المؤلفون: Douglas O. Escrivani (9746505), Rebecca L. Charlton (9746499), Marjolly B. Caruso (11708103), Gabriela A. Burle-Caldas (11708106), Maria Paula G. Borsodi (9746511), Russolina B. Zingali (104390), Natalia Arruda-Costa (11824904), Marcos V. Palmeira-Mello (11708109), Jéssica B. de Jesus (11708112), Alessandra M. T. Souza (6731954), Bárbara Abrahim-Vieira (11708115), Stefanie Freitag-Pohl (11624271), Ehmke Pohl (456761), Paul W. Denny (6729614), Bartira Rossi-Bergmann (682292), Patrick G. Steel (1599910)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Cell Biology, Pharmacology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Physical Sciences not elsewhere classified, structural modification provided, molecular docking studies, dramatically impacts upon, cytosolic tryparedoxin peroxidase, crucial cysteine residue, 4 ’- methoxychalcone, work identifies ctxnpx, chalcones identify ctxnpx, host macrophage toxicity, div >< p, ctxnpx suggest, ctxnpx ), silico <, ros accumulation, protein within, low efficacy, important target, homology model, dmc )

Relation: https://figshare.com/articles/journal_contribution/Synthetic_procedures_/17018079

الاتاحة: https://doi.org/10.1371/journal.pntd.0009951.s014

المؤلفون: Douglas O. Escrivani (9746505), Rebecca L. Charlton (9746499), Marjolly B. Caruso (11708103), Gabriela A. Burle-Caldas (11708106), Maria Paula G. Borsodi (9746511), Russolina B. Zingali (104390), Natalia Arruda-Costa (11824904), Marcos V. Palmeira-Mello (11708109), Jéssica B. de Jesus (11708112), Alessandra M. T. Souza (6731954), Bárbara Abrahim-Vieira (11708115), Stefanie Freitag-Pohl (11624271), Ehmke Pohl (456761), Paul W. Denny (6729614), Bartira Rossi-Bergmann (682292), Patrick G. Steel (1599910)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Cell Biology, Pharmacology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Physical Sciences not elsewhere classified, structural modification provided, molecular docking studies, dramatically impacts upon, cytosolic tryparedoxin peroxidase, crucial cysteine residue, 4 ’- methoxychalcone, work identifies ctxnpx, chalcones identify ctxnpx, host macrophage toxicity, div >< p, ctxnpx suggest, ctxnpx ), silico <, ros accumulation, protein within, low efficacy, important target, homology model, dmc )

Relation: https://figshare.com/articles/figure/Uncropped_SDS-PAGEs_corresponding_to_Fig_3C_/17018028

الاتاحة: https://doi.org/10.1371/journal.pntd.0009951.s002

المؤلفون: Douglas O. Escrivani (9746505), Rebecca L. Charlton (9746499), Marjolly B. Caruso (11708103), Gabriela A. Burle-Caldas (11708106), Maria Paula G. Borsodi (9746511), Russolina B. Zingali (104390), Natalia Arruda-Costa (11824904), Marcos V. Palmeira-Mello (11708109), Jéssica B. de Jesus (11708112), Alessandra M. T. Souza (6731954), Bárbara Abrahim-Vieira (11708115), Stefanie Freitag-Pohl (11624271), Ehmke Pohl (456761), Paul W. Denny (6729614), Bartira Rossi-Bergmann (682292), Patrick G. Steel (1599910)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Cell Biology, Pharmacology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Physical Sciences not elsewhere classified, structural modification provided, molecular docking studies, dramatically impacts upon, cytosolic tryparedoxin peroxidase, crucial cysteine residue, 4 ’- methoxychalcone, work identifies ctxnpx, chalcones identify ctxnpx, host macrophage toxicity, div >< p, ctxnpx suggest, ctxnpx ), silico <, ros accumulation, protein within, low efficacy, important target, homology model, dmc )

Relation: https://figshare.com/articles/figure/Uncropped_SDS-PAGEs_corresponding_to_Fig_3D_/17018034

