المؤلفون: James Z. Deng, Amy Calamari, Samuel L. Graham, Christopher S. Burgey, Eric L. Moore, Craig M. Potteiger, Jixin Wang, Carolyn Segerdell, Daniel V. Paone, James Mulhearn, Cuyue Tang, Diem N. Nguyen, Kerry L. Fillgrove, Shaun R. Stauffer, Michael D. Leitl, Annie Liang, Mark O. Urban, Anthony Ginnetti, Gong Cheng, Anthony W. Shaw, Stefanie A. Kane, Jacqueline Panigel, Christopher A. Salvatore, Sean P. Cook, Juliana Anquandah

المصدر: Bioorganic & Medicinal Chemistry Letters. 28:1392-1396

مصطلحات موضوعية: 0301 basic medicine, Purinergic P2X Receptor Antagonists, Pyridines, Clinical Biochemistry, Drug-drug interaction, Pain, Pharmaceutical Science, Pharmacology, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dogs, 0302 clinical medicine, Drug Discovery, Animals, Drug Interactions, Glucuronosyltransferase, Molecular Biology, Hyperbilirubinemia, Analgesics, Molecular Structure, Chemistry, Organic Chemistry, Purinergic receptor, Antagonist, Stereoisomerism, Small molecule, Rats, 030104 developmental biology, Drug Design, Benzamides, Molecular Medicine, Identification (biology), Lead compound, Receptors, Purinergic P2X3, 030217 neurology & neurosurgery, Half-Life, P2X3 Receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d9a5d8b32ff27b4abbd55923273b1fb
https://doi.org/10.1016/j.bmcl.2018.02.039

المؤلفون: Molecular Pain, Samer R Eid, Eric D Crown, Eric L Moore, Hongyu A Liang, Chan Choong, Shelley Dima, Darrell A Henze, Stefanie A Kane, Mark O Urban

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/a0/69/Mol_Pain_2008_Oct_27_4_48.tar.gz

وصف الملف: application/zip

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.278.370

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.278.370

المؤلفون: Andrea K. Houghton, Aneta Jovanovska, Tracey Filzen, Ying-Hong Wang, Jacqueline Panigel, Annie Liang, Michelle K. Clements, Rebecca M. Klein, Richard L. Kraus, John Majercak, Eleftheria N. Finger, Jixin Wang, Matthew J. Cato, Hannah D. G. F. Lehman, Christopher Daley, Yun Gregan, James Mulhearn, Yuxing Li, Michael A. Rossi, Darrell A. Henze, Mark O. Urban, Michael J. Kelly, Scott E. Wolkenberg, Mark E. Layton, Joseph E. Pero

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:2683-2688

مصطلحات موضوعية: 0301 basic medicine, Ligand efficiency, Chemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Bioavailability, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, In vivo, Oral administration, Drug Discovery, Molecular Medicine, Structure–activity relationship, Potency, Selectivity, Molecular Biology, Lead compound

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2fa8cc863252cd7ed266d6ff8eb35f8f
https://doi.org/10.1016/j.bmcl.2017.04.040

المؤلفون: Mark E. Layton, Eleftheria N. Finger, Edward C. Sherer, Amy Jo Koser, Aneta Jovanovska, Robert Gomez, Xiu Wang, Deping Wang, Xuanjia Peng, John Majercak, Melissa Egbertson, Paul J. Coleman, Rebecca M. Klein, Kristen L.G. Jones, Richard L. Kraus, Jixin Wang, Tracey Filzen, Mark O. Urban, Yuxing Li, Anthony J. Roecker, Matthew J. Cato, Ying-Hong Wang, Michelle K. Clements, Jacqueline Panigel, Leo A. Joyce, Vincent P. Santarelli, Irene Gregan, Christopher Daley, Haiyan Sun, Andrea K. Houghton

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:2087-2093

مصطلحات موضوعية: 0301 basic medicine, Gene isoform, Side effect, Chemistry, Sodium channel, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Bioavailability, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Drug Discovery, NAV1, Molecular Medicine, Potency, Molecular Biology, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6460ec06d229cf43b30709ab80de83e3
https://doi.org/10.1016/j.bmcl.2017.03.085

