المؤلفون: Maria Rafalski, Wei Han, Swamy Yeleswaram, Charles F. Albright, Melody Diamond, George L. Trainor, Nilsa R. Graciani, Randine Dowling, Xiang-Jun Jiang, Zilun Hu, Steven P. Seitz, Eddy W. Yue, Robert Bruckner, Mingzhu Zhang, Shu-Yun Zhang

المصدر: Bioorganic & Medicinal Chemistry Letters. 20:853-856

مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, macromolecular substances, Matrix metalloproteinase, Biochemistry, Mice, Therapeutic index, In vivo, Cell Line, Tumor, Drug Discovery, polycyclic compounds, medicine, Animals, Humans, Prodrugs, Doxorubicin, Molecular Biology, Neprilysin, Chemistry, organic chemicals, Organic Chemistry, technology, industry, and agriculture, Prodrug, Xenograft Model Antitumor Assays, Matrix Metalloproteinases, carbohydrates (lipids), Cancer research, Molecular Medicine, HT1080, Ex vivo, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d72120ec37658d8c3aefac28e114501
https://doi.org/10.1016/j.bmcl.2009.12.084

المؤلفون: Yu-Wen Li, Harvey Wong, Allison B. Brenner, James E. Grace, Jianqing Li, Maria Rafalski, Nicholas J. Lodge, Macor John E, Ronald J. Mattson, Jonathan L. Ditta, Thaddeus F. Molski, Joanne J. Bronson, Vijay T. Ahuja, Robert Zaczek, Richard A. Hartz, Snjezana Lelas, Argyrios G. Arvanitis, Jeffrey A. Deskus, Kimberley A. Lentz, Richard E. Olson, Andrew P. Combs, William D. Schmitz, Eddy W. Yue, Derek J. Denhart

المصدر: Journal of Medicinal Chemistry. 52:4161-4172

مصطلحات موضوعية: Male, Metabolic Clearance Rate, Chemistry, Antagonist, Pharmacology, Receptors, Corticotropin-Releasing Hormone, Rats, Corticotropin-releasing hormone receptor 1, Bioavailability, Inhibitory Concentration 50, Biochemistry, Pharmacokinetics, In vivo, Oral administration, Pyrazines, Drug Discovery, Animals, Humans, Molecular Medicine, Receptor, IC50

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10082f1c7071677e6ffd48d934291396
https://doi.org/10.1021/jm900302q

المؤلفون: Robert C. Bruckner, Andrew M. Stern, Anne Higley, Graciani Nilsa R, Sandya Mandlekar, Maria Rafalski, Melody Diamond, Ross L. Stein, Eddy W. Yue, Xiang Jiang, Pearl S. Huang, Randine Dowling, Dimeo Susan, Lisa C. Grimminger, Mingzhu Zhang, Zhihong Lai, Amy L. Musselman, Swamy Yeleswaram, Davette L. Behrens, Robert A. Copeland, Andrew P. Combs, Oliff Allen I, Wei Han, Shu-Yun Zhang, Rebecca Taub, Bruce Car, George L. Trainor, Charles F. Albright, Steve P. Seitz, Daniel Hu

المصدر: Molecular Cancer Therapeutics. 4:751-760

مصطلحات موضوعية: Cancer Research, Reticulocytes, Drug-Related Side Effects and Adverse Reactions, Matrix Metalloproteinases, Membrane-Associated, Fibrosarcoma, Transplantation, Heterologous, Pharmacology, Mice, Therapeutic index, Tumor Cells, Cultured, medicine, Animals, Humans, Prodrugs, Doxorubicin, Neprilysin, Chemistry, Metalloendopeptidases, Prodrug, medicine.disease, Peptide Fragments, In vitro, Transplantation, Matrix Metalloproteinase 9, Oncology, Matrix Metalloproteinase 2, HT1080, Drug Screening Assays, Antitumor, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45501a8fa2fc432573f20a1fa75bdc1c
https://doi.org/10.1158/1535-7163.mct-05-0006