الاتاحة: https://doi.org/10.1371/journal.pntd.0009951.s003

المؤلفون: Douglas O. Escrivani (9746505), Rebecca L. Charlton (9746499), Marjolly B. Caruso (11708103), Gabriela A. Burle-Caldas (11708106), Maria Paula G. Borsodi (9746511), Russolina B. Zingali (104390), Natalia Arruda-Costa (11824904), Marcos V. Palmeira-Mello (11708109), Jéssica B. de Jesus (11708112), Alessandra M. T. Souza (6731954), Bárbara Abrahim-Vieira (11708115), Stefanie Freitag-Pohl (11624271), Ehmke Pohl (456761), Paul W. Denny (6729614), Bartira Rossi-Bergmann (682292), Patrick G. Steel (1599910)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Cell Biology, Pharmacology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Physical Sciences not elsewhere classified, structural modification provided, molecular docking studies, dramatically impacts upon, cytosolic tryparedoxin peroxidase, crucial cysteine residue, 4 ’- methoxychalcone, work identifies ctxnpx, chalcones identify ctxnpx, host macrophage toxicity, div >< p, ctxnpx suggest, ctxnpx ), silico <, ros accumulation, protein within, low efficacy, important target, homology model, dmc )

Relation: https://figshare.com/articles/figure/Confirmation_of_cTXNPx_as_a_chalcone_target_by_two-dimensional_gel_analysis_/17018040

الاتاحة: https://doi.org/10.1371/journal.pntd.0009951.s004

المؤلفون: Douglas O. Escrivani (9746505), Rebecca L. Charlton (9746499), Marjolly B. Caruso (11708103), Gabriela A. Burle-Caldas (11708106), Maria Paula G. Borsodi (9746511), Russolina B. Zingali (104390), Natalia Arruda-Costa (11824904), Marcos V. Palmeira-Mello (11708109), Jéssica B. de Jesus (11708112), Alessandra M. T. Souza (6731954), Bárbara Abrahim-Vieira (11708115), Stefanie Freitag-Pohl (11624271), Ehmke Pohl (456761), Paul W. Denny (6729614), Bartira Rossi-Bergmann (682292), Patrick G. Steel (1599910)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Cell Biology, Pharmacology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Physical Sciences not elsewhere classified, structural modification provided, molecular docking studies, dramatically impacts upon, cytosolic tryparedoxin peroxidase, crucial cysteine residue, 4 ’- methoxychalcone, work identifies ctxnpx, chalcones identify ctxnpx, host macrophage toxicity, div >< p, ctxnpx suggest, ctxnpx ), silico <, ros accumulation, protein within, low efficacy, important target, homology model, dmc )

Relation: https://figshare.com/articles/figure/Mass_spectrometry_analysis_of_interaction_between_chalcone_and_Lm-cTXNPx_/17018052

الاتاحة: https://doi.org/10.1371/journal.pntd.0009951.s006

المؤلفون: Douglas O. Escrivani (9746505), Rebecca L. Charlton (9746499), Marjolly B. Caruso (11708103), Gabriela A. Burle-Caldas (11708106), Maria Paula G. Borsodi (9746511), Russolina B. Zingali (104390), Natalia Arruda-Costa (11824904), Marcos V. Palmeira-Mello (11708109), Jéssica B. de Jesus (11708112), Alessandra M. T. Souza (6731954), Bárbara Abrahim-Vieira (11708115), Stefanie Freitag-Pohl (11624271), Ehmke Pohl (456761), Paul W. Denny (6729614), Bartira Rossi-Bergmann (682292), Patrick G. Steel (1599910)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Cell Biology, Pharmacology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Physical Sciences not elsewhere classified, structural modification provided, molecular docking studies, dramatically impacts upon, cytosolic tryparedoxin peroxidase, crucial cysteine residue, 4 ’- methoxychalcone, work identifies ctxnpx, chalcones identify ctxnpx, host macrophage toxicity, div >< p, ctxnpx suggest, ctxnpx ), silico <, ros accumulation, protein within, low efficacy, important target, homology model, dmc )

Relation: https://figshare.com/articles/figure/Immunoblotting_analysis_of_chalcone_labelling_on_cTXNPx_in_different_parasite_stages_/17018046

