المؤلفون: Mauricio N. Ferrao Blanco, Raphaelle Lesage, Nicole Kops, Niamh Fahy, Fjodor T. Bekedam, Athina Chavli, Yvonne M. Bastiaansen-Jenniskens, Liesbet Geris, Mark G. Chambers, Andrew A. Pitsillides, Roberto Narcisi, Gerjo J.V.M. van Osch

المصدر: Heliyon, Vol 10, Iss 23, Pp e40871- (2024)

مصطلحات موضوعية: Chondrocyte hypertrophy, Inflammation, Kinase inhibitor, Virtual cell, Drug target, Author e-mails, Science (General), Q1-390, Social sciences (General), H1-99

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844024169022; https://doaj.org/toc/2405-8440

URL الوصول: https://doaj.org/article/48e3461e9a244cc184140f61e1073ffe

المؤلفون: Jeffrey S. Boyles, Dorota Sadowski, Scott Potter, Aleksandra Vukojicic, James Parker, William Y. Chang, Yanfei L. Ma, Mark G. Chambers, James Nelson, Barbra Barmettler, Eric M. Smith, Kara Kersjes, Evan R. Himes, Chaohua Lin, Jonathan Lucchesi, Jaladhi Brahmbhatt, Ramtin Sina, Jennifer A. Martin, Evan Maestri, Christopher M. Wiethoff, Gregory L. Dyas, Matthew D. Linnik, Songqing Na, Derrick R. Witcher, Alison Budelsky, Kira Rubtsova

المصدر: JCI Insight, Vol 8, Iss 13 (2023)

مصطلحات موضوعية: Autoimmunity, Immunology, Medicine

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2379-3708

URL الوصول: https://doaj.org/article/71aa2cc4be704328879505e403536058

المؤلفون: Mauricio N. Ferrao Blanco (11026653), Yvonne M. Bastiaansen-Jenniskens (9124842), Mark G. Chambers (1698076), Andrew A. Pitsillides (9048314), Roberto Narcisi (840518), Gerjo J.V.M. van Osch (5966345)

مصطلحات موضوعية: Orthopaedics, Surgery, Sports Medicine, Biological Sciences not elsewhere classified, osteoarthritis, articular chondrocytes, hypertrophy, inflammation, macrophages

Relation: https://figshare.com/articles/journal_contribution/sj-docx-1-car-10_1177_19476035211021907_Supplemental_material_for_Effect_of_Inflammatory_Signaling_on_Human_Articular_Chondrocyte_Hypertrophy_Potential_Involvement_of_Tissue_Repair_Macrophages/14847306

الاتاحة: https://doi.org/10.25384/sage.14847306.v1

المؤلفون: Charles W. Lugar (2232358), Christian A. Clarke (2232370), Richard Morphy (2532025), Helene Rudyk (2126176), Selma Sapmaz (7735805), Ryan E. Stites (2827811), Grant M. Vaught (10647772), Kelly Furness (2711545), Howard B. Broughton (1907377), Greg L. Durst (10647775), David K. Clawson (2123275), Stephanie L. Stout (1698064), Sherry Y. Guo (10647778), Jim D. Durbin (1698088), Keith R. Stayrook (10647781), Denise D. Edmondson (10647784), Kristy Kikly (10647787), Nicole E. New (10647790), Holly A. Bina (10647793), Mark G. Chambers (1698076), Pamela Shetler (10647796), William Y. Chang (2471992), Veavi Ching-Yun Chang (10647799), Rob Barr (10647802), Wendy H. Gough (10647805), Jimmy P. Steele (10647808), Brian Getman (10647811), Nita Patel (567848), Brian M. Mathes (2678551), Timothy I. Richardson (2232382)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Genetics, Molecular Biology, Pharmacology, Immunology, Cancer, Infectious Diseases, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, Th 17 cells, ADME, IL -17A ROR γt, duration, PK, ROR γt, Receptor-Related Orphan Receptor C 2, Th 17 pathway, IL -17A lymphoid cells, efficacy, arthritis mouse model, optimization, binding, retinoic acid receptor-related, receptor C 2, target engagement

