المؤلفون: Wheatley, K., Holt, G., Owens, C., Valteau-Couanet, D., Gambart, M., Castel, V., Van Eijkelenburg, N., Castellano, A., Nysom, K., Gerber, N., Laureys, G., Ladenstein, R., Makin, Guy W J, Vaidya, S., Thebaud, E., Kearns, P., Pearson, A., Moreno, L.

المساهمون: University of Birmingham, Cancer Research Uk Clinical Trials Unit, Birmingham, United Kingdom

Relation: Wheatley K, Holt G, Owens C, Valteau-Couanet D, Gambart M, Castel V, et al. Randomized comparisons of bevacizumab(B) and irinotecan(I),added to temozolomide(T), in children with relapsed/refractory high-risk neuroblastoma(RR-HRNB); survival results of the ITCC-SIOPEN beacon-neuroblastoma phase 2 trial. Pediatric Blood & Cancer. 2020;67:S31-S; http://hdl.handle.net/10541/623616; Pediatric Blood & Cancer

الاتاحة: http://hdl.handle.net/10541/623616

المؤلفون: Casanova, M., Bautista, F., Campbell-Hewson, Q., Makin, Guy W J, Marshall, L. V., Verschuur, A., Nieto, A. C., Corradini, N., Ploeger, B., Mueller, U., Zebger-Gong, H., Chung, J., Geoerger, B.

المساهمون: Fondazione IRCCS Istituto Nazionale dei Tumori, Pediatric Unit, Milano, Italy

Relation: Casanova M, Bautista F, Campbell-Hewson Q, Makin GWJ, Marshall LV, Verschuur A, et al. Phase 1 study of regorafenib in combination with vincristine and irinotecan in pediatric patients with recurrent or refractory solid tumors. Pediatric Blood & Cancer. 2020;67:S20-S; http://hdl.handle.net/10541/623614; Pediatric Blood & Cancer

الاتاحة: http://hdl.handle.net/10541/623614

المؤلفون: Bate, J, Baker, S, Breuer, J, Chisholm, J, Gray, J, Hambleton, S, Houlton, A, Jit, M, Lowis, S, Makin, Guy W J, O'Sullivan, C, Patel, S, Phillips, R, Ransinghe, N, Ramsay, M, Skinner, R, Wheatley, K, Heath, P

المساهمون: Department of Paediatric Oncology, University Hospital Southampton NHS Foundation Trust, Southampton, UK

Relation: PEPtalk2: results of a pilot randomised controlled trial to compare VZIG and aciclovir as postexposure prophylaxis (PEP) against chickenpox in children with cancer. 2018, Arch Dis Child; http://hdl.handle.net/10541/621033; Archives of disease in childhood

الاتاحة: http://hdl.handle.net/10541/621033
https://doi.org/10.1136/archdischild-2017-314212

المؤلفون: Amoroso, L, Erminio, G, Makin, Guy W J, Pearson, A, Brock, P, Valteau-Couanet, D, Castel, V, Pasquet, M, Laureys, G, Thomas, C, Luksch, R, Ladenstein, R, Haupt, R, Garaventa, A

المساهمون: Paediatric Oncology, Istituto Giannina Gaslini, Genova, Italy

Relation: Topotecan-Vincristine-Doxorubicin in stage 4 high-Risk neuroblastoma patients failing to achieve a complete metastatic response to rapid COJEC: A SIOPEN study. 2018, 50 (1):148-155 Cancer Res Treat; http://hdl.handle.net/10541/620873; Cancer Research and Treatment

الاتاحة: http://hdl.handle.net/10541/620873
https://doi.org/10.4143/crt.2016.511

المؤلفون: Basta, N, Halliday, G, Makin, Guy W J, Birch, J, Feltbower, R, Bown, N, Elliott, M, Moreno, L, Barone, G, Pearson, A, James, P, Tweddle, D, McNally, R

المساهمون: Institute of Health & Society, Newcastle University, Newcastle upon Tyne, UK

Relation: Factors associated with recurrence and survival length following relapse in patients with neuroblastoma. 2016, 115 (9):1048-1057 Br J Cancer; http://hdl.handle.net/10541/620024; British Journal of Cancer

الاتاحة: http://hdl.handle.net/10541/620024
https://doi.org/10.1038/bjc.2016.302

المؤلفون: Adamski, J K, Price, Andrew, Dive, Caroline, Makin, Guy W J

المساهمون: Clinical and Experimental Pharmacology, Paterson Institute for Cancer Research, Manchester, United Kingdom, Institute of Cancer Sciences, Manchester Cancer Research Centre, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom, Department of Paediatric Oncology, Royal Manchester Children's Hospital, Manchester, United Kingdom.