المؤلفون: Anthony J, Roecker, Melissa, Egbertson, Kristen L G, Jones, Robert, Gomez, Richard L, Kraus, Yuxing, Li, Amy Jo, Koser, Mark O, Urban, Rebecca, Klein, Michelle, Clements, Jacqueline, Panigel, Christopher, Daley, Jixin, Wang, Eleftheria N, Finger, John, Majercak, Vincent, Santarelli, Irene, Gregan, Matthew, Cato, Tracey, Filzen, Aneta, Jovanovska, Ying-Hong, Wang, Deping, Wang, Leo A, Joyce, Edward C, Sherer, Xuanjia, Peng, Xiu, Wang, Haiyan, Sun, Paul J, Coleman, Andrea K, Houghton, Mark E, Layton

المصدر: Bioorganicmedicinal chemistry letters. 27(10)

مصطلحات موضوعية: Voltage-Gated Sodium Channel Blockers, Sulfonamides, Nitrogen, NAV1.7 Voltage-Gated Sodium Channel, Drug Evaluation, Preclinical, Administration, Oral, Pain, Rats, Disease Models, Animal, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, Animals, Protein Isoforms, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::d9bbd5306725778e4f9bb0907a6353e2
https://pubmed.ncbi.nlm.nih.gov/28389149

المؤلفون: Joseph E, Pero, Michael A, Rossi, Hannah D G F, Lehman, Michael J, Kelly, James J, Mulhearn, Scott E, Wolkenberg, Matthew J, Cato, Michelle K, Clements, Christopher J, Daley, Tracey, Filzen, Eleftheria N, Finger, Yun, Gregan, Darrell A, Henze, Aneta, Jovanovska, Rebecca, Klein, Richard L, Kraus, Yuxing, Li, Annie, Liang, John M, Majercak, Jacqueline, Panigel, Mark O, Urban, Jixin, Wang, Ying-Hong, Wang, Andrea K, Houghton, Mark E, Layton

المصدر: Bioorganicmedicinal chemistry letters. 27(12)

مصطلحات موضوعية: Analgesics, Benzoxazoles, Sulfonamides, Dose-Response Relationship, Drug, Molecular Structure, Myocytes, Smooth Muscle, NAV1.7 Voltage-Gated Sodium Channel, Administration, Oral, Biological Availability, Pain, Rats, Disease Models, Animal, Mice, Structure-Activity Relationship, Formaldehyde, Animals, Humans

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::778a3d26f8386c5f7b36bf25f166c4da
https://pubmed.ncbi.nlm.nih.gov/28465103

المؤلفون: Samuel L. Graham, Christine Fandozzi, Eric L. Moore, Donnette D. Staas, Ian M. Bell, Nova Sain, Joseph G. Bruno, Steven N. Gallicchio, Harold G. Selnick, Christopher A. Salvatore, Mark O. Urban, Rebecca B. White, Matthew M. Zrada, Amy Calamari, C. Blair Zartman, Amanda L. Kemmerer, Joseph P. Vacca, Stefanie A. Kane, Craig A. Stump, Scott D. Mosser

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:3941-3945

مصطلحات موضوعية: medicine.medical_specialty, Pyridines, Migraine Disorders, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Calcitonin gene-related peptide, Pharmacology, Biochemistry, Mice, chemistry.chemical_compound, Dogs, Species Specificity, Calcitonin Gene-Related Peptide Receptor Antagonists, In vivo, Internal medicine, Drug Discovery, medicine, Animals, Humans, Potency, Spiro Compounds, Receptor, Molecular Biology, Analgesics, Chemistry, Organic Chemistry, Antagonist, Macaca mulatta, Rats, Blockade, Disease Models, Animal, Endocrinology, Pharmacodynamics, Molecular Medicine, Acetamide, Receptors, Calcitonin Gene-Related Peptide

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62e622cb95d0ea053c8a538444e4e67
https://doi.org/10.1016/j.bmcl.2012.04.105

المؤلفون: Donald S. Williams, Denise C. Welsh, Mark O. Urban, Fuqiang Zhao, Richard Hargreaves, Alexandre Coimbra, Mangay Williams, Jeffrey L. Evelhoch

المصدر: NeuroImage. 59:1168-1179

مصطلحات موضوعية: genetic structures, Haemodynamic response, Cognitive Neuroscience, Thalamus, Pain, Stimulus (physiology), Somatosensory system, Sensitivity and Specificity, behavioral disciplines and activities, Rats, Sprague-Dawley, Midbrain, Physical Stimulation, Animals, Blood Volume, Blood-oxygen-level dependent, Brain, Reproducibility of Results, Magnetic Resonance Imaging, Electric Stimulation, Pons, Rats, Nociception, nervous system, Neurology, Cerebrovascular Circulation, Nerve Net, Psychology, Neuroscience, Blood Flow Velocity, psychological phenomena and processes

