المؤلفون: Eric M. Kofoed, Ignacio Aliagas, Terry Crawford, Jialin Mao, Seth F. Harris, Min Xu, Shumei Wang, Ping Wu, Fang Ma, Kevin Clark, Jessica Sims, Yiming Xu, Yutian Peng, Elizabeth Skippington, Ying Yang, Janina Reeder, Savita Ubhayakar, Matt Baumgardner, Zhengyin Yan, Jacob Chen, Summer Park, Hua Zhang, Chun-Wan Yen, Maria Lorenzo, Nicholas Skelton, Xiaorong Liang, Liuxi Chen, Bridget Hoag, Chun Sing Li, Zhiguo Liu, John Wai, Xingrong Liu, Jun Liang, Man Wah Tan

المصدر: mBio, Vol 15, Iss 10 (2024)

مصطلحات موضوعية: antibiotic target validation, structural biology, Acinetobacter baumannii, bacterial genetics, medicinal chemistry, pharmacology, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2150-7511

URL الوصول: https://doaj.org/article/92da914a1cc64fff8b2ab55b0e41acbf

المؤلفون: Jack A. Terrett (1318581), Huifen Chen (1551313), Daniel G. Shore (1970782), Elisia Villemure (1833463), Robin Larouche-Gauthier (2095915), Martin Déry (1643473), Francis Beaumier (2097292), Léa Constantineau-Forget (4011557), Chantal Grand-Maître (1957834), Luce Lépissier (10340111), Stéphane Ciblat (10340114), Claudio Sturino (1912390), Yong Chen (109188), Baihua Hu (1600627), Aijun Lu (2312614), Yunli Wang (3091296), Andrew P. Cridland (2343910), Stuart I. Ward (2065105), David H. Hackos (10270058), Rebecca M. Reese (5094347), Shannon D. Shields (10270049), Jun Chen (4238), Alessia Balestrini (10340117), Lorena Riol-Blanco (1343064), Wyne P. Lee (3709543), John Liu (542229), Eric Suto (5550128), Xiumin Wu (3709537), Juan Zhang (48597), Justin Q. Ly (5094341), Hank La (438084), Kevin Johnson (684369), Matt Baumgardner (2069512), Kang-Jye Chou (2820169), Alexis Rohou (10340120), Lionel Rougé (4672339), Brian S. Safina (1429774), Steven Magnuson (1698004), Matthew Volgraf (1845592)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Physiology, Pharmacology, Biotechnology, Ecology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, rat AITC-induced pain assay, Ankyrin 1, novel tetrahydrofuran-based linker, Tetrahydrofuran-Based Transient Rec., nonselective calcium-permeable ion ., polymodal sensor, Rodent Asthma Model, Cryogenic Electron Microscopy Trans., TRPA 1 channel, molecule antagonists, compound 20, compound 21, neuropathic pain, vivo target engagement, physicochemical properties, binding site, bioavailable TRPA 1, dose-dependent reduction

Relation: https://figshare.com/articles/journal_contribution/Tetrahydrofuran-Based_Transient_Receptor_Potential_Ankyrin_1_TRPA1_Antagonists_Ligand-Based_Discovery_Activity_in_a_Rodent_Asthma_Model_and_Mechanism-of-Action_via_Cryogenic_Electron_Microscopy/14258939

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02023.s001

المؤلفون: James J. Crawford, Jianwen Feng, Hans D. Brightbill, Adam R. Johnson, Matthew Wright, Aleksandr Kolesnikov, Wendy Lee, Georgette M. Castanedo, Steven Do, Nicole Blaquiere, Steven T. Staben, Po-Chang Chiang, Peter W. Fan, Matt Baumgardner, Susan Wong, Robert Godemann, Alice Grabbe, Catharina Wiegel, Swathi Sujatha-Bhaskar, Sarah G. Hymowitz, Nicholas Liau, Peter L. Hsu, Paul A. McEwan, Moulay Hicham Alaoui Ismaili, Matthew L. Landry

مصطلحات موضوعية: Organic Chemistry, Clinical Biochemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Molecular Biology, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb21c9e6dbe8d70e0d41f1c745caf358
https://doi.org/10.2139/ssrn.4345205

المؤلفون: Jun Chen, Baihua Hu, Kevin M. Johnson, Kang-Jye Chou, Jack A. Terrett, Yunli Wang, Lea Constantineau-Forget, Steven Magnuson, Chantal Grand-Maître, Francis Beaumier, John Liu, Lorena Riol-Blanco, Shannon D. Shields, Yong Chen, Brian Safina, Martin Dery, Elisia Villemure, Claudio Sturino, Huifen Chen, Luce Lépissier, Matthew Volgraf, Alessia Balestrini, Xiumin Wu, Daniel G. Shore, Stuart Ward, Wyne P. Lee, David H. Hackos, Andrew Peter Cridland, Robin Larouche-Gauthier, Lionel Rouge, Stephane Ciblat, Aijun Lu, Matt Baumgardner, Justin Ly, Rebecca M. Reese, Alexis Rohou, Eric Suto, Juan Zhang, Hank La

