-
1
المؤلفون: Jeffrey W. Jacobs, Michael R. Leadbetter, Noah Bell, Samantha Koo-McCoy, Christopher W. Carreras, Limin He, Jill Kohler, Kenji Kozuka, Eric D. Labonté, Marc Navre, Andrew G. Spencer, Dominique Charmot
المصدر: ACS Medicinal Chemistry Letters. 13:1043-1051
مصطلحات موضوعية: Organic Chemistry, Drug Discovery, Biochemistry
-
2Academic Journal
المؤلفون: André Lochter, Marc Navre, Zena Werb, Mina J. Bissell
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.321.7628; http://www.molbiolcell.org/content/10/2/271.full.pdf
-
3Academic Journal
المؤلفون: Joy L. Silen, Amy T. Lu, Dennis W. Solas, Medini A. Gore, Nikil H. Shah, Jill M. Coffin, Naseema S. Bhinderwala, Yongwen Wang, Ken T. Tsutsui, Gary C. Look, David A, Ron L. Hale, Marc Navre, Camille R, Derek Maclean, David A. Campbell, Camille, R. Deluca-flaherty
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.424.3645; http://aac.asm.org/content/42/6/1447.full.pdf
-
4
المؤلفون: Marc Navre, Allan Coukell, Aileen Rubio, Joseph M. Thomas
المصدر: ACS infectious diseases. 4(11)
مصطلحات موضوعية: 0301 basic medicine, Knowledge management, Databases, Factual, Information Dissemination, MEDLINE, Global Health, 01 natural sciences, 03 medical and health sciences, Drug Discovery, Gram-Negative Bacteria, Global health, Humans, Intersectoral Collaboration, computer.programming_language, 010405 organic chemistry, business.industry, Research, 0104 chemical sciences, Anti-Bacterial Agents, 030104 developmental biology, Infectious Diseases, SPARK (programming language), Charities, business, computer
-
5
المؤلفون: Tao Chen, Andrew Spencer, Jeffrey W. Jacobs, Marc Navre, Patricia Finn, Jason G. Lewis, Christopher Carreras, Nicholas Reich, Jocelyn Tabora, Dominique Charmot, Samantha Koo-McCoy, Limin He, Noah Bell, Jeremy S. Caldwell, David Rodríguez, Jill Kohler, Kenji Kozuka
المصدر: Journal of medicinal chemistry. 61(17)
مصطلحات موضوعية: 0301 basic medicine, Male, medicine.drug_class, Drug Evaluation, Preclinical, Pharmacology, Madin Darby Canine Kidney Cells, Receptors, G-Protein-Coupled, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Dogs, Gastrointestinal Agents, Glucagon-Like Peptide 1, Drug Discovery, medicine, Animals, Humans, Receptor, Gastrointestinal tract, Bile acid, Chemistry, Gallbladder, Type 2 Diabetes Mellitus, Metabolism, G protein-coupled bile acid receptor, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, HEK293 Cells, Drug Design, Molecular Medicine, Thiazolidines, 030211 gastroenterology & hepatology, Female, Gallbladder Emptying
-
6
المؤلفون: Ron de Jong, Shawn M. O’Connell, Robert Melkus, Andrew John Jennings, Marc Navre, Jerome C. Bressi, Anthony R. Gangloff, Yiqin Wu, Charles E. Grimshaw, Robert J. Skene
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:3142-3145
مصطلحات موضوعية: Molecular model, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Histone Deacetylase 2, Pharmaceutical Science, Carboxamide, Crystal structure, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Catalytic Domain, Drug Discovery, medicine, Humans, Structure–activity relationship, Benzamide, Molecular Biology, chemistry.chemical_classification, Binding Sites, Organic Chemistry, Aromatic amine, HCT116 Cells, Receptor–ligand kinetics, Histone Deacetylase Inhibitors, Kinetics, chemistry, Benzamides, Molecular Medicine
-
7
المؤلفون: Bi-Ching Sang, Rongda Xu, Daniel B. Kassel, Marc Navre
