المؤلفون: Meena V, Patel, Hillary M, Peltier, Mark A, Matulenko, John R, Koenig, Marc J, C Scanio, Rebecca J, Gum, Odile F, El-Kouhen, Meagan M, Fricano, Greta L, Lundgaard, Torben, Neelands, Xu-Feng, Zhang, Cenchen, Zhan, Madhavi, Pai, Nayereh, Ghoreishi-Haack, Thomas, Hudzik, Gary, Gintant, Ruth, Martin, Steve, McGaraughty, Jun, Xu, Daniel, Bow, John C, Kalvass, Philip R, Kym, David A, DeGoey, Michael E, Kort

المصدر: Bioorganicmedicinal chemistry. 63

مصطلحات موضوعية: Structure-Activity Relationship, Humans, Pain, Pain Management, Protein Isoforms, Sodium Channels

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::cd1fb7249454a3a0f2ca17d9cb54dd42
https://pubmed.ncbi.nlm.nih.gov/35436748

المؤلفون: Wenqing Gao, Robert J. Altenbach, Gang Zhao, John R. Koenig, Greszler Stephen N, Searle Xenia B, Gregory A. Gfesser, Hong Yong, Corina Balut, Marc J. C. Scanio, Yihong Fan, Michael R. Schrimpf, Philip R. Kym, Timothy A. Vortherms, Andrew M. Swensen, Bo Liu, Arlene M. Manelli, Ying Jia, Xueqing Wang, Chris Tse, Andrew Bogdan, Ashvani K. Singh

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, 010405 organic chemistry, business.industry, Organic Chemistry, Genetic disorder, medicine.disease, 01 natural sciences, Biochemistry, Cystic fibrosis, Transmembrane protein, 0104 chemical sciences, Cftr gene, 010404 medicinal & biomolecular chemistry, Drug Discovery, Cancer research, Medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418648a24d9417696c73d206f53310b2
https://doi.org/10.1021/acsmedchemlett.9b00377

المؤلفون: Marc J C, Scanio, Xenia B, Searle, Bo, Liu, John R, Koenig, Robert J, Altenbach, Gregory A, Gfesser, Andrew, Bogdan, Stephen, Greszler, Gang, Zhao, Ashvani, Singh, Yihong, Fan, Andrew M, Swensen, Timothy, Vortherms, Arlene, Manelli, Corina, Balut, Wenqing, Gao, Hong, Yong, Michael, Schrimpf, Chris, Tse, Philip, Kym, Xueqing, Wang

المصدر: Bioorganic & Medicinal Chemistry Letters. 72:128843

مصطلحات موضوعية: Cystic Fibrosis, Proline, Organic Chemistry, Clinical Biochemistry, Cystic Fibrosis Transmembrane Conductance Regulator, Pharmaceutical Science, Biochemistry, Structure-Activity Relationship, Mutation, Drug Discovery, Humans, Molecular Medicine, Benzodioxoles, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a2a884faa7901f5e486831d30b03cd
https://doi.org/10.1016/j.bmcl.2022.128843

المؤلفون: Meena V. Patel, Hillary M. Peltier, Mark A. Matulenko, John R. Koenig, Marc J. C. Scanio, Rebecca J. Gum, Odile F. El-Kouhen, Meagan M. Fricano, Greta L. Lundgaard, Torben Neelands, Xu-Feng Zhang, Cenchen Zhan, Madhavi Pai, Nayereh Ghoreishi-Haack, Thomas Hudzik, Gary Gintant, Ruth Martin, Steve McGaraughty, Jun Xu, Daniel Bow, John C. Kalvass, Philip R. Kym, David A. DeGoey, Michael E. Kort

المصدر: Bioorganic & Medicinal Chemistry. 63:116743

مصطلحات موضوعية: Organic Chemistry, Clinical Biochemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Molecular Biology, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9360aff00f3964aaceb6096c8ef6bab3
https://doi.org/10.1016/j.bmc.2022.116743

