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1Academic Journal
المؤلفون: Ashita Singh, Monikaben Padariya, Jakub Faktor, Sachin Kote, Sara Mikac, Alicja Dziadosz, Tak W. Lam, Jack Brydon, Martin A. Wear, Kathryn L. Ball, Ted Hupp, Alicja Sznarkowska, Borek Vojtesek, Umesh Kalathiya
المصدر: Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2045-2322
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2Academic Journal
المؤلفون: Iain W. McNae, James Kinkead, Divya Malik, Li-Hsuan Yen, Martin K. Walker, Chris Swain, Scott P. Webster, Nick Gray, Peter M. Fernandes, Elmarie Myburgh, Elizabeth A. Blackburn, Ryan Ritchie, Carol Austin, Martin A. Wear, Adrian J. Highton, Andrew J. Keats, Antonio Vong, Jacqueline Dornan, Jeremy C. Mottram, Paul A. M. Michels, Simon Pettit, Malcolm D. Walkinshaw
المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
مصطلحات موضوعية: Science
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2041-1723
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3Academic Journal
المؤلفون: Martin A. Wear, Matthew W. Nowicki, Elizabeth A. Blackburn, Iain W. McNae, Malcolm D. Walkinshaw
المصدر: FEBS Open Bio, Vol 7, Iss 4, Pp 533-549 (2017)
مصطلحات موضوعية: cyclophilin‐A, inhibitor, nonpeptide, surface plasmon resonance, thermodynamics, Biology (General), QH301-705.5
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2211-5463
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4
المؤلفون: James Kinkead, Malcolm D. Walkinshaw, Martin A. Wear, Monserrat Vásquez-Valdivieso, Iain W. McNae, Peter M Fernandes, Paul A.M. Michels
المصدر: The Febs Journal
Fernandes, P, Kinkead, J, McNae, I, Vásquez-Valdivieso, M G, Wear, M, Michels, P & Walkinshaw, M 2019, ' Kinetic and structural studies of Trypanosoma and Leishmania phosphofructokinases show evolutionary divergence and identify AMP as a switch regulating glycolysis versus gluconeogenesis ', Febs Journal . https://doi.org/10.1111/febs.15177مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Trypanosoma, Protein Conformation, Allosteric regulation, Trypanosoma brucei brucei, Phosphofructokinase, Crystallography, X-Ray, Biochemistry, Glycosome, Substrate Specificity, 03 medical and health sciences, 0302 clinical medicine, Species Specificity, Catalytic Domain, parasitic diseases, Animals, Humans, Glycolysis, Enzyme kinetics, Phosphofructokinases, Amino Acid Sequence, Molecular Biology, Leishmania, allostery, biology, Chemistry, Gluconeogenesis, Cell Biology, Original Articles, glycolysis, biology.organism_classification, Biological Evolution, Adenosine Monophosphate, Kinetics, 030104 developmental biology, phosphofructokinase, 030220 oncology & carcinogenesis, Original Article, Guanosine Triphosphate
وصف الملف: application/pdf
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5Academic Journal
المؤلفون: Matthew W Nowicki, Elizabeth A Blackburn, Iain W McNae, Martin A Wear
المصدر: PLoS ONE, Vol 10, Iss 12, p e0146164 (2015)
وصف الملف: electronic resource
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6
المؤلفون: Zala Sekne, E. Suzanne Cohen, Georgia Perona-Wright, Matthew K. Higgins, Martin A. Wear, William F Gregory, Elizabeth C Hinchy, Adefunke Ogunkanbi, Graham Heieis, Abhishek Jamwal, Francesco Vacca, Henry J. McSorley, Holly Webster, Josquin A Nys, Caroline Chauché
المساهمون: Vacca, Francesco [0000-0001-6808-5221], Higgins, Matthew K [0000-0002-2870-1955], McSorley, Henry J [0000-0003-1300-7407], Apollo - University of Cambridge Repository
المصدر: Vacca, F, Chauché, C, Jamwal, A, Hinchy, E C, Heieis, G, Webster, H, Ogunkanbi, A, Sekne, Z, Gregory, W F, Wear, M, Perona-Wright, G, Higgins, M K, Nys, J A, Cohen, E S & Mcsorley, H J 2020, ' A helminth-derived suppressor of ST2 blocks allergic responses ', eLIFE, vol. 9, e54017 . https://doi.org/10.7554/eLife.54017