Relation: Hypoxia-induced cytotoxic drug resistance in osteosarcoma is independent of HIF-1alpha.2013, 8 (6):e65304 PLoS One; http://hdl.handle.net/10541/297408; PLoS One

الاتاحة: http://hdl.handle.net/10541/297408

المؤلفون: Holt, Sarah V., Brookes, Karen E., Dive, Caroline, Makin, Guy W J

المصدر: Holt , S V , Brookes , K E , Dive , C & Makin , G W J 2011 , ' Down-regulation of XIAP by AEG35156 in paediatric tumour cells induces apoptosis and sensitises cells to cytotoxic agents ' , Oncology Reports , vol. 25 , no. 4 , pp. 1177-1181 . https://doi.org/10.3892/or.2011.1167

مصطلحات موضوعية: Apoptosis, Cytotoxic agents, Paediatric cancer, XIAP, ResearchInstitutes_Networks_Beacons/mcrc, Manchester Cancer Research Centre

الاتاحة: https://research.manchester.ac.uk/en/publications/0ef64938-3f9d-4bed-bb6d-9720f21874f0
https://doi.org/10.3892/or.2011.1167
http://www.spandidos-publications.com/serveFile/or.2011.1167_AOP_PDF.pdf?type=article&article_id=or_25_4_1177&item=PDF

المؤلفون: Klymenko, Tetyana, Brandenburg, Martin, Morrow, Christopher J, Dive, Caroline, Makin, Guy W J

المساهمون: Clinical and Experimental Pharmacology Group, Paterson Institute for Cancer Research, Manchester, United Kingdom.

مصطلحات موضوعية: Antineoplastic Agents, Apoptosis, Biphenyl Compounds, Cell Hypoxia, Cell Line, Tumor, Drug Evaluation, Preclinical, Drug Resistance, Neoplasm, Gene Expression Regulation, Neoplastic, Humans, Neuroblastoma, Nitrophenols, Nuclear Proteins, Oncogene Proteins, Oxygen, Piperazines, Proto-Oncogene Proteins c-bcl-2, Sulfonamides, Treatment Outcome

Relation: The novel Bcl-2 inhibitor ABT-737 is more effective in hypoxia and is able to reverse hypoxia-induced drug resistance in neuroblastoma cells. 2011, 10 (12):2373-83 Mol Cancer Ther; http://hdl.handle.net/10541/245052; Molecular Cancer Therapeutics

الاتاحة: http://hdl.handle.net/10541/245052
https://doi.org/10.1158/1535-7163.MCT-11-0326

المؤلفون: Harrison, Luke R, Micha, Dimitra, Brandenburg, Martin, Simpson, Kathryn L, Morrow, Christopher J, Denneny, Olive, Hodgkinson, Cassandra L, Yunus, Zaira, Dempsey, Clare E, Roberts, Darren L, Blackhall, Fiona H, Makin, Guy W J, Dive, Caroline

المساهمون: Clinical and Experimental Pharmacology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, United Kingdom.

مصطلحات موضوعية: Animals, Anoxia, Apoptosis, Biphenyl Compounds, Cell Line, Tumor, Down-Regulation, Drug Resistance, Neoplasm, Drug Screening Assays, Antitumor, Humans, Inhibitory Concentration 50, Male, Mice, Neoplasm Transplantation, Neoplasms, Nitrophenols, Peptide Fragments, Piperazines, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-bcl-2, Sulfonamides

Relation: Hypoxic human cancer cells are sensitized to BH-3 mimetic–induced apoptosis via downregulation of the Bcl-2 protein Mcl-1. 2011, 121 (3):1075-87 J. Clin. Invest.; http://hdl.handle.net/10541/204710; Journal of Clinical Investigation

الاتاحة: http://hdl.handle.net/10541/204710
https://doi.org/10.1172/JCI43505

المؤلفون: Dean, Emma J, Ward, Timothy H, Pinilla, C, Houghten, R, Welsh, K, Makin, Guy W J, Ranson, Malcolm R, Dive, Caroline

المساهمون: Department of Clinical and Experimental Pharmacology, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, England, UK 2 Derek Crowther Unit, Christie Hospital NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, England, UK.

