المؤلفون: Konstantin Neukirch (11153961), Khaled Alsabil (11153964), Chau-Phi Dinh (11153967), Rossella Bilancia (11153970), Martin Raasch (11153973), Alexia Ville (6195272), Ida Cerqua (6865439), Guillaume Viault (5536127), Dimitri Bréard (5536124), Simona Pace (1779802), Veronika Temml (1308846), Elena Brunner (11153976), Paul M. Jordan (1449052), Marta C. Marques (5006471), Konstantin Loeser (11153979), André Gollowitzer (11153982), Stephan Permann (11153985), Jana Gerstmeier (468479), Stefan Lorkowski (16019), Hermann Stuppner (388594), Ulrike Garscha (1811065), Tiago Rodrigues (468531), Gonçalo J. L. Bernardes (7319006), Daniela Schuster (129641), Denis Séraphin (6195278), Pascal Richomme (591385), Antonietta Rossi (1779796), Alexander S. Mosig (11153988), Fiorentina Roviezzo (2512720), Oliver Werz (468489), Jean-Jacques Helesbeux (2130412), Andreas Koeberle (1426642)

مصطلحات موضوعية: Biochemistry, Genetics, Physiology, Pharmacology, Immunology, Cancer, Mental Health, Hematology, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, semisynthesized analogues, stability, lipid mediator biosynthesis, proresolving lipid mediator, Pharmacokinetic studies show distri., LCM-inspired drug candidate, limits inflammation, murine peritonitis, prostaglandin E 2 synthase -1, α- amplexichromanol, Limits Inflammation Endogenous long., Long-Chain Vitamin E Metabolites, vitamin E, 5- LOX, 5- LOX-derived leukotriene levels d., SAR studies, β- oxidation, Other enzymes

Relation: https://figshare.com/articles/journal_contribution/Exploration_of_Long-Chain_Vitamin_E_Metabolites_for_the_Discovery_of_a_Highly_Potent_Orally_Effective_and_Metabolically_Stable_5_LOX_Inhibitor_that_Limits_Inflammation/15016581

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00806.s001

المؤلفون: João Conde (1424986), Ruth A. Pumroy (10647971), Charlotte Baker (3074619), Tiago Rodrigues (468531), Ana Guerreiro (198740), Bárbara B. Sousa (10647974), Marta C. Marques (5006471), Bernardo P. de Almeida (6443921), Sohyon Lee (10647977), Elvira P. Leites (10647980), Daniel Picard (3508178), Amrita Samanta (10647983), Sandra H. Vaz (4543093), Florian Sieglitz (10647986), Maike Langini (10647989), Marc Remke (3508145), Rafael Roque (10647992), Tobias Weiss (2092234), Michael Weller (329740), Yuhang Liu (507131), Seungil Han (1811221), Francisco Corzana (1470730), Vanessa A. Morais (10647995), Cláudia C. Faria (10647998), Tânia Carvalho (10648001), Panagis Filippakopoulos (1280556), Berend Snijder (569807), Nuno L. Barbosa-Morais (9747023), Vera Y. Moiseenkova-Bell (10648004), Gonçalo J. L. Bernardes (7319006)

مصطلحات موضوعية: Medicine, Genetics, Neuroscience, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, calcium influx modulation, Calcium imaging experiments, decreases ROS production, rat TRPV 2 channel, Extensive tumor abrogation, Allosteric Antagonist Modulation, PL, Piperlongumine Impairs Glioblastoma., data-motivated research hypotheses, hTRPV 2, Thr 522 residues, GBM patient samples associates hTRP., TRPV 2 channel

Relation: https://figshare.com/articles/journal_contribution/Allosteric_Antagonist_Modulation_of_TRPV2_by_Piperlongumine_Impairs_Glioblastoma_Progression/14417666

