المؤلفون: Jessamyn I Perlmutter, Joanne R Chapman, Mason C Wilkinson, Isaac Nevarez-Saenz, Robert L Unckless

المصدر: PLoS Genetics, Vol 20, Iss 3, p e1011155 (2024)

مصطلحات موضوعية: Genetics, QH426-470

وصف الملف: electronic resource

Relation: https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1011155&type=printable; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

URL الوصول: https://doaj.org/article/23ff312ea92f4f8f934e01f14f099829

المؤلفون: Junya Kato, Supratim Dey, Jose E Soto, Carmen Butan, Mason C Wilkinson, Roberto N De Guzman, Jorge E Galan

المصدر: eLife, Vol 7 (2018)

مصطلحات موضوعية: protien secretion, bacterial pathogenesis, salmonella typhimurium, type III secretion, bacterial nanomachines, organelle assembly, Medicine, Science, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://elifesciences.org/articles/35886; https://doaj.org/toc/2050-084X

URL الوصول: https://doaj.org/article/0b4e2ae158644ceb800dce215a709b3c

المؤلفون: Jessamyn I. Perlmutter, Joanne R. Chapman, Mason C. Wilkinson, Isaac Nevarez-Saenz, Robert L. Unckless

مصطلحات موضوعية: Medicine, Genetics, Evolutionary Biology, Ecology, Immunology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, two main questions, coevolutionary arms race, host fitness cost, four different species, fitness cost ), distinct functional importance, previous work demonstrated, cas9 genome editing, certain pathogens depending, natural metchnikowin alleles, div >< p, based functional differences, systemic immune responses, specificity hypothesis )?, selection may act, results provide strong, life history tradeoffs, insect amps tend, different specific pathogens, autoimmune hypothesis )?, p allele outperforming, r allele performs

Relation: https://figshare.com/articles/journal_contribution/Oligos_used_in_CRISPR_Cas9_editing_of_i_Drosophila_Mtk_i_alleles_and_qPCR_/25385793

الاتاحة: https://doi.org/10.1371/journal.pgen.1011155.s015

المؤلفون: Jessamyn I. Perlmutter, Joanne R. Chapman, Mason C. Wilkinson, Isaac Nevarez-Saenz, Robert L. Unckless

مصطلحات موضوعية: Medicine, Genetics, Evolutionary Biology, Ecology, Immunology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, two main questions, coevolutionary arms race, host fitness cost, four different species, fitness cost ), distinct functional importance, previous work demonstrated, cas9 genome editing, certain pathogens depending, natural metchnikowin alleles, div >< p, based functional differences, systemic immune responses, specificity hypothesis )?, selection may act, results provide strong, life history tradeoffs, insect amps tend, different specific pathogens, autoimmune hypothesis )?, p allele outperforming, r allele performs

Relation: https://figshare.com/articles/journal_contribution/Microorganisms_used_in_this_study_/25385796

الاتاحة: https://doi.org/10.1371/journal.pgen.1011155.s016

المؤلفون: Jessamyn I. Perlmutter, Joanne R. Chapman, Mason C. Wilkinson, Isaac Nevarez-Saenz, Robert L. Unckless

مصطلحات موضوعية: Medicine, Genetics, Evolutionary Biology, Ecology, Immunology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, two main questions, coevolutionary arms race, host fitness cost, four different species, fitness cost ), distinct functional importance, previous work demonstrated, cas9 genome editing, certain pathogens depending, natural metchnikowin alleles, div >< p, based functional differences, systemic immune responses, specificity hypothesis )?, selection may act, results provide strong, life history tradeoffs, insect amps tend, different specific pathogens, autoimmune hypothesis )?, p allele outperforming, r allele performs

Relation: https://figshare.com/articles/journal_contribution/Pairwise_SNP_differences_among_whole_genomes_2L_2R_3L_3R_and_X_of_CRISPR_Cas9_genome_edited_lines_and_three_random_DGRP_lines_/25385790

الاتاحة: https://doi.org/10.1371/journal.pgen.1011155.s014

المؤلفون: Jessamyn I. Perlmutter, Joanne R. Chapman, Mason C. Wilkinson, Isaac Nevarez-Saenz, Robert L. Unckless

مصطلحات موضوعية: Medicine, Genetics, Evolutionary Biology, Ecology, Immunology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, two main questions, coevolutionary arms race, host fitness cost, four different species, fitness cost ), distinct functional importance, previous work demonstrated, cas9 genome editing, certain pathogens depending, natural metchnikowin alleles, div >< p, based functional differences, systemic immune responses, specificity hypothesis )?, selection may act, results provide strong, life history tradeoffs, insect amps tend, different specific pathogens, autoimmune hypothesis )?, p allele outperforming, r allele performs

