المؤلفون: Susanne Müller, Suzanne Ackloo, Cheryl H Arrowsmith, Marcus Bauser, Jeremy L Baryza, Julian Blagg, Jark Böttcher, Chas Bountra, Peter J Brown, Mark E Bunnage, Adrian J Carter, David Damerell, Volker Dötsch, David H Drewry, Aled M Edwards, James Edwards, Jon M Elkins, Christian Fischer, Stephen V Frye, Andreas Gollner, Charles E Grimshaw, Adriaan IJzerman, Thomas Hanke, Ingo V Hartung, Steve Hitchcock, Trevor Howe, Terry V Hughes, Stefan Laufer, Volkhart MJ Li, Spiros Liras, Brian D Marsden, Hisanori Matsui, John Mathias, Ronan C O'Hagan, Dafydd R Owen, Vineet Pande, Daniel Rauh, Saul H Rosenberg, Bryan L Roth, Natalie S Schneider, Cora Scholten, Kumar Singh Saikatendu, Anton Simeonov, Masayuki Takizawa, Chris Tse, Paul R Thompson, Daniel K Treiber, Amélia YI Viana, Carrow I Wells, Timothy M Willson, William J Zuercher, Stefan Knapp, Anke Mueller-Fahrnow

المصدر: eLife, Vol 7 (2018)

مصطلحات موضوعية: Chemical probes, Target validation, Open Science, Medicine, Science, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://elifesciences.org/articles/34311; https://doaj.org/toc/2050-084X

URL الوصول: https://doaj.org/article/959198e7fd31440495c0d4c7cf3c5c06

المؤلفون: Lars Wortmann (6190562), Nico Bräuer (6391313), Simon J. Holton (8769689), Horst Irlbacher (4243624), Jörg Weiske (2632942), Christian Lechner (6190574), Robin Meier (1804774), Jakob Karén (11608819), Catrine Berthold Siöberg (11608822), Vera Pütter (3989948), Clara D. Christ (2632918), Antonius ter Laak (8115629), Philip Lienau (2614111), Ralf Lesche (6190586), Barbara Nicke (794319), Shing-Hu Cheung (11608825), Marcus Bauser (1717309), Andrea Haegebarth (836207), Franz von Nussbaum (3022791), Dominik Mumberg (167909), Clara Lemos (6190559)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Cancer, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, valuable chemical probes, reactive oxygen species, highly selective 1, deficient tumor cells, cellular target engagement, study pip4k2a signaling, based inhibitors bay, kinase pip4k2a pip4k2a, kinase pip4k2a, based optimization, throughput screening, subsequent structure, possibly due, pathophysiological conditions, null tumors, mediated apoptosis, hypothesized mode, antiproliferative activity

Relation: https://figshare.com/articles/journal_contribution/Discovery_and_Characterization_of_the_Potent_and_Highly_Selective_1_7-Naphthyridine-Based_Inhibitors_BAY-091_and_BAY-297_of_the_Kinase_PIP4K2A/16879360

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01245.s001

المؤلفون: Andrea Hägebarth, Marcus Bauser, Holger Siebeneicher, Atanas Kamburov, Ralf Lesche, Claudia Merz, Joern Toedling, Carmen Richter, Roland Neuhaus, Luisella Toschi, Ashley Eheim, Wolfgang Schwede, Andreas Schlicker, Sylvia Grünewald, Charlotte Kopitz, Eckhard Bender, Maria Quanz

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ecc176275426db1e8e7d752f623ce531
https://doi.org/10.1158/1535-7163.c.6537978.v1

المؤلفون: Andrea Hägebarth, Marcus Bauser, Holger Siebeneicher, Atanas Kamburov, Ralf Lesche, Claudia Merz, Joern Toedling, Carmen Richter, Roland Neuhaus, Luisella Toschi, Ashley Eheim, Wolfgang Schwede, Andreas Schlicker, Sylvia Grünewald, Charlotte Kopitz, Eckhard Bender, Maria Quanz

