-
1Academic Journal
المؤلفون: Katherine A. Abrahams, Chun-wa Chung, Sonja Ghidelli-Disse, Joaquín Rullas, María José Rebollo-López, Sudagar S. Gurcha, Jonathan A. G. Cox, Alfonso Mendoza, Elena Jiménez-Navarro, María Santos Martínez-Martínez, Margarete Neu, Anthony Shillings, Paul Homes, Argyrides Argyrou, Ruth Casanueva, Nicholas J. Loman, Patrick J. Moynihan, Joël Lelièvre, Carolyn Selenski, Matthew Axtman, Laurent Kremer, Marcus Bantscheff, Iñigo Angulo-Barturen, Mónica Cacho Izquierdo, Nicholas C. Cammack, Gerard Drewes, Lluis Ballell, David Barros, Gurdyal S. Besra, Robert H. Bates
المصدر: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
مصطلحات موضوعية: Science
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2041-1723
-
2Academic Journal
المؤلفون: Christopher R. Wellaway (7148462), Ian R. Baldwin (1523716), Paul Bamborough (1343466), Daniel Barker (272779), Michelle A. Bartholomew (6566705), Chun-wa Chung (1343454), Birgit Dümpelfeld (2391988), John P. Evans (1312302), Neal J. Fazakerley (4714458), Paul Homes (1523515), Steven P. Keeling (11859605), Xiao Q. Lewell (1494235), Finlay W. McNab (11859608), Joanne Morley (633656), Deborah Needham (1859719), Margarete Neu (1840468), Antoon J. M. van Oosterhout (11859611), Anshu Pal (11859614), Friedrich B. M. Reinhard (8209701), Francesco Rianjongdee (9260972), Craig M. Robertson (1533145), Paul Rowland (1523731), Rishi R. Shah (8232807), Emma B. Sherriff (11859617), Lisa A. Sloan (1523527), Simon Teague (11859620), Daniel A. Thomas (1932538), Natalie Wellaway (2202247), Justyna Wojno-Picon (8551074), James M. Woolven (2119828), Diane M. Coe (1494211)
مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Virology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, subsequent investigations revealed, compromised kinome selectivity, mouse lung pharmacokinetic, computational docking studies, ao binding site, inhaled jak inhibitors, aldehyde oxidase metabolism, aldehyde oxidase, tyrosine kinases, specific substituents, severe asthma, receptor signaling, quinazoline series, quinazoline 2, potential issue, parent compound, lung delivery, low exposure, low concentrations, janus kinase, janus family, jak inhibitors, identify quinazolines
-
3
المؤلفون: Christopher R. Wellaway, Ian R. Baldwin, Paul Bamborough, Daniel Barker, Michelle A. Bartholomew, Chun-wa Chung, Birgit Dümpelfeld, John P. Evans, Neal J. Fazakerley, Paul Homes, Steven P. Keeling, Xiao Q. Lewell, Finlay W. McNab, Joanne Morley, Deborah Needham, Margarete Neu, Antoon J. M. van Oosterhout, Anshu Pal, Friedrich B. M. Reinhard, Francesco Rianjongdee, Craig M. Robertson, Paul Rowland, Rishi R. Shah, Emma B. Sherriff, Lisa A. Sloan, Simon Teague, Daniel A. Thomas, Natalie Wellaway, Justyna Wojno-Picon, James M. Woolven, Diane M. Coe
المصدر: Journal of Medicinal Chemistry. 65:633-664
مصطلحات موضوعية: Models, Molecular, Mice, Inbred BALB C, Binding Sites, Aldehyde Oxidase, Molecular Docking Simulation, Mice, Structure-Activity Relationship, Drug Delivery Systems, Liver, Drug Discovery, Quinazolines, Animals, Humans, Janus Kinase Inhibitors, Molecular Medicine, Administration, Intravenous, Female, Lung, Administration, Intranasal
-
4
المؤلفون: Paraskevi Kokkala, Aggelos Lelis, Athanasios Papakyriakou, John Liddle, Petros Giastas, Paul Rowland, Margarete Neu, Anastasia Mpakali, Dimitris Georgiadis, Efstratios Stratikos
المصدر: Proc Natl Acad Sci U S A
مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Multidisciplinary, biology, C-terminus, Allosteric regulation, Substrate (chemistry), Active site, Peptide, Biological Sciences, N-terminus, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Enzyme, chemistry, biology.protein, Biophysics, Structural motif, 030215 immunology