الاتاحة: https://doi.org/10.1371/journal.pntd.0009951.s005

المؤلفون: Douglas O. Escrivani (9746505), Rebecca L. Charlton (9746499), Marjolly B. Caruso (11708103), Gabriela A. Burle-Caldas (11708106), Maria Paula G. Borsodi (9746511), Russolina B. Zingali (104390), Natalia Arruda-Costa (11824904), Marcos V. Palmeira-Mello (11708109), Jéssica B. de Jesus (11708112), Alessandra M. T. Souza (6731954), Bárbara Abrahim-Vieira (11708115), Stefanie Freitag-Pohl (11624271), Ehmke Pohl (456761), Paul W. Denny (6729614), Bartira Rossi-Bergmann (682292), Patrick G. Steel (1599910)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Cell Biology, Pharmacology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Physical Sciences not elsewhere classified, structural modification provided, molecular docking studies, dramatically impacts upon, cytosolic tryparedoxin peroxidase, crucial cysteine residue, 4 ’- methoxychalcone, work identifies ctxnpx, chalcones identify ctxnpx, host macrophage toxicity, div >< p, ctxnpx suggest, ctxnpx ), silico <, ros accumulation, protein within, low efficacy, important target, homology model, dmc )

Relation: https://figshare.com/articles/figure/Screening_of_KO_clones_for_each_gene_/17018064

الاتاحة: https://doi.org/10.1371/journal.pntd.0009951.s009

المؤلفون: Douglas O. Escrivani (9746505), Rebecca L. Charlton (9746499), Marjolly B. Caruso (11708103), Gabriela A. Burle-Caldas (11708106), Maria Paula G. Borsodi (9746511), Russolina B. Zingali (104390), Natalia Arruda-Costa (11824904), Marcos V. Palmeira-Mello (11708109), Jéssica B. de Jesus (11708112), Alessandra M. T. Souza (6731954), Bárbara Abrahim-Vieira (11708115), Stefanie Freitag-Pohl (11624271), Ehmke Pohl (456761), Paul W. Denny (6729614), Bartira Rossi-Bergmann (682292), Patrick G. Steel (1599910)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Cell Biology, Pharmacology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Physical Sciences not elsewhere classified, structural modification provided, molecular docking studies, dramatically impacts upon, cytosolic tryparedoxin peroxidase, crucial cysteine residue, 4 ’- methoxychalcone, work identifies ctxnpx, chalcones identify ctxnpx, host macrophage toxicity, div >< p, ctxnpx suggest, ctxnpx ), silico <, ros accumulation, protein within, low efficacy, important target, homology model, dmc )

Relation: https://figshare.com/articles/dataset/Proteins_candidates_identified_from_the_band_on_1D-gel_in_S3_Fig_/17018067

الاتاحة: https://doi.org/10.1371/journal.pntd.0009951.s010

المؤلفون: Douglas O. Escrivani (9746505), Rebecca L. Charlton (9746499), Marjolly B. Caruso (11708103), Gabriela A. Burle-Caldas (11708106), Maria Paula G. Borsodi (9746511), Russolina B. Zingali (104390), Natalia Arruda-Costa (11824904), Marcos V. Palmeira-Mello (11708109), Jéssica B. de Jesus (11708112), Alessandra M. T. Souza (6731954), Bárbara Abrahim-Vieira (11708115), Stefanie Freitag-Pohl (11624271), Ehmke Pohl (456761), Paul W. Denny (6729614), Bartira Rossi-Bergmann (682292), Patrick G. Steel (1599910)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Cell Biology, Pharmacology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Physical Sciences not elsewhere classified, structural modification provided, molecular docking studies, dramatically impacts upon, cytosolic tryparedoxin peroxidase, crucial cysteine residue, 4 ’- methoxychalcone, work identifies ctxnpx, chalcones identify ctxnpx, host macrophage toxicity, div >< p, ctxnpx suggest, ctxnpx ), silico <, ros accumulation, protein within, low efficacy, important target, homology model, dmc )

Relation: https://figshare.com/articles/figure/TXNPx_sequence_alignment_/17018061

الاتاحة: https://doi.org/10.1371/journal.pntd.0009951.s008

المؤلفون: Douglas O. Escrivani (9746505), Rebecca L. Charlton (9746499), Marjolly B. Caruso (11708103), Gabriela A. Burle-Caldas (11708106), Maria Paula G. Borsodi (9746511), Russolina B. Zingali (104390), Natalia Arruda-Costa (11824904), Marcos V. Palmeira-Mello (11708109), Jéssica B. de Jesus (11708112), Alessandra M. T. Souza (6731954), Bárbara Abrahim-Vieira (11708115), Stefanie Freitag-Pohl (11624271), Ehmke Pohl (456761), Paul W. Denny (6729614), Bartira Rossi-Bergmann (682292), Patrick G. Steel (1599910)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Cell Biology, Pharmacology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Physical Sciences not elsewhere classified, structural modification provided, molecular docking studies, dramatically impacts upon, cytosolic tryparedoxin peroxidase, crucial cysteine residue, 4 ’- methoxychalcone, work identifies ctxnpx, chalcones identify ctxnpx, host macrophage toxicity, div >< p, ctxnpx suggest, ctxnpx ), silico <, ros accumulation, protein within, low efficacy, important target, homology model, dmc )

