Molecular Medicine, Animals, Nanoparticles, Original Article, RNA, Messenger, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d901226f1c937f312227f83786157589
https://europepmc.org/articles/PMC5986714/

المؤلفون: Matthew G. Stanton, Kerry E. Murphy-Benenato

المصدر: Topics in Medicinal Chemistry ISBN: 9783319680903

مصطلحات موضوعية: 0301 basic medicine, 03 medical and health sciences, Therapeutic approach, Messenger RNA, 030104 developmental biology, Immunogenicity, RNA, 02 engineering and technology, Computational biology, 021001 nanoscience & nanotechnology, 0210 nano-technology, Protein expression

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::da7497ce5ce311ec9730854209389905
https://doi.org/10.1007/7355_2016_30

المؤلفون: Klaus Charisse, Matthew G. Stanton, Christopher S. Theile, Kallanthottathil G. Rajeev, Rachel Meyers, Muthiah Manoharan, Laura Sepp-Lorenzino, Mark T. Cancilla, Rubina G. Parmar, Martin Maier, Walter Strapps, Yi Pei, Erin N. Guidry, Akin Akinc, Vasant Jadhav, Jennifer L. S. Willoughby, Donald Foster, Jingxuan Liu, Benjamin Brigham

المصدر: Chembiochem : a European journal of chemical biology. 17(11)

مصطلحات موضوعية: 0301 basic medicine, Small interfering RNA, Acetylgalactosamine, Vinyl Compounds, RNA-induced silencing complex, Organophosphonates, Biology, Biochemistry, Factor IX, 03 medical and health sciences, Mice, 0302 clinical medicine, RNA interference, Gene silencing, Animals, Humans, RNA-Induced Silencing Complex, Kinase activity, RNA, Small Interfering, Molecular Biology, Cells, Cultured, Apolipoproteins B, Kinase, Oligonucleotide, Organic Chemistry, RNA-Binding Proteins, Argonaute, Lipoproteins, LDL, Mice, Inbred C57BL, 030104 developmental biology, 030220 oncology & carcinogenesis, Argonaute Proteins, Hepatocytes, Molecular Medicine, RNA Interference, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c86e8a66f8a1a59b2a453762c924743
https://pubmed.ncbi.nlm.nih.gov/27121751

المؤلفون: Steven L. Colletti, Matthew G. Stanton

المصدر: Journal of Medicinal Chemistry. 53:7887-7901

مصطلحات موضوعية: Drug Carriers, Polymers, Drug discovery, Chemistry, RNA, Computational biology, Transfection, Lipids, Structure-Activity Relationship, Drug Discovery, Animals, Humans, Nanoparticles, Molecular Medicine, Structure–activity relationship, RNA, Small Interfering, Drug carrier

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5bb3c32ffd7a723ce598845d2494921
https://doi.org/10.1021/jm1003914

المؤلفون: George N. Nikov, Grace Bi, Benito Munoz, Matthew G. Stanton, Matthew T. Tudge, Richard E. Middleton, Jamie L. Crispino, Peter Sajonz, Mark S. Shearman, Black Regina M, Minilik Angagaw, Paula Andrade, Eric Fan, Flobert Tanga, Jonathan C. Cruz, Alexander A. Szewczak, Nirah H. Shomer, Bethany Hughes, Sanjiv J. Shah, Georgia Farris, Christopher Hamblett, Jed L. Hubbs, David L. Sloman, Candia M. Kenific

المصدر: Bioorganic & Medicinal Chemistry Letters. 20:755-758

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Mice, Transgenic, Acetates, Biochemistry, Chemical synthesis, Mice, Acetic acid, chemistry.chemical_compound, Piperidines, In vivo, Drug Discovery, Amyloid precursor protein, Animals, Molecular Biology, Amyloid beta-Peptides, Receptors, Notch, biology, Organic Chemistry, Biological activity, Diazonium Compounds, Fluorine, Peptide Fragments, Rats, Disease Models, Animal, chemistry, biology.protein, Molecular Medicine, Piperidine, Amyloid Precursor Protein Secretases, Selectfluor, Amyloid precursor protein secretase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7392b77aec791c32df48952dbb130dde
https://doi.org/10.1016/j.bmcl.2009.11.034