eLife, Vol 9 (2020)
eLifeمصطلحات موضوعية: 0301 basic medicine, Mouse, medicine.medical_treatment, Cell, immunology, Mice, Immunology and Inflammation, 0302 clinical medicine, Biology (General), Receptor, Mice, Inbred BALB C, Nematospiroides dubius, Microbiology and Infectious Disease, biology, Chemistry, General Neuroscience, Alternaria, General Medicine, Cell biology, Cytokine, medicine.anatomical_structure, parasite, Medicine, Research Article, Human, Ovalbumin, QH301-705.5, infectious disease, Science, General Biochemistry, Genetics and Molecular Biology, Cell Line, 03 medical and health sciences, Immune system, Helminth, medicine, Animals, Humans, Immunologic Factors, General Immunology and Microbiology, microbiology, asthma, Interleukin-33, allergy, ST2, biology.organism_classification, Interleukin-1 Receptor-Like 1 Protein, In vitro, Mice, Inbred C57BL, Interleukin 33, 030104 developmental biology, inflammation, Antigens, Helminth, IL-33, biology.protein, Heligmosomoides polygyrus, 030215 immunology, Complement control protein
وصف الملف: application/pdf; application/zip; text/xml
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المؤلفون: Graham Heieis, Francesco Vacca, Matthew K. Higgins, Abhishek Jamwal, Caroline Chauché, William F Gregory, Elizabeth C Hinchy, Holly Webster, Zala Sekne, Henry J. McSorley, E. Suzanne Cohen, Martin A. Wear, Adefunke Ogunkanbi, Josquin A Nys, Georgia Perona-Wright
مصطلحات موضوعية: law, Immunology, Suppressor, Helminths, Biology, law.invention
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8
المؤلفون: Caroline Chauché, Martin A. Wear, Henry J. McSorley, William F. Gregory, Francesco Vacca, Josh Richards, Adefunke Ogunkanbi, Shin Li Chia
المصدر: Frontiers in Immunology
Chauche, C, Vacca, F, Chia, S L, Richards, J, Gregory, W F, Ogunkanbi, A, Wear, M A & McSorley, H 2020, ' A truncated form of HpARI stabilises IL-33, amplifying responses to the cytokine ', Frontiers in Immunology, vol. 11, 1363 . https://doi.org/10.3389/fimmu.2020.01363
Frontiers in Immunology, Vol 11 (2020)مصطلحات موضوعية: 0301 basic medicine, lcsh:Immunologic diseases. Allergy, medicine.medical_treatment, Immunology, Heligmosomoides polygyrus, law.invention, Host-Parasite Interactions, ILC2, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Protein Domains, In vivo, law, medicine, cytokine, Immunology and Allergy, Animals, Nippostrongylus brasiliensis, Receptor, 030304 developmental biology, heligmosomoides polygyrus, Strongylida Infections, Original Research, 0303 health sciences, Nematospiroides dubius, biology, biology.organism_classification, Interleukin-33, allergy, 3. Good health, Cell biology, Interleukin 33, 030104 developmental biology, Cytokine, chemistry, Antigens, Helminth, Recombinant DNA, IL-33, lcsh:RC581-607, DNA, 030215 immunology
وصف الملف: application/pdf
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9
المصدر: Puzorjov, A, Ünal, M, Wear, M A & McCormick, A J 2021, ' Pilot scale production, extraction and purification of a thermostable phycocyanin from Synechocystis sp. PCC 6803 ', Bioresource technology, vol. 345, 126459 . https://doi.org/10.1016/j.biortech.2021.126459
مصطلحات موضوعية: Chlorophyll, scale-up, Flocculation, Environmental Engineering, Bioengineering, macromolecular substances, Chitosan, chemistry.chemical_compound, high pressure homogenisation, Phycocyanin, Biomass, Waste Management and Disposal, Ammonium sulfate precipitation, Chromatography, Allophycocyanin, Renewable Energy, Sustainability and the Environment, Extraction (chemistry), Synechocystis, General Medicine, Contamination, chemistry, ammonium sulfate, chitosan, Thermosynechococcus elongatus BP-1
وصف الملف: application/pdf
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10Academic Journal