-
5
المؤلفون: Pan F. Chan, Kaushik Raha, Shruti Jain, Geoffrey Quinque, Margarete Neu, Daniele Andreotti, Roberto Profeta, Reema K. Thalji, Brian Donovan, Simona Tommasi, Lynn McCloskey, Christopher J. Nixon, Giovanni Meneghelli, Tania Bakshi, Anna Checchia, Robert A. Stavenger, Benjamin D. Bax, Alison Howells, Federica Tonelli, Haifeng Cui
المصدر: Bioorganic & Medicinal Chemistry Letters. 29:1407-1412
مصطلحات موضوعية: Acinetobacter baumannii, Models, Molecular, medicine.drug_class, Clinical Biochemistry, Antibiotics, Pharmaceutical Science, Microbial Sensitivity Tests, Isomerase, Crystallography, X-Ray, 01 natural sciences, Biochemistry, DNA gyrase, Cell Line, Mice, Structure-Activity Relationship, Drug Discovery, Escherichia coli, medicine, Animals, Humans, Topoisomerase II Inhibitors, Molecular Biology, Ion channel, Mice, Knockout, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Chemistry, Topoisomerase, Organic Chemistry, Biochemical Activity, Anti-Bacterial Agents, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Ion channel activity, DNA Gyrase, Drug Design, biology.protein, Molecular Medicine, Antibacterial activity
وصف الملف: application/pdf
-
6
المؤلفون: Michael David Barker, Emma J. Jones, Robert J. Watson, Huw D. Lewis, Cesar Ramirez-Molina, David Matthew Wilson, Marion C. Dickson, Robert P. Davis, Francis Louis Atkinson, Margarete Neu, Donald O. Somers, John Liddle
المصدر: Bioorganic & Medicinal Chemistry Letters. 28:3458-3462
مصطلحات موضوعية: 0301 basic medicine, Pyridines, Administration, Topical, Clinical Biochemistry, Anti-Inflammatory Agents, Pharmaceutical Science, Syk, Topical treatment, Human skin, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Catalytic Domain, Cell Line, Tumor, Drug Discovery, Humans, Syk Kinase, Potency, Transferase, Protein Kinase Inhibitors, Molecular Biology, Skin, Molecular Structure, Chemistry, Inflammatory skin disease, Organic Chemistry, Molecular Docking Simulation, enzymes and coenzymes (carbohydrates), 030104 developmental biology, 030220 oncology & carcinogenesis, Skin penetration, Cancer research, Molecular Medicine, biological phenomena, cell phenomena, and immunity
-
7
المؤلفون: Jonathan D Lea, Robert J. Young, Duncan S. Holmes, Christopher P. Tinworth, Jonathan P. Hutchinson, Semra Kitchen, Justyna Wojno-Picon, Leng Nickels, Michelle Pemberton, Hester Sheehan, Justyna Korczynska, Margarete Neu, Jessica L. Schneck, Efstratios Stratikos, Despoina Koumantou, Iain Uings, Ted Cecconie, Alex Phillipou, Emma J. Jones, John Liddle, Paul Rowland
المصدر: Journal of medicinal chemistry. 63(6)
مصطلحات موضوعية: Antigen presentation, Allosteric regulation, Enzyme Activators, Regulatory site, Plasma protein binding, Crystallography, X-Ray, 01 natural sciences, Aminopeptidase, Aminopeptidases, Diterpenes, Clerodane, Minor Histocompatibility Antigens, 03 medical and health sciences, Epitopes, Mice, Catalytic Domain, Drug Discovery, Hydrolase, Animals, Humans, Protease Inhibitors, 030304 developmental biology, 0303 health sciences, Antigen Presentation, biology, Chemistry, Active site, Small molecule, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Biochemistry, Proteolysis, biology.protein, Molecular Medicine, Peptides, Allosteric Site, HeLa Cells, Protein Binding
-
8
المؤلفون: Alex Preston, Scott McCleary, Emma J. Jones, Huw D. Lewis, Michael David Barker, Robert J. Watson, Tracy Jane Shipley, Cesar Ramirez-Molina, Dave Lugo, Clement Douault, Robert P. Davis, David Matthew Wilson, Margarete Neu, Neil Stuart Garton, Edward Hooper-Greenhill, John Liddle, Don O. Somers