المصدر: Rapid Communications in Mass Spectrometry. 20:1643-1647
مصطلحات موضوعية: endocrine system, Hydrocortisone, Drug Evaluation, Preclinical, Dehydrogenase, Reductase, Tandem mass spectrometry, Analytical Chemistry, Mice, Tandem Mass Spectrometry, Liquid chromatography–mass spectrometry, In vivo, medicine, Animals, Humans, Enzyme Inhibitors, Receptor, Cells, Cultured, Chromatography, High Pressure Liquid, Spectroscopy, Chromatography, Chemistry, Organic Chemistry, Rats, Cortisone, Biochemistry, Calibration, 11-beta-Hydroxysteroid Dehydrogenases, hormones, hormone substitutes, and hormone antagonists, Glucocorticoid, HeLa Cells, medicine.drug
-
8
المؤلفون: Xianfeng Li, Liang Wang, Marc Navre, Christopher P. Holmes, J. Russell Grove, Anna Katrin Szardenings, Larry Jang, Ashok Bhandari, Lihong Shi
المصدر: Tetrahedron Letters. 47:19-22
مصطلحات موضوعية: Aqueous solution, Suzuki reaction, Chemistry, Organic Chemistry, Drug Discovery, Rapid access, Organic chemistry, Moiety, Biochemistry, Combinatorial chemistry
-
9
المؤلفون: Jill Kohler, Desiree Deshpande, Ziyang Zhong, Michael R. Leadbetter, Ingrid Langsetmo, Marc Navre, Christopher Carreras, Andrew Spencer, Kenji Kozuka, Jason G. Lewis, Edward Dy, Eric Labonte, Deborah Black, Limin He, Jeffrey W. Jacobs, Noah Bell, Dominique Charmot, Samantha Koo-McCoy
المصدر: Journal of the American Society of Nephrology : JASN. 26(5)
مصطلحات موضوعية: Male, medicine.medical_specialty, Sodium-Hydrogen Exchangers, chemistry.chemical_element, Metabolic bone disease, Excretion, Rats, Sprague-Dawley, chemistry.chemical_compound, Ectopic calcification, Random Allocation, Internal medicine, medicine, Animals, Renal Insufficiency, Chronic, Tenapanor, Creatinine, Sulfonamides, Proteinuria, business.industry, Sodium-Hydrogen Exchanger 3, Phosphorus, Sodium, Calcinosis, General Medicine, medicine.disease, Phosphate, Isoquinolines, Gastrointestinal Tract, Disease Models, Animal, Endocrinology, Basic Research, chemistry, Nephrology, medicine.symptom, business
-
10
المؤلفون: Noah Bell, Kenji Kozuka, Jeffrey W. Jacobs, David P. Rosenbaum, Kristin M. Joly, Marc Navre, Limin He, Jocelyn Tabora, Christopher Carreras, Dominique Charmot, Samantha Koo-McCoy, Andrew Spencer, Eric Labonte, Michael R. Leadbetter, Jill Kohler, Craig F. Plato
المصدر: Science Translational Medicine. 6
مصطلحات موضوعية: Male, medicine.medical_specialty, Sodium-Hydrogen Exchangers, Sodium, chemistry.chemical_element, Angiotensin-Converting Enzyme Inhibitors, Blood Pressure, Kidney, Nephrectomy, Rats, Sprague-Dawley, Electrolytes, Feces, chemistry.chemical_compound, Dogs, Enalapril, Internal medicine, medicine, Albuminuria, Animals, Humans, Intestinal Mucosa, Renal Insufficiency, Chronic, Sodium Chloride, Dietary, Tenapanor, Sulfonamides, Dose-Response Relationship, Drug, Sodium-Hydrogen Exchanger 3, business.industry, Myocardium, Kidney metabolism, Hypertrophy, General Medicine, Isoquinolines, medicine.disease, Healthy Volunteers, Rats, Intestines, Disease Models, Animal, Endocrinology, Blood pressure, medicine.anatomical_structure, chemistry, Hypervolemia, business, Kidney disease, medicine.drug
-
11
المؤلفون: André Lochter, Zena Werb, Yohei Hirai, Marc Navre, Marina Simian, Mina J. Bissell
المصدر: Scopus-Elsevier