المؤلفون: Harvey Wong, Ge Zhang, John F. McElroy, Carolyn Diane Dzierba, Paul J. Gilligan, Yu-Wen Li, Andrew P. Combs, Thaddeus F. Molski, Snjezana Lelas, Yong Peng, Robert Zaczek, Maria Rafalski, Amy G. Takvorian, Padmaja Kasireddy-Polam, Rebecca Taub, George L. Trainor

المصدر: Journal of Medicinal Chemistry. 47:5783-5790

مصطلحات موضوعية: Male, medicine.medical_specialty, Pyridines, Administration, Oral, Anxiety, In Vitro Techniques, Binding, Competitive, Receptors, Corticotropin-Releasing Hormone, Corticotropin-releasing hormone receptor 1, Rats, Sprague-Dawley, Radioligand Assay, Structure-Activity Relationship, Dogs, In vivo, Internal medicine, Drug Discovery, Reaction Time, medicine, Animals, Structure–activity relationship, Receptor, IC50, Behavior, Animal, Chemistry, Antagonist, Small molecule, In vitro, Frontal Lobe, Rats, Endocrinology, Anti-Anxiety Agents, Pyrazines, Molecular Medicine, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::166cc0cf739d3ffb15327f7027dc110d
https://doi.org/10.1021/jm049737f

المؤلفون: Douglas Guy Batt, William F. DeGrado, Arlene Rockwell, Prabhakar K. Jadhav, Joseph J. Petraitis, Shaker A. Mousa, Maria Rafalski, William J. Pitts

المصدر: Bioorganic & Medicinal Chemistry Letters. 9:937-942

مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, medicine.drug_class, Carboxylic acid, Molecular Mimicry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Isoxazoles, Biochemistry, Chemical synthesis, Sulfonamide, Chain length, chemistry, Phase (matter), Drug Discovery, Structural isomer, medicine, Molecular Medicine, Receptors, Vitronectin, Oligopeptides, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c8d9bbebccb82d3d8d9fdb06eb23e3
https://doi.org/10.1016/s0960-894x(99)00114-6

المؤلفون: Andrew P. Combs, Maria Rafalski, Simon Saubern, Patrick Y.S. Lam

المصدر: Tetrahedron Letters. 40:1623-1626

مصطلحات موضوعية: chemistry.chemical_compound, Chemistry, Microwave heating, Organic Chemistry, Drug Discovery, Pyridine, Microwave irradiation, chemistry.chemical_element, Photochemistry, Biochemistry, Copper, Coupling reaction, Polymer supported

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ac60f3d9573a248c8143f5318cc95a41
https://doi.org/10.1016/s0040-4039(99)00026-x

المؤلفون: John Roderick, Chu-Biao Xue, Sharon A. Jackson, Richard E. Olson, Shaker A. Mousa, William F. DeGrado, Maria Rafalski, Arlene Rockwell

المصدر: Bioorganic & Medicinal Chemistry. 5:693-705

مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Alkylation, Swine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Platelet Glycoprotein GPIIb-IIIa Complex, Benzoates, Biochemistry, Piperazines, Benzamidine, Structure-Activity Relationship, chemistry.chemical_compound, Piperidines, Drug Discovery, Aspartic acid, Animals, Humans, Structure–activity relationship, Moiety, Benzamide, Piperazine, Molecular Biology, Aspartic Acid, Sulfonamides, Alanine, Chemistry, Organic Chemistry, Esterases, Benzoic Acid, Benzamidines, Liver, Benzamides, beta-Alanine, Molecular Medicine, Platelet aggregation inhibitor, Carbamates, Glycoprotein IIb/IIIa, Oligopeptides, Platelet Aggregation Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97010bba2d9a8e62428b750068639dd9
https://doi.org/10.1016/s0968-0896(97)00013-8

المؤلفون: William F. DeGrado, John Roderick, Charles J. Eyermann, Shaker A. Mousa, Chu-Biao Xue, Maria Rafalski, Richard E. Olson

المصدر: Bioorganic & Medicinal Chemistry Letters. 6:339-344

مصطلحات موضوعية: chemistry.chemical_classification, Benzimidazole, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Peptide, Benzoxazole, Biochemistry, Benzamidine, Sulfonamide, chemistry.chemical_compound, chemistry, Glycoprotein IIb/IIIa inhibitors, Drug Discovery, medicine, Molecular Medicine, Moiety, Glycoprotein, Molecular Biology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::76cdc8891f985bb0698ffb8a7560c866
https://doi.org/10.1016/0960-894x(95)00590-p

