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1
المؤلفون: Richard Rampulla, Stacey Skala, Charu Chaudhry, Percy H. Carter, Alban Allentoff, Tracy L. Taylor, Ling Li, Andrew J. Tebben, Luisa Salter-Cid, Aberra Fura, Rulin Zhao, Ian M. Catlett, Richard A. Westhouse, Myra Beaudoin Bertrand, John E. Macor, Robin Moore, Celia D’Arienzo, Matt Pokross, Douglas G. Batt, Scott H. Watterson, Mary T. Obermeier, Qingjie Liu, Daniel Smith, Lorell Discenza, Michael Galella, Jun Dai, Arvind Mathur, Kathleen M. Gillooly, Elizabeth M. Heimrich, Jianqing Li, Zheng Yang, Michael Wallace, Kim W. McIntyre, James R. Burke, Mark A. Pattoli, Joseph A. Tino, Lihong Cheng, Naiyu Zheng, Rodney Vickery, Claudine Pulicicchio, Yifan Zhang, Qian Ruan, Paul A. Elzinga
المصدر: Journal of medicinal chemistry. 62(7)
مصطلحات موضوعية: Indoles, B-cell receptor, 01 natural sciences, Arthritis, Rheumatoid, 03 medical and health sciences, Inhibitory Concentration 50, Mice, Piperidines, immune system diseases, In vivo, hemic and lymphatic diseases, Drug Discovery, Agammaglobulinaemia Tyrosine Kinase, Bruton's tyrosine kinase, Animals, Humans, Lupus Erythematosus, Systemic, Receptor, Protein Kinase Inhibitors, 030304 developmental biology, 0303 health sciences, biology, Dose-Response Relationship, Drug, Kinase, Drug discovery, Chemistry, breakpoint cluster region, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Macaca fascicularis, Cancer research, biology.protein, Molecular Medicine, Tyrosine kinase
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2
المؤلفون: Matt Pokross, Jonathan Lippy, Guanglin Luo, Vinod Arora, Hong Xiao, Nengyin Liu, John E. Macor, Joseph Raybon, Wendy Clarke, Catherine R. Burton, David R. Langley, Carol M. Krause, Gene M. Dubowchik, Yang Cao, Ling Chen, Hal A. Lewis, Kimberly Snow, Prasanna Sivaprakasam, Kevin Kish
المصدر: Journal of Medicinal Chemistry. 59:1041-1051
مصطلحات موضوعية: Models, Molecular, Niacinamide, 0301 basic medicine, Transgene, Administration, Oral, Mice, Transgenic, Pharmacology, Crystallography, X-Ray, Serine, Glycogen Synthase Kinase 3, Mice, Structure-Activity Relationship, 03 medical and health sciences, GSK-3, Drug Discovery, Animals, Humans, Structure–activity relationship, Threonine, Protein Kinase Inhibitors, GSK3B, Glycogen Synthase Kinase 3 beta, Dose-Response Relationship, Drug, Molecular Structure, Drug discovery, Chemistry, Kinase, Brain, Mice, Inbred C57BL, 030104 developmental biology, Biochemistry, Molecular Medicine
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3
المؤلفون: Matt Pokross, Jonathan Lippy, Qingjie Liu, Yongmi An, Chiehying Chang, Joseph A. Tino, James R. Burke, Andrew J. Tebben, Zheng Yang, Lin Chen, Douglas G. Batt, Jodi K. Muckelbauer, Percy H. Carter, Neha Surti, Haiqing Wang
المصدر: Bioorganic & Medicinal Chemistry Letters. 25:4265-4269
مصطلحات موضوعية: Clinical Biochemistry, Carbazoles, Pharmaceutical Science, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Protein-Tyrosine Kinases, Humans, Structure–activity relationship, Bruton's tyrosine kinase, Protein Kinase Inhibitors, Molecular Biology, Janus kinase 2, Dose-Response Relationship, Drug, Molecular Structure, biology, Carbazole, Organic Chemistry, Janus Kinase 2, Amides, chemistry, Drug Design, biology.protein, Molecular Medicine, Tyrosine kinase
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4
المؤلفون: Eric T. Baldwin, Nigel W. Moriarty, Matt Pokross, Herbert E. Klei, Thomas C. Terwilliger, Nathaniel Echols, Shana L. Posy, Paul D. Adams