الاتاحة: https://doi.org/10.1021/acscentsci.1c00070.s001

المؤلفون: João Conde (1424986), Ruth A. Pumroy (10647971), Charlotte Baker (3074619), Tiago Rodrigues (468531), Ana Guerreiro (198740), Bárbara B. Sousa (10647974), Marta C. Marques (5006471), Bernardo P. de Almeida (6443921), Sohyon Lee (10647977), Elvira P. Leites (10647980), Daniel Picard (3508178), Amrita Samanta (10647983), Sandra H. Vaz (4543093), Florian Sieglitz (10647986), Maike Langini (10647989), Marc Remke (3508145), Rafael Roque (10647992), Tobias Weiss (2092234), Michael Weller (329740), Yuhang Liu (507131), Seungil Han (1811221), Francisco Corzana (1470730), Vanessa A. Morais (10647995), Cláudia C. Faria (10647998), Tânia Carvalho (10648001), Panagis Filippakopoulos (1280556), Berend Snijder (569807), Nuno L. Barbosa-Morais (9747023), Vera Y. Moiseenkova-Bell (10648004), Gonçalo J. L. Bernardes (7319006)

مصطلحات موضوعية: Medicine, Genetics, Neuroscience, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, calcium influx modulation, Calcium imaging experiments, decreases ROS production, rat TRPV 2 channel, Extensive tumor abrogation, Allosteric Antagonist Modulation, PL, Piperlongumine Impairs Glioblastoma., data-motivated research hypotheses, hTRPV 2, Thr 522 residues, GBM patient samples associates hTRP., TRPV 2 channel

Relation: https://figshare.com/articles/journal_contribution/Allosteric_Antagonist_Modulation_of_TRPV2_by_Piperlongumine_Impairs_Glioblastoma_Progression/14417669

الاتاحة: https://doi.org/10.1021/acscentsci.1c00070.s002

المؤلفون: João Conde (1424986), Ruth A. Pumroy (10647971), Charlotte Baker (3074619), Tiago Rodrigues (468531), Ana Guerreiro (198740), Bárbara B. Sousa (10647974), Marta C. Marques (5006471), Bernardo P. de Almeida (6443921), Sohyon Lee (10647977), Elvira P. Leites (10647980), Daniel Picard (3508178), Amrita Samanta (10647983), Sandra H. Vaz (4543093), Florian Sieglitz (10647986), Maike Langini (10647989), Marc Remke (3508145), Rafael Roque (10647992), Tobias Weiss (2092234), Michael Weller (329740), Yuhang Liu (507131), Seungil Han (1811221), Francisco Corzana (1470730), Vanessa A. Morais (10647995), Cláudia C. Faria (10647998), Tânia Carvalho (10648001), Panagis Filippakopoulos (1280556), Berend Snijder (569807), Nuno L. Barbosa-Morais (9747023), Vera Y. Moiseenkova-Bell (10648004), Gonçalo J. L. Bernardes (7319006)

مصطلحات موضوعية: Medicine, Genetics, Neuroscience, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, calcium influx modulation, Calcium imaging experiments, decreases ROS production, rat TRPV 2 channel, Extensive tumor abrogation, Allosteric Antagonist Modulation, PL, Piperlongumine Impairs Glioblastoma., data-motivated research hypotheses, hTRPV 2, Thr 522 residues, GBM patient samples associates hTRP., TRPV 2 channel

Relation: https://figshare.com/articles/journal_contribution/Allosteric_Antagonist_Modulation_of_TRPV2_by_Piperlongumine_Impairs_Glioblastoma_Progression/14417672

الاتاحة: https://doi.org/10.1021/acscentsci.1c00070.s003

المؤلفون: João Conde (1424986), Ruth A. Pumroy (10647971), Charlotte Baker (3074619), Tiago Rodrigues (468531), Ana Guerreiro (198740), Bárbara B. Sousa (10647974), Marta C. Marques (5006471), Bernardo P. de Almeida (6443921), Sohyon Lee (10647977), Elvira P. Leites (10647980), Daniel Picard (3508178), Amrita Samanta (10647983), Sandra H. Vaz (4543093), Florian Sieglitz (10647986), Maike Langini (10647989), Marc Remke (3508145), Rafael Roque (10647992), Tobias Weiss (2092234), Michael Weller (329740), Yuhang Liu (507131), Seungil Han (1811221), Francisco Corzana (1470730), Vanessa A. Morais (10647995), Cláudia C. Faria (10647998), Tânia Carvalho (10648001), Panagis Filippakopoulos (1280556), Berend Snijder (569807), Nuno L. Barbosa-Morais (9747023), Vera Y. Moiseenkova-Bell (10648004), Gonçalo J. L. Bernardes (7319006)