المصدر: Bioorganic & Medicinal Chemistry Letters. 26:4606-4612
مصطلحات موضوعية: 0301 basic medicine, Clinical Biochemistry, hERG, Administration, Oral, Biological Availability, Pharmaceutical Science, Syk, Pharmacology, Crystallography, X-Ray, Biochemistry, Compound 32, Ames test, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Pharmacokinetics, Morpholine, Drug Discovery, Animals, Humans, Naphthyridines, Protein Kinase Inhibitors, Molecular Biology, Whole blood, biology, Mutagenicity Tests, Organic Chemistry, Rats, Bioavailability, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine
-
9
المؤلفون: David Barros, Robert J. Young, Roman Šink, Chun-wa Chung, Matej Živec, Daniel Alvarez-Gomez, Emilio Alvarez-Ruiz, Lourdes Encinas, Esther Pérez-Herrán, María Martínez-Hoyos, Stanislav Gobec, Julia Castro-Pichel, Stane Pajk, Alfonso Mendoza-Losana, Margarete Neu, Izidor Sosič, Máire A. Convery, Lluís Ballell-Pages
المصدر: European Journal of Medicinal Chemistry. 112:252-257
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, medicine.drug_class, Stereochemistry, Antitubercular Agents, Microbial Sensitivity Tests, Antimycobacterial, 01 natural sciences, Bacterial protein, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Bacterial Proteins, Drug Discovery, medicine, Humans, Tuberculosis, Structure–activity relationship, Cytotoxicity, Pyrans, Pharmacology, 010405 organic chemistry, Chemistry, INHA, Organic Chemistry, Mycobacterium tuberculosis, General Medicine, Tetrahydropyran, Combinatorial chemistry, 0104 chemical sciences, 030104 developmental biology, Oxidoreductases
-
10
المؤلفون: Manish Burman, Chi-Man Tang, Gavin C. Jones, Chun-wa Chung, Thil Batuwangala, Michael J. Mullin, Vicky Chung, Nadia Tournier, Ian Richard Catchpole, Justyna Korczynska, Michael Steward, Margarete Neu, Adam K. Walker, Alan S. Lewis
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: Models, Molecular, Vascular Endothelial Growth Factor A, 0301 basic medicine, Swine, Angiogenesis, Recombinant Fusion Proteins, Angiogenesis Inhibitors, Pharmacology, Biology, Crystallography, X-Ray, vascular endothelial growth factor (VEGF), Biochemistry, protein-protein interaction, angiogenesis, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Antigen, Ranibizumab, Drug Discovery, medicine, Animals, Humans, drug action, Molecular Biology, Aflibercept, antibody engineering, Cell Biology, Single-Domain Antibodies, In vitro, Bevacizumab, Vascular endothelial growth factor, Vascular endothelial growth factor A, HEK293 Cells, Receptors, Vascular Endothelial Growth Factor, 030104 developmental biology, chemistry, single-domain antibody (sdAb, nanobody), 030220 oncology & carcinogenesis, retinal degeneration, biology.protein, Antibody, Molecular Biophysics, medicine.drug
-
11
-
12
المؤلفون: Petros Giastas, Paul Rowland, Efstratios Stratikos, Margarete Neu
المصدر: ACS Medicinal Chemistry Letters
مصطلحات موضوعية: Stereochemistry, Aminopeptidase, mechanism, Peptide, 01 natural sciences, Biochemistry, X-ray, antigen, Transition state analog, Drug Discovery, Hydrolase, MHC class I, structure, Binding site, chemistry.chemical_classification, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Active site, Featured Letter, peptide, 0104 chemical sciences, inhibitor, 010404 medicinal & biomolecular chemistry, enzyme, immune system, Enzyme, biology.protein
-
13