المؤلفون: Brett Antonio, Robert J. Gregg, Gricelda H. Simler, Matthew S Johnson, Yi Liu, Dong Liu, Marc J. C. Scanio, Prisca Honore, Alison Knox, James B. Thomas, Shailen K. Joshi, Mark L. Chapman, Brian E. Marron, Irene Drizin, Douglas S. Krafte, Connie R. Faltynek, Robert N. Atkinson, Xu-Feng Zhang, Michael J. Krambis, Kort Michael E, Michael F. Jarvis, Stephen Werness, Kennan C. Marsh, Lei Shi, Char-Chang Shieh

المصدر: Bioorganic & Medicinal Chemistry. 18:7816-7825

مصطلحات موضوعية: Clinical Biochemistry, Analgesic, Drug Evaluation, Preclinical, Administration, Oral, Pharmaceutical Science, Pharmacology, Biochemistry, Sodium Channels, NAV1.8 Voltage-Gated Sodium Channel, Structure-Activity Relationship, Sodium channel blocker, Oral administration, In vivo, Ganglia, Spinal, Microsomes, Drug Discovery, Animals, Humans, Molecular Biology, Neurons, Chemistry, Sodium channel, Organic Chemistry, Rats, Blockade, Disease Models, Animal, Nociception, Pyrazines, Neuropathic pain, Neuralgia, Molecular Medicine, Sodium Channel Blockers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ebd1fee852efa5ef6ea85bd394f0b15
https://doi.org/10.1016/j.bmc.2010.09.057

المؤلفون: Rosemarie Roeloffs, Stephen Werness, Brian E. Marron, Chengmin Zhong, Brett Antonio, Ahmed H. Hakeem, Irene Drizin, Char-Chang Shieh, Mark L. Chapman, Joseph P. Mikusa, Marc J. C. Scanio, James B. Thomas, Shailen K. Joshi, Dong Liu, Mark A. Matulenko, Douglas S. Krafte, Robert N. Atkinson, Lei Shi, Kennan C. Marsh, Gricelda H. Simler, Matthew S Johnson, Michael J. Krambis, Kort Michael E, Michael F. Jarvis, Xu-Feng Zhang, Robert J. Gregg, Connie R. Faltynek, Matthew A. Secrest, Prisca Honore

المصدر: Bioorganic & Medicinal Chemistry Letters. 20:6812-6815

مصطلحات موضوعية: Niacinamide, Stereochemistry, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Pharmacology, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Sodium channel blocker, Furan, Drug Discovery, Animals, Structure–activity relationship, Molecular Biology, Nicotinamide, Sodium channel, Organic Chemistry, Rats, Bioavailability, chemistry, Neuropathic pain, Molecular Medicine, Linker, Sodium Channel Blockers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a0d6b9da5e44daf33aabb753a354c07
https://doi.org/10.1016/j.bmcl.2010.08.121

المؤلفون: Jennifer M. Frost, Marc J. C. Scanio, Jens Halvard Grønlien, Jianguo Ji, Tao Li, Kirsten Thorin-Hagene, William H. Bunnelle, Hilde Ween, David J. Anderson, Lei Shi, Michael Meyer, Tino Dyhring, Karin R. Tietje, Dan Peters

المصدر: Journal of Medicinal Chemistry. 52:4126-4141

مصطلحات موضوعية: Cation binding, Binding Sites, alpha7 Nicotinic Acetylcholine Receptor, Chemistry, Stereochemistry, Diamines, Receptors, Nicotinic, Ligands, Ligand (biochemistry), Cell Line, Rats, Substrate Specificity, Structure-Activity Relationship, Nicotinic acetylcholine receptor, Nicotinic agonist, Drug Discovery, Animals, Humans, Molecular Medicine, Structure–activity relationship, Pyrroles, Nicotinic Agonists, Binding site, Receptor, Acetylcholine receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f95edc1f13156802b50953a488364939
https://doi.org/10.1021/jm900249k