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5181a6889d47bd7c24d7421a8fa2140f
https://doi.org/10.1016/j.neuroimage.2011.08.002

المؤلفون: Nicole Trainor, E V Lis, Anthony G. DiLella, Terrence P. McDonald, Annie Liang, Mark E. Layton, Duane R. Reiss, Michael J. Kelly, Sanderson Philip E, James Yergey, Kevin J. Rodzinak, Steven D. Young, Guy R. Seabrook, Christine Fandozzi, Michael E. Cunningham, Scott D. Mosser, Mark O. Urban, John F. Fay, Hao Wang, Kenneth S. Koblan, Rodney A. Bednar

المصدر: ACS Chemical Neuroscience. 2:352-362

مصطلحات موضوعية: Male, ERG1 Potassium Channel, Physiology, Cognitive Neuroscience, Administration, Oral, Biological Availability, Cyclopentanes, Catalepsy, Pharmacology, Receptors, N-Methyl-D-Aspartate, Biochemistry, Rotarod performance test, Rats, Sprague-Dawley, Dogs, Isomerism, Piperidines, Oral administration, Drug Discovery, medicine, Animals, Benzopyrans, Receptor, Ligation, Oxadiazoles, Chemistry, Antagonist, Parkinson Disease, Cell Biology, General Medicine, medicine.disease, Macaca mulatta, Ether-A-Go-Go Potassium Channels, Rats, Pyrimidines, Spinal Nerves, nervous system, Neuropathic pain, Excitatory Amino Acid Antagonists, Neuralgia, NMDA receptor, Female, Indicators and Reagents, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd2684ec1a091b2da7e8fdaae9487129
https://doi.org/10.1021/cn200013d

المؤلفون: Michael D. Leitl, Darrell A. Henze, B. Wesley Trotter, Kimberly Della Penna, Ahren Iver Green, Mark T. Bilodeau, Zhicai Wu, Christopher S. Burgey, Wei Lemaire, Stefanie A. Kane, Craig M. Potteiger, Reshma Desai, Mark O. Urban, Suzie Yeh, Rebecca B. White, Nathan R. Kett, James Z. Deng, George D. Hartman, John C. Hartnett, Kausik K. Nanda

المصدر: Bioorganic & Medicinal Chemistry Letters. 21:2354-2358

مصطلحات موضوعية: Agonist, Imidazopyridine, Cannabinoid receptor, Pyridines, medicine.drug_class, medicine.medical_treatment, Freund's Adjuvant, Clinical Biochemistry, Analgesic, Pharmaceutical Science, Pharmacology, Biochemistry, Receptor, Cannabinoid, CB2, Receptor, Cannabinoid, CB1, In vivo, Drug Discovery, medicine, Animals, Humans, Receptor, Molecular Biology, Analgesics, Chemistry, Organic Chemistry, In vitro, Rats, Disease Models, Animal, Hyperalgesia, Molecular Medicine, lipids (amino acids, peptides, and proteins), Cannabinoid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14244f428a1317fe2d743c1692b389db
https://doi.org/10.1016/j.bmcl.2011.02.082

المؤلفون: Annie Liang, Michael D. Leitl, Stefanie A. Kane, Matthew J. Cato, Victor M. Garsky, Mark O. Urban, Robert H. Spencer, Jerzy Karczewski, Sean P. Cook

المصدر: British Journal of Pharmacology. 161:950-960

مصطلحات موضوعية: Pharmacology, Chemistry, Analgesic, Bradykinin, Inflammation, chemistry.chemical_compound, Nociception, Freund's adjuvant, In vivo, Anesthesia, medicine, Nociceptor, medicine.symptom, Acid-sensing ion channel

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c86609c25ea0c9f878d80e9d82d485e8
https://doi.org/10.1111/j.1476-5381.2010.00918.x

المؤلفون: Michael D. Leitl, Nova Sain, Annie Liang, Mark T. Bilodeau, Vera Bodmer-Narkevitch, Stefanie A. Kane, Scott D. Kuduk, Sean P. Cook, Robert H. Spencer, George D. Hartman, Matthew J. Cato, Aneta Jovanovska, Christina N. Di Marco, Mark O. Urban