مصطلحات موضوعية: XIAP Antagonist Compound, XIAP, Apoptosis, Non-Small-Cell Lung Cancer

Relation: A small molecule inhibitor of XIAP induces apoptosis and synergises with vinorelbine and cisplatin in NSCLC. 2009: Br. J. Cancer; http://hdl.handle.net/10541/87700; British Journal of Cancer

الاتاحة: http://hdl.handle.net/10541/87700
https://doi.org/10.1038/sj.bjc.6605418

المؤلفون: Hussein, Deema, Holt, Sarah V, Brookes, K E, Klymenko, T, Adamski, J K, Hogg, Alison, Estlin, E J, Ward, Timothy H, Dive, Caroline, Makin, Guy W J

المساهمون: Clinical and Experimental Pharmacology Group, Paterson Institute for Cancer Research, Manchester, UK.

مصطلحات موضوعية: Childhood Cancer, Bone Cancer, Cell Line Tumour, Animals, Antineoplastic Agents, Alkylating, Antineoplastic Combined Chemotherapy Protocols, Apoptosis, Aziridines, Benzoquinones, Bone Neoplasms, Cell Growth Processes, Cell Line, Tumor, Child, Cisplatin, Diphtheria Toxin, Doxorubicin, Drug Screening Assays, Antitumor, Drug Synergism, Humans, Mice, Inbred BALB C, Nude, NAD(P)H Dehydrogenase (Quinone), Neuroblastoma, Osteosarcoma, Sarcoma, Ewing's

Relation: Preclinical efficacy of the bioreductive alkylating agent RH1 against paediatric tumours. 2009, 101 (1):55-63 Br. J. Cancer; http://hdl.handle.net/10541/87534; British Journal of Cancer

الاتاحة: http://hdl.handle.net/10541/87534
https://doi.org/10.1038/sj.bjc.6605100

المؤلفون: Adamski, Jennifer, Steggall, Margaret, Yeoh, Kar Xian, Sutton, Rachel, Makin, Guy W J

المصدر: Adamski , J , Steggall , M , Yeoh , K X , Sutton , R & Makin , G W J 2008 , ' Outcome of gram negative infection in immunocompromised children ' , Pediatric Blood and Cancer , vol. 51 , no. 4 , pp. 499-503 . https://doi.org/10.1002/pbc.21587

مصطلحات موضوعية: Chemotherapy, Children, Gram negative infection, Neutropenia, Stem cell transplantation

الاتاحة: https://research.manchester.ac.uk/en/publications/5c4ade49-b9c2-44ec-b6cb-4392920db1a2
https://doi.org/10.1002/pbc.21587

المؤلفون: Adamski, J K, Estlin, Edward J, Makin, Guy W J

المساهمون: School of Cancer and Imaging Studies, Faculty of Medical and Human Studies, University of Manchester, United Kingdom. JAdamski@picr.man.ac.uk

مصطلحات موضوعية: Hypoxia, Childhood Cancer, Novel Agents, Adaptation, Physiological, Cell Hypoxia, Child, Drug Delivery Systems, Drug Resistance, Neoplasm, Energy Metabolism, Genomic Instability, Humans, Hypoxia-Inducible Factor 1, Neoplasms, Neovascularization, Pathologic, Signal Transduction

Relation: The cellular adaptations to hypoxia as novel therapeutic targets in childhood cancer. 2008, 34 (3):231-46 Cancer Treat. Rev.; http://hdl.handle.net/10541/55813; Cancer Treatment Reviews

الاتاحة: http://hdl.handle.net/10541/55813
https://doi.org/10.1016/j.ctrv.2007.11.005

المؤلفون: Hussein, Deema, Estlin, Edward J., Dive, Caroline, Makin, Guy W J

المصدر: Hussein , D , Estlin , E J , Dive , C & Makin , G W J 2006 , ' Chronic hypoxia promotes hypoxia-inducible factor-1-α-dependent resistance to etoposide and vincristine in neuroblastoma cells ' , Molecular Cancer Therapeutics , vol. 5 , no. 9 , pp. 2241-2250 . https://doi.org/10.1158/1535-7163.MCT-06-0145

مصطلحات موضوعية: ResearchInstitutes_Networks_Beacons/mcrc, Manchester Cancer Research Centre

الاتاحة: https://research.manchester.ac.uk/en/publications/bc44c433-e400-4873-b761-5198cde06e7e
https://doi.org/10.1158/1535-7163.MCT-06-0145

المؤلفون: Edge, B, Holmes, D, Makin, Guy W J

المساهمون: Faculty of Medical and Human Sciences, University of Manchester, UK.