المؤلفون: Hugh P. Morgan, Peter Estibeiro, Martin A. Wear, Klaas E. A. Max, Udo Heinemann, Liza Cubeddu, Maurice P. Gallagher, Peter J. Sadler, Malcolm D. Walkinshaw
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.333.4294; http://nar.oxfordjournals.org/content/35/10/e75.full-text-lowres.pdf
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11
المؤلفون: Alistair J. McCormick, Martin A. Wear, Ursula Simon, Alex Zouliatis, Simone Dimartino, Livia C T Scorza
المصدر: Scorza, L, Simon, U, Wear, M A, Zouliatis, A, Dimartino, S & McCormick, A J 2021, ' Evaluation of novel 3D-printed monolithic adsorbers against conventional chromatography columns for the purification of c-phycocyanin from Spirulina ', Algal Research, vol. 55, 102253 . https://doi.org/10.1016/j.algal.2021.102253
مصطلحات موضوعية: 3d printed, Materials science, allophycocyanin, Arthrospira platensis, 02 engineering and technology, 01 natural sciences, anion exchange, disc, chemistry.chemical_classification, Spirulina (genus), Downstream processing, Chromatography, biology, Ion exchange, Biomolecule, Phycobiliprotein, 010401 analytical chemistry, Extraction (chemistry), 021001 nanoscience & nanotechnology, biology.organism_classification, phycobilisome, 0104 chemical sciences, downstream processing, chemistry, 0210 nano-technology, Agronomy and Crop Science
وصف الملف: application/pdf
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12
المؤلفون: Alice Rose, Mitchell, Meng, Yuan, Hugh P, Morgan, Iain W, McNae, Elizabeth A, Blackburn, Thierry, Le Bihan, Rafael A, Homem, Manda, Yu, Gary J, Loake, Paul A, Michels, Martin A, Wear, Malcolm D, Walkinshaw
المصدر: Biochemical Journal
مصطلحات موضوعية: Nitrosation, Pyruvate Kinase, redox signalling, Protein Structure, Secondary, enzyme activity, Isoenzymes, Humans, Cysteine, Crystallization, Oxidation-Reduction, Research Articles, Research Article
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13
المؤلفون: David W. Melton, Douglas R. Houston, Preeti Bakrania, Martin A. Wear, Barbara Saxty, Ann Marie Ritchie, Steven Shave, Tim Chapman, Katy R. Astell, Puneet Khurana, Claire Wallace, Ewan M. McNeil, Malcolm D. Walkinshaw, Hayley M. Jones
المصدر: McNeil, E M, Astell, K R, Ritchie, A-M, Shave, S, Houston, D R, Bakrania, P, Jones, H M, Khurana, P, Wallace, C, Chapman, T, Wear, M A, Walkinshaw, M D, Saxty, B & Melton, D W 2015, ' Inhibition of the ERCC1-XPF structure-specific endonuclease to overcome cancer chemoresistance ', DNA Repair, vol. 31, pp. 19-28 . https://doi.org/10.1016/j.dnarep.2015.04.002
مصطلحات موضوعية: DNA Repair, REPAIR/RECOMBINATION NUCLEASE, Biochemistry, Endonuclease, chemistry.chemical_compound, Catalytic Domain, CRYSTAL-STRUCTURE, Melanoma, FANCQ, Ovarian Neoplasms, biology, INTERACTION DOMAINS, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, DNA-REPAIR, Female, MESSENGER-RNA, Interstrand Crosslink Repair, medicine.drug, GENE ERCC1, DNA repair, CELL LUNG-CANCER, In silico, CISPLATIN, Ovarian cancer, Cell Line, Tumor, medicine, Humans, Molecular Biology, Cisplatin, Reproducibility of Results, Cancer, Sequence Analysis, DNA, Cell Biology, Endonucleases, medicine.disease, Molecular biology, High-Throughput Screening Assays, NUCLEOTIDE EXCISION-REPAIR, chemistry, Drug Resistance, Neoplasm, DNA repair inhibitor, biology.protein, Cancer research, ERCC1-XPF, Nucleotide Excision Repair, SMALL-MOLECULE INHIBITORS, ERCC1, DNA, Nucleotide excision repair
وصف الملف: application/msword
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المؤلفون: Harris Ioannidis, Julien Michel, Martin A. Wear, Malcolm D. Walkinshaw, Charis Georgiou, Iain W. McNae