المؤلفون: Fanyu Meng, Jonathan C. Cruz, Astrid M. Kral, Robert E. Settlage, Victoria M. Richon, Cloud P. Paweletz, Ronald C. Hendrickson, J. Paul Secrist, Roy M. Pollock, Thomas A. Miller, Nathan A. Yates, Anita Y. H. Lee, Nicole Ozerova, Matthew G. Stanton

المصدر: Journal of Proteome Research. 7:5177-5186

مصطلحات موضوعية: Proteomics, Spectrometry, Mass, Electrospray Ionization, animal structures, Proteome, Antineoplastic Agents, Biochemistry, Gene Expression Regulation, Enzymologic, Histone Deacetylases, Mass Spectrometry, Histones, Histone H3, In vivo, Cell Line, Tumor, Histone H2B, Humans, Protein Isoforms, False Positive Reactions, Regulation of gene expression, biology, Chemistry, General Chemistry, HDAC1, enzymes and coenzymes (carbohydrates), Histone, ROC Curve, embryonic structures, biology.protein, Histone deacetylase, biological phenomena, cell phenomena, and immunity, Peptides, Chromatography, Liquid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb7d272e344e421759a4a6a246ad557
https://doi.org/10.1021/pr800510p

المؤلفون: Janet Lineberger, Matthew G. Stanton, Amy S. Espeseth, Beth Pietrak, Min Xu, Katherine Tugusheva, Harold G. Selnick, Dennis Colussi, Guy R. Seabrook, John Swestock, Jason Kahana, Ming-Chih Crouthamel, Viswanath Devanarayan, Keala X. Tyler, Guoxin Wu, Daria J. Hazuda, Shaun R. Stauffer, Joan D. Ellis, Marie A. Holahan, Joseph P. Vacca, Philippe G. Nantermet, Melissa A. Steinbeiser, Georgia B. McGaughey, Eric A. Price, Jerome Hochman, Hemaka A. Rajapakse, Sethu Sankaranarayanan, Adam J. Simon, Samuel L. Graham, Keith P. Moore, M. Katharine Holloway, Ming-Tain Lai, Lixia Jin, Adam Gates, Xiao-Ping Shi, Jacky Wong, Jacquelynn J. Cook, Allison R. Gregro

المصدر: Journal of Pharmacology and Experimental Therapeutics. 328:131-140

مصطلحات موضوعية: medicine.medical_specialty, Membrane permeability, Mice, Transgenic, Pharmacology, Transfection, Cisterna magna, Amyloid beta-Protein Precursor, Mice, Cerebrospinal fluid, Pharmacokinetics, Oral administration, In vivo, Internal medicine, medicine, Amyloid precursor protein, Animals, Aspartic Acid Endopeptidases, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Enzyme Inhibitors, Infusions, Intravenous, biology, Macaca mulatta, Endocrinology, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01219a959e3def2dc15d6af0a2e96474
https://doi.org/10.1124/jpet.108.143628

المؤلفون: Christopher Hamblett, Richard G. Ball, Laura T. Kliman, Matthew G. Stanton, Bruce Adams, David L. Sloman

المصدر: Tetrahedron Letters. 48:2079-2082

مصطلحات موضوعية: Steric effects, Stereochemistry, Aryl, Organic Chemistry, Substrate (chemistry), General Medicine, Biochemistry, Combinatorial chemistry, Catalysis, chemistry.chemical_compound, chemistry, Nucleophile, Reagent, Drug Discovery, Cuprate, Cis–trans isomerism

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59dacf72ea824db8956210cec5334cbc
https://doi.org/10.1016/j.tetlet.2007.01.135

