المؤلفون: Jeffrey W. Johannes (1414039), Amber Balazs (9436515), Derek Barratt (8921054), Michal Bista (160356), Matthew D. Chuba (11486389), Sabina Cosulich (466728), Susan E. Critchlow (1613527), Sébastien L. Degorce (1436623), Paolo Di Fruscia (3748813), Scott D. Edmondson (1416967), Kevin Embrey (1637887), Stephen Fawell (5867138), Avipsa Ghosh (1329021), Sonja J. Gill (11486392), Anders Gunnarsson (1454497), Sudhir M. Hande (2047519), Tom D. Heightman (236769), Paul Hemsley (4414534), Giuditta Illuzzi (11486395), Jordan Lane (11486398), Carrie Larner (11486401), Elisabetta Leo (16336), Lina Liu (227490), Andrew Madin (2369338), Scott Martin (8770), Lisa McWilliams (3115182), Mark J. O’Connor (512930), Jonathan P. Orme (2570623), Fiona Pachl (1643695), Martin J. Packer (1716334), Xiaohui Pei (8775905), Andrew Pike (689657), Marianne Schimpl (208250), Hongyao She (11486404), Anna D. Staniszewska (11486407), Verity Talbot (6084164), Elizabeth Underwood (9210380), Jeffrey G. Varnes (2499496), Lin Xue (826042), Tieguang Yao (9761206), Ke Zhang (115386), Andrew X. Zhang (1371321), Xiaolan Zheng (1638844)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Pharmacology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, overlapping hematological toxicities, good secondary pharmacology, brca mutant hbcx, brca mutant background, achieved regulatory approval, 17 pdx model, parp family members, oxo ‑ 5, dihydro ‑ 1, selective parp1 inhibitor, 25 , n <, highly selective, vivo efficacy, usually due, reduced effects, recent literature, preclinical species, physicochemical properties, parps poly, parp1 inhibition, line chemotherapies

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_5_4-_7-Ethyl-6-oxo_5_6-dihydro_1_5-naphthyridin-3-yl_methyl_piperazin-1-yl_i_N_i_methyl_pyridine-2-carboxamide_AZD5305_A_PARP1_DNA_Trapper_with_High_Selectivity_for_PARP1_over_PARP2_and_Other_PARPs/16688962

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01012.s001

المؤلفون: Jeffrey W. Johannes (1414039), Amber Balazs (9436515), Derek Barratt (8921054), Michal Bista (160356), Matthew D. Chuba (11486389), Sabina Cosulich (466728), Susan E. Critchlow (1613527), Sébastien L. Degorce (1436623), Paolo Di Fruscia (3748813), Scott D. Edmondson (1416967), Kevin Embrey (1637887), Stephen Fawell (5867138), Avipsa Ghosh (1329021), Sonja J. Gill (11486392), Anders Gunnarsson (1454497), Sudhir M. Hande (2047519), Tom D. Heightman (236769), Paul Hemsley (4414534), Giuditta Illuzzi (11486395), Jordan Lane (11486398), Carrie Larner (11486401), Elisabetta Leo (16336), Lina Liu (227490), Andrew Madin (2369338), Scott Martin (8770), Lisa McWilliams (3115182), Mark J. O’Connor (512930), Jonathan P. Orme (2570623), Fiona Pachl (1643695), Martin J. Packer (1716334), Xiaohui Pei (8775905), Andrew Pike (689657), Marianne Schimpl (208250), Hongyao She (11486404), Anna D. Staniszewska (11486407), Verity Talbot (6084164), Elizabeth Underwood (9210380), Jeffrey G. Varnes (2499496), Lin Xue (826042), Tieguang Yao (9761206), Ke Zhang (115386), Andrew X. Zhang (1371321), Xiaolan Zheng (1638844)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Pharmacology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, overlapping hematological toxicities, good secondary pharmacology, brca mutant hbcx, brca mutant background, achieved regulatory approval, 17 pdx model, parp family members, oxo ‑ 5, dihydro ‑ 1, selective parp1 inhibitor, 25 , n <, highly selective, vivo efficacy, usually due, reduced effects, recent literature, preclinical species, physicochemical properties, parps poly, parp1 inhibition, line chemotherapies