مصطلحات موضوعية: Fibroblast Growth Factor 7, Morphogenesis, Apoptosis, Biology, Matrix metalloproteinase, Fibroblast growth factor, Article, Mice, Plasminogen Activators, Epidermal growth factor, medicine, Animals, Breast, Fibrinolysin, Growth Substances, Molecular Biology, Cells, Cultured, Membrane Glycoproteins, Dose-Response Relationship, Drug, Epidermal Growth Factor, Cell growth, Epithelial Cells, Dipeptides, Actins, Matrix Metalloproteinases, Recombinant Proteins, Cell biology, Fibroblast Growth Factors, Microscopy, Fluorescence, Keratins, Fibroblast Growth Factor 2, Matrix Metalloproteinase 3, Hepatocyte growth factor, Cell Division, Protein Binding, Signal Transduction, Developmental Biology, Morphogen, medicine.drug
-
12
المصدر: Journal of Biological Chemistry. 276:10788-10793
مصطلحات موضوعية: chemistry.chemical_classification, Protease, Phage display, medicine.diagnostic_test, medicine.medical_treatment, Proteolysis, Proteolytic enzymes, Substrate (chemistry), Peptide, Cell Biology, Biochemistry, Chemical kinetics, Enzyme, chemistry, medicine, Molecular Biology
-
13
المؤلفون: Mathew Smith, Marc Navre, Goutam Das, Lihong Shi, Nita Roy, Sriram Padmanabhan
المصدر: Protein Expression and Purification. 16:324-330
مصطلحات موضوعية: Signal peptide, Saccharomyces cerevisiae, Chromatography, Affinity, Pichia, Pichia pastoris, law.invention, law, Humans, Secretion, Collagenases, Cloning, Molecular, Gene, Polyacrylamide gel electrophoresis, DNA Primers, Cloning, Base Sequence, biology, Chemistry, biology.organism_classification, Molecular biology, Recombinant Proteins, Matrix Metalloproteinase 9, Biochemistry, Chromatography, Gel, Recombinant DNA, Electrophoresis, Polyacrylamide Gel, Biotechnology
-
14
المؤلفون: John A. Tainer, Marc Navre, Gary S. Coombs, Jean-Luc Pellequer, Edwin L. Madison, Scott I. Baker, Robert C. Bergstrom, Matthew M. Smith, David R. Corey
المساهمون: University of Texas Southwestern Medical Center [Dallas], The Scripps Research Institute - La Jolla (TSRI), The Scripps Research Institute
المصدر: Chemistry and Biology
Chemistry and Biology, Elsevier, 1998, 5 (9), pp.475-488. ⟨10.1016/S1074-5521(98)90004-7⟩مصطلحات موضوعية: Models, Molecular, Phage display, Protein Conformation, [SDV]Life Sciences [q-bio], Molecular Sequence Data, Clinical Biochemistry, urologic and male genital diseases, Peptide Mapping, Biochemistry, Substrate Specificity, 03 medical and health sciences, 0302 clinical medicine, Terminology as Topic, substrate phage display, Consensus Sequence, Drug Discovery, Biomarkers, Tumor, medicine, [CHIM]Chemical Sciences, Chymotrypsin, Humans, prostate-specific antigen, Amino Acid Sequence, Binding site, Molecular Biology, Peptide sequence, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, Pharmacology, Serine protease, 0303 health sciences, biology, Hydrolysis, protease specificity, General Medicine, Kallikrein, Trypsin, Molecular biology, Peptide Fragments, Kinetics, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, subsite occupancy, Semenogelin, medicine.drug
-
15
المؤلفون: Marc Navre
المصدر: Expert Opinion on Investigational Drugs. 7:1257-1271
مصطلحات موضوعية: Pharmacology, Drug discovery, Chemical diversity, Compound management, Pharmacology (medical), General Medicine, Biology, Antimicrobial, Healthcare providers, Combinatorial chemistry, Antimicrobial drug
-
16
المؤلفون: Dinesh V. Patel, Xiao-Yi Xiao, Lihong Shi, Marc Navre, David Campbell, Jerauld S. Skotnicki, Loran M. Killar, Michele A. Sharr, John F. DiJoseph, Jeremy I. Levin