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b9c449390e8d6d58b8fd14c10da3442
https://doi.org/10.1158/1535-7163.22505181

المؤلفون: Andrea Hägebarth, Marcus Bauser, Holger Siebeneicher, Atanas Kamburov, Ralf Lesche, Claudia Merz, Joern Toedling, Carmen Richter, Roland Neuhaus, Luisella Toschi, Ashley Eheim, Wolfgang Schwede, Andreas Schlicker, Sylvia Grünewald, Charlotte Kopitz, Eckhard Bender, Maria Quanz

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d4b47918c194f9c7b520dda50e82cba
https://doi.org/10.1158/1535-7163.22505184.v1

المؤلفون: Andrea Hägebarth, Marcus Bauser, Holger Siebeneicher, Atanas Kamburov, Ralf Lesche, Claudia Merz, Joern Toedling, Carmen Richter, Roland Neuhaus, Luisella Toschi, Ashley Eheim, Wolfgang Schwede, Andreas Schlicker, Sylvia Grünewald, Charlotte Kopitz, Eckhard Bender, Maria Quanz

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f37e408a23840755a8e7e27d10ad6b
https://doi.org/10.1158/1535-7163.22505187

المؤلفون: Ingo Hartung, Masoud Vedadi, Magda Szewczyk, Volker Badock, Carlo Stresemann, Holger Steuber, Dalia Barsyte-Lovejoy, Shawna Organ, Norbert Schmees, Clara D. Christ, Detlef Stoeckigt, Steven Kennedy, Stefan Gradl, Cheryl H. Arrowsmith, Megha Abbey, Stephan Siegel, Andrea Haegebarth, Manfred Husemann, Fengling Li, Marcus Bauser, Joerg Weiske, Irene Chau, Viacheslav V. Trush, Peter Brown

المصدر: SLAS Discovery. 26:947-960

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Thermal shift assay, High-throughput screening, Antineoplastic Agents, MAP3K2, Biochemistry, Analytical Chemistry, Small Molecule Libraries, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, Humans, Binding site, Protein kinase A, Kinase, Drug discovery, Chemistry, Hydrogen Bonding, Isothermal titration calorimetry, Histone-Lysine N-Methyltransferase, High-Throughput Screening Assays, 030104 developmental biology, 030220 oncology & carcinogenesis, Molecular Medicine, Hydrophobic and Hydrophilic Interactions, Protein Binding, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31088aa45c9fd48a4764afae98765927
https://doi.org/10.1177/24725552211019409

المؤلفون: Jessica Lohrke, Markus Berger, Thomas Frenzel, Christoph-Stephan Hilger, Gregor Jost, Olaf Panknin, Marcus Bauser, Wolfgang Ebert, Hubertus Pietsch

المصدر: Investigative radiology. 57(10)

مصطلحات موضوعية: Zinc, Organometallic Compounds, Animals, Contrast Media, Humans, Water, Radiology, Nuclear Medicine and imaging, Gadolinium, Tissue Distribution, General Medicine, Glioblastoma, Magnetic Resonance Imaging, Rats

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d96cf77715bb95066c9223a7922ace6
https://pubmed.ncbi.nlm.nih.gov/35703267

المؤلفون: Andrea Hägebarth, Carl Friedrich Nising, Philip Lienau, Julien Lefranc, Benjamin Bader, Clara D. Christ, Volker K Schulze, Clara Lemos, Simon Holton, Tobias Heinrich, Ulf Bömer, Franz von Nussbaum, Hans Briem, Ekaterina Nevedomskaya, Simon J. Baumgart, Dominik Mumberg, Bernard Haendler, Marcus Bauser, Lara Kuhnke

المصدر: Cellular Oncology. 44:581-594

مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, Antineoplastic Agents, AMP-Activated Protein Kinases, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Cell Line, Tumor, Lipid droplet, medicine, Humans, Enzyme Inhibitors, Protein kinase A, Chemistry, Kinase, Prostatic Neoplasms, AMPK, Lipid metabolism, General Medicine, medicine.disease, Androgen receptor, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cancer research, Molecular Medicine, Chromatin immunoprecipitation, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c3ebc06fe1821f53c3d1ac1c328fe0
https://doi.org/10.1007/s13402-020-00584-8