المؤلفون: Georgia B. McGaughey, Adam J. Simon, Ming Tain Lai, Dennis Collusi, Shaun R. Stauffer, Beth Pietrak, Alison R. Gregro, James C. Barrow, Harold G. Selnick, Samuel L. Graham, M. Katharine Holloway, Joseph P. Vacca, Matthew G. Stanton, Amy S. Espeseth, Philippe G. Nantermet, Sanjeev Munshi, Jennifer R. Shaffer, Melissa A. Steinbeiser, Kenneth E. Rittle, Jerome H. Hochman

المصدر: Bioorganic & Medicinal Chemistry Letters. 17:1788-1792

مصطلحات موضوعية: Models, Molecular, Niacinamide, Magnetic Resonance Spectroscopy, Stereochemistry, Isostere, medicine.drug_class, Clinical Biochemistry, Molecular Conformation, Biological Availability, Pharmaceutical Science, Carboxamide, Biochemistry, Cyclopropane, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Hydrolase, Amyloid precursor protein, medicine, Animals, Aspartic Acid Endopeptidases, Isonicotinamide, Enzyme Inhibitors, Molecular Biology, Cells, Cultured, chemistry.chemical_classification, biology, Organic Chemistry, Rats, Molecular Weight, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases, Baculoviridae

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468bd9c3a802f9540ce3f4c1d5078a38
https://doi.org/10.1016/j.bmcl.2006.12.051

المؤلفون: Lee Warren, Suzanne C. Edavettal, Jacob Marcus, Matthew G. Stanton, Hugh Nuthall, David L. Sloman, Tammy Dellovade, Alexander A. Szewczak, Deborah Walker, Sanjeev Munshi, Andrea C. Mislak, Michael Hutton, Michael D. Altman, Zhenhua Wu, Mansuo Hayashi, Dapeng Chen, Hua-Poo Su, Njamkou Noucti

المصدر: Bioorganicmedicinal chemistry letters. 26(17)

مصطلحات موضوعية: 0301 basic medicine, Clinical Biochemistry, Pharmaceutical Science, Protein Serine-Threonine Kinases, Crystallography, X-Ray, Biochemistry, Pyrazolopyrimidine, Cns penetration, 03 medical and health sciences, chemistry.chemical_compound, Inhibitory Concentration 50, 0302 clinical medicine, Dogs, Microtubule, Heterocyclic Compounds, Drug Discovery, medicine, Potency, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Improved solubility, Kinase, Organic Chemistry, Neurofibrillary tangle, medicine.disease, Rats, Enzyme Activation, Molecular Weight, 030104 developmental biology, chemistry, Solubility, Molecular Medicine, Efflux, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c7ecae5b310e12910bfeea4ba9e5416
https://pubmed.ncbi.nlm.nih.gov/27491711

المؤلفون: Sethu Sankaranarayanan, Samuel L. Graham, Matthew G. Stanton, Adam J. Simon, Amy S. Espeseth, Alison R. Gregro, Ming-Chih Crouthamel, Guoxin Wu, Xiao-Ping Shi, Shaun R. Stauffer, Qian Huang, Eric A. Price, Joseph P. Vacca, Lixia Jin, Philippe G. Nantermet, Dennis Colussi, Joan D. Ellis, Harold G. Selnick, Beth Pietrak, Min Xu, Melissa A. Steinbeiser, Ming-Tain Lai

المصدر: Journal of Medicinal Chemistry. 50:3431-3433

مصطلحات موضوعية: Isostere, Biological Availability, Blood–brain barrier, Mice, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Drug Discovery, Amyloid precursor protein, medicine, Animals, Structure–activity relationship, Isonicotinamide, Amyloid beta-Peptides, Dose-Response Relationship, Drug, biology, Brain, Amides, Peptide Fragments, Rats, medicine.anatomical_structure, chemistry, Biochemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases, Isonicotinic Acids, Amyloid precursor protein secretase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc725699af7f687ec6cd3012d9e11ad9
https://doi.org/10.1021/jm070272d

