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1
المؤلفون: S. Shah, Caroline Kisker, Pan Pan, Gopal R. Bommineni, Jochen Kuper, Maria Hirschbeck, Annica Pschibul, Nina Liu, Fereidoon Daryaee, Carla Neckles, Junjie Zou, Cheng Tsung Lai, Shabnam Davoodi, Carlos Simmerling, Peter J. Tonge, Cristina Lai
المصدر: Biochemistry. 55:2992-3006
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Protein Conformation, Pyridones, Yersinia pestis, Stereochemistry, 030106 microbiology, Molecular Dynamics Simulation, Reductase, Crystallography, X-Ray, medicine.disease_cause, Biochemistry, Catalysis, Article, Mycobacterium tuberculosis, 03 medical and health sciences, chemistry.chemical_compound, Oxidoreductase, Catalytic Domain, medicine, Enzyme Inhibitors, chemistry.chemical_classification, biology, Phenyl Ethers, Diphenyl ether, NAD, biology.organism_classification, Enoyl-(Acyl-Carrier-Protein) Reductase (NADH), 030104 developmental biology, Enzyme, chemistry, Staphylococcus aureus, Mutation, Mutagenesis, Site-Directed, NAD+ kinase, Crystallization, Protein Binding
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2
المؤلفون: Kristina Lorenz, Caroline Kisker, Sivaraj Sivaramakrishnan, Maria Hirschbeck, Colin Ong, John J. Skinner, Sheng Wang, Marsha Rich Rosner, Ruth F. Sommese, W. Koelmel, Jiyoung Lee, Tobin R. Sosnick, Hermann Schindelin
المصدر: The FASEB Journal. 32
مصطلحات موضوعية: Conformational change, biology, Kinase, Biochemistry, Interactome, Cell biology, Protein–protein interaction, chemistry.chemical_compound, chemistry, Phosphoserine, Mitogen-activated protein kinase, Genetics, biology.protein, Phosphorylation, Salt bridge, Molecular Biology, Biotechnology
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3
المؤلفون: Maria Hirschbeck, Christoph A. Sotriffer, Gopal R. Bommineni, Peter J. Tonge, S. Shah, Jason E. Cummings, Sandra Eltschkner, Andrew Chang, Susan E. Knudson, Weixuan Yu, Pan Pan, Yang Lu, Mona Tareilus, Richard A. Slayden, Johannes Schiebel, Li Liu, Caroline Kisker, Stephen G. Walker
المصدر: Journal of Biological Chemistry. 289:15987-16005
مصطلحات موضوعية: Staphylococcus aureus, Pyridones, Stereochemistry, Microbial Sensitivity Tests, Reductase, Crystallography, X-Ray, medicine.disease_cause, Polymerase Chain Reaction, Biochemistry, Mice, medicine, Animals, Enzyme Inhibitors, Molecular Biology, DNA Primers, Mice, Inbred ICR, Base Sequence, Molecular Structure, biology, Drug discovery, Rational design, Cell Biology, Enoyl-(Acyl-Carrier-Protein) Reductase (NADH), Enzyme structure, Anti-Bacterial Agents, Acyl carrier protein, Enzyme inhibitor, Drug Design, Enzymology, biology.protein, Female, Antibacterial activity
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4
المؤلفون: Gopal R. Bommineni, Weixuan Yu, Jason E. Cummings, Lauren A. Spagnuolo, Carla Neckles, Maria Hirschbeck, Shabnam Davoodi, Sandra Eltschkner, Caroline Kisker, Zhuo Zhang, Richard A. Slayden, Peter J. Tonge, Fereidoon Daryaee
المصدر: Biochemistry. 56(13)
مصطلحات موضوعية: 0301 basic medicine, Burkholderia pseudomallei, Stereochemistry, 030106 microbiology, Kinetics, Colony Count, Microbial, Gene Expression, Microbial Sensitivity Tests, Reductase, Molecular Dynamics Simulation, Crystallography, X-Ray, Biochemistry, Protein Structure, Secondary, Article, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Bacterial Proteins, Oxidoreductase, Structure–activity relationship, Animals, Enzyme Inhibitors, Lung, chemistry.chemical_classification, Mice, Inbred BALB C, Binding Sites, biology, Phenyl Ethers, Diphenyl ether, biology.organism_classification, Enoyl-(Acyl-Carrier-Protein) Reductase (NADH), Receptor–ligand kinetics, Transition state, Anti-Bacterial Agents, 030104 developmental biology, chemistry, Melioidosis, Female, Spleen, Protein Binding
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5
المؤلفون: Hermann Schindelin, Jiyoung Lee, Marsha Rich Rosner, Caroline Kisker, Ruth F. Sommese, W. Koelmel, Kristina Lorenz, Tobin R. Sosnick, Sivaraj Sivaramakrishnan, Sheng Wang, John J. Skinner, Maria Hirschbeck, Colin Ong
مصطلحات موضوعية: 0301 basic medicine, Conformational change, Vesicular Transport Proteins, Medizin, Phosphatidylethanolamine Binding Protein, Interactome, Protein–protein interaction, Evolution, Molecular, 03 medical and health sciences, chemistry.chemical_compound, Serine, Animals, Humans, Protein Interaction Maps, Phosphorylation, Conserved Sequence, bcl-2-Associated X Protein, Multidisciplinary, 030102 biochemistry & molecular biology, biology, Kinase, Lysine, Biological Sciences, humanities, Cell biology, 030104 developmental biology, chemistry, Amino Acid Substitution, Phosphoserine, Mitogen-activated protein kinase, biology.protein, Salt bridge, Troponin C, Protein Processing, Post-Translational, Protein Binding
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6
المؤلفون: Maria Hirschbeck, Hermann Schindelin, Jiyoung Lee, Marsha Rich Rosner, Sheng Wang, John J. Skinner, Tobin R. Sosnick, Kristina Lorenz, Wolfgang Kölmel, Sivaraj Sivaramakrishnan, Caroline Kisker, Ruth F. Sommese
المصدر: Biophysical Journal. 112:63a-64a
مصطلحات موضوعية: MAPK/ERK pathway, Biophysics, Biology, Serine, chemistry.chemical_compound, Biochemistry, chemistry, Mitogen-activated protein kinase, Phosphoserine, biology.protein, Phosphorylation, Salt bridge, Protein kinase A, Structural motif
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7
المؤلفون: Caroline Kisker, Maria Hirschbeck, S. Shah, Nina Liu, Peter J. Tonge, Carla Neckles, Steffen Wagner, Christoph A. Sotriffer, Hao Lu, Jochen Kuper
مصطلحات موضوعية: Models, Molecular, Protein Conformation, Pyridones, Yersinia pestis, Molecular Sequence Data, Dehydrogenase, Reductase, 010402 general chemistry, 01 natural sciences, Cofactor, Article, 03 medical and health sciences, Oxidoreductase, Structural Biology, Catalytic Domain, Amino Acid Sequence, Molecular Biology, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, biology, Molecular Structure, Active site, Substrate (chemistry), biology.organism_classification, NAD, Enoyl-(Acyl-Carrier-Protein) Reductase (NADH), 0104 chemical sciences, Enzyme, chemistry, Biochemistry, biology.protein, Sequence Alignment, Protein Binding