Relation: https://figshare.com/articles/dataset/Proteins_candidates_identified_for_each_2D_dot_from_S4_Fig_/17018070

الاتاحة: https://doi.org/10.1371/journal.pntd.0009951.s011

المؤلفون: Douglas O. Escrivani (9746505), Rebecca L. Charlton (9746499), Marjolly B. Caruso (11708103), Gabriela A. Burle-Caldas (11708106), Maria Paula G. Borsodi (9746511), Russolina B. Zingali (104390), Natalia Arruda-Costa (11824904), Marcos V. Palmeira-Mello (11708109), Jéssica B. de Jesus (11708112), Alessandra M. T. Souza (6731954), Bárbara Abrahim-Vieira (11708115), Stefanie Freitag-Pohl (11624271), Ehmke Pohl (456761), Paul W. Denny (6729614), Bartira Rossi-Bergmann (682292), Patrick G. Steel (1599910)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Cell Biology, Pharmacology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Physical Sciences not elsewhere classified, structural modification provided, molecular docking studies, dramatically impacts upon, cytosolic tryparedoxin peroxidase, crucial cysteine residue, 4 ’- methoxychalcone, work identifies ctxnpx, chalcones identify ctxnpx, host macrophage toxicity, div >< p, ctxnpx suggest, ctxnpx ), silico <, ros accumulation, protein within, low efficacy, important target, homology model, dmc )

Relation: https://figshare.com/articles/dataset/Primers_used_to_knockout_cTXNPx_in_i_L_mexicana_i_using_pT_plasmids_/17018073

الاتاحة: https://doi.org/10.1371/journal.pntd.0009951.s012

المؤلفون: Douglas O. Escrivani (9746505), Rebecca L. Charlton (9746499), Marjolly B. Caruso (11708103), Gabriela A. Burle-Caldas (11708106), Maria Paula G. Borsodi (9746511), Russolina B. Zingali (104390), Natalia Arruda-Costa (11824904), Marcos V. Palmeira-Mello (11708109), Jéssica B. de Jesus (11708112), Alessandra M. T. Souza (6731954), Bárbara Abrahim-Vieira (11708115), Stefanie Freitag-Pohl (11624271), Ehmke Pohl (456761), Paul W. Denny (6729614), Bartira Rossi-Bergmann (682292), Patrick G. Steel (1599910)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Cell Biology, Pharmacology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Physical Sciences not elsewhere classified, structural modification provided, molecular docking studies, dramatically impacts upon, cytosolic tryparedoxin peroxidase, crucial cysteine residue, 4 ’- methoxychalcone, work identifies ctxnpx, chalcones identify ctxnpx, host macrophage toxicity, div >< p, ctxnpx suggest, ctxnpx ), silico <, ros accumulation, protein within, low efficacy, important target, homology model, dmc )

Relation: https://figshare.com/articles/figure/Chemical_structures_of_compounds_1_4_/17018082

الاتاحة: https://doi.org/10.1371/journal.pntd.0009951.g001

المؤلفون: Douglas O. Escrivani (9746505), Rebecca L. Charlton (9746499), Marjolly B. Caruso (11708103), Gabriela A. Burle-Caldas (11708106), Maria Paula G. Borsodi (9746511), Russolina B. Zingali (104390), Natalia Arruda-Costa (11824904), Marcos V. Palmeira-Mello (11708109), Jéssica B. de Jesus (11708112), Alessandra M. T. Souza (6731954), Bárbara Abrahim-Vieira (11708115), Stefanie Freitag-Pohl (11624271), Ehmke Pohl (456761), Paul W. Denny (6729614), Bartira Rossi-Bergmann (682292), Patrick G. Steel (1599910)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Cell Biology, Pharmacology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Physical Sciences not elsewhere classified, structural modification provided, molecular docking studies, dramatically impacts upon, cytosolic tryparedoxin peroxidase, crucial cysteine residue, 4 ’- methoxychalcone, work identifies ctxnpx, chalcones identify ctxnpx, host macrophage toxicity, div >< p, ctxnpx suggest, ctxnpx ), silico <, ros accumulation, protein within, low efficacy, important target, homology model, dmc )

