المؤلفون: Anja Dölle (10794992), Bikash Adhikari (704191), Andreas Krämer (3286917), Janik Weckesser (10794995), Nicola Berner (10794998), Lena-Marie Berger (10795001), Mathias Diebold (10795004), Magdalena M. Szewczyk (3119427), Dalia Barsyte-Lovejoy (1399687), Cheryl H. Arrowsmith (246847), Jakob Gebel (10795007), Frank Löhr (1871500), Volker Dötsch (1910650), Martin Eilers (164041), Stephanie Heinzlmeir (1456441), Bernhard Kuster (3990), Christoph Sotriffer (3544643), Elmar Wolf (164036), Stefan Knapp (244328)

مصطلحات موضوعية: Biophysics, Biochemistry, Genetics, Molecular Biology, Pharmacology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, dysfunctional HMT complexes, WDR 5, upregulated MYC levels, 3K, protein interaction interfaces, WDR 5 interactions, WDR 5 degrader series, influence degradation efficacy, WD-repeat-containing protein 5, RNA, WIN site binding scaffolds

Relation: https://figshare.com/articles/journal_contribution/Design_Synthesis_and_Evaluation_of_WD-Repeat-Containing_Protein_5_WDR5_Degraders/14587298

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00146.s001

المؤلفون: Anja Dölle (10794992), Bikash Adhikari (704191), Andreas Krämer (3286917), Janik Weckesser (10794995), Nicola Berner (10794998), Lena-Marie Berger (10795001), Mathias Diebold (10795004), Magdalena M. Szewczyk (3119427), Dalia Barsyte-Lovejoy (1399687), Cheryl H. Arrowsmith (246847), Jakob Gebel (10795007), Frank Löhr (1871500), Volker Dötsch (1910650), Martin Eilers (164041), Stephanie Heinzlmeir (1456441), Bernhard Kuster (3990), Christoph Sotriffer (3544643), Elmar Wolf (164036), Stefan Knapp (244328)

مصطلحات موضوعية: Biophysics, Biochemistry, Genetics, Molecular Biology, Pharmacology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, dysfunctional HMT complexes, WDR 5, upregulated MYC levels, 3K, protein interaction interfaces, WDR 5 interactions, WDR 5 degrader series, influence degradation efficacy, WD-repeat-containing protein 5, RNA, WIN site binding scaffolds

Relation: https://figshare.com/articles/dataset/Design_Synthesis_and_Evaluation_of_WD-Repeat-Containing_Protein_5_WDR5_Degraders/14587301

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00146.s002

المؤلفون: Anja Dölle (10794992), Bikash Adhikari (704191), Andreas Krämer (3286917), Janik Weckesser (10794995), Nicola Berner (10794998), Lena-Marie Berger (10795001), Mathias Diebold (10795004), Magdalena M. Szewczyk (3119427), Dalia Barsyte-Lovejoy (1399687), Cheryl H. Arrowsmith (246847), Jakob Gebel (10795007), Frank Löhr (1871500), Volker Dötsch (1910650), Martin Eilers (164041), Stephanie Heinzlmeir (1456441), Bernhard Kuster (3990), Christoph Sotriffer (3544643), Elmar Wolf (164036), Stefan Knapp (244328)

مصطلحات موضوعية: Biophysics, Biochemistry, Genetics, Molecular Biology, Pharmacology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, dysfunctional HMT complexes, WDR 5, upregulated MYC levels, 3K, protein interaction interfaces, WDR 5 interactions, WDR 5 degrader series, influence degradation efficacy, WD-repeat-containing protein 5, RNA, WIN site binding scaffolds

Relation: https://figshare.com/articles/dataset/Design_Synthesis_and_Evaluation_of_WD-Repeat-Containing_Protein_5_WDR5_Degraders/14587304

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00146.s003