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1Academic Journal
المؤلفون: Line Lauritsen, Maria Szomek, Mick Hornum, Peter Reinholdt, Jacob Kongsted, Poul Nielsen, Jonathan R. Brewer, Daniel Wüstner
المصدر: Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2045-2322
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2Academic Journal
المؤلفون: Vibeke Akkerman, Holger A. Scheidt, Peter Reinholdt, Mohammad Bashawat, Maria Szomek, Max Lehmann, Pablo Wessig, Douglas F. Covey, Jacob Kongsted, Peter Müller, Daniel Wüstner
المصدر: BBA Advances, Vol 4, Iss , Pp 100102- (2023)
مصطلحات موضوعية: Polyene macrolide, Yeast, Antifungals, Ergosterol, Cholesterol, Lipid phase, Biochemistry, QD415-436, Genetics, QH426-470
وصف الملف: electronic resource
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المؤلفون: Mads W. Mulberg, Mick Hornum, Peter Reinholdt, Brian Bjarke Jensen, Maria Szomek, Jonathan R. Brewer, Daniel Wüstner, Jacob Kongsted, Poul Nielsen
المصدر: European Journal of Organic Chemistry.
مصطلحات موضوعية: Organic Chemistry, Physical and Theoretical Chemistry
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المؤلفون: Jacob Marcus Egebjerg, Maria Szomek, Katja Thaysen, Alice Dupont Juhl, Stephan Werner, Christoph Pratsch, Gerd Schneider, Richard Röttger, Daniel Wüstner
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المؤلفون: Jacob Marcus Egebjerg, Maria Szomek, Katja Thaysen, Alice Dupont Juhl, Suzana Kozakijevic, Stephan Werner, Christoph Pratsch, Gerd Schneider, Sergey Kapishnikov, Axel Ekman, Richard Röttger, Daniel Wüstner
مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Cell Biology, Genetics, Biotechnology, Cancer, Physical Sciences not elsewhere classified, Information Systems not elsewhere classified, Deep learning, lipophagy, Niemann-Pick disease, segmentation, tomography, X-ray
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المؤلفون: Maria Szomek, Peter Reinholdt, Hanna-Loisa Walther, Holger A. Scheidt, Peter Müller, Sebastian Obermaier, Bert Poolman, Jacob Kongsted, Daniel Wüstner
المساهمون: Enzymology
المصدر: Biochimica et Biophysica Acta-Biomembranes, 1864(11):184012
مصطلحات موضوعية: Simulations, Antifungal Agents, Saccharomyces cerevisiae Proteins, Natamycin, Lysine, Biophysics, Membrane, Cell Biology, Polyenes, Saccharomyces cerevisiae, Biochemistry, Fluorescence, Yeast, Anti-Bacterial Agents, Sterols, Cholesterol, Ergosterol, Amino Acid Transport Systems, Basic, Infection, Polyene macrolide
وصف الملف: application/pdf
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المؤلفون: Maria Szomek, Peter Reinholdt, Daniel Wüstner, Adam Cohen Simonsen, Daniel C. Petersen, Jacob Kongsted, Lütje E Joensen, Anna Mularski
المصدر: Reinholdt, P, Joensen, L E, Petersen, D, Szomek, M, Mularski, A, Simonsen, A C, Kongsted, J & Wüstner, D 2021, ' Photophysical and Structural Characterization of Intrinsically Fluorescent Sterol Aggregates ', Journal of Physical Chemistry B, vol. 125, no. 22, pp. 5838–5852 . https://doi.org/10.1021/acs.jpcb.1c00628
مصطلحات موضوعية: 010304 chemical physics, Intermolecular force, Electronic structure, 010402 general chemistry, 01 natural sciences, Fluorescence, Fluorescence spectroscopy, 0104 chemical sciences, Surfaces, Coatings and Films, Sterols, Molecular dynamics, chemistry.chemical_compound, Cholesterol, Spectrometry, Fluorescence, Monomer, Microscopy, Fluorescence, chemistry, Ergosterol, 0103 physical sciences, Microscopy, Materials Chemistry, Biophysics, Physical and Theoretical Chemistry, Solubility
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المؤلفون: Maonian Xu, Ernest Oppong-Danquah, Xiaoyu Wang, Sebastian Oddsson, Asmaa Abdelrahman, Simon Vilms Pedersen, Maria Szomek, Aron Elvar Gylfason, Bergthora Sigridur Snorradottir, Eva Arnspang Christensen, Deniz Tasdemir, Cynthia J. Jameson, Sohail Murad, Olafur Sigmar Andresson, Kristinn Petur Magnusson, Hugo J. de Boer, Margret Thorsteinsdottir, Sesselja Omarsdottir, Starri Heidmarsson, Elin Soffia Olafsdottir