Relation: https://figshare.com/articles/figure/Schematics_of_CRISPR-generated_i_Mtk_i_fly_lines_/25385751

الاتاحة: https://doi.org/10.1371/journal.pgen.1011155.s001

المؤلفون: Jessamyn I. Perlmutter, Joanne R. Chapman, Mason C. Wilkinson, Isaac Nevarez-Saenz, Robert L. Unckless

مصطلحات موضوعية: Medicine, Genetics, Evolutionary Biology, Ecology, Immunology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, two main questions, coevolutionary arms race, host fitness cost, four different species, fitness cost ), distinct functional importance, previous work demonstrated, cas9 genome editing, certain pathogens depending, natural metchnikowin alleles, div >< p, based functional differences, systemic immune responses, specificity hypothesis )?, selection may act, results provide strong, life history tradeoffs, insect amps tend, different specific pathogens, autoimmune hypothesis )?, p allele outperforming, r allele performs

Relation: https://figshare.com/articles/figure/Survival_against_some_infections_depends_on_host_sex_along_with_i_Mtk_i_allele_and_pathogen_species_/25385769

الاتاحة: https://doi.org/10.1371/journal.pgen.1011155.s007

المؤلفون: Jessamyn I. Perlmutter, Joanne R. Chapman, Mason C. Wilkinson, Isaac Nevarez-Saenz, Robert L. Unckless

مصطلحات موضوعية: Medicine, Genetics, Evolutionary Biology, Ecology, Immunology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, two main questions, coevolutionary arms race, host fitness cost, four different species, fitness cost ), distinct functional importance, previous work demonstrated, cas9 genome editing, certain pathogens depending, natural metchnikowin alleles, div >< p, based functional differences, systemic immune responses, specificity hypothesis )?, selection may act, results provide strong, life history tradeoffs, insect amps tend, different specific pathogens, autoimmune hypothesis )?, p allele outperforming, r allele performs

Relation: https://figshare.com/articles/figure/Offspring_numbers_survival_from_larvae_to_adults_and_the_proportion_of_F1_females_exhibit_small_to_no_differences_among_i_Mtk_i_alleles_/25385754

الاتاحة: https://doi.org/10.1371/journal.pgen.1011155.s002

المؤلفون: Jessamyn I. Perlmutter, Joanne R. Chapman, Mason C. Wilkinson, Isaac Nevarez-Saenz, Robert L. Unckless

مصطلحات موضوعية: Medicine, Genetics, Evolutionary Biology, Ecology, Immunology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, two main questions, coevolutionary arms race, host fitness cost, four different species, fitness cost ), distinct functional importance, previous work demonstrated, cas9 genome editing, certain pathogens depending, natural metchnikowin alleles, div >< p, based functional differences, systemic immune responses, specificity hypothesis )?, selection may act, results provide strong, life history tradeoffs, insect amps tend, different specific pathogens, autoimmune hypothesis )?, p allele outperforming, r allele performs

Relation: https://figshare.com/articles/figure/Survival_curves_for_males_infected_with_bacteria_or_yeast_/25385763

الاتاحة: https://doi.org/10.1371/journal.pgen.1011155.s005

المؤلفون: Jessamyn I. Perlmutter, Joanne R. Chapman, Mason C. Wilkinson, Isaac Nevarez-Saenz, Robert L. Unckless

مصطلحات موضوعية: Medicine, Genetics, Evolutionary Biology, Ecology, Immunology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, two main questions, coevolutionary arms race, host fitness cost, four different species, fitness cost ), distinct functional importance, previous work demonstrated, cas9 genome editing, certain pathogens depending, natural metchnikowin alleles, div >< p, based functional differences, systemic immune responses, specificity hypothesis )?, selection may act, results provide strong, life history tradeoffs, insect amps tend, different specific pathogens, autoimmune hypothesis )?, p allele outperforming, r allele performs

Relation: https://figshare.com/articles/figure/Survival_curves_for_males_infected_with_fungi_corresponding_to_Fig_2_/25385760

الاتاحة: https://doi.org/10.1371/journal.pgen.1011155.s004

المؤلفون: Jessamyn I. Perlmutter, Joanne R. Chapman, Mason C. Wilkinson, Isaac Nevarez-Saenz, Robert L. Unckless

مصطلحات موضوعية: Medicine, Genetics, Evolutionary Biology, Ecology, Immunology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, two main questions, coevolutionary arms race, host fitness cost, four different species, fitness cost ), distinct functional importance, previous work demonstrated, cas9 genome editing, certain pathogens depending, natural metchnikowin alleles, div >< p, based functional differences, systemic immune responses, specificity hypothesis )?, selection may act, results provide strong, life history tradeoffs, insect amps tend, different specific pathogens, autoimmune hypothesis )?, p allele outperforming, r allele performs