المؤلفون: Maria Rafalski, Thais M. Sielecki, Bireshwar Dasgupta, Paul J. Gilligan, Padmaja Kasireddy-Polam, Thaddeus F. Molski, Argyrios G. Arvanitis, Nicholas J. Lodge, John E. Macor, Andrew P. Combs, Amy Galka, Shikha Vig, Amy G. Takvorian, Harvey Wong, George L. Trainor, Tricia L. Johnson, Carolyn Diane Dzierba, Joanne J. Bronson, Ge Zhang, Robert Zaczek

المصدر: Bioorganicmedicinal chemistry letters. 22(15)

مصطلحات موضوعية: medicine.medical_specialty, Chemistry, Pteridines, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Receptors, Corticotropin-Releasing Hormone, Rats, Structure-Activity Relationship, Endocrinology, Pharmacokinetics, Anti-Anxiety Agents, Internal medicine, Pyrazines, Drug Discovery, medicine, Molecular Medicine, Animals, Receptor, Molecular Biology, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9de2c21a43edd40165261a5c39c3c08
https://pubmed.ncbi.nlm.nih.gov/22749422

المؤلفون: Yue-Zhong Shu, Macor John E, Richard A. Hartz, Richard E. Olson, Maria Rafalski, Yu-Wen Li, William D. Schmitz, Snjezana Lelas, Ronald J. Mattson, Gail K. Mattson, Joanne J. Bronson, Eddy W. Yue, Robert Zaczek, Yong Peng, Jingfang Qian-Cutrone, Nicholas J. Lodge, Frank W. Hobbs, Xiaoliang Zhuo, Argyrios G. Arvanitis, Andrew P. Combs, Vijay T. Ahuja, Kimberley A. Lentz, Jonathan L. Ditta, Jeffrey A. Deskus, Harvey Wong, Allison B. Brenner, Derek J. Denhart, James E. Grace, Joseph Payne, Thaddeus F. Molski

المصدر: Journal of medicinal chemistry. 52(14)

مصطلحات موضوعية: Male, Chemistry, medicine.drug_class, Antagonist, Pharmacology, Receptor antagonist, Receptors, Corticotropin-Releasing Hormone, In vitro, Rats, Rats, Sprague-Dawley, Macaca fascicularis, Structure-Activity Relationship, Pharmacokinetics, In vivo, Cell culture, Cell Line, Tumor, Pyrazines, Drug Discovery, medicine, Molecular Medicine, Structure–activity relationship, Animals, Humans, Receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acf6fce28b1a442887f7f1287fe1f47b
https://pubmed.ncbi.nlm.nih.gov/19552437

المؤلفون: Jd Lear, Maria Rafalski, Lc Vanginkel, A Rockwell, Antonio Ortiz, Wf Degrado, Jan Wilschut

المصدر: Biochemistry. 30:10211-10220

مصطلحات موضوعية: Circular dichroism, Hot Temperature, Molecular Sequence Data, Phospholipid, Hemagglutinins, Viral, Hemagglutinin Glycoproteins, Influenza Virus, Peptide, Membrane Fusion, Biochemistry, chemistry.chemical_compound, Amino Acid Sequence, Peptide sequence, POPC, Micelles, Phospholipids, chemistry.chemical_classification, Liposome, Circular Dichroism, Vesicle, Hydrogen-Ion Concentration, Orthomyxoviridae, Calcein, chemistry, Liposomes, Biophysics, Peptides

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aaf6c00ed90a4093901164cba09cf2a
https://doi.org/10.1021/bi00106a020

المؤلفون: Richard G. Wilde, Zhicai Yang, Maria Rafalski, Amy G. Takvorian, and Andrew P. Combs, Padmaja Kasireddy-Polam, Mark P. Sweet, Anthony D. Pechulis, Robert C. Zaczek, Alex M. Woo, Paul J. Gilligan, Andrew J. Tebben, Amy L. Davis, George L. Trainor, Thaddeus F. Molski, Ge Zhang, Sarah M. Ebeltoft, John D. Klaczkiewicz, Carolyn D. Dzierba