مصطلحات موضوعية: Lichens, Iceland, Plant Science, General Medicine, Horticulture, Molecular Biology, Biochemistry, Anti-Bacterial Agents, Benzofurans
وصف الملف: text
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المؤلفون: Maria Szomek, Christian W. Heegaard, Gerd Schneider, James G. McNally, Stephan Werner, Sergey Kapishnikov, Frederik W. Lund, Maria Louise V. Jensen, Alice Dupont Juhl, Peter Guttmann, Daniel Wüstner
المصدر: Dupont Juhl, A, Lund, F W, Jensen, M L V, Szomek, M, Würtz Heegaard, C, Guttmann, P, Werner, S, McNally, J, Schneider, G, Kapishnikov, S & Wüstner, D 2021, ' Niemann Pick C2 protein enables cholesterol transfer from endo-lysosomes to the plasma membrane for efflux by shedding of extracellular vesicles ', Chemistry and Physics of Lipids, vol. 235, 105047 . https://doi.org/10.1016/j.chemphyslip.2020.105047
Juhl, A D, Lund, F W, Jensen, M L V, Szomek, M, Heegaard, C W, Guttmann, P, Werner, S, McNally, J, Schneider, G, Kapishnikov, S & Wüstner, D 2021, ' Niemann Pick C2 protein enables cholesterol transfer from endo-lysosomes to the plasma membrane for efflux by shedding of extracellular vesicles ', Chemistry and Physics of Lipids, vol. 235, 105047 . https://doi.org/10.1016/j.chemphyslip.2020.105047مصطلحات موضوعية: Niemann-Pick type C disease, Endosome, 030303 biophysics, Vesicular Transport Proteins, ATP-binding cassette transporter, Cholesterol analog, Biochemistry, Fluorescence, Image analysis, Extracellular Vesicles, 03 medical and health sciences, chemistry.chemical_compound, Humans, Cholesterol efflux, Liver X receptor, Molecular Biology, Cells, Cultured, 030304 developmental biology, 0303 health sciences, Cholesterol, Vesicle, Cell Membrane, Organic Chemistry, Cell Biology, Extracellular vesicles, Soft X-ray tomography, Sterol, chemistry, Biophysics, lipids (amino acids, peptides, and proteins), Efflux, Lysosomes
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a76f9478bdad7e701143ad54278647e3
https://pure.au.dk/portal/da/publications/niemann-pick-c2-protein-enables-cholesterol-transfer-from-endolysosomes-to-the-plasma-membrane-for-efflux-by-shedding-of-extracellular-vesicles(7a992662-d6a3-453b-80ce-61a38542a38a).html -
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المؤلفون: Peter Reinholdt, Maria Szomek, Daniel C. Petersen, Atenisa Caci, Daniel Wüstner, Jacob Kongsted
المصدر: Szomek, M, Reinholdt, P, Petersen, D, Caci, A, Kongsted, J & Wüstner, D 2021, ' Direct observation of nystatin binding to the plasma membrane of living cells ', Biochimica et Biophysica Acta-Biomembranes, vol. 1863, no. 2, 183528 . https://doi.org/10.1016/j.bbamem.2020.183528
مصطلحات موضوعية: 0301 basic medicine, Nystatin, Antifungal Agents, Fluorophore, Endocytic cycle, Biophysics, CHO Cells, Saccharomyces cerevisiae, UV fluorescence, 01 natural sciences, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Cricetulus, stomatognathic system, Antibiotics, 0103 physical sciences, medicine, polycyclic compounds, Animals, Yeast, ergosterol, Polyene macrolide, Ergosterol, 010304 chemical physics, Chinese hamster ovary cell, organic chemicals, Cell Membrane, Cell Biology, respiratory system, Polyene, Yeast, 030104 developmental biology, Membrane, chemistry, lipids (amino acids, peptides, and proteins), medicine.drug, Plasma membrane
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المؤلفون: Daniel Wüstner, Poul Nielsen, Peter Reinholdt, Jacob Kongsted, Mick Hornum, Maria Szomek, Mads W. Mulberg, Jonathan R. Brewer
المصدر: Hornum, M, Mulberg, M W, Szomek, M, Reinholdt, P, Brewer, J R, Wüstner, D, Kongsted, J & Nielsen, P 2021, ' Substituted 9-Diethylaminobenzo[a]phenoxazin-5-ones (nile red analogues) : Synthesis and photophysical properties ', Journal of Organic Chemistry, vol. 86, no. 2, pp. 1471–1488 . https://doi.org/10.1021/acs.joc.0c02346
