-
1
المؤلفون: Ruo Xu, Monica Vicarel, Lili Zhang, Duane A. Burnett, Giuseppe Terracina, Lynn A. Hyde, Wen-Lian Wu, Qi Zhang, Thomas Bara, William J. Greenlee, Robert A. Del Vecchio, Amin A. Nomeir, Mcbriar Mark D, Mary Cohen-Williams, Josien Hubert B, Murali Rajagopalan, Julie Lee, Theodros Asberom, Martin S. Domalski, John W. Clader, Chad Bennett, Lixin Song, Eric M. Parker
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:844-849
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Sulfone, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Side chain, Humans, Structure–activity relationship, Benzopyrans, Sulfones, γ secretase, Enzyme Inhibitors, Molecular Biology, Pyrans, chemistry.chemical_classification, Molecular Structure, Organic Chemistry, Enzyme Activation, chemistry, Cyclization, Molecular Medicine, Amyloid Precursor Protein Secretases, Linker, Tricyclic
-
2
المؤلفون: William J. Greenlee, Lixin Song, Julie Lee, Qin Jiang, Lili Zhang, Robert A. Del Vecchio, Wen-Lian Wu, Eric M. Parker, Qi Zhang, John W. Clader, Amin A. Nomeir, Mary Cohen-Williams, Giuseppe Terracina, Lynn A. Hyde, Duane A. Burnett
المصدر: Bioorganicmedicinal chemistry letters. 26(23)
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, 01 natural sciences, Biochemistry, 03 medical and health sciences, Dogs, In vivo, Alzheimer Disease, Drug Discovery, Side chain, Potency, Animals, Humans, Benzopyrans, Sulfones, Solubility, Enzyme Inhibitors, Molecular Biology, ADME, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Water, Haplorhini, In vitro, 0104 chemical sciences, Rats, 030104 developmental biology, Water soluble, nervous system, Drug Design, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase
-
3
المؤلفون: Dmitri A. Pissarnitski, Zhiqiang Zhao, Mary Cohen-Williams, Troy McCraken, Lili Zhang, George Sun, Wei Zhou, Mihirbaran Mandal, Hongmei Li, Xianhai Huang, Duane A. Burnett, Zhaoning Zhu, Xiaoxiang Liu, Inhou Chu, Anandan Palani, Robert G. Aslanian, John W. Clader, Gallo Gioconda, Lynn A. Hyde, Chad Bennett, David Cole, Monica Vicarel, Alexei V. Buevich, Michael Czarniecki, William J. Greenlee, Lixin Song, Xiaohong Zhu
المصدر: ACS Medicinal Chemistry Letters. 3:931-935
مصطلحات موضوعية: biology, business.industry, Organic Chemistry, Cleavage (embryo), Biochemistry, Combinatorial chemistry, Structural framework, In vitro, chemistry.chemical_compound, chemistry, In vivo, Morpholine, Drug Discovery, Amyloid precursor protein, biology.protein, Medicine, γ secretase, business
-
4
المؤلفون: Xianhai Huang, Eric M. Parker, Xiaoxiang Liu, Gioconda V. Gallo, Thomas A. Bara, Lili Zhang, Lixin Song, Ruo Xu, Hongmei Li, William J. Greenlee, Troy Mccracken, Xiaohong Zhu, Theodros Asberom, Nicholas Jones, Monica L. Vicarel, Mihir B. Mandal, Julie Lee, Zhaoning Zhu, Qi Zhang, John W. Clader, Dmitri A. Pissarnitski, Mary Cohen-Williams, Lynn A. Hyde, Johannes H. Voigt, Irina Kazakevich, James Durkin, Jun Qin, Michael Czarniecki, Hubert B. Josien, Amin A. Nomeir, Duane A. Burnett, Chad E. Bennett, Zhong-Yue Sun, Robert Mazzola, Giuseppe Terracina, David Cole, Zhiqiang Zhao, Inhou Chu, Malcolm Maccoss, Anandan Palani