المؤلفون: Philip Alan Skone, Donald O. Somers, Marion C. Dickson, Nick Smithers, Ann Louise Walker, Thomas George Christopher Hayhow, Stuart G. Leach, Karen Leavens, Clement Douault, Emma J. Jones, Dorothy Elwes, Robert J. Watson, Margarete Neu, Robert P. Davis, Matthew Gray, Neil Stuart Garton, Clare I. Hobbs, Alex Preston, Michael David Barker, Vipulkumar Kantibhai Patel, Cesar Ramirez-Molina, Paul S. Carter, Scott McCleary, Gordon G. Weingarten, Huw D. Lewis, Francis Louis Atkinson, John Liddle, Tracy Jane Shipley, Neil R. Curtis
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:6188-6194
مصطلحات موضوعية: Models, Molecular, medicine.drug_class, Clinical Biochemistry, hERG, Anti-Inflammatory Agents, Administration, Oral, Pharmaceutical Science, Syk, Carboxamide, Pharmacology, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Arthus Reaction, medicine, Animals, Humans, Syk Kinase, Tyrosine, Protein Kinase Inhibitors, Molecular Biology, Aniline Compounds, biology, Arthus reaction, Drug discovery, Kinase, Organic Chemistry, Intracellular Signaling Peptides and Proteins, Protein-Tyrosine Kinases, medicine.disease, Rats, Pyrimidines, Diaminopyrimidine, chemistry, biology.protein, Molecular Medicine
-
14
المؤلفون: Margarete Neu, Christopher David Edlin, J. Nicole Hamblin, Yemisi E. Solanke, Christopher J. Delves, Mika Kristian Lindvall, Don O. Somers, Michael Kranz, Caroline Mary Cook, Diane M. Coe, Sue E. Keeling, Naimisha Trivedi, Stuart Holman, Joanne O. Wiseman, Charlotte Jane Mitchell, Paul Spencer Jones, Fiona S. Lucas, Mike D. Dowle, Stuart P. Ballantine, Martin R. Johnson
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:5803-5806
مصطلحات موضوعية: Models, Molecular, Phosphodiesterase Inhibitors, Pyridines, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Peripheral blood mononuclear cell, Structure-Activity Relationship, PDE4B, Heterocyclic Compounds, Drug Discovery, Pyrazolopyridine, Humans, Computer Simulation, Molecular Biology, chemistry.chemical_classification, Binding Sites, biology, Tumor Necrosis Factor-alpha, Chemistry, Organic Chemistry, Phosphodiesterase, 3',5'-cyclic-AMP phosphodiesterase, Cyclic Nucleotide Phosphodiesterases, Type 4, Protein Structure, Tertiary, Enzyme, Models, Chemical, Enzyme inhibitor, biology.protein, Pyrazoles, Molecular Medicine
-
15
المؤلفون: John Dawson, Michael David Barker, Stuart Holman, Joanne O. Wiseman, Margarete Neu, Lisa E. Ranshaw, Fiona S. Lucas, Duncan S. Holmes, Michael Kranz, Christopher J. Delves, Beth J. Clarke, Woodrow Michael David, Tony W. Dean, Don O. Somers, Steven B. Guntrip, Stuart P. Ballantine, Yemisi E. Solanke, Mika K. Lindvaal, Sharon Lisa Gough, Brian Evans, Ward Peter
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:1380-1385
مصطلحات موضوعية: Male, Phosphodiesterase Inhibitors, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Biochemistry, Peripheral blood mononuclear cell, Protein Structure, Secondary, Rats, Sprague-Dawley, Structure-Activity Relationship, PDE4B, In vivo, Drug Discovery, Animals, Humans, Structure–activity relationship, Molecular Biology, biology, Chemistry, Organic Chemistry, Phosphodiesterase, 3',5'-cyclic-AMP phosphodiesterase, In vitro, Cyclic Nucleotide Phosphodiesterases, Type 4, Protein Structure, Tertiary, Rats, Enzyme inhibitor, Quinolines, biology.protein, Molecular Medicine, Cattle, Phosphodiesterase 4 Inhibitors
-
16
المؤلفون: Robert H. Bates, Alfonso Mendoza, Joaquín Rullas, Joël Lelièvre, Chun Wa Chung, Ruth Casanueva, Sudagar S. Gurcha, Maria Santos Martinez-Martinez, Patrick J. Moynihan, Margarete Neu, Nicholas Cammack, Gurdyal S. Besra, Nicholas J. Loman, Jonathan A. G. Cox, Katherine A. Abrahams, Paul Homes, Marcus Bantscheff, Anthony Shillings, Gerard Drewes, Elena Jimenez-Navarro, Lluis Ballell, Matthew Axtman, Carolyn Selenski, Argyrides Argyrou, Monica Cacho Izquierdo, Iñigo Angulo-Barturen, Laurent Kremer, María José Rebollo-López, David Barros, Sonja Ghidelli-Disse