المصدر: ACS Chemical Neuroscience. 1:19-24

مصطلحات موضوعية: Male, Physiology, Cognitive Neuroscience, Sedation, Freund's Adjuvant, Pain, Iodoacetates, Naphthalenes, Pharmacology, Biochemistry, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Physical Stimulation, Osteoarthritis, medicine, Animals, Structure–activity relationship, Channel blocker, Postural Balance, Ion channel, Acid-sensing ion channel, Pain Measurement, Neurons, Analgesics, Behavior, Animal, Chemistry, Cell Biology, General Medicine, Acid Sensing Ion Channel Blockers, Isoquinolines, Electrophysiological Phenomena, Rats, Acid Sensing Ion Channels, Freund's adjuvant, Knockout mouse, medicine.symptom

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88033080b862f04c8750fd9bc68c654b
https://doi.org/10.1021/cn9000186

المؤلفون: J. Fred Hess, Kathy M. Schirripa, Robert M. DiPardo, Christina N. Di Marco, Kathy L. Murphy, C. Meacham Harrell, Nova Sain, Jenny Wai, Marie A. Holahan, Douglas J. Pettibone, Ronald K. Chang, Mark G. Bock, Richard W. Ransom, June J. Kim, Jacquelynn J. Cook, Duane R. Reiss, Mark O. Urban, Cuyue Tang, Scott D. Kuduk, Thomayant Prueksaritanont, Michael R. Wood

المصدر: Journal of Medicinal Chemistry. 50:272-282

مصطلحات موضوعية: Cyclopropanes, Male, medicine.drug_class, Administration, Oral, Biological Availability, Bradykinin, Carboxamide, CHO Cells, Pharmacology, Blood–brain barrier, Benzoates, Animals, Genetically Modified, Mice, Radioligand Assay, Structure-Activity Relationship, chemistry.chemical_compound, Cricetulus, Species Specificity, In vivo, Cricetinae, Acetamides, Chlorocebus aethiops, Drug Discovery, medicine, Aminobiphenyl Compounds, Animals, Humans, Receptor, Analgesics, Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Antagonist, Brain, Amides, Macaca mulatta, Rats, Bradykinin B1 Receptor Antagonists, medicine.anatomical_structure, Spinal Cord, Blood-Brain Barrier, Molecular Medicine, Female, Rabbits, Penetrant (biochemical), Ex vivo

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ea572c63be0412753d1118489dc4b38
https://doi.org/10.1021/jm061094b

المؤلفون: Kunkun Ren, Mark O. Urban, Kenneth T. Park, Marciano Sablad

المصدر: NeuroReport. 16:563-566

مصطلحات موضوعية: Male, medicine.medical_specialty, Microinjections, chemistry.chemical_element, Calcium, omega-Conotoxins, Rats, Sprague-Dawley, Calcium Channels, N-Type, omega-Agatoxin IVA, Internal medicine, medicine, Animals, Ligation, Microinjection, Medulla, Medulla Oblongata, Voltage-dependent calcium channel, Chemistry, General Neuroscience, Calcium channel, Anatomy, Calcium Channel Blockers, Rats, Spinal Nerves, Endocrinology, Allodynia, Hyperalgesia, Touch, Peripheral nerve injury, Neuralgia, Rostral ventromedial medulla, medicine.symptom

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc04883c74cb1474cf2f575ef4f7c8f3
https://doi.org/10.1097/00001756-200504250-00009

المؤلفون: Kenneth T. Park, Kunkun Ren, Brian T. Campbell, Linda J. Bristow, Brian Andrew Stearns, Mark O. Urban, Charles J. Cohen, Michel Belley, Naomi Anker, Jayashree Aiyar

المصدر: Journal of Pharmacology and Experimental Therapeutics. 313:1209-1216

مصطلحات موضوعية: Male, Benzylamines, Cyclohexanecarboxylic Acids, Gabapentin, medicine.drug_class, medicine.medical_treatment, Pain, Acetates, Pharmacology, Rats, Sprague-Dawley, medicine, Animals, Amines, gamma-Aminobutyric Acid, Analgesics, Voltage-dependent calcium channel, business.industry, Receptor antagonist, Phosphinic Acids, Rats, Disease Models, Animal, Anticonvulsant, Nociception, Receptors, GABA-B, Mechanism of action, Hyperalgesia, Acute Disease, Chronic Disease, Neuropathic pain, Molecular Medicine, medicine.symptom, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::909b14cc05004ab7958d224b66f0bc69
https://doi.org/10.1124/jpet.104.081778