مصطلحات موضوعية: chemistry.chemical_compound, Fluorescence-lifetime imaging microscopy, chemistry, Excited state, Organic Chemistry, Microscopy, Solvatochromism, Fluorescence microscope, Substituent, Nile red, Photochemistry, Fluorescence
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المؤلفون: Mick, Hornum, Mads W, Mulberg, Maria, Szomek, Peter, Reinholdt, Jonathan R, Brewer, Daniel, Wüstner, Jacob, Kongsted, Poul, Nielsen
المصدر: The Journal of organic chemistry. 86(2)
مصطلحات موضوعية: Spectrometry, Fluorescence, Microscopy, Fluorescence, Optical Imaging, Oxazines, Fluorescent Dyes
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المؤلفون: Daniel Wüstner, Kelly May Frain, Bjørn Panyella Pedersen, Peter Müller, Jacob Kongsted, Laust Moesgaard, Maria Szomek, Mikael B. L. Winkler, Daniel C. Petersen, Peter Reinholdt
المصدر: Moesgaard, L, Petersen, D, Szomek, M, Reinholdt, P, Winkler, M B L, Frain, K M, Müller, P, Pedersen, B P, Kongsted, J & Wüstner, D 2020, ' Mechanistic Insight into Lipid Binding to Yeast Niemann Pick Type C2 Protein ', Biochemistry, vol. 59, no. 45, pp. 4407-4420 . https://doi.org/10.1021/acs.biochem.0c00574
Moesgaard, L, Petersen, D, Szomek, M, Reinholdt, P, Winkler, M, Frain, K M, Müller, P, Pedersen, B P, Kongsted, J & Wüstner, D 2020, ' Mechanistic Insight into Lipid Binding to Yeast Niemann Pick Type C2 Protein ', Biochemistry, vol. 59, no. 45, pp. 4407–4420 . https://doi.org/10.1021/acs.biochem.0c00574
Biochemistryمصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, Saccharomyces cerevisiae Proteins, Protein Conformation, Saccharomyces cerevisiae, Phospholipid, Plasma protein binding, Molecular Dynamics Simulation, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, hemic and lymphatic diseases, Binding site, Binding selectivity, 0303 health sciences, Ergosterol, biology, Chemistry, 030302 biochemistry & molecular biology, nutritional and metabolic diseases, Lipid metabolism, biology.organism_classification, Lipid Metabolism, Biophysics, lipids (amino acids, peptides, and proteins), Sterol binding, Carrier Proteins, Protein Binding
وصف الملف: application/pdf
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14Membrane organization and intracellular transport of a fluorescent analogue of 27-hydroxycholesterol
المؤلفون: Sophia Bell Haarhøj Hald, Douglas F. Covey, Daniel Wüstner, Jacob Kongsted, Laust Moesgaard, Maria Szomek, Kathiresan Krishnan, Daniel C. Petersen, Peter Reinholdt
المصدر: Szomek, M, Moesgaard, L, Reinholdt, P, Haarhøj Hald, S B, Petersen, D, Krishnan, K, Covey, D F, Kongsted, J & Wüstner, D 2020, ' Membrane organization and intracellular transport of a fluorescent analogue of 27-hydroxycholesterol ', Chemistry and Physics of Lipids, vol. 233, 105004 . https://doi.org/10.1016/j.chemphyslip.2020.105004
مصطلحات موضوعية: Oxysterol, Endosome, 030303 biophysics, Cellular homeostasis, Molecular dynamics, Molecular Dynamics Simulation, Biochemistry, Quantum calculations, Fluorescence, 03 medical and health sciences, chemistry.chemical_compound, Synthesis, Lipid droplet, polycyclic compounds, Humans, Molecular Biology, Livecell imaging, Spectroscopy, Cells, Cultured, 030304 developmental biology, Fluorescent Dyes, 0303 health sciences, Single-cell, Vesicle, Organic Chemistry, Cell Membrane, Fluorescence recovery after photobleaching, Biological Transport, Cell Biology, Sterol, Hydroxycholesterols, Cholesterol, chemistry, 27-Hydroxycholesterol, Biophysics, lipids (amino acids, peptides, and proteins), Probes, Non-vesicular transport
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المؤلفون: Christer S. Ejsing, Alice Dupont, Zane Berzina, Ahmed S Mehadi, Frederik W. Lund, Maria Szomek, Maria Louise V. Jensen, Maciej Modzel, Christian W. Heegaard, Lukasz M. Solanko, Katarzyna A. Solanko, Gitte Nielsen, Daniel Wüstner