المصدر: Journal of Medicinal Chemistry. 64:3843-3869

مصطلحات موضوعية: Male, Ovalbumin, Guinea Pigs, CHO Cells, Ligands, 01 natural sciences, Rats, Sprague-Dawley, Structure-Activity Relationship, 03 medical and health sciences, Transient receptor potential channel, Cricetulus, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Ankyrin, Binding site, Furans, TRPA1 Cation Channel, Ion channel, 030304 developmental biology, Inflammation, chemistry.chemical_classification, Oxadiazoles, 0303 health sciences, Molecular Structure, biology, Chemistry, biology.organism_classification, Small molecule, Asthma, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Mechanism of action, Purines, Biophysics, Molecular Medicine, medicine.symptom, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17e5be6b310c8cbde93a6ecff3b6232
https://doi.org/10.1021/acs.jmedchem.0c02023

المؤلفون: Matt Baumgardner, Amy Baumgardner

Resource Type: eBook.

Categories: SELF-HELP / Substance Abuse & Addictions / General, RELIGION / Christian Living / General

المؤلفون: Emily J. Hanan, Hank La, Ivana Yen, Xiao-Hui Gu, Stephen Schmidt, Christine Yu, Timothy P. Heffron, Yuan Chen, Marian C. Bryan, Gabriele Schaefer, Peter W. Fan, Matt Baumgardner, Shiva Malek, Charles Eigenbrot, Steve Sideris, Hans E. Purkey

المصدر: Bioorganicmedicinal chemistry letters. 26(2)

مصطلحات موضوعية: 0301 basic medicine, Indazoles, Clinical Biochemistry, Mutant, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, 03 medical and health sciences, T790M, Erlotinib Hydrochloride, Mice, 0302 clinical medicine, Dogs, Growth factor receptor, Drug Discovery, Animals, Humans, Point Mutation, Growth factor receptor inhibitor, ERBB3, Epidermal growth factor receptor, Furans, Molecular Biology, Protein Kinase Inhibitors, EGFR inhibitors, Acrylamides, Aniline Compounds, Binding Sites, biology, Chemistry, Organic Chemistry, Hydrogen Bonding, Molecular biology, respiratory tract diseases, High-Throughput Screening Assays, Rats, ErbB Receptors, 030104 developmental biology, Pyrimidines, 030220 oncology & carcinogenesis, biology.protein, Hepatocytes, Microsomes, Liver, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d6a13b5cdc12e56dc879935b81c287
https://pubmed.ncbi.nlm.nih.gov/26639762

المؤلفون: Chenghong Zhang, Teresa Mulde, Quynh Ho, Matt Baumgardner, Cornelis E. C. A. Hop, Xiaorong Liang, Savita Ubhayakar, Yuan Chen, S. Cyrus Khojasteh, Peter W. Fan, Hoa Le

المصدر: Free Radical Biology and Medicine. 87:S115-S116

مصطلحات موضوعية: CHAOS (operating system), chemistry.chemical_compound, Stereochemistry, Chemistry, Order (business), Physiology (medical), Biochemistry, Combinatorial chemistry, Boronic acid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2f559ca680854a35cbeac24d85f5bba1
https://doi.org/10.1016/j.freeradbiomed.2015.10.305

المؤلفون: Steve Price, Georgette Castanedo, Fernando Padilla, Bohdan Waszkowycz, Christine Chabot, Neil Anthony Pegg, Laurent Salphati, Alan Nadin, Jun Li, Karin Reif, Raj K. Handa, Arnaud J. Cheguillaume, Timothy Hancox, Suzanne Tay, Pascal Savy, Parcharee Tivitmahaisoon, Zachary Kevin Sweeney, Jeremy Murray, Binqing Wei, Krintel Sussie Lerche, Qin Yue, Eileen Mary Seward, Sophie Mukadam, Rama K. Kondru, Pravin Iyer, Sukhjit Sohal, Jasmit Kaur, John Lesnick, Yung-Hsiang Chen, Daniel P. Sutherlin, Stephen J. Shuttleworth, Matthew W. Cartwright, Bindu Goyal, Paul M. Blaney, Paul Goldsmith, Jodie Pang, Matthew C. Lucas, Stewart J. Baker, Jim Nonomiya, Cristina Lewis, Wylie Solang Palmer, Chenghong Zhang, Brian Safina, Matt Baumgardner, Bryan K. Chan, David Michael Goldstein, Jane R. Kenny

المصدر: Journal of medicinal chemistry. 55(12)

مصطلحات موضوعية: Gene isoform, Models, Molecular, Time Factors, Protein Conformation, B-cell receptor, Cell Line, Substrate Specificity, Arthritis, Rheumatoid, Inhibitory Concentration 50, Phosphatidylinositol 3-Kinases, Drug Discovery, medicine, Cytochrome P-450 CYP3A, Humans, Enzyme Inhibitors, PI3K/AKT/mTOR pathway, B cell, Phosphoinositide-3 Kinase Inhibitors, chemistry.chemical_classification, Chemistry, Kinase, medicine.anatomical_structure, Enzyme, Biochemistry, Molecular Medicine, Phosphorylation, Cytochrome P-450 CYP3A Inhibitors, Benzimidazoles, Pharmacophore

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f3151193dd85c9e07e1ac655378624
https://pubmed.ncbi.nlm.nih.gov/22626259