المؤلفون: Marc J. C. Scanio, Kort Michael E, Mark A. Matulenko

المصدر: Current Topics in Medicinal Chemistry. 9:362-376

مصطلحات موضوعية: business.industry, Sodium channel, Sodium, Chronic pain, Pain, chemistry.chemical_element, Sensory system, General Medicine, Pharmacology, medicine.disease, Sodium Channels, Pathophysiology, Peripheral, Structure-Activity Relationship, Sodium channel blocker, chemistry, Drug Discovery, medicine, Humans, Voltage-Gated Sodium Channel Blockers, business, Ion Channel Gating, Sodium Channel Blockers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ad1ace59d9b19415cc2389e1f7fd55
https://doi.org/10.2174/156802609788317883

المؤلفون: Matthew S Johnson, Dong Liu, Robert J. Gregg, Irene Drizin, Michael F. Gross, Gricelda Hernandez, Kennan C. Marsh, James B. Thomas, Mark L. Chapman, Chang Z. Zhu, Brian E. Marron, Connie R. Faltynek, Shailen K. Joshi, Prisca Honore, Stephen Werness, Michael E. Kort, Douglas S. Krafte, Robert N. Atkinson, Rosemarie Roeloffs, William A. Carroll, Marc J. C. Scanio, Xu-Feng Zhang, Donna M. Gauvin, Michael J. Krambis, Michael F. Jarvis, Char-Chang Shieh, Lei Shi, Joseph P. Mikusa

المصدر: Bioorganic & Medicinal Chemistry. 16:6379-6386

مصطلحات موضوعية: Male, Clinical Biochemistry, Analgesic, Pharmaceutical Science, Lamotrigine, Pharmacology, Biochemistry, Piperazines, Sodium Channels, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Sodium channel blocker, Mexiletine, Drug Discovery, medicine, Animals, Humans, Potency, Furans, Molecular Biology, Voltage-gated ion channel, Chemistry, Sodium channel, Organic Chemistry, Analgesics, Non-Narcotic, Ether-A-Go-Go Potassium Channels, Rats, Neuropathic pain, Neuralgia, Molecular Medicine, Sodium Channel Blockers, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bdfd333e1e1c8103d37b0c3b7e0a15f
https://doi.org/10.1016/j.bmc.2008.05.003

المؤلفون: William A Carroll, Chengmin Zhong, Stephen Werness, Jinrong Liu, Matthew S Johnson, Lei Shi, Michael F Jarvis, James B. Thomas, Xu-Feng Zhang, Mark L. Chapman, Michael F. Gross, Shailen Joshi, Michael E. Kort, Marc J. C. Scanio, Dong Liu, Robert J Gregg, Rosemarie Roeloffs, Prisca Honore, Gricelda Hernandez, Gregory J Pacofsky, Douglas S. Krafte, Robert N. Atkinson, Brian E. Marron, Irene I. Drizin, Kennan C Marsh, Joseph P Mikusa, Michael J. Krambis, Bernard P Murray, Char-Chang Shieh, Connie R. Faltynek

المصدر: Journal of Medicinal Chemistry. 51:407-416

مصطلحات موضوعية: Male, Patch-Clamp Techniques, Stereochemistry, Analgesic, hERG, Pain, Nerve Tissue Proteins, Inflammation, In Vitro Techniques, Pharmacology, Sodium Channels, Cell Line, NAV1.8 Voltage-Gated Sodium Channel, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Cricetulus, Sodium channel blocker, Cricetinae, Ganglia, Spinal, Drug Discovery, medicine, Animals, Humans, Furans, Neurons, Analgesics, biology, Chemistry, Sodium channel, Anti-Inflammatory Agents, Non-Steroidal, Chronic pain, Peripheral Nervous System Diseases, medicine.disease, Amides, Recombinant Proteins, Rats, Neuropathic pain, Systemic administration, biology.protein, Molecular Medicine, medicine.symptom, Sodium Channel Blockers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4dee5ae6db88bda78289080d9f0fe12
https://doi.org/10.1021/jm070637u