Relation: https://figshare.com/articles/figure/Survival_curves_for_males_infected_with_bacteria_corresponding_to_Fig_3_/25385766

الاتاحة: https://doi.org/10.1371/journal.pgen.1011155.s006

المؤلفون: Jessamyn I. Perlmutter, Joanne R. Chapman, Mason C. Wilkinson, Isaac Nevarez-Saenz, Robert L. Unckless

مصطلحات موضوعية: Medicine, Genetics, Evolutionary Biology, Ecology, Immunology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, two main questions, coevolutionary arms race, host fitness cost, four different species, fitness cost ), distinct functional importance, previous work demonstrated, cas9 genome editing, certain pathogens depending, natural metchnikowin alleles, div >< p, based functional differences, systemic immune responses, specificity hypothesis )?, selection may act, results provide strong, life history tradeoffs, insect amps tend, different specific pathogens, autoimmune hypothesis )?, p allele outperforming, r allele performs

Relation: https://figshare.com/articles/figure/The_longevity_of_adult_male_i_Mtk_i_sup_i_R_i_sup_varies_but_i_Mtk_i_sup_i_R_i_sup_females_consistently_die_earlier_/25385757

الاتاحة: https://doi.org/10.1371/journal.pgen.1011155.s003

المؤلفون: Jessamyn I. Perlmutter, Joanne R. Chapman, Mason C. Wilkinson, Isaac Nevarez-Saenz, Robert L. Unckless

مصطلحات موضوعية: Medicine, Genetics, Evolutionary Biology, Ecology, Immunology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, two main questions, coevolutionary arms race, host fitness cost, four different species, fitness cost ), distinct functional importance, previous work demonstrated, cas9 genome editing, certain pathogens depending, natural metchnikowin alleles, div >< p, based functional differences, systemic immune responses, specificity hypothesis )?, selection may act, results provide strong, life history tradeoffs, insect amps tend, different specific pathogens, autoimmune hypothesis )?, p allele outperforming, r allele performs

Relation: https://figshare.com/articles/figure/Survival_curves_for_females_infected_with_bacteria_fungal_spores_or_yeast_corresponding_to_S7_Fig_/25385772

الاتاحة: https://doi.org/10.1371/journal.pgen.1011155.s008

المؤلفون: Jessamyn I. Perlmutter, Joanne R. Chapman, Mason C. Wilkinson, Isaac Nevarez-Saenz, Robert L. Unckless

مصطلحات موضوعية: Medicine, Genetics, Evolutionary Biology, Ecology, Immunology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, two main questions, coevolutionary arms race, host fitness cost, four different species, fitness cost ), distinct functional importance, previous work demonstrated, cas9 genome editing, certain pathogens depending, natural metchnikowin alleles, div >< p, based functional differences, systemic immune responses, specificity hypothesis )?, selection may act, results provide strong, life history tradeoffs, insect amps tend, different specific pathogens, autoimmune hypothesis )?, p allele outperforming, r allele performs

Relation: https://figshare.com/articles/figure/Survival_curves_for_side-by-side_male_and_female_fungal_spore_infections_corresponding_to_Fig_4_/25385775

الاتاحة: https://doi.org/10.1371/journal.pgen.1011155.s009

المؤلفون: Jessamyn I. Perlmutter, Joanne R. Chapman, Mason C. Wilkinson, Isaac Nevarez-Saenz, Robert L. Unckless

مصطلحات موضوعية: Medicine, Genetics, Evolutionary Biology, Ecology, Immunology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, two main questions, coevolutionary arms race, host fitness cost, four different species, fitness cost ), distinct functional importance, previous work demonstrated, cas9 genome editing, certain pathogens depending, natural metchnikowin alleles, div >< p, based functional differences, systemic immune responses, specificity hypothesis )?, selection may act, results provide strong, life history tradeoffs, insect amps tend, different specific pathogens, autoimmune hypothesis )?, p allele outperforming, r allele performs

Relation: https://figshare.com/articles/figure/Males_infected_with_i_dnaK_i_-deficient_i_E_i_i_faecalis_i_i_dnak_i_survive_at_similar_rates_across_alleles_/25385778

الاتاحة: https://doi.org/10.1371/journal.pgen.1011155.s010

المؤلفون: Jessamyn I. Perlmutter, Joanne R. Chapman, Mason C. Wilkinson, Isaac Nevarez-Saenz, Robert L. Unckless