المؤلفون: Cara B. Allen, and Alice L. Lincoln, Rebecca M. Kissling, Matthew G. Stanton, Michel R. Gagné

المصدر: Journal of the American Chemical Society. 120:5981-5989

مصطلحات موضوعية: Quenching (fluorescence), Inorganic chemistry, Substituent, General Chemistry, Methyl benzoate, Alkali metal, Biochemistry, Medicinal chemistry, Catalysis, Reaction rate, chemistry.chemical_compound, Colloid and Surface Chemistry, chemistry, Tetrahedral carbonyl addition compound, Alkoxide

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9256a8b03327a2cfa715491e211cbea2
https://doi.org/10.1021/ja980584t

المؤلفون: Matthew G. Stanton, David J. Witter, Christopher Hamblett, Nicole Ozerova, Brian B. Haines, Richard E. Middleton, Judith C. Fleming, Phieng Siliphaivanh, Dawn Marie Mampreian Hoffman, Hongmei Wang, Alexander A. Szewczak, Jed L. Hubbs, Melissa Chenard, Astrid M. Kral, Bethany Hughes, Kevin J. Wilson, Paul Harrington, J. Paul Secrist, Richard W. Heidebrecht, Joey L. Methot, Thomas A. Miller, Jonathan C. Cruz, Andreas Harsch, Candia M. Kenific

مصطلحات موضوعية: biology, Histone deacetylase 2, medicine.drug_class, Organic Chemistry, Histone deacetylase inhibitor, Pharmacology, Biochemistry, In vitro, HDAC1, Histone, In vivo, Acetylation, Drug Discovery, Gene expression, biology.protein, medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe238132473cf3e20a702fe00be4018
https://europepmc.org/articles/PMC4027730/

المؤلفون: Weimin Wang, Leticia Arrington, David Boardman, Anthony Leone, Marian Gindy, Ye Zhang, John Bawiec, Matthew G. Stanton, Jared Davis, Brian W. Budzik, Steve Stirdivant, Katie DiFelice, James Z. Deng, Yan Xu, Darla Danile Seifried, Gregory L. Beutner

المصدر: Journal of controlled release : official journal of the Controlled Release Society. 174

مصطلحات موضوعية: Serum, Small interfering RNA, Endosome, Pharmaceutical Science, Endosomes, Biology, Sybr gold, Rats, Sprague-Dawley, Mice, In vivo, Lipid based nanoparticles, Animals, RNA, Messenger, RNA, Small Interfering, Apolipoproteins B, Endosomal membrane, Hydrogen-Ion Concentration, Lipids, Macaca mulatta, In vitro, Rats, Biochemistry, Liver, Liposomes, Systemic administration, Nanoparticles, Biological Assay, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00399981839f2fbb512d990fb40d796
https://pubmed.ncbi.nlm.nih.gov/24240015

المؤلفون: Antong Chen, Bruce Ng, Belma Dogdas, Edward Keough, Bonnie J Howell, Saurin Mehta, Joseph P. Davide, Weikang Tao, Kathleen M. Haskell, Amy G. Aslamkhan, Laura Sepp-Lorenzino, Matthew G. Stanton, Ansuman Bagchi, D. Adam Meacham

المصدر: EMBC

مصطلحات موضوعية: Pathology, medicine.medical_specialty, Template matching, Molecular biophysics, Green Fluorescent Proteins, technology, industry, and agriculture, Image registration, Mice, Transgenic, Signal Processing, Computer-Assisted, Image segmentation, Biology, Carbocyanines, Signal, Fluorescence, Green fluorescent protein, Mice, Imaging, Three-Dimensional, Microscopy, Fluorescence, Multiphoton, Microscopy, medicine, Animals, RNA, Small Interfering, Biomedical engineering

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad25e7bcaeed0f05b3c4761a29fdc510
https://pubmed.ncbi.nlm.nih.gov/23366734