المصدر: Nature Communications
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)مصطلحات موضوعية: 0301 basic medicine, Indazoles, Science, 030106 microbiology, Mutant, Antitubercular Agents, General Physics and Astronomy, Microbial Sensitivity Tests, Biology, Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, Article, Mycobacterium tuberculosis, 03 medical and health sciences, Minimum inhibitory concentration, Mice, Bacterial Proteins, In vivo, 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase, Drug Resistance, Bacterial, Animals, Tuberculosis, Pulmonary, chemistry.chemical_classification, Sulfonamides, Multidisciplinary, Drug discovery, General Chemistry, biology.organism_classification, Molecular biology, In vitro, 3. Good health, Mice, Inbred C57BL, Enzyme, Biochemistry, chemistry, Biological target, Female
وصف الملف: application/pdf
-
17
المؤلفون: Sandeep Modi, Gary R. Manchee, Anne Hersey, Robert M. Cooke, Harren Jhoti, Anne Cleasby, Margarete Neu, Alan J. Wonacott, Alan M. Hood, Jyrki Taskinen, Michael W.H. Coughtrie, Rana Dajani
المصدر: Journal of Biological Chemistry. 274:37862-37868
مصطلحات موضوعية: chemistry.chemical_classification, 0303 health sciences, Quantitative structure–activity relationship, Sulfotransferase, Molecular model, Stereochemistry, Dimer, Cell Biology, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Enzyme, Protein structure, chemistry, 030220 oncology & carcinogenesis, Structure–activity relationship, Estrogen Sulfotransferase, Molecular Biology, 030304 developmental biology
-
18
المصدر: Proteins: Structure, Function, and Genetics. 27:204-209
مصطلحات موضوعية: chemistry.chemical_classification, Vesicle, Kinetics, GTPase, Biology, Biochemistry, Cell biology, Hydrolysis, Membrane, chemistry, Structural Biology, Nucleotide, Rab, Molecular Biology, Intracellular
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::41ee757f4becbecbbf1cff0462958939
https://doi.org/10.1002/(sici)1097-0134(199702)27:2<204::aid-prot6>3.0.co;2-f -
19
المؤلفون: Angela Bridges, Gang Yao, Geoffrey J. Cutler, Paul Bamborough, Svetlana L. Belyanskaya, Caroline Brough, Gabriella Gentile, Benjamin D. Bax, Margarete Neu, Aaron Coffin, Giancarlo Merlo, Paul S. Carter, Giovanni Bernasconi, Alfonso Pozzan
المصدر: Bioorganicmedicinal chemistry letters. 22(5)
مصطلحات موضوعية: Models, Molecular, Bipolar Disorder, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Cell activity, chemistry.chemical_compound, Glycogen Synthase Kinase 3, Structure-Activity Relationship, GSK-3, Drug Discovery, medicine, Animals, Humans, Molecular Biology, Oxazoles, Protein Kinase Inhibitors, Chemistry, Aryl, Organic Chemistry, Brain, Combinatorial chemistry, Rats, Molecular Medicine
-
20
المؤلفون: Giancarlo Merlo, Geoffrey J. Cutler, Paul S. Carter, Caroline Brough, Mia Takada, Paul Bamborough, Margarete Neu, Giovanni Bernasconi, Paola Marzorati, Gabriella Gentile, Angela Bridges, Alfonso Pozzan, Benjamin D. Bax
المصدر: Bioorganicmedicinal chemistry letters. 21(16)
مصطلحات موضوعية: Central Nervous System, Models, Molecular, Cellular activity, Stereochemistry, Pyridones, Clinical Biochemistry, Pharmaceutical Science, Thiophenes, Crystallography, X-Ray, Biochemistry, Permeability, Cns penetration, Cell Line, Glycogen Synthase Kinase 3, Structure-Activity Relationship, Drug Discovery, Humans, Molecular Biology, Protein Kinase Inhibitors, Glycogen Synthase Kinase 3 beta, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Stereoisomerism, Molecular Medicine
Full Text Finder