المصدر: Journal of Medicinal Chemistry. 55:489-502
مصطلحات موضوعية: Male, Oxadiazoles, Amyloid beta-Peptides, Chemistry, Amidines, Brain, Stereoisomerism, Combinatorial chemistry, Peptide Fragments, Rats, Macaca fascicularis, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, HEK293 Cells, In vivo, Amide, Oxazines, Drug Discovery, Animals, Humans, Molecular Medicine, γ secretase, Amyloid Precursor Protein Secretases, Structural motif
-
5
المؤلفون: Sherry X. Lu, Carina J. Bleickardt, Donald H. Guthrie, Robert A. Hodgson, Geoffrey B. Varty, Eric M. Parker, Prescott T. Leach, Lynn A. Hyde, Mary Cohen-Williams, Tatiana M. Kazdoba
المصدر: Pharmacology Biochemistry and Behavior. 98:181-187
مصطلحات موضوعية: Male, Reflex, Startle, Allosteric modulator, Clinical Biochemistry, Motor Activity, Receptors, Metabotropic Glutamate, Toxicology, Biochemistry, Mice, Behavioral Neuroscience, Animals, Learning, Rats, Long-Evans, Biological Psychiatry, Motor skill, Pharmacology, Glutamate receptor, Antagonist, Rats, Mice, Inbred C57BL, Metabotropic receptor, Metabotropic glutamate receptor, Models, Animal, Quinolines, Metabotropic glutamate receptor 1, Motor learning, Psychology, Excitatory Amino Acid Antagonists, Neuroscience, Psychomotor Performance
-
6
المؤلفون: Nicholas Jones, Robert G. Aslanian, Jun Qin, Zhaoning Zhu, William J. Greenlee, Xianhai Huang, Pawan Dhondi, Anandan Palani, Lynn A. Hyde, Wei Zhou, Lili Zhang, Mary Cohen-Williams
المصدر: ACS Medicinal Chemistry Letters. 2:471-476
مصطلحات موضوعية: business.industry, Organic Chemistry, γ secretase modulator, Pharmacology, Bioinformatics, Biochemistry, In vitro, Amyloid β peptide, In vivo, Drug Discovery, Pyrazolopyridine, Medicine, Potency, γ secretase, business
-
7
المؤلفون: John C. Hunter, Leonard E. Parra, Guy A. Higgins, Eric M. Parker, Angelo Reggiani, Francesco Impagnatiello, Silva Fredduzzi, Rosalia Bertorelli, Elisa Nicolussi, Robert A. Hodgson, Mary Cohen-Williams, Jean E. Lachowicz, Geoffrey B. Varty, Bernie R. Neustadt, Andrew Stamford, Carolyn Foster, Ying Zhai, Angelo Forlani
المصدر: Journal of Pharmacology and Experimental Therapeutics. 330:294-303
مصطلحات موضوعية: Pharmacology, Agonist, Chemistry, medicine.drug_class, Adenosine receptor, Tail suspension test, chemistry.chemical_compound, Preladenant, In vivo, Haloperidol, medicine, Molecular Medicine, Receptor, medicine.drug, Behavioural despair test
-
8
المؤلفون: Leyla Arik, Geoffrey B. Varty, Hongtao Zhang, Jean E. Lachowicz, Bernard R. Neustadt, Rosalia Bertorelli, Hong Liu, William J. Greenlee, Andrew Stamford, Mary Cohen-Williams, Silva Fredduzzi, Carolyn Foster, Jinsong Hao, Kwokei Ng
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:967-971
مصطلحات موضوعية: Stereochemistry, Chemistry, Pharmaceutical, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Pharmacology, Catalepsy, Biochemistry, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Structure–activity relationship, Receptor, Molecular Biology, Bicyclic molecule, Chemistry, Organic Chemistry, Antagonist, Parkinson Disease, Triazoles, medicine.disease, Adenosine receptor, Adenosine, Adenosine A2 Receptor Antagonists, Rats, Pyrimidines, Models, Chemical, Area Under Curve, Drug Design, Haloperidol, Molecular Medicine, Antagonism, medicine.drug