المؤلفون: J. Schroeder, Stefan Gradl, Volker Badock, Knut Eis, Benjamin Bader, Hans Briem, Clara D. Christ, Patrick Steigemann, Roman C. Hillig, Duy Nguyen, Jérémie Mortier, Marcus Bauser, Anders Friberg, Dieter Moosmayer, Franziska Siegel

المصدر: ChemMedChem. 15:827-832

مصطلحات موضوعية: Pharmacology, 010405 organic chemistry, Chemistry, Organic Chemistry, Allosteric regulation, Naphthyridinone, Druggability, Computational biology, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Workflow, Covalent bond, Docking (molecular), Drug Discovery, Molecular Medicine, General Pharmacology, Toxicology and Pharmaceutics, Pharmacophore

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::cd3a78dae00c2acf021360ef88b2d38f
https://doi.org/10.1002/cmdc.201900727

المؤلفون: Jeffrey Mowat, Alexander H. M. Ehrmann, Sven Christian, Carolyn Sperl, Stephan Menz, Judith Günther, Roman C. Hillig, Marcus Bauser, Wolfgang Schwede

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: Organic Chemistry, Drug Discovery, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1250b35377a119721ea0416d4f315a94
https://pubmed.ncbi.nlm.nih.gov/35300083

المؤلفون: Steven M. Corsello, Huajia Zhang, Rajesha Rupaimoole, Volker K. Schulze, Clara Lemos, Kasia B. Handing, Douglas L. Orsi, Mrinal Shekhar, Ulrike Sack, Sven Christian, Wilhelm Bone, Ranad Humeidi, William Colgan, Stephanie Hoyt, Andrew Cherniack, Jens Schroder, Stefan Kaulfuss, Krzysztof Brzezinka, Oliver von Ahsen, Anne Mengel, Roman C. Hillig, Detlev Suelzle, Jeremie Mortier, Caitlin Harrington, Rohith Nagari, Justyna Wierzbinska, Derek Chiang, Georg Beckmann, Meagan Olive, Namrata Udeshi, Annie Apffel, Steven Carr, Philip Lienau, Christian Lechner, Ulf Boemer, Alisha Caliman, David McKinney, Florence Wagner, Dominik Mumberg, Marcus Bauser, Andrea Haegebarth, Knut Eis, Ashley Eheim, Todd R. Golub

المصدر: Cancer Research. 82:3588-3588

مصطلحات موضوعية: Cancer Research, Oncology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::eda27f4110e552a48e195fe20ca593a7
https://doi.org/10.1158/1538-7445.am2022-3588

المؤلفون: Stefan Gradl (1947637), Holger Steuber (389496), Joerg Weiske (4532608), Magda M. Szewczyk (11020448), Norbert Schmees (9465651), Stephan Siegel (3989942), Detlef Stoeckigt (8549592), Clara D. Christ (2632918), Fengling Li (176389), Shawna Organ (129008), Megha Abbey (11020451), Steven Kennedy (1622182), Irene Chau (2276365), Viacheslav Trush (11020454), Dalia Barsyte-Lovejoy (1399687), Peter J. Brown (499896), Masoud Vedadi (210076), Cheryl Arrowsmith (196614), Manfred Husemann (11020457), Volker Badock (2632921), Marcus Bauser (1717309), Andrea Haegebarth (836207), Ingo V. Hartung (2281924), Carlo Stresemann (167880)

مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences not elsewhere classified, chemical probe, SMYD3, thermal shift assay, drug discovery

Relation: https://figshare.com/articles/journal_contribution/sj-pdf-1-jbx-10_1177_24725552211019409_Supplemental_material_for_Discovery_of_the_SMYD3_Inhibitor_BAY-6035_Using_Thermal_Shift_Assay_TSA_-Based_High-Throughput_Screening/14838602