المؤلفون: Travis J. Williams, Paul A. Wender, Robert D. Hubbard, Robert Sun, Francis Gosselin, F. Christopher Bi, Lei Zhang, Gabriel G. Gamber, Marc J. C. Scanio

المصدر: Pure and Applied Chemistry. 74:25-31

مصطلحات موضوعية: Ideal (set theory), Transition metal, General interest, Chemistry, General Chemical Engineering, Intramolecular force, Organic chemistry, General Chemistry, Ring (chemistry), Combinatorial chemistry, Cycloaddition, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::62cabac60cf324dea8751b8eb2e333c8
https://doi.org/10.1351/pac200274010025

المؤلفون: Marc J. C. Scanio, William H. Bunnelle, Lei Shi, Kennan C. Marsh, David J. Anderson, Ceclia E Van Handel, Murali Gopalakrishnan, John Malysz, Rosalind J. Helfrich, Chih-Hung Lee, Kirsten Thorin-Hagene

المصدر: Journal of medicinal chemistry. 54(21)

مصطلحات موضوعية: Agonist, Pyrrolidines, medicine.drug_class, Stereochemistry, Pyridines, Stereoisomerism, Carboxamide, In Vitro Techniques, Receptors, Nicotinic, Ligands, chemistry.chemical_compound, Radioligand Assay, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, Nicotinic Agonists, Receptor, Octane, Neurons, Chemistry, Ligand, Brain, Bridged Bicyclo Compounds, Heterocyclic, Recombinant Proteins, Rats, Drug Partial Agonism, Nicotinic acetylcholine receptor, HEK293 Cells, Pyrazines, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33bce6ecc104bbc475e0aeede1211751
https://pubmed.ncbi.nlm.nih.gov/21962147

المؤلفون: Di Zhang, Sridhar Peddi, Marc J. C. Scanio, Prisca Honore, Betty B. Yao, Carol S. Surowy, Jyoti R. Patel, David A. DeGoey, Zhi Wang, Murali Gopalakrishnan, Xu-Feng Zhang, Rama Thimmapaya, Arturo Perez-Medrano, John L. Baranowski, David J. Anderson

المصدر: Journal of neuroscience methods. 200(1)

مصطلحات موضوعية: Membrane potential, KCNQ Potassium Channels, Chemistry, General Neuroscience, Retigabine, HEK 293 cells, Channel modulator, Molecular Pharmacology, Pharmacology, Phenylenediamines, Potassium channel, KCNQ3 Potassium Channel, chemistry.chemical_compound, HEK293 Cells, Mutation, Biophysics, Homomeric, Humans, KCNQ2 Potassium Channel, Carbamates, Thallium, Selectivity, Ion Channel Gating

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6663b4b058e8b729f991789ccae8f9cd
https://pubmed.ncbi.nlm.nih.gov/21723881

المؤلفون: Marc J. C. Scanio, Gabriel G. Gamber, Paul A. Wender

المصدر: Angewandte Chemie. 113:4013-4015

مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Bicyclic molecule, Simple (abstract algebra), Component (thermodynamics), Organic chemistry, General Chemistry, General Medicine, Chemoselectivity, Undecane, Catalysis, Cycloaddition, Stereocenter

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::815151253a87cc74edb3d13a400c615f
https://doi.org/10.1002/1521-3757(20011015)113:20<4013::aid-ange4013>3.0.co;2-j

المؤلفون: Marc J. C. Scanio, Paul A. Wender, Craig O. Husfeld, Alaric J. Dyckman

المصدر: ChemInform. 31

مصطلحات موضوعية: Metal, Chemical engineering, Scale (ratio), Chemistry, Component (UML), visual_art, visual_art.visual_art_medium, chemistry.chemical_element, General Medicine, Carbon, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::79498113977d81c6a74ce1184e36e361
https://doi.org/10.1002/chin.200036074