المصدر: Acta Crystallographica Section D: Biological Crystallography
مصطلحات موضوعية: Models, Molecular, GLR, Pipeline (computing), Degrees of freedom (statistics), Crystal structure, Crystallography, X-Ray, Ligands, p38 Mitogen-Activated Protein Kinases, Set (abstract data type), HIV Protease, Structural Biology, Humans, Replacement method, Computational model, Chemistry, Ligand, guided ligand-replacement method, fungi, Graph theory, General Medicine, ligand placement, Research Papers, 3. Good health, Crystallography, Drug Design, HIV-1, Biological system, Protein Binding
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5
المؤلفون: Matt Pokross, Jonathan Lippy, Kevin Kish, Prasanna Sivaprakasam, Nicolas Szapiel, Michelle Nophsker, Xiaojun Han, Rita L. Civiello, John E. Macor, Hal A. Lewis, Eric T. Baldwin, David R. Langley, Hong Xiao, Carol M. Krause, Nazia Ahmed, John A. Newitt, Hyunsoo Park, Catherine R. Burton, Gene M. Dubowchik, Swanee Jacutin-Porte
المصدر: Bioorganicmedicinal chemistry letters. 25(9)
مصطلحات موضوعية: Genetically modified mouse, Models, Molecular, Pyridones, Clinical Biochemistry, Pharmaceutical Science, Aminopyridines, Mice, Transgenic, macromolecular substances, Computational biology, Pharmacology, Crystallography, X-Ray, Biochemistry, Glycogen Synthase Kinase 3, Mice, Structure-Activity Relationship, GSK-3, Drug Discovery, Animals, Humans, Pyrroles, Glycogen synthase, Molecular Biology, Protein Kinase Inhibitors, biology, Dose-Response Relationship, Drug, Molecular Structure, Kinase, Chemistry, Organic Chemistry, Chemical space, Disease Models, Animal, Tau phosphorylation, biology.protein, Molecular Medicine, Phosphorylation
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6
المؤلفون: Shana L. Posy, Matt Pokross, Brian L. Claus, Stephen R. Johnson
المصدر: Journal of chemical information and modeling. 53(7)
مصطلحات موضوعية: Models, Molecular, Databases, Pharmaceutical, General Chemical Engineering, Molecular Conformation, Computational biology, Plasma protein binding, Library and Information Sciences, Biology, computer.software_genre, Ligands, Mitogen-Activated Protein Kinase 14, Annotation, Structure-Activity Relationship, Structure–activity relationship, Humans, Binding site, Receptor, Binding Sites, Ligand, Molecular Sequence Annotation, General Chemistry, Computer Science Applications, Drug Design, Pairwise comparison, Data mining, computer, Protein Binding
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7
المؤلفون: Ramprasad Akavaram, Steven Sheriff, Matt Pokross, Barry C. Finzel, Aravind Ragipindi, Matthew H. Cahn, Malcolm E. Davis, Eric T. Baldwin, Jeffrey R. Van Voorst
المصدر: Journal of chemical information and modeling. 51(8)
مصطلحات موضوعية: Models, Molecular, Similarity (geometry), Protein family, Computer science, General Chemical Engineering, Chemistry, Pharmaceutical, Sequence (biology), Library and Information Sciences, Ligands, Substrate Specificity, Small Molecule Libraries, Structure-Activity Relationship, Position (vector), Catalytic Domain, Drug Discovery, Data Mining, Humans, Computer Simulation, Binding site, Databases, Protein, Binding Sites, General Chemistry, Ligand (biochemistry), Staurosporine, Computer Science Applications, Crystallography, Pharmaceutical Preparations, Drug Design, Substructure, Biological system, Protein Kinases, Sequence Alignment, Software, Protein ligand, Protein Binding