Relation: https://figshare.com/articles/dataset/Primers_used_for_the_validation_of_cTXNPx_knockouts_/17018076

الاتاحة: https://doi.org/10.1371/journal.pntd.0009951.s013

المؤلفون: Douglas O. Escrivani (9746505), Rebecca L. Charlton (9746499), Marjolly B. Caruso (11708103), Gabriela A. Burle-Caldas (11708106), Maria Paula G. Borsodi (9746511), Russolina B. Zingali (104390), Natalia Arruda-Costa (11824904), Marcos V. Palmeira-Mello (11708109), Jéssica B. de Jesus (11708112), Alessandra M. T. Souza (6731954), Bárbara Abrahim-Vieira (11708115), Stefanie Freitag-Pohl (11624271), Ehmke Pohl (456761), Paul W. Denny (6729614), Bartira Rossi-Bergmann (682292), Patrick G. Steel (1599910)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Cell Biology, Pharmacology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Physical Sciences not elsewhere classified, structural modification provided, molecular docking studies, dramatically impacts upon, cytosolic tryparedoxin peroxidase, crucial cysteine residue, 4 ’- methoxychalcone, work identifies ctxnpx, chalcones identify ctxnpx, host macrophage toxicity, div >< p, ctxnpx suggest, ctxnpx ), silico <, ros accumulation, protein within, low efficacy, important target, homology model, dmc )

Relation: https://figshare.com/articles/figure/_i_In_vitro_i_and_i_in_vivo_i_antileishmanial_activity_/17018085

الاتاحة: https://doi.org/10.1371/journal.pntd.0009951.g002

المؤلفون: Douglas O. Escrivani (9746505), Rebecca L. Charlton (9746499), Marjolly B. Caruso (11708103), Gabriela A. Burle-Caldas (11708106), Maria Paula G. Borsodi (9746511), Russolina B. Zingali (104390), Natalia Arruda-Costa (11824904), Marcos V. Palmeira-Mello (11708109), Jéssica B. de Jesus (11708112), Alessandra M. T. Souza (6731954), Bárbara Abrahim-Vieira (11708115), Stefanie Freitag-Pohl (11624271), Ehmke Pohl (456761), Paul W. Denny (6729614), Bartira Rossi-Bergmann (682292), Patrick G. Steel (1599910)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Cell Biology, Pharmacology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Physical Sciences not elsewhere classified, structural modification provided, molecular docking studies, dramatically impacts upon, cytosolic tryparedoxin peroxidase, crucial cysteine residue, 4 ’- methoxychalcone, work identifies ctxnpx, chalcones identify ctxnpx, host macrophage toxicity, div >< p, ctxnpx suggest, ctxnpx ), silico <, ros accumulation, protein within, low efficacy, important target, homology model, dmc )

Relation: https://figshare.com/articles/figure/Intracellular_probe_binding_and_identification_of_cytosolic_tryparedoxin_peroxidase_as_protein_target_/17018088

الاتاحة: https://doi.org/10.1371/journal.pntd.0009951.g003

المؤلفون: Douglas O. Escrivani (9746505), Rebecca L. Charlton (9746499), Marjolly B. Caruso (11708103), Gabriela A. Burle-Caldas (11708106), Maria Paula G. Borsodi (9746511), Russolina B. Zingali (104390), Natalia Arruda-Costa (11824904), Marcos V. Palmeira-Mello (11708109), Jéssica B. de Jesus (11708112), Alessandra M. T. Souza (6731954), Bárbara Abrahim-Vieira (11708115), Stefanie Freitag-Pohl (11624271), Ehmke Pohl (456761), Paul W. Denny (6729614), Bartira Rossi-Bergmann (682292), Patrick G. Steel (1599910)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Cell Biology, Pharmacology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Physical Sciences not elsewhere classified, structural modification provided, molecular docking studies, dramatically impacts upon, cytosolic tryparedoxin peroxidase, crucial cysteine residue, 4 ’- methoxychalcone, work identifies ctxnpx, chalcones identify ctxnpx, host macrophage toxicity, div >< p, ctxnpx suggest, ctxnpx ), silico <, ros accumulation, protein within, low efficacy, important target, homology model, dmc )