المصدر: Georgiou, C, Mcnae, I, Wear, M, Ioannidis, H, Michel, J & Walkinshaw, M 2017, ' Pushing the limits of detection of weak binding using fragment based drug discovery: identification of new cyclophilin binders ', Journal of Molecular Biology . https://doi.org/10.1016/j.jmb.2017.06.016
مصطلحات موضوعية: 0301 basic medicine, Gene isoform, Protein family, Drug discovery, Chemistry, Fragment-based lead discovery, Computational biology, Molecular Dynamics Simulation, Surface Plasmon Resonance, Weak binding, 03 medical and health sciences, Cyclophilins, 030104 developmental biology, X-Ray Diffraction, Biochemistry, Structural Biology, Limit of Detection, Drug Discovery, Protein Isoforms, Identification (biology), Surface plasmon resonance, Molecular Biology, Binding selectivity, Cyclophilin, Protein Binding
وصف الملف: application/pdf
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15
المؤلفون: Malcolm D. Walkinshaw, Elizabeth A. Blackburn, Martin A. Wear, Fazia Adyani Ahmad Fuad, Hugh P. Morgan, Paul A.M. Michels, Matthew W. Nowicki, Linda A. Fothergill-Gilmore
المصدر: Biochemical and Biophysical Research Communications. 450:936-941
مصطلحات موضوعية: Models, Molecular, Conformational change, Protein Conformation, Leishmania mexicana, Biophysics, Crystallography, X-Ray, Biochemistry, Substrate Specificity, Phosphoglycerate mutase, chemistry.chemical_compound, Apoenzymes, parasitic diseases, Molecular Biology, Phosphoglycerate Mutase, chemistry.chemical_classification, Phosphoglycerate kinase, biology, Cell Biology, Chromatography, Ion Exchange, biology.organism_classification, Monomer, Enzyme, chemistry, Chromatography, Gel, Protein Multimerization, Holoenzymes
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16
المؤلفون: Iain L. Mainprize, S.R. Bushell, James H. Naismith, Chris Whitfield, Martin A. Wear, Hubing Lou
المساهمون: The Wellcome Trust, University of St Andrews. School of Chemistry, University of St Andrews. Biomedical Sciences Research Complex, University of St Andrews. EaSTCHEM
المصدر: Structure. 21(5):844-853
مصطلحات موضوعية: Bacterial capsule, Protein Folding, Gram-negative bacteria, Protein Conformation, QH301 Biology, medicine.disease_cause, Bacterial cell structure, Surface-plasmon resonance, QH301, Protein structure, Structural Biology, Lectins, Structural basis, Extracellular, medicine, Escherichia coli, Gene-expression, Molecular Biology, Bacterial Capsules, Phylogeny, biology, Colanic acid biosynthesis, Escherichia coli Proteins, Klebsiella-pneumoniae, Periplasmic space, biology.organism_classification, Cell biology, Functional-analysis, Biochemistry, Crystal-structure, K antigens, Antigens, Surface, Concanavalin-A, Bacterial outer membrane, Bacterial Outer Membrane Proteins
وصف الملف: application/pdf
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17
المؤلفون: Frances, Spiller, Bethan, Medina-Pritchard, Maria Alba, Abad, Martin A, Wear, Oscar, Molina, William C, Earnshaw, A Arockia, Jeyaprakash
المصدر: EMBO Reports
مصطلحات موضوعية: Cdk1, Chromosomal Proteins, Non-Histone, Cell Cycle, Centromere, Scientific Report, Scientific Reports, macromolecular substances, Nucleosomes, HJURP, DNA-Binding Proteins, Mis18 complex, Gene Expression Regulation, Structural Biology, CDC2 Protein Kinase, Humans, Phosphorylation, Centromere Protein A, Adaptor Proteins, Signal Transducing, Protein Binding, CENP‐A deposition
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المؤلفون: Hugh P. Morgan, Paul A.M. Michels, Matthew W. Nowicki, Elizabeth A. Blackburn, Malcolm D. Walkinshaw, Douglas S. Auld, Min Shen, Martin A. Wear, Linda A. Fothergill-Gilmore, Iain W. McNae, Henrike Veith, Martin J. Walsh, Matthew B. Boxer
المصدر: Morgan, H P, Walsh, M J, Blackburn, E A, Wear, M A, Boxer, M B, Shen, M, Veith, H, McNae, I W, Nowicki, M W, Michels, P A M, Auld, D S, Fothergill-Gilmore, L A & Walkinshaw, M D 2012, ' A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase ', Biochemical Journal, vol. 448, no. 1, pp. 67-72 . https://doi.org/10.1042/BJ20121014