المصدر: Berzina, Z, Solanko, L M, Mehadi, A S, Jensen, M L V, Lund, F W, Modzel, M, Szomek, M, Solanko, K A, Dupont, A, Nielsen, G K, Heegaard, C W, Ejsing, C S & Wüstner, D 2018, ' Niemann-Pick C2 protein regulates sterol transport between plasma membrane and late endosomes in human fibroblasts ', Chemistry and Physics of Lipids, vol. 213, pp. 48-61 . https://doi.org/10.1016/j.chemphyslip.2018.03.006
مصطلحات موضوعية: 0301 basic medicine, Lipid storage disorder, Endosome, Vesicular Transport Proteins, Endosomes, Endoplasmic Reticulum, Cholesterol analog, Time-Lapse Imaging, Biochemistry, Fluorescence recovery after photobleaching, Cell Line, Diffusion, Lipid mass spectrometry, 03 medical and health sciences, chemistry.chemical_compound, Ergosterol, hemic and lymphatic diseases, Lysosome, medicine, Humans, Molecular Biology, Glycoproteins, Vesicle tracking, Carbon Isotopes, Chemistry, Cholesterol, Cell Membrane, Organic Chemistry, Biological Transport, Cell Biology, Fibroblasts, medicine.disease, Sterol transport, Sterol, Cell biology, Kinetics, Niemann-Pick disease type C2, 030104 developmental biology, medicine.anatomical_structure, Microscopy, Fluorescence, Non-vesicular, lipids (amino acids, peptides, and proteins), Carrier Proteins, Lysosomes, Fluorescence Recovery After Photobleaching
وصف الملف: application/pdf
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المؤلفون: Jacob Kongsted, Lina J. Nåbo, Alice Dupont, Daniel Wüstner, Maciej Modzel, S. K. Hansen, Maria Szomek, Katarzyna A. Solanko
المصدر: Journal of Microscopy. 271:36-48
مصطلحات موضوعية: 0301 basic medicine, 030103 biophysics, Histology, Conjugated system, Polyene, Intracellular cholesterol transport, Filipin, Photobleaching, Fluorescence, Sterol, Pathology and Forensic Medicine, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, chemistry, Fluorescence microscope, Biophysics, lipids (amino acids, peptides, and proteins)
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المؤلفون: Maria Szomek, Mikael B. L. Winkler, Bjørn Panyella Pedersen, Daniel Wüstner, Katja Thaysen, Shaun Rawson, Stephen P. Muench, Rune T. Kidmose
المصدر: Winkler, M B L, Kidmose, R T, Szomek, M, Thaysen, K, Rawson, S, Muench, S P, Wüstner, D & Pedersen, B P 2019, ' Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins ', Cell, vol. 179, no. 2, pp. 485-497.e18 . https://doi.org/10.1016/j.cell.2019.08.038
Winkler, M B L, Kidmose, R T, Szomek, M, Thaysen, K, Rawson, S, Muench, S P, Wüstner, D & Pedersen, B P 2019, ' Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins ', Cell, vol. 179, no. 2, e18, pp. 485-497 . https://doi.org/10.1016/j.cell.2019.08.038
Cell 179(2), 485-497.e18 (2019). doi:10.1016/j.cell.2019.08.038
Cellمصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, Saccharomyces cerevisiae Proteins, Cryo-electron microscopy, Saccharomyces cerevisiae, Vesicular Transport Proteins, Biology, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Protein Domains, hemic and lymphatic diseases, polycyclic compounds, Niemann-Pick type C proteins, ddc:610, Lipid Transport, 030304 developmental biology, X-ray crystallography, 0303 health sciences, Crystallography, Cryoelectron Microscopy, Sterol homeostasis, Biological Transport, Intracellular Membranes, NCR1, biology.organism_classification, NPC2, Sterol transport, Sterol, Cell biology, NPC1, Sterols, Membrane, Vacuoles, lipid trafficking, cryo-EM, lipids (amino acids, peptides, and proteins), Carrier Proteins, Lysosomes, 030217 neurology & neurosurgery, sterol homeostasis, sterol membrane integration
وصف الملف: application/pdf
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المؤلفون: Douglas F. Covey, Maria Szomek, Vasanthanathan Poongavanam, Daniel Wüstner, Kathiresan Krishnan, Jacob Kongsted, Hideji Fujiwara, Selina Kruuse Hansen, Christian W. Heegaard, Alice Dupont, Daniel C. Petersen, Peter Reinholdt, Daniel S. Ory