Relation: https://figshare.com/articles/dataset/Discovery_of_5_4-_7-Ethyl-6-oxo_5_6-dihydro_1_5-naphthyridin-3-yl_methyl_piperazin-1-yl_i_N_i_methyl_pyridine-2-carboxamide_AZD5305_A_PARP1_DNA_Trapper_with_High_Selectivity_for_PARP1_over_PARP2_and_Other_PARPs/16688968

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01012.s003

المؤلفون: Jeffrey W. Johannes (1414039), Amber Balazs (9436515), Derek Barratt (8921054), Michal Bista (160356), Matthew D. Chuba (11486389), Sabina Cosulich (466728), Susan E. Critchlow (1613527), Sébastien L. Degorce (1436623), Paolo Di Fruscia (3748813), Scott D. Edmondson (1416967), Kevin Embrey (1637887), Stephen Fawell (5867138), Avipsa Ghosh (1329021), Sonja J. Gill (11486392), Anders Gunnarsson (1454497), Sudhir M. Hande (2047519), Tom D. Heightman (236769), Paul Hemsley (4414534), Giuditta Illuzzi (11486395), Jordan Lane (11486398), Carrie Larner (11486401), Elisabetta Leo (16336), Lina Liu (227490), Andrew Madin (2369338), Scott Martin (8770), Lisa McWilliams (3115182), Mark J. O’Connor (512930), Jonathan P. Orme (2570623), Fiona Pachl (1643695), Martin J. Packer (1716334), Xiaohui Pei (8775905), Andrew Pike (689657), Marianne Schimpl (208250), Hongyao She (11486404), Anna D. Staniszewska (11486407), Verity Talbot (6084164), Elizabeth Underwood (9210380), Jeffrey G. Varnes (2499496), Lin Xue (826042), Tieguang Yao (9761206), Ke Zhang (115386), Andrew X. Zhang (1371321), Xiaolan Zheng (1638844)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Pharmacology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, overlapping hematological toxicities, good secondary pharmacology, brca mutant hbcx, brca mutant background, achieved regulatory approval, 17 pdx model, parp family members, oxo ‑ 5, dihydro ‑ 1, selective parp1 inhibitor, 25 , n <, highly selective, vivo efficacy, usually due, reduced effects, recent literature, preclinical species, physicochemical properties, parps poly, parp1 inhibition, line chemotherapies

Relation: https://figshare.com/articles/dataset/Discovery_of_5_4-_7-Ethyl-6-oxo_5_6-dihydro_1_5-naphthyridin-3-yl_methyl_piperazin-1-yl_i_N_i_methyl_pyridine-2-carboxamide_AZD5305_A_PARP1_DNA_Trapper_with_High_Selectivity_for_PARP1_over_PARP2_and_Other_PARPs/16688965

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01012.s002

المؤلفون: Mark J. O’Connor (512930), Philip Schroeder (11771828), Alicia Huerta-Chagoya (739312), Paula Cortés-Sánchez (11771834), Silvía Bonàs-Guarch (11771840), Marta Guindo-Martínez (11771842), Joanne B. Cole (3080733), Varinderpal Kaur (713069), David Torrents (17960), Kumar Veerapen (11771843), Niels Grarup (154019), Mitja Kurki (177228), Carsten F. Rundsten (11771847), Oluf Pedersen (140525), Ivan Brandslund (54529), Allan Linneberg (139773), Torben Hansen (140523), Aaron Leong (430710), Jose C. Florez (8811083), Josep M. Mercader (7439093)

مصطلحات موضوعية: Biological Sciences not elsewhere classified, Genomics, Genome Association, Genetics, Genetic Susceptibility, Genetic Risk Factors, Genetic Research, Genetic Predisposition, Genetic Association, Genetic Analysis, Genomic Variation, Gene Expression, LDL Cholesterol, Triglycerides

Relation: https://figshare.com/articles/figure/Recessive_Genome-wide_Meta-analysis_Illuminates_Genetic_Architecture_of_Type_2_Diabetes/17099780

الاتاحة: https://doi.org/10.2337/figshare.17099780.v1