-
9
المؤلفون: Claire M. Lankin, Geoffrey B. Varty, Samuel Chackalamannil, William J. Greenlee, Kwokei Ng, Guy A. Higgins, Mary Cohen-Williams, Craig D. Boyle, Unmesh Shah, Jean E. Lachowicz, Hongtao Zhang, Bernard R. Neustadt
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:4204-4209
مصطلحات موضوعية: Adenosine, Stereochemistry, Chemistry, Pharmaceutical, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Adenosine A2A receptor, Biochemistry, Chemical synthesis, SCH-58261, chemistry.chemical_compound, Adenosine A1 receptor, In vivo, Drug Discovery, medicine, Animals, Receptor, Molecular Biology, Organic Chemistry, Quinoline, Water, Parkinson Disease, Hydrogen-Ion Concentration, Triazoles, Combinatorial chemistry, Adenosine A2 Receptor Antagonists, Rats, Disease Models, Animal, Pyrimidines, Models, Chemical, Solubility, chemistry, Area Under Curve, Drug Design, Molecular Medicine, medicine.drug
-
10
المؤلفون: Guy A. Higgins, Hongtao Zhang, Julius J. Matasi, Deen Tulshian, Geoffrey B. Varty, Ahmad Fawzi, John P. Caldwell, Mary Cohen-Williams
المصدر: Bioorganic & Medicinal Chemistry Letters. 15:3675-3678
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, hERG, Drug Evaluation, Preclinical, Administration, Oral, Pharmaceutical Science, Motor Activity, Biochemistry, Chemical synthesis, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Animals, Humans, Molecular Biology, Catalepsy, Molecular Structure, biology, Chemistry, Organic Chemistry, Antagonist, Triazoles, Adenosine receptor, Adenosine, In vitro, Adenosine A2 Receptor Antagonists, Rats, Disease Models, Animal, Pyrimidines, biology.protein, Molecular Medicine, Amine gas treating, medicine.drug
-
11
المؤلفون: Dennis V. Nazareno, Guowei Zhou, Herbert Binch, William J. Greenlee, Mary Cohen-Williams, Jayaram R. Tagat, Diane E. Grotz, Jean E. Lachowicz, James J. Kaminski, Joseph A. Kozlowski, Gordon Crosby, Stuart W. McCombie, Vicki L. Coffin, Kathleen Cox, Vilma Ruperto, Craig D. Boyle, Samuel Chackalamannil, Ruth A. Duffy, Hubert B. Josien, Yuguang Wang, John W. Clader, William Billard
المصدر: Bioorganic & Medicinal Chemistry Letters. 11:2311-2314
مصطلحات موضوعية: Stereochemistry, Microdialysis, Clinical Biochemistry, Drug Evaluation, Preclinical, Administration, Oral, Pharmaceutical Science, Dioxoles, Muscarinic Antagonists, Benzylidene Compounds, Biochemistry, Structure-Activity Relationship, Cytochrome P-450 Enzyme System, Drug Stability, Pharmacokinetics, Drug Discovery, Muscarinic acetylcholine receptor, medicine, Animals, Humans, Moiety, Sulfones, Molecular Biology, Receptor, Muscarinic M2, Oxidative metabolism, Chemistry, Organic Chemistry, Muscarinic antagonist, Receptors, Muscarinic, Acetylcholine, Rats, Bioavailability, Macaca fascicularis, Area Under Curve, Drug Design, Microsomes, Liver, Microsome, Molecular Medicine, Selectivity, medicine.drug
-
12