المؤلفون: Marc J. C. Scanio, Gabriel G. Gamber, Paul A. Wender

المصدر: ChemInform. 33

مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Bicyclic molecule, Component (thermodynamics), Simple (abstract algebra), General Medicine, Undecane, Combinatorial chemistry, Stereocenter

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::99fc65c37a0a49a916049b631fa54fbb
https://doi.org/10.1002/chin.200206036

المؤلفون: Robert D. Hubbard, Marc J. C. Scanio, Paul A. Wender, Travis J. Williams, Lei Zhang, F. Christopher Bi, Francis Gosselin, Robert Sun, Gabriel G. Gamber

المصدر: ChemInform. 33

مصطلحات موضوعية: Ideal (set theory), General interest, Transition metal, Chemistry, Intramolecular force, General Medicine, Ring (chemistry), Combinatorial chemistry, Cycloaddition, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::aa271ba718a555fdd5faf90ee370dc9e
https://doi.org/10.1002/chin.200241295

المؤلفون: Marc J. C. Scanio, Craig O. Husfeld, Alaric J. Dyckman, Paul A. Wender

المصدر: Organic Letters. 2:1609-1611

مصطلحات موضوعية: Component (thermodynamics), Organic Chemistry, chemistry.chemical_element, Biochemistry, Cycloaddition, Catalysis, Metal, chemistry, visual_art, Reagent, visual_art.visual_art_medium, Organic chemistry, Physical and Theoretical Chemistry, Carbon

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::776c273aec8b8396300b7d4ddc86e569
https://doi.org/10.1021/ol0058691

المؤلفون: Michael E. Kort, Prisca Honore, Marc J. C. Scanio, Arthur Gomtsyan, Robert G. Schmidt, Michael F. Jarvis, S.K. Joshi, Gricelda Hernandez

المصدر: The journal of pain. 10(3)

مصطلحات موضوعية: Male, Pain Threshold, Substance-Related Disorders, Freund's Adjuvant, TRPV1, Pain, TRPV Cation Channels, Nerve Tissue Proteins, Pharmacology, Sodium Channels, NAV1.8 Voltage-Gated Sodium Channel, Rats, Sprague-Dawley, In vivo, Threshold of pain, Antinociceptive Agents, Medicine, Animals, Urea, Furans, Pain Measurement, Inflammation, Analgesics, Aniline Compounds, Dose-Response Relationship, Drug, business.industry, Chronic pain, Antagonist, medicine.disease, Isoquinolines, Rats, Disease Models, Animal, Anesthesiology and Pain Medicine, Nociception, Spinal Nerves, Treatment Outcome, Neurology, Neuropathic pain, Neurology (clinical), business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3d76d65f133ca7ce92ed72966ba92a
https://pubmed.ncbi.nlm.nih.gov/19070548

المؤلفون: Marc J. C. Scanio, Michael F. Jarvis, Connie R. Faltynek, Steve McGaraughty, Michael E. Kort, Katharine L. Chu

المصدر: The Journal of pharmacology and experimental therapeutics. 324(3)

مصطلحات موضوعية: Agonist, Male, medicine.drug_class, Resiniferatoxin, TRPV1, Pain, Nerve Tissue Proteins, Pharmacology, Synaptic Transmission, Sodium Channels, NAV1.8 Voltage-Gated Sodium Channel, Rats, Sprague-Dawley, Transient receptor potential channel, chemistry.chemical_compound, Sodium channel blocker, Dorsal root ganglion, medicine, Premovement neuronal activity, Animals, Furans, Pain Measurement, Aniline Compounds, Chemistry, Sodium channel, Rats, medicine.anatomical_structure, Spinal Nerves, nervous system, Molecular Medicine, Neuroscience, Sodium Channel Blockers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fbffd099476938fb292de045364a270
https://pubmed.ncbi.nlm.nih.gov/18089840