المصدر: Petersen, D, Reinholdt, P, Szomek, M, Kruuse Hansen, S, Poongavanam, V, Juhl, A D, Heegaard, C W, Krishnan, K, Fujiwara, H, Covey, D F, Ory, D S, Kongsted, J & Wüstner, D 2020, ' Binding and intracellular transport of 25-hydroxycholesterol by Niemann-Pick C2 protein ', B B A-Biomembranes, vol. 1862, no. 2, 183063 . https://doi.org/10.1016/j.bbamem.2019.183063
Petersen, D, Reinholdt, P, Szomek, M, Hansen, S K, Poongavanam, V, Dupont, A, Heegaard, C W, Krishnan, K, Fujiwara, H, Covey, D F, Ory, D S, Kongsted, J & Wüstner, D 2020, ' Binding and intracellular transport of 25-hydroxycholesterol by Niemann-Pick C2 protein ', Biochimica et Biophysica Acta-Biomembranes, vol. 1862, no. 2, 183063 . https://doi.org/10.1016/j.bbamem.2019.183063مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, Endosome, Biophysics, Vesicular Transport Proteins, Electronic structure calculation, Endosomes, 01 natural sciences, Biochemistry, Fluorescence, 03 medical and health sciences, chemistry.chemical_compound, hemic and lymphatic diseases, Lysosome, 0103 physical sciences, polycyclic compounds, medicine, Humans, Cells, Cultured, 030304 developmental biology, 0303 health sciences, Quenching (fluorescence), 010304 chemical physics, Cholesterol, nutritional and metabolic diseases, Fluorescence recovery after photobleaching, Biological Transport, Niemann-Pick Disease, Type C, Cell Biology, Binding, Free energy calculation, Fibroblasts, Sterol, Hydroxycholesterols, Sterols, medicine.anatomical_structure, Lysosomal lumen, chemistry, lipids (amino acids, peptides, and proteins), Lysosomes, Fluorescence Recovery After Photobleaching, Protein Binding
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المؤلفون: Gerd Schneider, Frederik W. Lund, Christian W. Heegaard, Maria Szomek, Peter Guttmann, Jensen Mlv, Stephan Werner, Sergey Kapishnikov, Alice Dupont, Daniel Wüstner, Gitte Nielsen, James G. McNally
المصدر: Dupont, A, Lund, F W, Jensen, M L V, Szomek, M, Nielsen, G K, Heegaard, C W, Guttmann, P, Werner, S, McNally, J, Schneider, G, Kapishnikov, S & Wüstner, D 2018, ' Analysis of cholesterol export from endo-lysosomes by Niemann Pick C2 protein using combined fluorescence and X-ray microscopy ', BioRxiv . https://doi.org/10.1101/462481
مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, Cholesterol, Endosome, Endoplasmic reticulum, Endocytic cycle, nutritional and metabolic diseases, Cholesterol analog, Sterol, Cell biology, chemistry.chemical_compound, Membrane, chemistry, hemic and lymphatic diseases, Organelle
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المؤلفون: Daniel Wüstner, Azra Pizovic, Yves Y. Sere, Anant K. Menon, Katarzyna A. Solanko, Lukasz M. Solanko, Thomas Günther Pomorski, Anita Lunding, Lyubomir Dimitrov Stanchev, Maria Szomek, David P. Sullivan
المصدر: Solanko, L M, Sullivan, D P, Sere, Y Y, Szomek, M, Lunding, A, Solanko, K A, Pizovic, A, Stanchev, L D, Pomorski, T G, Menon, A K & Wüstner, D 2018, ' Ergosterol is mainly located in the cytoplasmic leaflet of the yeast plasma membrane ', Traffic, vol. 19, no. 3, pp. 198-214 . https://doi.org/10.1111/tra.12545
مصطلحات موضوعية: 0301 basic medicine, Saccharomyces cerevisiae Proteins, Phospholipid, Saccharomyces cerevisiae, Biology, yeast, plasma membrane, Biochemistry, Cell membrane, collisional quenching, 03 medical and health sciences, chemistry.chemical_compound, Structural Biology, Phosphatidylcholine, Ergosterol, Genetics, medicine, dehydroergosterol, Electrochemical gradient, Lipid bilayer, heme, Molecular Biology, Sphingolipids, ergosterol, Cell Membrane, Cell Biology, Actin cytoskeleton, TNBS, Sterol, Cell biology, 030104 developmental biology, medicine.anatomical_structure, chemistry, Biophysics, lipids (amino acids, peptides, and proteins), fluorescence, asymmetry, 5-Aminolevulinate Synthetase
وصف الملف: application/pdf
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