المصدر: Journal of medicinal chemistry. 50(9)

مصطلحات موضوعية: Models, Molecular, Molecular model, Bicyclic molecule, Chemistry, Stereochemistry, Swine, Pteridines, Mutant, Antagonist, Quantitative Structure-Activity Relationship, In Vitro Techniques, Ring (chemistry), Receptors, Corticotropin-Releasing Hormone, Frontal Lobe, Rats, Pyridazines, Radioligand Assay, Drug Discovery, Choroid Plexus, Molecular Medicine, Potency, Animals, Pharmacophore, Receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a8e632aca6a96d282524d11fd7a6b1
https://pubmed.ncbi.nlm.nih.gov/17402721

المؤلفون: Andrew P. Combs, Seifu Tadesse, Tasir Shamsul Haque, Maria Rafalski, Patrick Y.S. Lam

المصدر: Journal of combinatorial chemistry. 4(2)

مصطلحات موضوعية: chemistry.chemical_compound, Primary (chemistry), chemistry, Chemistry, Organic, Organic chemistry, chemistry.chemical_element, Combinatorial Chemistry Techniques, General Chemistry, Amines, Triethylamine, Copper

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f47d84cad2f3a7f8779eb14a7f9ffb4
https://pubmed.ncbi.nlm.nih.gov/11886294

المؤلفون: Richard A. Hartz, Yu-Wen Li, Jeffrey A. Deskus, James E. Grace, Vijay T. Ahuja, Argyrios G. Arvanitis, Joanne J. Bronson, Kimberley A. Lentz, William D. Schmitz, Macor John E, Harvey Wong, Robert Zaczek, Allison B. Brenner, Derek J. Denhart, Thaddeus F. Molski, Eddy W. Yue, Richard E. Olson, Jonathan L. Ditta, Maria Rafalski, Ronald J. Mattson, Andrew P. Combs, Jianqing Li, Snjezana Lelas, Nicholas J. Lodge

المصدر: Journal of Medicinal Chemistry. 52:5770-5770

مصطلحات موضوعية: Chemistry, Drug Discovery, Crf1 receptor, Biophysics, Molecular Medicine, In vitro

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::284c44dce3647a8ca23b3ff6b32d5469
https://doi.org/10.1021/jm9011033

المؤلفون: Jan Wilschut, Lucina C. van Ginkel, Jan Kornelis Dijkstra, James D. Lear, Maria Rafalski, Romke Bron, William F. DeGrado, Antonio Ortiz

المصدر: Progress in Membrane Biotechnology ISBN: 9783034874564

مصطلحات موضوعية: Viral envelope, Cytoplasm, Chemistry, Endosome, viruses, Biophysics, Viral membrane, Lipid bilayer, Endocytosis, Virology, Virus, Membrane Fusion Activity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8b608bc0814819788d2bb6efd9d13a10
https://doi.org/10.1007/978-3-0348-7454-0_23

المؤلفون: Carolyn D. Dzierba, Andrew J. Tebben, Richard G. Wilde, Amy G. Takvorian, Maria Rafalski, Padmaja Kasireddy-Polam, John D. Klaczkiewicz, Anthony D. Pechulis, Amy L. Davis, Mark P. Sweet, Alex M. Woo, Zhicai Yang, Sarah M. Ebeltoft, Thaddeus F. Molski, Ge Zhang, Robert C. Zaczek, George L. Trainor, Andrew P. Combs, Paul J. Gilligan

المصدر: Journal of Medicinal Chemistry; May2007, Vol. 50 Issue 9, p2269-2272, 4p

المؤلفون: C. James McKnight, Maria Rafalski, Lila M. Gierasch

المصدر: Biochemistry. 30:9120-9120

مصطلحات موضوعية: Signal peptide, Biochemistry, Tryptophan, Biology, Lipid bilayer, Fluorescence

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6c6bd40e286651b3a728f10f49b39d02
https://doi.org/10.1021/bi00101a031