Relation: https://figshare.com/articles/figure/_i_La_i_TXNPx_3D_model_and_3D_2D_binding_mode_of_1c_and_3_/17018094

الاتاحة: https://doi.org/10.1371/journal.pntd.0009951.g005

المؤلفون: Douglas O. Escrivani (9746505), Rebecca L. Charlton (9746499), Marjolly B. Caruso (11708103), Gabriela A. Burle-Caldas (11708106), Maria Paula G. Borsodi (9746511), Russolina B. Zingali (104390), Natalia Arruda-Costa (11824904), Marcos V. Palmeira-Mello (11708109), Jéssica B. de Jesus (11708112), Alessandra M. T. Souza (6731954), Bárbara Abrahim-Vieira (11708115), Stefanie Freitag-Pohl (11624271), Ehmke Pohl (456761), Paul W. Denny (6729614), Bartira Rossi-Bergmann (682292), Patrick G. Steel (1599910)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Cell Biology, Pharmacology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Physical Sciences not elsewhere classified, structural modification provided, molecular docking studies, dramatically impacts upon, cytosolic tryparedoxin peroxidase, crucial cysteine residue, 4 ’- methoxychalcone, work identifies ctxnpx, chalcones identify ctxnpx, host macrophage toxicity, div >< p, ctxnpx suggest, ctxnpx ), silico <, ros accumulation, protein within, low efficacy, important target, homology model, dmc )

Relation: https://figshare.com/articles/figure/Chalcone_impairs_the_cTXNPx_antioxidant_effect_in_the_parasite_by_a_stable_interaction_mediated_by_enone_group_/17018091

الاتاحة: https://doi.org/10.1371/journal.pntd.0009951.g004

المؤلفون: Douglas O. Escrivani (9746505), Rebecca L. Charlton (9746499), Marjolly B. Caruso (11708103), Gabriela A. Burle-Caldas (11708106), Maria Paula G. Borsodi (9746511), Russolina B. Zingali (104390), Natalia Arruda-Costa (11824904), Marcos V. Palmeira-Mello (11708109), Jéssica B. de Jesus (11708112), Alessandra M. T. Souza (6731954), Bárbara Abrahim-Vieira (11708115), Stefanie Freitag-Pohl (11624271), Ehmke Pohl (456761), Paul W. Denny (6729614), Bartira Rossi-Bergmann (682292), Patrick G. Steel (1599910)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Cell Biology, Pharmacology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Physical Sciences not elsewhere classified, structural modification provided, molecular docking studies, dramatically impacts upon, cytosolic tryparedoxin peroxidase, crucial cysteine residue, 4 ’- methoxychalcone, work identifies ctxnpx, chalcones identify ctxnpx, host macrophage toxicity, div >< p, ctxnpx suggest, ctxnpx ), silico <, ros accumulation, protein within, low efficacy, important target, homology model, dmc )

Relation: https://figshare.com/articles/figure/Chalcone_antiparasitic_activity_is_partially_dependent_on_cTXNPx_/17018097

الاتاحة: https://doi.org/10.1371/journal.pntd.0009951.g006

المؤلفون: Douglas O. Escrivani (9746505), Rebecca L. Charlton (9746499), Marjolly B. Caruso (11708103), Gabriela A. Burle-Caldas (11708106), Maria Paula G. Borsodi (9746511), Russolina B. Zingali (104390), Natalia Arruda-Costa (11824904), Marcos V. Palmeira-Mello (11708109), Jéssica B. de Jesus (11708112), Alessandra M. T. Souza (6731954), Bárbara Abrahim-Vieira (11708115), Stefanie Freitag-Pohl (11624271), Ehmke Pohl (456761), Paul W. Denny (6729614), Bartira Rossi-Bergmann (682292), Patrick G. Steel (1599910)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Cell Biology, Pharmacology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Physical Sciences not elsewhere classified, structural modification provided, molecular docking studies, dramatically impacts upon, cytosolic tryparedoxin peroxidase, crucial cysteine residue, 4 ’- methoxychalcone, work identifies ctxnpx, chalcones identify ctxnpx, host macrophage toxicity, div >< p, ctxnpx suggest, ctxnpx ), silico <, ros accumulation, protein within, low efficacy, important target, homology model, dmc )

Relation: https://figshare.com/articles/figure/Synthetic_routes_for_preparation_of_compounds_2_3_/17018022

الاتاحة: https://doi.org/10.1371/journal.pntd.0009951.s001