المؤلفون: Dmitri A. Pissarnitski, Guy A. Higgins, Theodros Asberom, Robert A. Del Vecchio, Qi Zhang, Joseph C. Chen, Nansie A. McHugh, Amin A. Nomeir, Lynn A. Hyde, Lei Chen, Lili Zhang, Mary Cohen-Williams, Eric M. Parker, Wei Li, John W. Clader, Prescott T. Leach, Gwendolyn T. Wong, Diane Levitan
المصدر: International Journal of Alzheimer's Disease, Vol 2013 (2013)
International Journal of Alzheimer's Diseaseمصطلحات موضوعية: Aging, biology, Article Subject, business.industry, Cognitive Neuroscience, Notch signaling pathway, lcsh:Geriatrics, Pharmacology, lcsh:RC321-571, lcsh:RC952-954.6, Behavioral Neuroscience, Cellular and Molecular Neuroscience, Neurology, In vivo, Amyloid precursor protein, biology.protein, Medicine, Neurology (clinical), γ secretase, business, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Research Article
وصف الملف: text/xhtml
-
13
المؤلفون: Lynn A. Hyde, Jun Qin, John W. Clader, David Cole, Michael Czarniecki, William J. Greenlee, Pawan Dhondi, Thomas Bara, Wei Zhou, Anandan Palani, Xianhai Huang, Mary Cohen-Williams, Inhou Chu, Josien Hubert B, Dmitri A. Pissarnitski, Monica Vicarel, Lixin Song, Robert G. Aslanian, Hongmei Li, Lili Zhang, Zhaoning Zhu
المصدر: Bioorganicmedicinal chemistry letters. 23(2)
مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, ERG1 Potassium Channel, Clinical Biochemistry, hERG, Pharmaceutical Science, Disease, Pharmacology, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, In vivo, Alzheimer Disease, Drug Discovery, Amyloid precursor protein, Animals, Humans, cardiovascular diseases, Enzyme Inhibitors, Molecular Biology, Gamma secretase, biology, Molecular Structure, Chemistry, Organic Chemistry, Azepines, Ether-A-Go-Go Potassium Channels, Rats, Enzyme Activation, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases
-
14
المؤلفون: Joel M. Harris, Bernard R. Neustadt, Hongtao Zhang, Jean Lachowicz, Mary Cohen-Williams, Geoff Varty, Jinsong Hao, Andrew W. Stamford
المصدر: Bioorganicmedicinal chemistry letters. 21(8)
مصطلحات موضوعية: Structure-Activity Relationship, Receptor, Adenosine A2A, Organic Chemistry, Clinical Biochemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Humans, Parkinson Disease, Pyrimidinones, Molecular Biology, Biochemistry, Adenosine A2 Receptor Antagonists
-
15
المؤلفون: Zhaoning Zhu, Mckittrick Brian A, Lixin Song, Alexei V. Buevich, Hubert Josein, Thomas Bara, Troy Mccracken, Julie Lee, Duane A. Burnett, Inhou Chu, Robert Mazzola, Johannes H. Voigt, John P. Caldwell, Chad Bennett, Mary Cohen-Williams, Lili Zhang, Giuseppe Terracina, Lynn A. Hyde
المصدر: Bioorganicmedicinal chemistry letters. 20(18)
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Mice, Transgenic, Biochemistry, chemistry.chemical_compound, Mice, Structure-Activity Relationship, In vivo, Alzheimer Disease, Drug Discovery, Amyloid precursor protein, Structure–activity relationship, Animals, Humans, γ secretase, Molecular Biology, Amyloid beta-Peptides, biology, Bicyclic molecule, Chemistry, fungi, Organic Chemistry, Brain, Bridged Bicyclo Compounds, Heterocyclic, In vitro, Peptide Fragments, Rats, Benzene derivatives, biology.protein, Lactam, Molecular Medicine, Imines, Amyloid Precursor Protein Secretases