Relation: https://figshare.com/articles/journal_contribution/Defining_Target_Engagement_Required_for_Efficacy_i_In_Vivo_i_at_the_Retinoic_Acid_Receptor-Related_Orphan_Receptor_C2_ROR_t_/14417548

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c01918.s001

المؤلفون: Mauricio N. Ferrao Blanco, Raphaelle Lesage, Nicole Kops, Niamh Fahy, Fjodor T. Bekedam, Athina Chavli, Yvonne M. Bastiaansen-Jenniskens, Liesbet Geris, Mark G. Chambers, Andrew A. Pitsillides, Roberto Narcisi, Gerjo J.V.M. van Osch

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1853c819808dcb32f36c16d50676f880
https://doi.org/10.1101/2022.06.12.495737

المؤلفون: Charles W, Lugar, Christian A, Clarke, Richard, Morphy, Helene, Rudyk, Selma, Sapmaz, Ryan E, Stites, Grant M, Vaught, Kelly, Furness, Howard B, Broughton, Greg L, Durst, David K, Clawson, Stephanie L, Stout, Sherry Y, Guo, Jim D, Durbin, Keith R, Stayrook, Denise D, Edmondson, Kristy, Kikly, Nicole E, New, Holly A, Bina, Mark G, Chambers, Pamela, Shetler, William Y, Chang, Veavi Ching-Yun, Chang, Rob, Barr, Wendy H, Gough, Jimmy P, Steele, Brian, Getman, Nita, Patel, Brian M, Mathes, Timothy I, Richardson

المصدر: Journal of medicinal chemistry. 64(9)

مصطلحات موضوعية: Binding Sites, Arthritis, Interleukin-17, Thiophenes, Molecular Dynamics Simulation, Nuclear Receptor Subfamily 1, Group F, Member 3, Crystallography, X-Ray, Ligands, Disease Models, Animal, Mice, Structure-Activity Relationship, Drug Design, Leukocytes, Mononuclear, Animals, Humans, Female, Half-Life, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::ef03d39fb502b855beadc34c7a19e1e7
https://pubmed.ncbi.nlm.nih.gov/33852312

المؤلفون: Srinivasan Chandrasekhar, Anita K Harvey, Xiao-Peng Yu, Mark G Chambers, Jennifer L Oskins, Chaohua Lin, Thomas W Seng, Stefan J Thibodeaux, Bryan H Norman, Norman E Hughes, Matthew A Schiffler, Matthew J Fisher

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://jpet.aspetjournals.org/content/jpet/early/2016/01/20/jpet.115.228932.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1090.5771; http://jpet.aspetjournals.org/content/jpet/early/2016/01/20/jpet.115.228932.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1090.5771
http://jpet.aspetjournals.org/content/jpet/early/2016/01/20/jpet.115.228932.full.pdf

المؤلفون: Srinivasan Chandrasekhar, Anita K Harvey, Xiao-Peng Yu, Mark G Chambers, Jennifer L Oskins, Chaohua Lin, Thomas W Seng, Stefan J Thibodeaux, Bryan H Norman, Norman E Hughes, Matthew A Schiffler, Matthew J Fisher

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://jpet.aspetjournals.org/content/jpet/356/3/635.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1090.5737; http://jpet.aspetjournals.org/content/jpet/356/3/635.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1090.5737
http://jpet.aspetjournals.org/content/jpet/356/3/635.full.pdf

المؤلفون: Kristen M. Clements, Joanne S. Price, Mark G. Chambers, Denise M. Visco, A. Robin Poole, Roger M. Mason

المصدر: Arthritis & Rheumatism; Dec2003, Vol. 48 Issue 12, p3452-3463, 12p

مصطلحات موضوعية: OSTEOARTHRITIS, LIGAMENTS, MENISCECTOMY, INTERLEUKINS, NITRIC oxide, IMMUNOGLOBULINS