مصطلحات موضوعية: Medicine, Genetics, Neuroscience, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, calcium influx modulation, Calcium imaging experiments, decreases ROS production, rat TRPV 2 channel, Extensive tumor abrogation, Allosteric Antagonist Modulation, PL, Piperlongumine Impairs Glioblastoma., data-motivated research hypotheses, hTRPV 2, Thr 522 residues, GBM patient samples associates hTRP., TRPV 2 channel

Relation: https://figshare.com/articles/journal_contribution/Allosteric_Antagonist_Modulation_of_TRPV2_by_Piperlongumine_Impairs_Glioblastoma_Progression/14417675

الاتاحة: https://doi.org/10.1021/acscentsci.1c00070.s004

المؤلفون: Konstantin Neukirch (11153961), Khaled Alsabil (11153964), Chau-Phi Dinh (11153967), Rossella Bilancia (11153970), Martin Raasch (11153973), Alexia Ville (6195272), Ida Cerqua (6865439), Guillaume Viault (5536127), Dimitri Bréard (5536124), Simona Pace (1779802), Veronika Temml (1308846), Elena Brunner (11153976), Paul M. Jordan (1449052), Marta C. Marques (5006471), Konstantin Loeser (11153979), André Gollowitzer (11153982), Stephan Permann (11153985), Jana Gerstmeier (468479), Stefan Lorkowski (16019), Hermann Stuppner (388594), Ulrike Garscha (1811065), Tiago Rodrigues (468531), Gonçalo J. L. Bernardes (7319006), Daniela Schuster (129641), Denis Séraphin (6195278), Pascal Richomme (591385), Antonietta Rossi (1779796), Alexander S. Mosig (11153988), Fiorentina Roviezzo (2512720), Oliver Werz (468489), Jean-Jacques Helesbeux (2130412), Andreas Koeberle (1426642)

مصطلحات موضوعية: Biochemistry, Genetics, Physiology, Pharmacology, Immunology, Cancer, Mental Health, Hematology, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, semisynthesized analogues, stability, lipid mediator biosynthesis, proresolving lipid mediator, Pharmacokinetic studies show distri., LCM-inspired drug candidate, limits inflammation, murine peritonitis, prostaglandin E 2 synthase -1, α- amplexichromanol, Limits Inflammation Endogenous long., Long-Chain Vitamin E Metabolites, vitamin E, 5- LOX, 5- LOX-derived leukotriene levels d., SAR studies, β- oxidation, Other enzymes

Relation: https://figshare.com/articles/dataset/Exploration_of_Long-Chain_Vitamin_E_Metabolites_for_the_Discovery_of_a_Highly_Potent_Orally_Effective_and_Metabolically_Stable_5_LOX_Inhibitor_that_Limits_Inflammation/15016584

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00806.s002

المؤلفون: João Conde (1424986), Ruth A. Pumroy (10647971), Charlotte Baker (3074619), Tiago Rodrigues (468531), Ana Guerreiro (198740), Bárbara B. Sousa (10647974), Marta C. Marques (5006471), Bernardo P. de Almeida (6443921), Sohyon Lee (10647977), Elvira P. Leites (10647980), Daniel Picard (3508178), Amrita Samanta (10647983), Sandra H. Vaz (4543093), Florian Sieglitz (10647986), Maike Langini (10647989), Marc Remke (3508145), Rafael Roque (10647992), Tobias Weiss (2092234), Michael Weller (329740), Yuhang Liu (507131), Seungil Han (1811221), Francisco Corzana (1470730), Vanessa A. Morais (10647995), Cláudia C. Faria (10647998), Tânia Carvalho (10648001), Panagis Filippakopoulos (1280556), Berend Snijder (569807), Nuno L. Barbosa-Morais (9747023), Vera Y. Moiseenkova-Bell (10648004), Gonçalo J. L. Bernardes (7319006)

مصطلحات موضوعية: Medicine, Genetics, Neuroscience, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, calcium influx modulation, Calcium imaging experiments, decreases ROS production, rat TRPV 2 channel, Extensive tumor abrogation, Allosteric Antagonist Modulation, PL, Piperlongumine Impairs Glioblastoma., data-motivated research hypotheses, hTRPV 2, Thr 522 residues, GBM patient samples associates hTRP., TRPV 2 channel

Relation: https://figshare.com/articles/dataset/Allosteric_Antagonist_Modulation_of_TRPV2_by_Piperlongumine_Impairs_Glioblastoma_Progression/14417678

الاتاحة: https://doi.org/10.1021/acscentsci.1c00070.s005