الاتاحة: https://doi.org/10.25384/sage.14838602.v1

المؤلفون: Volker Schulze, Franz von Nussbaum, Clara Lemos, Philip Lienau, Ulf Bömer, Clara Christ, Marcus Bauser, Carl Friedrich Nising, Simon J. Baumgart, Simon Holton, Tobias Heinrich, Hans Briem, Benjamin Bader, Bernard Haendler, Julien Lefranc, Andrea Hägebarth, Dominik Mumberg, Ekaterina Nevedomskaya, Lara Kuhnke

مصطلحات موضوعية: Prostate cancer, Androgen dependent, business.industry, medicine, Cancer research, AMPK, medicine.disease, business, Bay

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::de28afe92f682da433e5d167b7b11ea8
https://doi.org/10.21203/rs.3.rs-47637/v1

المؤلفون: Charlotte Kopitz, Marcus Bauser, Roland Neuhaus, Sylvia Grünewald, Claudia Merz, Joern Toedling, Atanas Kamburov, Ashley Eheim, Eckhard Bender, Wolfgang Schwede, Holger Siebeneicher, Carmen Richter, Maria Quanz, Ralf Lesche, Andreas Schlicker, Andrea Hägebarth, Luisella Toschi

المصدر: Molecular Cancer Therapeutics. 17:2285-2296

مصطلحات موضوعية: Monocarboxylic Acid Transporters, 0301 basic medicine, Lactate transport, Cancer Research, Cell, Muscle Proteins, Mice, SCID, Pyrimidinones, Thiophenes, Benzoates, Fluorescence, Xenopus laevis, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Cell Line, Tumor, Pyruvic Acid, Biomarkers, Tumor, medicine, Animals, Humans, Aminobenzoates, Carbon Radioisotopes, Lactic Acid, Sulfones, Cell Proliferation, Symporters, biology, Chemistry, Cancer, Biological Transport, Hydrogen-Ion Concentration, medicine.disease, Ubiquitin ligase, Pleckstrin homology domain, Treatment Outcome, 030104 developmental biology, Monocarboxylate transporter 1, medicine.anatomical_structure, Oncology, Drug Resistance, Neoplasm, Cell culture, 030220 oncology & carcinogenesis, biology.protein, Cancer research

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a02e5acad41f278b696aad948328f3c2
https://doi.org/10.1158/1535-7163.mct-17-1253

المؤلفون: Jessica Lohrke, Andre Mueller, Ludger Dinkelborg, Markus Berger, Holger Siebeneicher, Marcus Bauser, Joachim Huetter, Matthias Friebe, Michael Reinhardt, Felix Oden, Norman Koglin, Marion Zerna, Mathias Berndt, Andrew W. Stephens

المصدر: Journal of Nuclear Medicine. 58:1094-1099

مصطلحات موضوعية: Biodistribution, Pathology, medicine.medical_specialty, medicine.diagnostic_test, Chemistry, Heparin, Blood flow, 030204 cardiovascular system & hematology, medicine.disease, 030218 nuclear medicine & medical imaging, Pulmonary embolism, 03 medical and health sciences, 0302 clinical medicine, In vivo, Positron emission tomography, medicine, Radiology, Nuclear Medicine and imaging, Thrombus, Receptor, circulatory and respiratory physiology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::cf3ce5ee463b53c531098e63eb264aed
https://doi.org/10.2967/jnumed.116.188896

المؤلفون: Claudia Merz, Marcus Bauser, Martin Michels, Ashley Eheim, David T. Scadden, Henrik Seidel, Ralf Lesche, Timo Stellfeld, Hanna Meyer, Pascale Lejeune, Thomas Mueller, Detlef Stoeckigt, David B. Sykes, Steven James Ferrara, Sven Christian, Andrea Haegebarth, Judith Guenther, Andreas Janzer, Katja Zimmermann, Sherif El Sheikh, Stefan Gradl, Michael Bruening