مصطلحات موضوعية: Models, Molecular, Protein Conformation, Stereochemistry, Pyruvate Kinase, Leishmania mexicana, Lysine, Suramin, Plasma protein binding, Arginine, Crystallography, X-Ray, Benzoates, Biochemistry, Article, Structure-Activity Relationship, Residue (chemistry), chemistry.chemical_compound, Saccharin, Adenosine Triphosphate, Protein structure, Species Specificity, Catalytic Domain, Animals, Humans, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, Conserved Sequence, biology, Chemistry, Active site, Cell Biology, Recombinant Proteins, High-Throughput Screening Assays, Adenosine Diphosphate, Isoenzymes, biology.protein, Adenosine triphosphate, Pyruvate kinase, Protein Binding
وصف الملف: application/pdf
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المؤلفون: Dinesh C. Soares, Shaun Mackie, Sheila Christie, Elizabeth A. Blackburn, Gareth James Briggs, David J. Porteous, Jennifer E. Eykelenboom, Walter J. Muir, Nicholas J. Bradshaw, Elise L.V. Malavasi, M. P. Malloy, J. Kirsty Millar, Fumiaki Ogawa, Janice Bramham, Martin A. Wear, Paraskevi Makedonopoulou, Andrew M. McIntosh, Douglas Blackwood
المصدر: Human Molecular Genetics
Eykelenboom, J E, Briggs, G J, Bradshaw, N J, Soares, D C, Ogawa, F, Christie, S, Malavasi, E L V, Makedonopoulou, P, Mackie, S, Malloy, M P, Wear, M A, Blackburn, E A, Bramham, J, Mcintosh, A M, Blackwood, D H, Muir, W J, Porteous, D J & Millar, J K 2012, ' A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins ', Human Molecular Genetics, vol. 21, no. 15, pp. 3374-3386 . https://doi.org/10.1093/hmg/dds169مصطلحات موضوعية: mitochondria, amino acids, cell line, chimera organism, fusion protein, chromosomes, human, pair 11, exons, genes, mental disorders, mitochondrial proteins, mood disorder, neurons, schizophrenia, translocation (genetics), Balanced Chromosomal Translocation, Nerve Tissue Proteins, Chromosomal translocation, Haploinsufficiency, Mitochondrion, Transfection, Translocation, Genetic, Mitochondrial Proteins, 03 medical and health sciences, DISC1, Exon, 0302 clinical medicine, Chlorocebus aethiops, Genetics, Animals, Humans, Genetics(clinical), Molecular Biology, Gene, Genetics (clinical), 030304 developmental biology, 0303 health sciences, biology, Mood Disorders, Chromosomes, Human, Pair 11, Articles, General Medicine, Fusion protein, Molecular biology, Chromosomes, Human, Pair 1, COS Cells, Schizophrenia, biology.protein, 030217 neurology & neurosurgery
وصف الملف: application/pdf
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20
المؤلفون: Malcolm D. Walkinshaw, Martin A. Wear, Cornelia Ludwig
المصدر: Ludwig, C, Wear, M A & Walkinshaw, M D 2010, ' Streamlined, automated protocols for the production of milligram quantities of untagged recombinant human cyclophilin-A (hCypA) and untagged human proliferating cell nuclear antigen (hPCNA) using AKTAxpress (TM) ', Protein Expression and Purification, vol. 71, no. 1, pp. 54-61 . https://doi.org/10.1016/j.pep.2009.12.001
Protein Expression and Purificationمصطلحات موضوعية: Sample processing, Size-exclusion chromatography, Liquid chromatography, Biology, User input, Article, law.invention, Automation, 03 medical and health sciences, law, Proliferating Cell Nuclear Antigen, ÄKTAXpress™, Humans, PCNA, Automated protein purification, 030304 developmental biology, Protocol (science), 0303 health sciences, Chromatography, 030302 biochemistry & molecular biology, Linear sequence, Chromatography liquid, Recombinant Proteins, 6. Clean water, Cyclophilin-A, Yield (chemistry), Recombinant DNA, Cyclophilin A, Chromatography, Liquid, Biotechnology
وصف الملف: application/pdf
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