-
16
المؤلفون: Robert G. Aslanian, Xianhai Huang, Lynn A. Hyde, Wei Zhou, Inhou Chu, Lili Zhang, Jun Qin, Anandan Palani, Xiaohong Zhu, Mary Cohen-Williams, William J. Greenlee, Zhaoning Zhu
مصطلحات موضوعية: In vivo, Hydrogen bond, Chemistry, Organic Chemistry, Drug Discovery, Rat model, Side chain, γ secretase, Pharmacology, Selectivity, Biochemistry, Combinatorial chemistry, In vitro
-
17
المؤلفون: Galen J Carey, Mary Cohen-Williams, Vicki L. Coffin, Julius J. Matasi, Michael P. Graziano, Sherry X. Lu, April Smith-Torhan, Geoffrey B. Varty, Robert A. Hodgson, Cynthia A. Morgan, Ginny D. Ho, Deen Tulshian, Ahmad Fawzi, Hongtao Zhang
المصدر: The Journal of pharmacology and experimental therapeutics. 326(2)
مصطلحات موضوعية: Agonist, Male, medicine.drug_class, Narcotic Antagonists, NOP, Guinea Pigs, CHO Cells, Pharmacology, Naltrexone, Nociceptin Receptor, Chlordiazepoxide, Cricetulus, Piperidines, Opioid receptor, Cricetinae, medicine, Animals, Humans, Rats, Wistar, Behavior, Animal, Molecular Structure, Chemistry, Antagonist, Receptor antagonist, Rats, carbohydrates (lipids), Nociceptin receptor, Animals, Newborn, Anti-Anxiety Agents, Receptors, Opioid, Molecular Medicine, Benzimidazoles, Female, Gerbillinae, Azabicyclo Compounds, medicine.drug, Protein Binding
-
18
المؤلفون: Guy A. Higgins, Michael Grzelak, Robert A. Hodgson, Mary Cohen-Williams, Pond Annamarie, Geoffrey B. Varty
المصدر: Behavioural brain research. 185(1)
مصطلحات موضوعية: Agonist, Male, Reflex, Startle, Adenosine, medicine.drug_class, Dopamine, Adenosine A2A receptor, Pharmacology, Motor Activity, Choice Behavior, Developmental psychology, Behavioral Neuroscience, chemistry.chemical_compound, Caffeine, Phenethylamines, medicine, Reaction Time, Animals, Attention, Receptor, Amphetamine, Dose-Response Relationship, Drug, Antagonist, Istradefylline, Adenosine A2 Receptor Antagonists, Rats, chemistry, Purines, Xanthines, Central Nervous System Stimulants, Psychomotor Performance, medicine.drug, Antipsychotic Agents
-
19
المؤلفون: Xiao-Wei Dong, Mary Cohen-Williams, Sherry X. Lu, Robert A. Hodgson, Tony Priestley, Yuping Jia, Huiqing Li, Xiaoping Zhou
المصدر: Psychopharmacology. 195(4)
مصطلحات موضوعية: Fluphenazine, Male, medicine.medical_treatment, Pharmacology, Motor Activity, Sodium Channels, Sciatica, Sodium channel blocker, Dopamine receptor D2, Ganglia, Spinal, Physical Stimulation, medicine, Animals, Rats, Wistar, Antipsychotic, Dose-Response Relationship, Drug, business.industry, Nerve Compression Syndromes, medicine.disease, Sciatic Nerve, Rats, Disease Models, Animal, Allodynia, Spinal Nerves, Schizophrenia, Motor Skills, Neuropathic pain, Neuralgia, medicine.symptom, business, Neuroscience, medicine.drug, Antipsychotic Agents
-
20
المؤلفون: Julius J. Matasi, Hongtao Zhang, Deen Tulshian, Geoffrey B. Varty, Mary Cohen-Williams, Guy A. Higgins, Ahmad Fawzi, John P. Caldwell
المصدر: ChemInform. 37
مصطلحات موضوعية: Reduction (complexity), biology, Chemistry, hERG, biology.protein, medicine, Amine gas treating, General Medicine, Medicinal chemistry, Adenosine, medicine.drug