المصدر: Cancer Research. 78:DDT02-04

مصطلحات موضوعية: 0301 basic medicine, Acute promyelocytic leukemia, Cancer Research, Acute leukemia, Myeloid, business.industry, Myeloid leukemia, Cancer, medicine.disease, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, Oncology, Differentiation therapy, 030220 oncology & carcinogenesis, Cancer research, Dihydroorotate dehydrogenase, medicine, Cytarabine, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::810e228e308047a51f2ef7b9122f3063
https://doi.org/10.1158/1538-7445.am2018-ddt02-04

المؤلفون: Jérémie, Mortier, Anders, Friberg, Volker, Badock, Dieter, Moosmayer, Jens, Schroeder, Patrick, Steigemann, Franziska, Siegel, Stefan, Gradl, Marcus, Bauser, Roman C, Hillig, Hans, Briem, Knut, Eis, Benjamin, Bader, Duy, Nguyen, Clara D, Christ

المصدر: Chemmedchem

مصطلحات موضوعية: free-energy perturbation (FEP), Dose-Response Relationship, Drug, Molecular Structure, Communication, Communications, molecular dynamics, Proto-Oncogene Proteins p21(ras), Structure-Activity Relationship, virtual library design, Allosteric Regulation, medicinal chemistry, Mutation, KRAS, Humans, Enzyme Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::38543b1608cf2b145245231d713abef9
https://pubmed.ncbi.nlm.nih.gov/32237114

المؤلفون: Jenny Viklund, Martin Andersson, Ashley Eheim, Johan Lindström, Maria Quanz, Ulrika Ericsson, Ellermann Manuel, Andrea Glasauer, Benjamin Bader, Judith Guenther, Jörg Weiske, Katrin Nowak-Reppel, Nina Queisser, Camilla Silvander, Stefanie Bunse, Anja Giese, Tobias Ginman, Rickard Forsblom, Horst Irlbacher, Lionel Trésaugues, Hanna Meyer, Marcus Bauser, Andrea Haegebarth, Roland Neuhaus, Mátyás Gorjánácz, F. Rahm

المصدر: 'ACS Chemical Biology ', vol: 12, pages: 1986-1992 (2017)

مصطلحات موضوعية: 0301 basic medicine, Purine, Models, Molecular, Morpholines, Mice, Nude, Antineoplastic Agents, Pharmacology, Biology, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Drug Delivery Systems, In vivo, Neoplasms, medicine, Animals, Humans, Cells, Cultured, chemistry.chemical_classification, Cancer, General Medicine, medicine.disease, In vitro, Phosphoric Monoester Hydrolases, Rats, Enzyme Activation, 030104 developmental biology, Enzyme, DNA Repair Enzymes, Pyrimidines, chemistry, 030220 oncology & carcinogenesis, Cancer cell, Hepatocytes, MCF-7 Cells, Microsomes, Liver, Molecular Medicine, Caco-2 Cells, Nucleoside, DNA, HeLa Cells

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6b2c6ca127fb71bb1dadea18236e7f
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:47719

المؤلفون: Christoph Stephan Hilger, Hubertus Pietsch, Markus Berger, Christian Neis, Christa Hegele-Hartung, Kaspar Hegetschweiler, Björn Riefke, Thomas Frenzel, Gregor Jost, Detlev Suelzle, Marcus Bauser

المصدر: Investigative Radiology. 51:776-785

مصطلحات موضوعية: Materials science, media_common.quotation_subject, Analytical chemistry, Contrast Media, chemistry.chemical_element, Computed tomography, Iodine, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Liver Neoplasms, Experimental, 0302 clinical medicine, medicine, Animals, Contrast (vision), Radiology, Nuclear Medicine and imaging, Rats, Wistar, Absorption (electromagnetic radiation), media_common, medicine.diagnostic_test, Phantoms, Imaging, X-ray, General Medicine, Rats, Characterization (materials science), Hafnium, Radiographic Image Enhancement, Disease Models, Animal, Liver, chemistry, 030220 oncology & carcinogenesis, Rabbits, Tomography, Tomography, X-Ray Computed

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1ae43429d153b5dc8ec38d437e708a4
https://doi.org/10.1097/rli.0000000000000291