مصطلحات موضوعية: Cancer, Adolescent, Adult, Age Factors, Anxiety, Attitude to Health, Cryopreservation, England, Fertility, Health Knowledge, Attitudes, Practice, Humans, Male, Neoplasms, Patient Acceptance of Health Care, Patient Education as Topic, Professional-Patient Relations, Questionnaires, Sperm Banks

Relation: Sperm banking in adolescent cancer patients. 2006, 91 (2):149-52 Arch. Dis. Child.; http://hdl.handle.net/10541/72540; Archives of Disease in Childhood

الاتاحة: http://hdl.handle.net/10541/72540
https://doi.org/10.1136/adc.2005.075242

المؤلفون: Howell, Lisa, Mensah, Adjoa, Brennan, Bernadette M, Makin, Guy W J

المساهمون: Department of Pediatric Oncology, Royal Manchester Children's Hospital, Pendlebury, Manchester, United Kingdom.

مصطلحات موضوعية: Cancer Invasiveness, Cancer Recurrence, Cancer Staging, Cancer, Age Distribution, Child, Preschool, Cohort Studies, Disease-Free Survival, Female, Humans, Incidence, Infant, Magnetic Resonance Imaging, Male, Neoplasm Invasiveness, Neoplasm Recurrence, Local, Neoplasm Staging, Neoplasms, Retrospective Studies, Risk Assessment, Sex Distribution, Survival Analysis, Tomography, X-Ray Computed

Relation: Detection of recurrence in childhood solid tumors. 2005, 103 (6):1274-9 Cancer; http://hdl.handle.net/10541/74923; Cancer

الاتاحة: http://hdl.handle.net/10541/74923
https://doi.org/10.1002/cncr.20896

المؤلفون: Makin, Guy W J, Eden, Tim O B

مصطلحات موضوعية: Cancer, Child, Humans, Medical Oncology, Neoplasms, Pediatrics, Randomized Controlled Trials as Topic, Research

Relation: The success of paediatric oncological research. 2001, 62 (10):588-9 Hosp Med; http://hdl.handle.net/10541/84071; Hospital Medicine

الاتاحة: http://hdl.handle.net/10541/84071

المؤلفون: Makin, Guy W J, Eden, Tim O B, Lashford, Linda S, Moppett, John, Gerrard, Mary P, Davies, Helena A, Powell, Colin V, Campbell, Alastair N, Child, H Frances

المساهمون: Academic Unit of Pediatric Oncology, Christie Hospital NHS Trust, Withington, Manchester, United Kingdom.

مصطلحات موضوعية: Skin Cancer, Central Nervous System Cancer, Central Nervous System Neoplasms, Child, Preschool, Fatal Outcome, Female, Humans, Male, Melanoma, Nevus, Pigmented, Skin Neoplasms

Relation: Leptomeningeal melanoma in childhood. 1999, 86 (5):878-86 Cancer; http://hdl.handle.net/10541/88014; Cancer

الاتاحة: http://hdl.handle.net/10541/88014
https://doi.org/10.1002/(SICI)1097-0142(19990901)86:5<878::AID-CNCR26>3.0.CO;2-Y

المؤلفون: Makin, Guy W. J., Eden, Osborn B., Lashford, Linda S., Moppett, John, Gerrard, Mary P., Davies, Helena A., Powell, Colin V. E., Campbell, Alastair N., Child, H. Frances

المصدر: Cancer ; volume 86, issue 5, page 878-886 ; ISSN 0008-543X 1097-0142

الاتاحة: http://dx.doi.org/10.1002/(sici)1097-0142(19990901)86:5%3C878::aid-cncr26%3E3.0.co%3B2-y
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2F(SICI)1097-0142(19990901)86:5%3C878::AID-CNCR26%3E3.0.CO%3B2-Y
https://onlinelibrary.wiley.com/doi/full/10.1002/(SICI)1097-0142(19990901)86:5%3C878::AID-CNCR26%3E3.0.CO%3B2-Y