مصطلحات موضوعية: Medicine, Genetics, Evolutionary Biology, Ecology, Immunology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, two main questions, coevolutionary arms race, host fitness cost, four different species, fitness cost ), distinct functional importance, previous work demonstrated, cas9 genome editing, certain pathogens depending, natural metchnikowin alleles, div >< p, based functional differences, systemic immune responses, specificity hypothesis )?, selection may act, results provide strong, life history tradeoffs, insect amps tend, different specific pathogens, autoimmune hypothesis )?, p allele outperforming, r allele performs

Relation: https://figshare.com/articles/figure/_i_Mtk_i_is_expressed_at_low_baseline_levels_without_infection_and_is_highly_induced_with_infection_/25385781

الاتاحة: https://doi.org/10.1371/journal.pgen.1011155.s011

المؤلفون: Jessamyn I. Perlmutter, Joanne R. Chapman, Mason C. Wilkinson, Isaac Nevarez-Saenz, Robert L. Unckless

مصطلحات موضوعية: Medicine, Genetics, Evolutionary Biology, Ecology, Immunology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, two main questions, coevolutionary arms race, host fitness cost, four different species, fitness cost ), distinct functional importance, previous work demonstrated, cas9 genome editing, certain pathogens depending, natural metchnikowin alleles, div >< p, based functional differences, systemic immune responses, specificity hypothesis )?, selection may act, results provide strong, life history tradeoffs, insect amps tend, different specific pathogens, autoimmune hypothesis )?, p allele outperforming, r allele performs

Relation: https://figshare.com/articles/dataset/Proportion_of_R_alleles_in_various_i_D_i_i_melanogaster_i_fly_populations_on_the_PopFly_Database_/25385784

الاتاحة: https://doi.org/10.1371/journal.pgen.1011155.s012

المؤلفون: Jessamyn I. Perlmutter, Joanne R. Chapman, Mason C. Wilkinson, Isaac Nevarez-Saenz, Robert L. Unckless

مصطلحات موضوعية: Medicine, Genetics, Evolutionary Biology, Ecology, Immunology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, two main questions, coevolutionary arms race, host fitness cost, four different species, fitness cost ), distinct functional importance, previous work demonstrated, cas9 genome editing, certain pathogens depending, natural metchnikowin alleles, div >< p, based functional differences, systemic immune responses, specificity hypothesis )?, selection may act, results provide strong, life history tradeoffs, insect amps tend, different specific pathogens, autoimmune hypothesis )?, p allele outperforming, r allele performs

Relation: https://figshare.com/articles/dataset/Complete_statistical_analysis_outputs_for_all_figures_/25385787

الاتاحة: https://doi.org/10.1371/journal.pgen.1011155.s013

المؤلفون: Jessamyn I. Perlmutter, Joanne R. Chapman, Mason C. Wilkinson, Isaac Nevarez-Saenz, Robert L. Unckless

مصطلحات موضوعية: Medicine, Genetics, Evolutionary Biology, Ecology, Immunology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, two main questions, coevolutionary arms race, host fitness cost, four different species, fitness cost ), distinct functional importance, previous work demonstrated, cas9 genome editing, certain pathogens depending, natural metchnikowin alleles, div >< p, based functional differences, systemic immune responses, specificity hypothesis )?, selection may act, results provide strong, life history tradeoffs, insect amps tend, different specific pathogens, autoimmune hypothesis )?, p allele outperforming, r allele performs

Relation: https://figshare.com/articles/dataset/Potential_off-targets_from_CRIPSR_/25385799

الاتاحة: https://doi.org/10.1371/journal.pgen.1011155.s017

المؤلفون: Jessamyn I. Perlmutter, Joanne R. Chapman, Mason C. Wilkinson, Isaac Nevarez-Saenz, Robert L. Unckless

مصطلحات موضوعية: Medicine, Genetics, Evolutionary Biology, Ecology, Immunology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, two main questions, coevolutionary arms race, host fitness cost, four different species, fitness cost ), distinct functional importance, previous work demonstrated, cas9 genome editing, certain pathogens depending, natural metchnikowin alleles, div >< p, based functional differences, systemic immune responses, specificity hypothesis )?, selection may act, results provide strong, life history tradeoffs, insect amps tend, different specific pathogens, autoimmune hypothesis )?, p allele outperforming, r allele performs

Relation: https://figshare.com/articles/figure/_i_Mtk_i_sup_i_R_i_sup_male_flies_survive_as_well_or_better_than_other_genotypes_against_a_variety_of_filamentous_fungal_and_yeast_infections_/25385805

الاتاحة: https://doi.org/10.1371/journal.pgen.1011155.g002