المصدر: Bioorganic & Medicinal Chemistry Letters. 8:1163-1168
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Matrix Metalloproteinase Inhibitors, Matrix metalloproteinase, Biochemistry, Chemical synthesis, Stromelysin 1, Structure-Activity Relationship, Drug Discovery, Protease Inhibitors, Sulfhydryl Compounds, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Chemistry, Organic Chemistry, Enantioselective synthesis, Diastereomer, Metalloendopeptidases, Succinates, Ketones, In vitro, Kinetics, Enzyme, Matrix Metalloproteinase 9, Enzyme inhibitor, Alcohols, Drug Design, biology.protein, Molecular Medicine, Indicators and Reagents, Matrix Metalloproteinase 1
-
17Malonyl α-mercaptoketones and α-mercaptoalcohols, a new class of matrix metalloproteinase inhibitors
المؤلفون: David A. Harris, Loran M. Killar, Michele A. Sharr, Xiao-Yi Xiao, David Tien, Lihong Shi, Dinesh V. Patel, David Alan Campbell, Jeremy I. Levin, Jerauld S. Skotnicki, Reza Mortezaei, John F. DiJoseph, Marc Navre, Satoru Ida, Yongwen Wang, Christina Louise Leone, Khehyong Ngu
المصدر: Bioorganic & Medicinal Chemistry Letters. 8:1157-1162
مصطلحات موضوعية: Matrix metalloproteinase inhibitor, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Matrix Metalloproteinase Inhibitors, Matrix metalloproteinase, Hydroxamic Acids, Biochemistry, Chemical synthesis, Stromelysin 1, Structure-Activity Relationship, Drug Discovery, Protease Inhibitors, Sulfhydryl Compounds, Molecular Biology, chemistry.chemical_classification, Binding Sites, Molecular Structure, biology, Chemistry, Organic Chemistry, Metalloendopeptidases, Ketones, In vitro, Kinetics, Zinc, Enzyme, Matrix Metalloproteinase 9, Enzyme inhibitor, Alcohols, Drug Design, biology.protein, Thiol, Molecular Medicine, Matrix Metalloproteinase 1
-
18
المؤلفون: Edwin L. Madison, Marc Navre, David R. Corey, Song Hua Ke, Kathy Tachias, Gary S. Coombs
المصدر: Journal of Biological Chemistry. 272:16603-16609
مصطلحات موضوعية: Urokinase, Proteases, Phage display, Substrate (chemistry), Cell Biology, Biology, Biochemistry, Serine, medicine, Consensus sequence, Molecular Biology, Peptide sequence, Plasminogen activator, medicine.drug
-
19
المؤلفون: Linda C. Giudice, Juan C. Irwin, Marc Navre, D. Kirk, P. Cannon, R. B. L. Gwatkin
المصدر: Journal of Clinical Investigation. 97:438-447
مصطلحات موضوعية: medicine.medical_specialty, Metalloproteinase, Stromal cell, media_common.quotation_subject, General Medicine, Matrix metalloproteinase, Biology, Endometrium, Extracellular matrix, Blot, Endocrinology, medicine.anatomical_structure, Internal medicine, medicine, Secretion, Menstrual cycle, media_common
-
20
المؤلفون: Marc Navre, Gary S. Coombs, Edwin L. Madison, David R. Corey, Leif Strandberg, Li Ding
المصدر: Proceedings of the National Academy of Sciences. 92:7627-7631
مصطلحات موضوعية: Inovirus, Databases, Factual, medicine.medical_treatment, Proteolysis, Molecular Sequence Data, Peptide, Tissue plasminogen activator, Substrate Specificity, Escherichia coli, medicine, Amino Acid Sequence, Cloning, Molecular, Peptide sequence, chemistry.chemical_classification, Multidisciplinary, Protease, Base Sequence, biology, medicine.diagnostic_test, biology.organism_classification, Molecular biology, Amino acid, Kinetics, Oligodeoxyribonucleotides, chemistry, Biochemistry, Tissue Plasminogen Activator, Peptides, Oligopeptides, Plasminogen activator, Research Article, medicine.drug