المؤلفون: Gerald F. Gebhart, Santosh V Coutinho, Mark O. Urban

المصدر: European Journal of Pharmacology. 429:319-325

مصطلحات موضوعية: Central Nervous System, Male, medicine.medical_specialty, Colon, Central nervous system, Distension, Nitric Oxide, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, chemistry.chemical_compound, Internal medicine, medicine, Animals, Enzyme Inhibitors, Pharmacology, Medulla Oblongata, business.industry, Zymosan, Rectum, Rats, Viscera, Endocrinology, Nociception, medicine.anatomical_structure, Allodynia, Spinal Cord, nervous system, chemistry, Hyperalgesia, Touch, NMDA receptor, Rostral ventromedial medulla, medicine.symptom, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6687441fda1c3f06e60efaab0d96e8cd
https://doi.org/10.1016/s0014-2999(01)01331-0

المؤلفون: Mark O. Urban, Deborah L. Smith, David J. Smith, Danielle Gully, Philip J. Monroe

المصدر: Analgesia. 1:750-753

مصطلحات موضوعية: chemistry.chemical_compound, Nociception, Chemistry, Morphine, medicine, Antagonist, Geriatrics and Gerontology, Pharmacology, Non peptide, medicine.drug, Neurotensin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::60b764ac876fa301d9136572b49dd900
https://doi.org/10.3727/107156995819563032

المؤلفون: Mark O. Urban, David J. Smith

المصدر: Brain Research. 652:9-16

مصطلحات موضوعية: Male, medicine.medical_specialty, Microinjections, Periaqueductal gray, Basal Ganglia, Rats, Sprague-Dawley, Internal medicine, Neural Pathways, medicine, Animals, Periaqueductal Gray, Molecular Biology, Microinjection, Pain Measurement, Nucleus raphe magnus, Analgesics, Medulla Oblongata, Morphine, Chemistry, General Neuroscience, Lidocaine, Rats, Nociception, Endocrinology, Anesthesia, Reflex, Medulla oblongata, Raphe Nuclei, Neurology (clinical), Rostral ventromedial medulla, Skin Temperature, Developmental Biology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81ea0c1528489d1775349dc02f709a9
https://doi.org/10.1016/0006-8993(94)90311-5

المؤلفون: Aneta Jovanovska, Ronald K. Chang, Christina N. Di Marco, Mark O. Urban, Stefanie A. Kane, Sean P. Cook, Robert M. DiPardo, Scott D. Kuduk, Mark T. Bilodeau, George D. Hartman, Robert H. Spencer, Michael D. Leitl, Matthew J. Cato

المصدر: Bioorganicmedicinal chemistry letters. 21(14)

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Amidines, Pharmaceutical Science, Nerve Tissue Proteins, Biochemistry, Chemical synthesis, Sodium Channels, Amidine, Amiloride, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Structure–activity relationship, Animals, Channel blocker, Polypharmacology, Molecular Biology, Acid-sensing ion channel, Chemistry, Organic Chemistry, Benzothiophene, Therapeutic evaluation, Rats, Acid Sensing Ion Channels, Molecular Medicine, Sodium Channel Blockers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29b5d2eec11a4fd770fc6adb7a16fcd
https://pubmed.ncbi.nlm.nih.gov/21669528

المؤلفون: Michael D. Leitl, Peter J. Manley, Suzie Yeh, Daniel V. Paone, Wei Lemaire, George D. Hartman, Darrell A. Henze, Amy E. Zartman, Reshma Desai, Mark O. Urban, Kimberly Della Penna, Rebecca B. White, Mark T. Bilodeau, B. Wesley Trotter, Stefanie A. Kane, Christopher S. Burgey

المصدر: Bioorganicmedicinal chemistry letters. 21(8)

مصطلحات موضوعية: Agonist, Cannabinoid receptor, medicine.drug_class, Stereochemistry, medicine.medical_treatment, Clinical Biochemistry, Analgesic, Pharmaceutical Science, Pain, Carboxamide, Mice, Transgenic, Biochemistry, Receptor, Cannabinoid, CB2, Mice, Structure-Activity Relationship, Receptor, Cannabinoid, CB1, In vivo, Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, Receptor, Molecular Biology, Analgesics, Chemistry, Organic Chemistry, Amides, Rats, Disease Models, Animal, Quinolines, Molecular Medicine, lipids (amino acids, peptides, and proteins), Cannabinoid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a168ef8554eac8532c4d10c7137f30
https://pubmed.ncbi.nlm.nih.gov/21420857